CN108261534A - A kind of Chinese medicine that tumour knurl is promoted to wither away and preparation method thereof - Google Patents

A kind of Chinese medicine that tumour knurl is promoted to wither away and preparation method thereof Download PDF

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CN108261534A
CN108261534A CN201810097535.3A CN201810097535A CN108261534A CN 108261534 A CN108261534 A CN 108261534A CN 201810097535 A CN201810097535 A CN 201810097535A CN 108261534 A CN108261534 A CN 108261534A
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parts
radix
chinese
blood
chinese medicine
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刘晓宁
刘翠娥
薄惠
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Huanghe Science and Technology College
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Huanghe Science and Technology College
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The present invention relates to the field of Chinese medicines:Particularly a kind of Chinese medicine that tumour knurl is promoted to wither away and preparation method thereof.For the deficiency of the traditional Chinese medical science ulcer theory on treatment tumour of the prior art:The present invention is from proposing a kind of method of new treatment tumour;Its technical solution solved the problems, such as is:By following parts by weight:10 15 parts of oxhide gelatin, 68 parts of tribulus terrestris, 15 20 parts of Radix Astragali, 20 30 parts of Chinese herbaceous peony, 68 parts of Rhizoma Atractylodis Macrocephalae, 35 parts of Fructus Aurantii, 68 parts of the tuber of dwarf lilyturf, 20 30 parts of radix rehmanniae recen, 36 parts of Rhizoma Chuanxiong, 35 parts of Chinese cassia tree, 20 30 parts of gypsum, 8 10 parts of radix scutellariae, 10 15 parts of Fructus Forsythiae, 69 parts of lophatherum gracile, 5 10 parts of radix achyranthis bidentatae, 10 15 parts of pangolin, 68 parts of ginger juice, 10 15 parts of Bulbus Allii Fistulosi, 68 parts of Radix Glycyrrhizae are made.Drug therapy of the present invention can promote the extinction of the knurl of tumour, and toxic side effect is small, and treatment is definite, and medical expense is low.

Description

A kind of Chinese medicine that tumour knurl is promoted to wither away and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines:Particularly a kind of Chinese medicine that tumour knurl is promoted to wither away and preparation method thereof.
Background technology
Carbuncle is the acute festering type disease sent out between skin and muscle;Carbuncle be hair in skin and thicker muscle it Between acute festering type disease, easily spread to deep and surrounding, shape such as honeycomb belongs to yang syndrome mostly;Deep abscess be hair in bone and The purulence ulcer of muscle depths, skin lesion appearing without definite location, belong to mostly it is difficult disappear, it is difficult burst, difficult hold back and chronic cloudy card.
Due to blood-head, high blood pressure, bleeding can not absorb, and occur as soon as redness, red and swollen blood stasis corruption is just raw malicious, this is with regard to shape Into heat toxin.The overabundance of yang is exactly heat, and excess heat is exactly fire, and it is exactly poison that fire, which is contained, toxic then to give birth to ulcer.It is sun by the ulcer that the overabundance of yang is given birth to Ulcer, by sun declines, the ulcer that cold sensation of the genitalia, blood clotting are given birth to is cloudy ulcer.
Described in The Yellow Emperor's Canon of Internal Medicine:" Yellow Emperor, a legendary ruler day is remaining to hear stomach by paddy, part of the body cavity above the diaphragm housing the heart and lungs outlet, with warm boundary between muscles, and nourishing the bone section, lead to the natural fibre line of meat Reason.Middle coke outlet is as revealed, and upper note slits paddy, and oozes grandson's arteries and veins, body fluid and tune, variation and it is red for blood, blood and then grandson's arteries and veins elder generation spill-over, be It notes in channels, is all full of, be to note in passages through which vital energy circulates.Negative and positive have been opened, and because breath is that row is named, row has manager, and week is reasonable, must not with day contract Stop.It cuts and adjusts it, reality is gone from void, rush down then insufficient.Then gas subtracts disease, stays then successively.Void is gone from real, benefit is then had a surplus.Vim and vigour are It adjusts, shape gas is to hold.Remaining known vim and vigour it is flat with uneven, extremely the phase of life, there is distance in the institute of unknown ulcer when the life, success or failure, How it is spent, can must be heard
Qi uncle says passages through which vital energy circulates and stays row more than, unison with day, conforms to discipline with ground.Therefore day place mistake degree, the thin erosion of life, ground are recorded through losing, water Road slime flux, not into drawing, five cereals do not grow careless tawny daylily, and pathway is obstructed, and the people do not come and go, Xiang Ju Yi Ju, then take leave of different place, and vim and vigour still, please Say its event.Fu Xuemaiying is defended, and circumfluence endlessly, above answers constellation, down should be through number.Cold-evil visitor among channels and collaterals then weep by blood, and blood is wept then Obstructed, general rule does not defend gas and returns it, must not be anti-again, therefore carbuncle swells.Cold air turns to heat, and then slough, rottenness of muscle forming pus, purulence do not rush down heat victory Then rotten muscle, the rotten then injury of the bone of muscle, then marrow disappears bone fracture, and improper bone is empty, must not diarrhea, blood depletion is hollow, then bones muscle is not mutually flourish, warp Arteries and veins loses leakage, smokes in the five internal organs, and dirty wound event is dead.”
Cancer card is divided into carcinoma in situ (primary carcinoma) and invades profit cancer.Carcinoma in situ refer to epithelial malignancy be confined to skin or It in mucous membrane, is not invaded by the basilar memebrane below skin or mucous membrane to surrounding tissue also, is the earliest period of cancer card, therefore also known as 0 Phase cancer.Carcinoma in situ is such as not treated in time, then can develop into infiltrating carcinoma.The formation of tumour first consists in the qi depression to blood stasis of body, Including:Cold sensation of the genitalia qi depression to blood stasis;What blood was heated decocts, and concentrates and blood stasis;Blood-heat bleeding, bleeding form blood stasis;Or the deficiency of yang is not taken the photograph The blood stasis that blood and bleeding are formed.
By ulcer and cancer at the generation position of human body, the origin cause of formation it was found that ulcer have with cancer it is much similar common Logical part, cancer start to be equivalent to grow the ulcer on skin or mucous membrane.The traditional Chinese medical science is also the treatment zone of cancer to the treatment of ulcer Enlightenment is carried out:
Traditional traditional Chinese medical science thinks:The ulcer of surgery is divided into negative and positive, can respectively with the vertical soup that disappears (honeysuckle, dandelion, when Return, radix scrophulariae);
The magical effect (work() Tuoli dissipates (honeysuckle, Radix Astragali, Radix Angelicae Sinensis, Radix Glycyrrhizae);
Disinfection is sacred red (honeysuckle, dandelion, Radix Angelicae Sinensis, Radix Glycyrrhizae, root of Chinese trichosanthes);
The Eight Immortals dissipate malicious soup (honeysuckle, Radix Astragali, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Paeoniae Alba, Radix Rehmanniae, cultivated land, root of Chinese trichosanthes);
Secret recipe Tuoli dissipates (honeysuckle, Radix Astragali, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Paeoniae Alba, cultivated land, root of Chinese trichosanthes, Snakegourd Fruit, spina gleditsiae) and negative and positive are led to Control red (honeysuckle, Radix Angelicae Sinensis, plantain seed, Radix Glycyrrhizae, cloudy disease add monkshood), Yanghe Tang,Yang-Activating Decoction (deer horn glue, cultivated land, baked ginger, Chinese cassia tree, Chinese ephedra, in vain Mustard seed, licorice) etc. treatments.
Patent of invention:A kind of drug for treating tumour ulcer and preparation method thereof application number: 200610102160.2
The object of the present invention is to provide a kind of external used medicines for treating tumour ulcer, directly outer using this drug Illing skin is spread on, acts on skin, detoxification dissipates, and achievees the purpose that treatment.
In the drug of present invention treatment tumour pain subcutaneous ulcer illness, the raw material that active constituent is made is matched by following weight Component composition:Radix Astragali 15-30, Chinese violet 15-30, coptis 50-80, akebi 20-50, pangolin 20-50, calomel mercurous chloride 2-8, Moschus 1-5, honeycomb 20-50, minium 100-400, dandelion 10-30, honeysuckle flower 20-50, kuh-seng 15-30, spina gleditsiae 20-50, dragon's blood 2-8, toad 2-8, rosin 50-80, beeswax 100-400, lard 800-1500.
The present invention is according to theory of traditional Chinese medical science, it is believed that and the generation of sore, furuncle and carbuncle is mostly because the heresy of damp and hot poison is affixed one's name in impression, internal organs accumulated heat, Accumulate in skin or because damaging skin, malicious heresy is taken advantage of a loophole intrusion, visitor in passages through which vital energy circulates, cause qi and blood stagnation, fire toxin stagnation and send out, with the passing of time accumulate Knurl is polymerized to, the drug to relieve the pain in the treatment using promoting blood circulationization addiction, resolving mass and swelling, detumescence, with acupuncture-stimulating blood stasis dispersing, the reason of torr sore myogenic By externally applied ointment is made, by the synergistic effect between various drugs, reaches ventilation, invigorate blood circulation, addiction of dispelling, removing toxic substances, dissipate solution lump Purpose, have that the activating blood circulation and dispersing blood clots of highly significant, the effect of swelling and pain relieving and poly- poison carry purulence, clearing heat and detoxicating, detoxification, prevent poison The effect that heresy is wandered away.
Patent of invention:A kind of formula 201610124633.2 for the treatment of cancer tumour prescription
The invention discloses the formulas for the treatment of cancer tumour prescription, are prepared by following raw material by weight:Radix Angelicae Sinensis 30-50 grams, 30-50 grams of sky dragon, 55-75 grams of leech, tortoise pulls 55-70 grams, 50-75 grams of turtle shell, full 30-50 grams of worm, centipede 30- 55,40-75 grams of pangolin, 50-75 grams of Sanguis Draxonis, 45-70 grams of frankincense, 50-75 grams of myrrh, 55-75 grams of catechu, cloves 25-50 grams, 40-75 grams of wine army, 35-50 grams of ginseng, 35-50 grams of asafoetide, 25-50 grams of Rhizoma Atractylodis Macrocephalae, 25-50 grams of Radix Astragali.
By rational drug matching, there is softening and resolving hard mass, promoting blood circulation and removing blood stasis, nourishing qi and blood, combat poison with poison and other effects;In Medicine treatment is from entirety, had not only considered the treatment of local tumor, but also whole body physical condition can be improved, and had prevented from swelling The recurrence and transfer of knurl;Radiotherapy chemotherapy is avoided to have suitable side effect to alimentary canal and hemopoietic system.
Patent of invention:A kind of dissipating bind disappears knurl herbal composite and its preparation method and application 201710644098.8
The present invention proposes a kind of dissipating bind and disappears knurl herbal composite, can softening and resolving hard mass, swelling and pain relieving, to various carbuncles Swollen, sore, goitre, knurl have significant curative effect.The present invention also provides the preparation method and application of said herbal medicine composition.
The technical proposal of the invention is realized in this way:A kind of dissipating bind disappears knurl herbal composite, including following parts by weight Several components:3-15 parts of tassel flower, 3-15 parts of Zornia diphylla (Linn.) Pers, oldenlandia diffusa:3-15 parts, 3-15 parts of ground courage head, paris polyphylla 2-10 parts, nine 2-10 parts of sections, 2-10 parts of pseudo-ginseng, 2-10 parts of Radix Angelicae Sinensis, 2-10 parts of Radix Astragali, 2-10 parts of ganoderma lucidum, 2-10 parts of Radix Salviae Miltiorrhizae, pig 2-10 parts of Siberian cocklebur, 2-10 parts of Rhizoma Atractylodis Macrocephalae, 2-10 parts of Radix Curcumae, 2-10 parts of turpentine, 2-10 parts of Rhizoma Chuanxiong, 2-10 parts of method summer, 2-10 parts of almond, 1-3 parts of centipede, 1-3 parts of scorpio, 1-3 parts of green bamboo snake, 1-3 parts of stir-baked SQUAMA MANITIS.
Dissipating bind of the present invention disappears the herbal composite of pain, with reference to clinical experience and Chinese medicine proved recipe, using natural Chinese herbal medicine is formed by Processing methods, has the work(such as promoting blood circulation and removing obstruction in channels, clearing heat and detoxicating, softening and resolving hard mass, swelling and pain relieving, invigorating the spleen dehumidifying Effect.
By above ulcer, tumour Chinese traditional treatment method can be seen that:All it is the ulcer according to the traditional Chinese medical science, tumour is generally former Reason:Follow softening and resolving hard mass, promoting blood circulation and removing blood stasis, nourishing qi and blood, combat poison with poison expeling ulcer, tumour are the effective of anti-curing oncoma more The basic theories of measure.
Although ulcer theory brings enlightenment to the treatment of tumour, certain effect is also achieved however, inventor It is found by long-term clinical practice:Treat tumour according to this traditional ulcer therapy, the basic cause of disease, the interpretation of the cause, onset and process of an illness, In terms of the state of an illness, excessively it is conceived to symptom performance.Reason and essential problem are not solved, knurl has temporarily got control, but easily Recurrence.
And treating malignant tumor, use is promoting blood circulation and removing blood stasis, if method of combatting poison with poison is improper, cannot not only receive expected effect Fruit can increase disease severity instead.Tumour is the cell of itself mutation, is not external ingredient.In case of this Situation, then the state of an illness of malignant tumour cannot not only control, and can also encourage growth, and sb.'s illness took a turn for the worse so as to make.
Invention content
For the deficiency of the traditional Chinese medical science ulcer theory on treatment tumour of the prior art:The present invention is from clinical research;It obtains: Stagnation of blood stasis is a kind of as a result, being not essence and reason can't outargue to ulcer and tumour.So as to propose a kind of new treatment The method of tumour;It can promote the extinction of the knurl of tumour, the technical solution solved the problems, such as is:
A kind of Chinese medicine that tumour knurl is promoted to wither away:There are following parts by weight:
10-15 parts of oxhide gelatin, 6-8 parts of tribulus terrestris, 15-20 parts of Radix Astragali, 20-30 parts of Chinese herbaceous peony, 6-8 parts of Rhizoma Atractylodis Macrocephalae, Fructus Aurantii 3-5 Part, 6-8 parts of the tuber of dwarf lilyturf, 20-30 parts of radix rehmanniae recen, 3-6 parts of Rhizoma Chuanxiong, 3-5 parts of Chinese cassia tree, 20-30 parts of gypsum, 8-10 parts of radix scutellariae, Fructus Forsythiae 10-15 parts, 6-9 parts of lophatherum gracile, 5-10 parts of radix achyranthis bidentatae, 10-15 parts of pangolin, 6-8 parts of ginger juice, 10-15 parts of Bulbus Allii Fistulosi, Radix Glycyrrhizae 6-8 parts are made.
Preferably:10-13 parts of oxhide gelatin, 6-7 parts of tribulus terrestris, 15-18 parts of Radix Astragali, 20-25 parts of Chinese herbaceous peony, 6-7 parts of Rhizoma Atractylodis Macrocephalae, 3-4 parts of Fructus Aurantii, 6-7 parts of the tuber of dwarf lilyturf, 20-25 parts of radix rehmanniae recen, 3-5 parts of Rhizoma Chuanxiong, 3-4 parts of Chinese cassia tree, 20-25 parts of gypsum, radix scutellariae 8-9 Part, 10-12 parts of Fructus Forsythiae, 6-8 parts of lophatherum gracile, 5-8 parts of radix achyranthis bidentatae, 10-12 parts of pangolin, 6-7 parts of ginger juice, Bulbus Allii Fistulosi 10-13 Part, 6-7 parts of Radix Glycyrrhizae are made.
Further preferably:13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, 25 parts of radix rehmanniae recen, 5 parts of Rhizoma Chuanxiong, 4 parts of Chinese cassia tree, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, bosom 8 parts of the root of bidentate achyranthes, 12 parts of pangolin, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae are made.
Plurality of Chinese dosage form can be made in the present invention, and the Chinese medicinal material active ingredient of Chinese medicine preparation is pressed with pharmaceutical carrier appoints Meaning ratio forms, and wherein active ingredient, which accounts for weight ratio, to be 0.1-99.9%, and it can be 99.9- that pharmaceutical carrier, which accounts for weight ratio, 0.1%.Pharmaceutical carrier can be starch, dextrin, protein sugar, sugarcane ward off, superfine silica gel powder, refined honey or other common carriers.
Decoction preparation method is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae The water of 2 times of weight of addition is boiled with strong fire to change and is cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, radix scutellariae, Fructus Forsythiae, lophatherum gracile, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the oxhide gelatin toast for adding corresponding weight had done finely ground powder both It can.
Process for producing granula is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae The water of 2 times of weight of addition is boiled with strong fire to change and is cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, radix scutellariae, Fructus Forsythiae, lophatherum gracile, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the dry finely ground powder of oxhide gelatin toast for adding corresponding weight is dense It shortens relative density 1.35 or so (80 DEG C heat survey) thick medicinal extract into, is dried in vacuo, crush, add in appropriate pharmaceutical carrier mixing, 75% Alcohol is pelletized, dry, is packed to obtain the final product.
Wherein:
Heat toxin seriously adds 20-30 parts of honeysuckle, 20-30 parts of dandelion;
Qi stagnation blood stasis seriously adds 5-8 parts of Radix Curcumae, 10-15 parts of Radix Salviae Miltiorrhizae;
The deficiency of liver-yin and kidney-yin seriously adds 15-20 parts of the fruit of glossy privet, 10-12 parts of American Ginseng;
Lump difficulty, which disappears, adds 8-10 parts of spina gleditsiae, 8-10 parts of semen brassicae,
Drug therapy tumour toxic side effect of the present invention is small, almost without bone marrow suppression, the heart, liver, kidney, gastrointestinal lesions;Have really Real therapeutic effect, and majority is the end-stage patients that Western medicine can not treat;Medical expense is low, when reaching similary curative effect, controls Treat 1/50th to ten for taking and being only chemotherapy, performing the operation.
Specific embodiment
The content of invention is further detailed with reference to embodiments:
Embodiment one
A kind of Chinese medicine that tumour knurl is promoted to wither away:There are following parts by weight:
10 parts of oxhide gelatin, 6 parts of tribulus terrestris, 15 parts of Radix Astragali, 20 parts of Chinese herbaceous peony, 6 parts of Rhizoma Atractylodis Macrocephalae, 3 parts of Fructus Aurantii, 6 parts of the tuber of dwarf lilyturf, life 20 parts of glutinous rehmannia, 3 parts of Rhizoma Chuanxiong, 20 parts of gypsum, 8 parts of radix scutellariae, 10 parts of Fructus Forsythiae, 6 parts of lophatherum gracile, 5 parts of radix achyranthis bidentatae, wear mountain at 3 parts of Chinese cassia tree 10 parts of first, 6 parts of ginger juice, 10 parts of Bulbus Allii Fistulosi, 6 parts of Radix Glycyrrhizae are made;
Decoction preparation method is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae The water of 2 times of weight of addition is boiled with strong fire to change and is cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, radix scutellariae, Fructus Forsythiae, lophatherum gracile, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the oxhide gelatin toast for adding corresponding weight had done finely ground powder both It can.
Embodiment two
A kind of Chinese medicine that tumour knurl is promoted to wither away:There are following parts by weight:
15 parts of oxhide gelatin, 8 parts of tribulus terrestris, 20 parts of Radix Astragali, 30 parts of Chinese herbaceous peony, 8 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Fructus Aurantii, 8 parts of the tuber of dwarf lilyturf, life 30 parts of glutinous rehmannia, 6 parts of Rhizoma Chuanxiong, 30 parts of gypsum, 10 parts of radix scutellariae, 15 parts of Fructus Forsythiae, 9 parts of lophatherum gracile, 10 parts of radix achyranthis bidentatae, are worn at 5 parts of Chinese cassia tree 15 parts of naze, 8 parts of ginger juice, 15 parts of Bulbus Allii Fistulosi, 8 parts of Radix Glycyrrhizae are made;
Decoction preparation method is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae The water of 2 times of weight of addition is boiled with strong fire to change and is cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, radix scutellariae, Fructus Forsythiae, lophatherum gracile, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the oxhide gelatin toast for adding corresponding weight had done finely ground powder both It can.
Embodiment three
A kind of Chinese medicine that tumour knurl is promoted to wither away:There are following parts by weight:
13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, life 25 parts of glutinous rehmannia, 5 parts of Rhizoma Chuanxiong, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, wear mountain at 4 parts of Chinese cassia tree 12 parts of first, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae are made.
Decoction preparation method is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae The water of 2 times of weight of addition is boiled with strong fire to change and is cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, radix scutellariae, Fructus Forsythiae, lophatherum gracile, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the oxhide gelatin toast for adding corresponding weight had done finely ground powder both It can.
Example IV
A kind of Chinese medicine that tumour knurl is promoted to wither away:There are following parts by weight:
13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, life 25 parts of glutinous rehmannia, 5 parts of Rhizoma Chuanxiong, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, wear mountain at 4 parts of Chinese cassia tree 12 parts of first, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae are made;
Process for producing granula is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae The water of 2 times of weight of addition is boiled with strong fire to change and is cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, radix scutellariae, Fructus Forsythiae, lophatherum gracile, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the dry finely ground powder of oxhide gelatin toast for adding corresponding weight is dense It shortens relative density 1.35 or so (80 DEG C heat survey) thick medicinal extract into, is dried in vacuo, crush, add in appropriate pharmaceutical carrier mixing, 75% Alcohol is pelletized, dry, is packed to obtain the final product.
Embodiment five
A kind of Chinese medicine that tumour knurl is promoted to wither away:There are following parts by weight:
13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, life 25 parts of glutinous rehmannia, 5 parts of Rhizoma Chuanxiong, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, wear mountain at 4 parts of Chinese cassia tree 12 parts of first, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae, 20 parts of honeysuckle, 20 parts of dandelion are made.
Decoction preparation method is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae The water of 2 times of weight of addition is boiled with strong fire to change and is cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, radix scutellariae, Fructus Forsythiae, lophatherum gracile, honeysuckle, dandelion, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the oxhide gelatin toast for adding corresponding weight had done finely ground powder both It can.
Embodiment six
A kind of Chinese medicine that tumour knurl is promoted to wither away:There are following parts by weight:
13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, life 25 parts of glutinous rehmannia, 5 parts of Rhizoma Chuanxiong, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, wear mountain at 4 parts of Chinese cassia tree 12 parts of first, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae, 5 parts of Radix Curcumae, 12 parts of Radix Salviae Miltiorrhizae;
It is made.
Decoction preparation method is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae, Radix Curcumae, Radix Salviae Miltiorrhizae 2 times of weight of addition water boil with strong fire to change and be cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, radix scutellariae, Fructus Forsythiae, lophatherum gracile, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the oxhide gelatin toast for adding corresponding weight had done finely ground powder both It can.
Embodiment seven
A kind of Chinese medicine that tumour knurl is promoted to wither away:There are following parts by weight:
13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, life 25 parts of glutinous rehmannia, 5 parts of Rhizoma Chuanxiong, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, wear mountain at 4 parts of Chinese cassia tree 12 parts of first, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae, the fruit of glossy privet 15,12 parts of American Ginseng are made.
Decoction preparation method is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae, The water of the fruit of glossy privet 2 times of weight of addition, which boils with strong fire to change, to be cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, meat Osmanthus, radix scutellariae, Fructus Forsythiae, lophatherum gracile, Bulbus Allii Fistulosi, American Ginseng mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the oxhide gelatin toast for adding corresponding weight had done finely ground powder both It can.
Embodiment eight
A kind of Chinese medicine that tumour knurl is promoted to wither away:There are following parts by weight:
13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, life 25 parts of glutinous rehmannia, 5 parts of Rhizoma Chuanxiong, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, wear mountain at 4 parts of Chinese cassia tree 12 parts of first, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae, 10 parts of spina gleditsiae, 10 parts of semen brassicae are made;
Decoction preparation method is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae, The water of spina gleditsiae 2 times of weight of addition is boiled with strong fire to change and is cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, Radix scutellariae, Fructus Forsythiae, lophatherum gracile, semen brassicae, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the oxhide gelatin toast for adding corresponding weight had done finely ground powder both It can.
Comparative example one
Remove on the basis of embodiment 3 formula in tribulus terrestris other without modification.
Comparative example two
Remove on the basis of embodiment 3 formula in oxhide gelatin other without modification.
Comparative example three
Remove on the basis of embodiment 3 formula in Radix Astragali other without modification.
Comparative example four
Remove on the basis of embodiment 3 formula in Chinese herbaceous peony other without modification.
Drug in the present invention:
Oxhide gelatin
Nature and flavor:It is flat sweet;
Channel tropism:Lung, large intestine;
Effect:Help;
Major function:Nourishing Yin and moistening dryness;Nourishing blood and hemoslasis;Activating blood circulation and reducing swelling;Removing toxic substances.It is main:Consumptive disease consumptive lung disease;Cough spitting of blood;Hematemesis; Uterine bleeding;Diarrhea is had blood in stool;Traumatic injury;Skin sore;Burn and scald
Radix Astragali
Nature and flavor:It is sweet, tepor;
Channel tropism:Returns spleen, lung channel;
Effect:Invigorating qi for consolidating superficies, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration, inducing diuresis for removing edema;
It cures mainly:For treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, from juice night sweat, blood deficiency chlorosis, cloudy subcutaneous ulcer It is unrestrained swollen, deficiency of vital energy oedema, Heat Diabetes.
Tribulus terrestris
Nature and flavor:It is bitter, pungent, it puts down;
Channel tropism:Return liver warp;
Effect:Suppressing liver-YANG, soothing liver-qi stagnation, improving eyesight, dispelling wind and arresting itching;
It cures mainly:For dizziness of having a headache, sternal rib pain, alactation, the more tears of hot eyes, rubella itch.
Radix Paeoniae Alba
Nature and flavor:Bitter, acid, is slightly cold;
Channel tropism:Return liver, the spleen channel.
Effect:The moon, soft liver analgesic, suppressing liver-YANG are held back in blood-nourishing;
Rhizoma Atractylodis Macrocephalae
Nature and flavor:Bitter, sweet, warm;
Channel tropism:Returns spleen, stomach;
Effect:Air making-up and spleen enlivening, eliminate dampness and have diuretic effect, hidroschesis, tocolysis;
It cures mainly:For deficiency-weakness of spleen-QI, anorexia and loose stool, phlegm and retained fluid oedema, exterior deficiency spontaneous perspiration, fetal irritability.
The dried immature fruit of citron orange
Nature and flavor:It is bitter, pungent, it is slightly cold;
Channel tropism:Returns spleen, stomach, large intestine channel;
Effect:Relieving stagnant Qi disperse accumulation, resolving sputum remove ruffian;
It cures mainly:It is stagnated for dyspepsia, abdominal pain constipation, weight after rush down dysentery, the phlegm resistance feeling of stuffiness in chest, obstruction of qi in the chest accumulation of pathogens in chest, the prolapse of uterus, under stomach It hangs down, rectal prolapse.
Radix scutellariae
Nature and flavor:Hardship is trembled with fear;
Channel tropism:Return lung, courage, stomach, large intestine channel;
Effect:Heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, tocolysis.
It cures mainly:For damp-warm syndrome, jaundice, rush down dysentery, heat gonorrhea, hyperpyrexia polydipsia, cough with lung heat, blood-head tells nosebleed, carbuncle sore tumefacting virus, tire It is hot uneasy.
Fructus Forsythiae
Nature and flavor:Hardship is slightly cold;
Channel tropism:Return lung, the heart, gallbladder channel;
Effect:It is clearing heat and detoxicating, carbuncle that disappears dissipating bind;
It cures mainly:For affection of exogenous wind-heat, warm disease heating, sore swell and ache curative, scrofula.
The root of bidentate achyranthes
Nature and flavor:Bitter, acid, puts down;
Channel tropism:Return liver, kidney channel;
Effect:Promoting blood circulation, filling liver kidney, strengthening the bones and muscles, promoting diuresis for stranguria are ensuringd proper downward flow of the blood;
It cures mainly:For irregular menstruation, dysmenorrhoea, amenorrhoea, postpartum stasis, injuries from falls as well, soreness of waist and knee joint, lower limb are weak, urine Unfavorable, leaching drips puckery pain, spits blood, bleeding from five sense organs or subcutaneous tissue, dentalgia, aphtha, dizziness of having a headache.
Pangolin
Nature and flavor:It is salty, it is slightly cold;
Channel tropism:Return liver, stomach;
Effect:Invigorate blood circulation, lower breast, detumescence and apocenosis;
It cures mainly:For Amenorrhea , Disorder lumps in the abdomen, alactation, arthralgia pain due to rheumatism, spasm of limbs, carbuncle swells, scrofula subcutaneous nodule.
Rhizoma Chuanxiong
Nature and flavor:It is acrid in flavour and warm in nature;
Channel tropism:Return liver, courage, pericardium channel;
Effect:Blood-activating and qi-promoting, wind-expelling pain-stopping;
It cures mainly:For irregular menstruation, hypochondriac pain, the obstruction of qi in the chest, sore swell and ache curative, traumatic injury, headache, arthralgia pain due to rheumatism.
Gypsum
Nature and flavor:It is pungent, sweet, Great Cold;
Channel tropism:It attaches to the lung and stomach meridians;
Effect:Clearing heat-fire, relieving restlessness are quenched the thirst;
It cures mainly:For warm heat disease high fever polydipsia, lung heat cough and asthma, stomach fire headache, swelling and aching of gum;Sore is burst long, eczema, is scalded Wound.
Lophatherum gracile
Nature and flavor:It is cold in nature, it is sweet in flavor, light;
Channel tropism:The thoughts of returning home, stomach, small intestinl channel;
Effect:Clearing heat and relieving fidgetness, diuresis;
It cures mainly:For property pyreticosis polydipsia, hot urination leaching pain, aphthae.
Radix Ophiopogonis
Nature and flavor:Sweet, slight bitter, is slightly cold;
Channel tropism:Return lung, the heart, stomach;
Effect:Yin nourishing and lung moistening, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire;
It cures mainly:It is thick for cough caused by dryness phlegm, overstrain cough spitting of blood, thirsty and dry pharynx, vexed insomnia.
Radix rehmanniae recen
Nature and flavor:It is sweet, bitter, it trembles with fear;
Channel tropism:The thoughts of returning home, liver and kidney channel;
Effect:Clearing heat and cooling blood, nourishing Yin and promoting production of body fluid;
It cures mainly:For Vexed, tongue is deep red, blood-head tells nosebleed, atropurpureus macula, consumption of YIN caused by febrile disease, drink of quenching one's thirst more.
Chinese cassia tree
Nature and flavor:It is pungent, sweet, heat;
Channel tropism:Return kidney, spleen, the heart, Liver Channel;
Effect:Mends fire supporing yang, eliminating cold to stop pain, warming meridian;
It cures mainly:For the insufficiency of the kidney yang, positive fistula Gong Leng, the cold abdomen of gastral cavity abdomen, arthritis pain in the back, cold hernia stomachache, cold blood stasis, Amenorrhea Dysmenorrhoea, chest impediment and cardialgia.
Ginger
Nature and flavor:It is pungent, tepor;
Channel tropism:Return lung, the spleen channel;
Effect:Inducing sweat and dispelling exogenous evils, warming middle energizer to stop vomiting, warm lung cough-relieving;
It cures mainly:For exterior syndrome due to wind-cold, gastrofrigid vomiting, cough due to wind-cold evil.
Bulbus Allii Fistulosi
Nature and flavor:It is pungent, warm;
Channel tropism:It attaches to the lung and stomach meridians;
Effect:Inducing sweat and dispelling exogenous evils, cold dispelling activate yang;
It cures mainly:For exterior syndrome due to wind-cold, cold sensation of the genitalia abdominal pain.
Radix Glycyrrhizae
Nature and flavor:Sweet and neutral;
Channel tropism:The thoughts of returning home, spleen, lung, stomach;
Effect:It invigorates the spleen and benefits qi, moistens the lung and relieve the cough, it is clearing heat and detoxicating, alleviate analgesic, mitigate pharmacological property;
It cures mainly:For weakness of the spleen and the stomach, shortness of breath and fatigue, palpitation and severe palpitation, cough phlegm is few, pathopyretic ulcer, medicine food poisoning, gastral cavity abdomen Shoot, four limbs contraction pain.
Applicant is obtained by clinical research:As long as the lump at initial stage by promoting blood circulation and removing blood stasis or heat clearing and blood stasis dispersing, makes blood Recycle unimpeded, lump will disappear.However tumour can still recur, and because the basic origin cause of formation still remains, malignant tumour, just Although the performance of the phase state of an illness is light shallow, essence has been extremely serious.To middle and advanced stage, since the growth of tumour makes body It consumes excessively, shows the extremely empty state to decline.This is all from light to heavy by tumour in the overall process by actual arrival void The cause of disease rise a leading dominating role.The cause of disease cannot control, if only taking promoting blood circulation and removing blood stasis, toxic removing, softening and resolving hard mass, with It is vicious be on the rise, vital essence is taken by force, and perverse trend is increasingly flourishing or even can not contain.
The traditional Chinese medical science treats, be particular about fundamentally treated, in pernicious ulcer theory, ulcer always using blood as Disease, and in the state of an illness constitution status of patient, disease property is divided into extremely complex for negative and positive.
The origin cause of formation and development of the present invention by analogy tumour, the performance genetic analysis of ulcer, based on the liver of Traditional Chinese Medicine Lung, QI and blood theory by a large amount of clinical practical proof, adjust:
The present invention is theoretical according to the liver pulmonary air blood of the traditional Chinese medical science:
Doctor Tang of Qing Dynasty ancestor sea exists《Treatise on blood trouble》Middle sermon:" liver storing blood, blood are born in the heart, are for the sea of blood in downlink born of the same parents. The blood on all whole body always regards the sea of blood as eliminate-disorder.The sea of blood is not disturbed, then the blood on the whole body, is pacified therewith invariably.Precise and tiny liver-yang gasification is blood, Qi and blood mutually embraces " three coke of parade, up in space between skin and muscles.”
Qing Dynasty doctor Zhou Xuehai exists《Zhou Shi medicine book series》Middle theory:" the main blood of liver, and gas person is so row blood, the stagnation of the circulation of vital energy then blood Solidifying, the gas in promoting circulation of blood is just with promoting circulation of blood.”
Main gas takes charge of ascending or descending movement of vital Qi altogether in lung, regulating the qi flowing in the channels in liver, the two.Lung governing qi, gas is suitable to be reduced to, drop then mechanism of qi assign, Water channel tonneau;Liver controlling conveyance and dispersion is used with being upgraded to, and rises then that mechanism of qi is fluent, blood vessels circulation, and liver maintains mechanism of qi jointly with lung one rise and one drop Lifting.The gas of the person again, although its master, in lung, root is in kidney, and in liver, gas has tune to have master, receives out its tune, there is liter Have drop, can not it is strongly fragrant, do not stop up, dirty function is enable normally to play.
Oxhide gelatin of the present invention enters lung channel, and has the work(of nourishing Yin and moistening dryness, nourishing blood and hemoslasis, activating blood circulation and reducing swelling removing toxic substances;Radix Astragali is longer than benefit The gas of spleen and lung rises and lifts yang-energy, there is the work(of good promoting pus discharge and tissue regeneration, and two medicines can enhance the removing toxic substances of oxhide gelatin activating blood circulation and reducing swelling with Radix Astragali Property, while oxhide gelatin can be overcome to grow greasy property, be controlled from lung;The pungent scattered hardship of tribulus terrestris is let out, energy soothing liver-qi stagnation, suppressing liver-YANG, The moon is held back in Radix Paeoniae Alba taste sour in taste acting on the liver, blood-nourishing, can suppressing liver-YANG, two medicines are collocated with each other, you can the work(of enhancing tribulus terrestris soothing liver-qi stagnation, together Shi Yike strengthens Radix Paeoniae Alba nourishing blood and liver and holds back the disadvantage that the property of the moon goes its cold and cool, is supported from liver;Radix Astragali, Chinese herbaceous peony share, can tonifying Qi, Regulating qi to disperse stagnation stasis again, four traditional Chinese medicine are arranged in pairs or groups mutually the liver lung people having the same aspiration and interest, and qi and blood syntrophism is monarch drug in a prescription altogether;
Liver controlling conveyance and dispersion, lung governing coordinative activities of viscera, it is smooth that the two is total to main qi and blood tune.Traditional Chinese medicine emphasizes that qi as the commander of blood, blood being the mother of qi, qi and blood It is interdependent.The theory of visceral outward manifestation points out, " blood stored in the liver, liver controlling conveyance and dispersion ";" lung governing qi, control here save out ", the adjusting of the catharsis function, lung of liver Impetus is to personal gas, blood, Tianjin, the operation of essence and defeated cloth all important roles, and therefore, liver lung two is dirty to personal qi and blood It adjusts smooth most important.The spleen being the foundation of acquired constitution source of generating QI and blood, Rhizoma Atractylodis Macrocephalae of the invention, Gan Wen, with the dried immature fruit of citron orange it is pungent it is scattered it is bitter drop, promoting the circulation of qi Power is strong, with using, promotes that air making-up and spleen enlivening effect can be enhanced mutually, makes qi and blood biochemistry active, while can enhance Radix Astragali air making-up and spleen enlivening Work(;The pungent scattered temperature of Rhizoma Chuanxiong is logical, is the gas medicine in blood, can promoting blood circulation relieved pain with menstruation regulating and promote breath and open depression, while with The same work(that can promote Radix Astragali yang invigorating of Radix Astragali, with the same property that can be urged into Radix Paeoniae Alba nourishing blood and liver of Radix Paeoniae Alba, three taste medicines are mutual Phase separation can enhance monarch drug in a prescription air making-up and spleen enlivening, nourishing blood and liver, and it is ministerial drug altogether that tonifying lung, which defends outer work(,;
Ming Dynasty Yuan class volume exists《It is passed by the heart is controlled》In it is described:" husband liver body admittedly rely painstaking effort be foster, and itself thus be general Property, the prestige of imperial phase is posted, with the sheet of kidney-Yang.Deficiecny of liver-YIN is mostly to suffer from admittedly, and liver-yang is also to weight.”
The yang-energy of liver is held back strongly fragrant, it is impossible to which the duty of promoting the circulation of qi, precise and tiny to be bred for blood without gasification, non-blood is then extra Object, be detained part is gradually polymerized to knurl.It is precise and tiny poly- without changing, therefore without coating, also just without constraint, just overgrowing is random, and shape overlaps such as Rock, so referred to as cancer
The root of bidentate achyranthes is nourishing liver and kidney, strong muscles and bones, but can promoting blood circulation and sharp joint, the work(for thering is drop to let out, the fiery and life of inflammation can drop Glutinous rehmannia, gypsum drop the heat of blood system with using, can nourishing blood and liver and suppressing liver-YANG with same use of Radix Paeoniae Alba;Pangolin is apt to walk It alters, with Rhizoma Chuanxiong with using, the power enhancing of promoting blood circulation to remove blood stasis, pangolin has the work(of detumescence and apocenosis, and carbuncle swells can not make to swell into purulence person to disappear, Speed can be made to burst into purulence person, with tribulus terrestris with soothing liver-qi stagnation is used, with the same tonifying Qi and lifting yang of Radix Astragali.Radix Ophiopogonis it is sweet in flavor enter lung, can dry moistening lung, Lung yin is supported, can be relaxed bowel again with radix rehmanniae recen, with being calmed the nerves with energy reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire;Radix rehmanniae recen bitter cold is apt to clear ying blood point Heat evil, energy cooling blood and hemostasis, with Radix Ophiopogonis same sweet cold nourishing Yin and promoting production of body fluid, Chinese cassia tree inclined promoting circulation of blood point has the benefits of warming meridian, same with Radix Astragali To warming YANG and invigorating blood, cold dispelling is led to stagnant, and hot, can mend fire from the gater of life, guiding fire to origin the moon and Yiyang disappears has the work(of mends fire supporing yang. Radix scutellariae, clearing heat-fire, especially kind clearing lung-heat heat, Fructus Forsythiae gently float by clear property, be good at it is clearing heat and detoxicating, especially kind clearing away the heart-fire and dissipate part of the body cavity above the diaphragm housing the heart and lungs wind-heat, even Stick up not only can purging intense heat and detonicating, but also can carbuncle that disappears dissipating bind, acted on the clearing away heat to stop bleeding of Fructus Forsythiae apparatus and removing pattogenic heat from the blood and toxic material from the body.Gypsum pungent sweet Great Cold, clearly Gas purging intense heat diathermanous can be gone out and be expelled the heat-evil in interior with radix rehmanniae recen clearing heat and cooling blood compatibility, gypsum clearing heat-fire and return lung Through for the key medicine of clearing lung-heat, returning stomach, with radix rehmanniae recen, root of bidentate achyranthes compatibility, being longer than rushing down clearly stomach fire.The clear gas purging intense heat class Chinese medicine of lophatherum gracile, Ginger is apt to warm stomach preventing or arresting vomiting, gypsum Great Cold, injuring spleen-stomach yang-energy, and the two is the same as with can overcome the property of gypsum cold sensation of the genitalia to add medicine to mutually Cooperation, system adjusts the negative and positive of the whole body, blood vessels, and can overcome the bias of drug by being collocated with each other for drug, preferably hair The therapeutic effect of drug is waved, treats due to symptoms such as pain caused by cancer, anxieties, is altogether adjutant;
Bulbus Allii Fistulosi temperature leads to cold dispelling, and energy cold dispelling activates yang, and also has detoxication, and with sore and toxic is controlled, Radix Glycyrrhizae can invigorate the spleen and benefit qi, Not only be apt to removing toxic substances, but can heat-clearing can be acted on relieving spasm to stop pain, also tool mitigate pharmacological property, coordinating the drug actions of a prescription work(to make medicine.
The present invention chooses drug by long-term clinical and a large amount of source investigation from numerous Chinese medicine and obtains well Effect,
The present invention by set comparative example and it is similar the effect of drug replacement study Comparison of clinical effect, it is found that Comparative example one, comparative example two, comparative example three, comparative example four are compared with embodiment three, oxhide gelatin in the present invention, tribulus terrestris, Huang It is stilbene, Chinese herbaceous peony, indispensable;Removing the effect of any medicine simply invention can all reduce, and the course for the treatment of is elongated, and inventor was also once With donkey-hide gelatin though to replace oxhide gelatin the two be all the in love product of flesh and blood clinical discovery clinical treatment action deprivation of the present invention, Patient's aggravation replaces Radix Astragali clinical therapeutic efficacy to be deteriorated with Rhizoma Atractylodis Macrocephalae dosage, and treatment cycle lengthens, and occasionally has patient to ache Pain is aggravated, anorexia, the adverse reactions such as hiccup;Only ratio does not work then faster after addition Chinese herbaceous peony, while to limbs fiber crops The symptoms effect such as wood, bedsore becomes apparent from, and moutan bark shares therapeutic effect without strengthening and the vomiting of patient with Chinese herbaceous peony, and diarrhea is not Good reaction occurs now and then, and the present invention is by adding Qi-tonifying drug, and stagnation resolvation medicine, heat-clearing and detoxifying drug, body fluid complementing medicine is all long-term clinic In by constantly adjusting the optimal effectiveness reached.
Clinical observation and curative effect
Liver neoplasm
Pharmaceutical composition of the present invention is to the Inhibition test of tumor cells of hepatocellular carcinoma strain
It is prepared by model:
1st, under aseptic condition, the H22 liver cancer mouses of 8~10d of passage are taken, cervical dislocation is put to death, after skin of abdomen disinfection It cuts off and peels off skin of abdomen, pass through abdominal muscles with empty needle, well-grown ascites of extraction is put into sterile chamber, Put ice cube preservation.Kunming mice is taken, tumor cell suspension 0.2mL/ prepared per the armpit subcutaneous vaccination of mouse forelimb right side is (about Containing 1 × 10/mL of oncocyte), prepare solid tumor models.
2nd, it is grouped:Mouse is randomly divided into control group and test group (embodiment 1, embodiment 2, embodiment by inoculation afterwards for 24 hours 3rd, embodiment 4), every group each 20, the gavage capacity of administration group is relative medicine 0.3mL/10g mouse weights, model control group The physiological saline of gavage isometric(al), 1 times/day, continuous 15 days.
3rd, experimental method:Disconnected neck is selected to put to death experimental group and control group mice respectively, swollen with operating scissors blunt separation Knurl, precision claim knurl weight, tumour inhibiting rate are calculated as follows:Tumour inhibiting rate (%)=(control group average knurl weight-experimental group average knurl weight)/ Control group average knurl weight × 100%.It the results are shown in Table 1.
Quantity (only) Dosage (g/kg) Tumour inhibiting rate (%)
Control group 20 0 ---------
Embodiment 1 20 25 55.6
Embodiment 2 20 25 58.9
Embodiment 3 20 25 75.3
Embodiment 4 20 25 65.3
1 inventive compound of table is to the inhibiting effect of H22 tumour growths
As seen from the above table, the embodiment of the present invention 1, embodiment 2, embodiment 3, embodiment 4 have tumour cell inhibition to make With wherein embodiment 3, embodiment 4 have significant inhibition.
The clinical experimental data of 100 liver cancer patients of pharmaceutical composition of the present invention
1) diagnostic criteria:
2) Western medicine diagnostic criteria revises examining for primary carcinoma of liver in 2001 according to liver cancer Professional Committee of Chinese Anti-Cancer Association Disconnected standard is formulated:
Standards of Chinese Medical Syndrome Differentiation:Reference《New Chinese medicine guideline of clinical investigations》(China Medical Science Press)
2) case inclusion criteria:
Pathological diagnosis:
1. liver histological inspection turns out to be primary carcinoma of liver person;
2. the histological examination of extrahepatic tissue turns out to be hepatocellular carcinoma person;
CM syndrome differentiation criterion:
The upper swollen bored discomfort of abdominal lump, becomes thin weak, and burnout is losed heart, abdominal distention and anorexia, after feed it is swollen very, dry is not liked to drink, greatly Loose stool number, urine Huang is short, ascites, jaundice, edema of lower extremity very then occurs, and tongue nature is fat, tongue fur is white, small and wiry pulse.It is expected that existence is 3 A month or more person.Patient of the age at 18-70 Sui excludes Pregnant and lactant women.
According to above-mentioned standard, 100 liver tumour patients are selected, wherein man 50, female 50 is age 38-65 Sui, average 46 years old.
3) test method:
Patient takes decoction made from the embodiment of the present invention 3,2 times a day.1 month be 1 course for the treatment of, 2 courses for the treatment of of medication.
4) curative effect determinate standard:
It is effective:Cardinal symptom is obviously improved or disappears, and lesion reduces more than 1/2, and continues 1 month or more.
Effectively:Cardinal symptom makes moderate progress or is obviously improved, and lesion reduces more than 1/4, and continues 1 month or more.
In vain:For cardinal symptom without improving or aggravating, lesion is unchanged or develops.
5) treatment results:
Clinical effectiveness show pharmaceutical composition of the present invention have to the treatment of 100 liver cancer patients effective 35, effective 42 Example, total effective rate reach 77%, it is seen that the present invention has obvious therapeutic action to some cases, is a kind of ideal control Treat the drug of liver cancer.
Tumor in digestive tract
Pharmaceutical composition of the present invention is to the Inhibition test of gastric cancer tumor cell strain
It is prepared by model:
1st, kunming mice is taken, under aseptic operation, in glandular stomach mucous membrane face impaling knot containing MC.Knot containing MC is with common Filament after knotting at one end, knot is placed in and is filled in MC vials, is heated slightly on ethyl alcohol lamp, oozes MC liquefaction Enter knot.10~20 lines are immersed in a concentration of 0.05~0.1g 20- methyl cholanthrenes of MC.Operation 4~8 months can after sunkening cord Successfully gastric cancer is induced, prepares solid tumor models.
2nd, it is grouped:Mouse is randomly divided into control group and test group (embodiment 1, embodiment 2, embodiment 3, embodiment 4), every group each 20, the gavage capacity of administration group is the appearances such as relative medicine 0.3mL/10g mouse weights, model control group gavage Long-pending physiological saline, 1 times/day, continuous 15 days.
3rd, experimental method:Disconnected neck is selected to put to death experimental group and control group mice respectively, swollen with operating scissors blunt separation Knurl, precision claim knurl weight, tumour inhibiting rate are calculated as follows:Tumour inhibiting rate (%)=(control group average knurl weight-experimental group average knurl weight)/ Control group average knurl weight × 100%.It the results are shown in Table 2
2 pharmaceutical preparation of the present invention of table is to the inhibiting effect of Gastric Carcinoma Growth
As seen from the above table, the embodiment of the present invention 1, embodiment 2, embodiment 3, embodiment 4 have tumour cell inhibition to make With wherein embodiment 3, embodiment 4 have significant inhibition.
The clinical experimental data of 50 patients with cancer in digestive tract of pharmaceutical composition of the present invention
2.1 general information:
Choose the late digestive tract cancer patient 50 treated in Henan Province's traditional Chinese medical science in April, -2015 in May, 2013 Example, 26~71 years old age, average (44.7 ± 8.5) year;
Gastric cancer 12, cancer of the esophagus 22, colorectal cancer 16;
Clinical stages:III phases 32, IV phases 18;
Tumour cell parting:Gland cancer 24, squamous carcinoma 18, adenosquamous carcinoma 8.
2.2 method:
Patient takes decoction made from the embodiment of the present invention 3,2 doses/d, is decocted in water for oral dose, collecting decoction about 300mL, point morning and evening It warmly takes twice, 1 month as a treatment course, and curative effect is evaluated after 2 months.
2.3 observation index:
(1) clinical efficacy:Clinical efficacy is divided into complete incidence graph (CR), part alleviates (PR), stablizes (SD), progress (PD) 4 grades,
Wherein lesion completely disappear and the time be more than 4 weeks be CR;
And reduction degree preceding significantly lower than treatment is more than after lesion maximum major diameter and maximum perpendicular diameter are multiplied after treatment 50%, other lesions are unchanged, and it is PR that no new lesion time of occurrence, which is more than 4 weeks,;
Lesion maximum major diameter and maximum perpendicular diameter reduce degree less than 50% after being multiplied, increase degree is less than 25%, without new It is SD that lesion time of occurrence, which is more than 4 weeks,;
Lesion maximum major diameter and maximum perpendicular diameter be multiplied after with increase obvious before treatment and degree more than 25% or There is new lesion to occur for PD.Total effective=CR+PR.
(2) changes in immune function:Respectively at taking patient empty stomach peripheric venous blood 3mL before and after treatment, t lymphocyte subset is detected The variation of group (including CD4+, CD8+, CD4+/CD8+).
(3) quality of life:According to pretherapy and post-treatment Cattell score (KPS) situation of change by quality of life be divided into raising, decline, Stablize 3 ranks,
Score increase degree compared with before treatment is not less than 10 points to improve after wherein treating;
Score reduction degree compared with before treatment is not less than 10 points to decline after treatment,
After treatment score with treat before compared between raising and reduction be stable.
2.4 statistical procedures:
Data are handled using 17.0 data softwares of SPSS, measurement data is represented with (xs), is compared and is examined using t, is counted Data is represented with rate (%), is compared and is examined using x2, with P<0.05 represents that difference is statistically significant.
2.5 clinical test results:
(1) patient clinical curative effect:
Clinical efficacy is counted after observation group's treatment, patient's complete incidence graph has 24.00% after taking this medicine, and part, which is alleviated, to be had 44.00%, stablize the state of an illness up to 24.00%, total effective rate reaches 68.00%.
3 clinical efficacy statistical result of table
(2) the comparison of the pretherapy and post-treatment t lymphocyte subset group of patient:
CD4+, CD4+/CD8+ are significantly raised compared with before treatment after observation group's treatment, the statistically significant (P of difference< 0.05);CD8+ is reduced, but no significant difference (P compared with before treatment after observation group's treatment>0.05), result of the test is shown in Table 4;
The comparison (x ± s) of the pretherapy and post-treatment t lymphocyte subset group of 4 patient of table
(3) patients ' life quality improves the comparison of degree:
5 patients ' life quality of table improves the statistical result of degree
Group It improves Decline Stablize
Observation group 25 (50.00%) 10 (20.00%) 15 (30.00%)
After observation group's treatment, quality of life stabilization or the Proportion of patients improved reach 80.00%, it is seen that medicine of the invention Object preparation can be effectively improved patients ' life quality, and the postoperative disease relapse ratio of patient significantly reduces.
Observation of curative effect
For short term effect up to 78% or so, late result also has nearly 52%.And it all takes effect within 3~7 days in medication.
The total of due to weakness of spleen and stomach is 51.2%, and the total of qi stagnation blood stasis type is 78.3%, and liver-kidney yin deficiency is always 73.5%.
" short term effect " refers to:
(1) in 3~7 days, remission or disappearance:Such as pain, numbness, cough, cough of choking, bleeding, intracranial pressure, chest and abdomen Water, expiratory dyspnea, dysphagia, difficult defecation, lump compressing, local swelling, discharge slough etc. reduce (light), stop Or it disappears;
(2) patient mental, muscle power increase, and can participate in certain manual labor or recreation.
(3) sign is alleviated or disappears:As lump quality softens, swelling lightens, hydrops amount is reduced, lymph node softens, becomes smaller Deng;
(4) auxiliary examination:Lump volume becomes smaller or disappears, hydrops is reduced, related antigen index returns drop or restores normal;
(5) quality of life improves:Sleep improvement, diet, daily life, two just can take care of oneself, can carry out general manual labor, Or recreation.
" late result " is:
Refer to the above-mentioned curative effect after treatment and continue 1~2 year even longer time, mass reduction more than half, and can be engaged in certain Manual labor.Main auxiliary examination index, which has, more than moderate to be changed.
Model case
One patient:Liu, 53 years old female patient upper abdomen pain more than 10 years repeatedly, is treated, effect repeatedly by " gastric ulcer " It is bad.Patient is because upper abdomen pain aggravates, and gasteremphraxis, Nausea and vomiting 3 days, gastrocopy is diagnosed as gastric cancer, in October, 2014 The big portion's operation excision of 14 First People's Hospital of Dao cities row stomaches, it is postoperative to send pathologic finding report prompting:The low differentiation gland of lesser curvature Cancer, leaching and placenta percreta, 2 pieces of placenta percreta lymph node have cancer metastasis, start oral chemotherapeutic on October 22nd, 2014, rear to feel It has a delicate constitution, weight loss, solution urine is difficult, and especially night received the symptoms such as poor, weak, constipation for very, in 2014 10 Yue30Lai our hospital treats, and gives Chinese medicine preparation of the present invention, 13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, 25 parts of radix rehmanniae recen, 5 parts of Rhizoma Chuanxiong, 4 parts of Chinese cassia tree, 25 parts of gypsum, 9 parts of radix scutellariae, Fructus Forsythiae 12 Decoction is made in part, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, 12 parts of pangolin, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae:One day 2 Secondary, one time one packet feels that the state of mind is good after patient medication, and antisecosis, appetite increases, and stool and urine is normal, weight gain, After 3 courses for the treatment of of medication, 2 months as a treatment course, is checked to First People's Hospital, no abnormality seen, immunoassay prompting:Cancer embryo resists Original is less than 0.5ng/ml, still adheres to treating at present, and appetite increases, and sleep, complexion is good, weight gain, supreme abdominal pain Sense, multiple comprehensive review do not find relapse and metastasis sign.
One patient:Often certain, female 18 years old, at the beginning of 2013, it is found that body skin is itched, from the beginning of being that epidermis a millet occurs Grain is to pisiformis waxy lesser tubercle, and epidermis is quite hard, and the skin on surface is slightly to lower recess.It is soft that patient smears erythromycin Cream, PIKANGWANG etc. do not have effect;On April 12nd, 2013 is to our hospital, diagnosis:Tubercle expands mutually fusion, is formed waxy Brown, yellowish-brown or dim grey scab are formed in the dish type patch of gloss, center, occur ulcer under scab, formed round, ellipse or Not shaping ulcer, size differ in size from nail cover to copper coin, and ulcer edge is solid and rolls, and be often translucent shape and convex Recessed not flat bottoms are in pearl-like or waxy appearance, and it is entirely that scab is covered to damage surface sometimes.It festers slowly around and deep Extension, just like damaged by rats shape, is diagnosed as basal-cell carcinoma;Give Chinese medicine preparation of the present invention, 13 parts of oxhide gelatin, 7 parts of tribulus terrestris, Huang 18 parts of stilbene, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, 25 parts of radix rehmanniae recen, 5 parts of Rhizoma Chuanxiong, 4 parts of Chinese cassia tree, gypsum 25 Part, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, 12 parts of pangolin, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, Radix Glycyrrhizae 7 Part, 20 parts of honeysuckle, 20 parts of dandelion are made decoction and take;Simultaneously agent soup Herbal medicines for external use is stained with towel;Carcinoma tissue after 7 days Start necrosis to come off, continue medication 1 month, the surface of a wound heals substantially, then continuous use 2 months, symptom recovery from illness.It is returned after half a year It visits, does not recur.
One patient:Mr. Wang, female, 30 years old, cadre.On June 16th, 2006 is to hospital, and patient was on November 20th, 2005 Certain hospital Hang You breast cancer local excision.Postoperative row " CAF " scheme chemotherapy 3 times, it is medicinal:CTX、ACM、5-FU.It is anti-after chemotherapy Should be very big, epilation, waist is ached, and CT, which is looked into, to be shown:Bone tumour.Go to our hospital symptoms include:It walks and shakes.Left breast is outside upper Side touches the about big matter hard tubercle of jujube, a depressed nipple and gently rubs, and flows out yellow liquid, and that hears is tasteless, has no color liquid. Deep thready pulse slightly chord number.Give Chinese medicine preparation of the present invention, 13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, Rhizoma Atractylodis Macrocephalae 7 parts, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, 25 parts of radix rehmanniae recen, 5 parts of Rhizoma Chuanxiong, 4 parts of Chinese cassia tree, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, 12 parts of pangolin, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae, 5 parts of Radix Curcumae, 12 parts of Radix Salviae Miltiorrhizae; Decoction is made:2 times a day, one time one packet, two examine (July 1 the same year):Spirit is shaken greatly after medicine, and no significant discomfort has the soreness of waist only, Left breast lump does not disappear, and eumenorrhea is risen, and urine is slightly yellow, and tongue vein is the same.13 days three November of the same year examines, and lump in breast is It eliminates.ECT bone scanning no abnormality seens, effect are very aobvious.To follow-up in July, 2007, no abnormality seen is as healthy as usual.
One patient:Women, it is pungent certain, female, 53 years old.On July 8th, 2015 treats because of operation of liver cancer.In art on November 8th, 05 After recur.Tumor size 5.7 × 3.2cm, AFP800.And have moderate ascites, come institute of traditional Chinese medicine and go to a doctor.Clinical diagnosis is:Recurrence Property liver cancer.Symptoms include:Right flank flank pain, body are become thin, and spirit is poor, weak, receives difference, ascites, big loose stool, the micro- Huang of urine.It examines It controls:Tongue nature has ecchymosis, and color is livid purple, yellow and greasy fur, and arteries and veins moistens late.This disease is after Liver Cancer Operation, heresy contains weakened body resistance, deficient qi and blood, middle coke transporting Have no right, raw in mental disorder, water-damp not being transformed, with the passing of time disease is strongly fragrant to change thermal resistance blood, because of the stasis of blood, poison is evil to be tied under poly- rib vim and vigour.Give Chinese medicine of the present invention Preparation, 13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, Radix Rehmanniae It is 25 parts yellow, 5 parts of Rhizoma Chuanxiong, 4 parts of Chinese cassia tree, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, pangolin Decoction is made in 12 parts, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae, the fruit of glossy privet 15,12 parts of American Ginseng, 2 times a day, one time one Packet, medication check tumor regression to 2.3 × 1.5cm, AFP280 after two months.The 5th course for the treatment of check tumor regression take medicine extremely 1.0 × 0.6cm, AFP11.Though lesion does not completely disappear, patient survives with knurl, and such as ordinary person that lives, and has 5 years so far.
One patient:Male, Pan, 52 years old.Patient on 2 24th, 2013 because on left neck swell object examined over 3 months, earless Ring, without nosebleed epistaxis, once looked into Epstein-Barr virus (VCA-IgA) feminine gender during this.Cranial Computed Tomography:Double maxillary sinuses, sieve sinus, left side sinus frontalis and sphenoid sinus Inflammation, nasopharynx no abnormality seen.Check to be examined when seeing and treating patients and sees the accessible bird ovum of group object swollen greatly on left chest musculus cleidomastoideus, substrate is deeper, It is not easy to elapse, surface is without red and swollen and tenderness.Through biopsy:It is diagnosed as nasopharyngeal carcinoma (T2N1M0), patient is come when examining symptoms include pharyngalgia, mouth It is dry, abundant expectoration is dilute white, has phlegm blood, ability to speak structure sound owes Cheongju after radiotherapy, limitation of mouth opening, lymph enlargement under double jaws, red tongue body, tongue Thin, slippery distinguishes that poison is polymerized to knurl to be contained in heat symptoms caused by an exopathgen.Give Chinese medicine preparation of the present invention, 13 parts of oxhide gelatin, 7 parts of tribulus terrestris, Radix Astragali 18 parts, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, 25 parts of radix rehmanniae recen, 5 parts of Rhizoma Chuanxiong, 4 parts of Chinese cassia tree, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, 12 parts of pangolin, 7 parts of ginger juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae, Decoction is made in 10 parts of spina gleditsiae, 10 parts of semen brassicae, and 2 times a day, one time one packet, to March 31 after medicine, left neck swells the apparent shrinking of object To diameter 1.5cm.It has been eliminated after medicine to May 31, swollen object lump.ECT bone scanning no abnormality seens, effect are very aobvious.To 2013 Year follow-up in July, no abnormality seen are as healthy as usual.

Claims (8)

1. a kind of Chinese medicine that tumour knurl is promoted to wither away:It is characterized in that by following parts by weight:
10-15 parts of oxhide gelatin, 6-8 parts of tribulus terrestris, 15-20 parts of Radix Astragali, 20-30 parts of Chinese herbaceous peony, 6-8 parts of Rhizoma Atractylodis Macrocephalae, 3-5 parts of Fructus Aurantii, wheat Door winter 6-8 part, 20-30 parts of radix rehmanniae recen, 3-6 parts of Rhizoma Chuanxiong, 3-5 parts of Chinese cassia tree, 20-30 parts of gypsum, 8-10 parts of radix scutellariae, Fructus Forsythiae 10-15 Part, 6-9 parts of lophatherum gracile, 5-10 parts of radix achyranthis bidentatae, 10-15 parts of pangolin, 6-8 parts of ginger juice, 6-8 parts of 10-15 parts of Bulbus Allii Fistulosi, Radix Glycyrrhizae systems Into.
2. a kind of Chinese medicine that tumour knurl is promoted to wither away according to claim 1:It is characterized in that by following parts by weight: 10 parts of oxhide gelatin, 6 parts of tribulus terrestris, 15 parts of Radix Astragali, 20 parts of Chinese herbaceous peony, 6 parts of Rhizoma Atractylodis Macrocephalae, 3 parts of Fructus Aurantii, 6 parts of the tuber of dwarf lilyturf, 20 parts of radix rehmanniae recen, 3 parts of Rhizoma Chuanxiong, 3 parts of Chinese cassia tree, 20 parts of gypsum, 8 parts of radix scutellariae, 10 parts of Fructus Forsythiae, 6 parts of lophatherum gracile, 5 parts of radix achyranthis bidentatae, 10 parts of pangolin, ginger 6 parts of juice, 10 parts of Bulbus Allii Fistulosi, 6 parts of Radix Glycyrrhizae are made.
3. a kind of Chinese medicine that tumour knurl is promoted to wither away according to claim 1:It is characterized in that by following parts by weight: 15 parts of oxhide gelatin, 8 parts of tribulus terrestris, 20 parts of Radix Astragali, 30 parts of Chinese herbaceous peony, 8 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Fructus Aurantii, 8 parts of the tuber of dwarf lilyturf, 30 parts of radix rehmanniae recen, 6 parts of Rhizoma Chuanxiong, 5 parts of Chinese cassia tree, 30 parts of gypsum, 10 parts of radix scutellariae, 15 parts of Fructus Forsythiae, 9 parts of lophatherum gracile, 10 parts of radix achyranthis bidentatae, 15 parts of pangolin, life 8 parts of ginger juice, 15 parts of Bulbus Allii Fistulosi, 8 parts of Radix Glycyrrhizae are made.
4. a kind of Chinese medicine that tumour knurl is promoted to wither away according to claim 1:It is characterized in that by following parts by weight: 13 parts of oxhide gelatin, 7 parts of tribulus terrestris, 18 parts of Radix Astragali, 25 parts of Chinese herbaceous peony, 7 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Fructus Aurantii, 7 parts of the tuber of dwarf lilyturf, 25 parts of radix rehmanniae recen, 5 parts of Rhizoma Chuanxiong, 4 parts of Chinese cassia tree, 25 parts of gypsum, 9 parts of radix scutellariae, 12 parts of Fructus Forsythiae, 8 parts of lophatherum gracile, 8 parts of radix achyranthis bidentatae, 12 parts of pangolin, ginger 7 parts of juice, 13 parts of Bulbus Allii Fistulosi, 7 parts of Radix Glycyrrhizae are made.
5. the Chinese medicine that a kind of promotion tumour knurl according to claim 1,2,3 or 4 is withered away:It is characterized in that decoction system Preparation Method is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae addition weight 2 times of water of amount, which boils with strong fire to change, to be cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, radix scutellariae, Fructus Forsythiae, light The leaf of bamboo, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the dry finely ground powder of oxhide gelatin toast for adding corresponding weight both may be used.
6. the Chinese medicine that a kind of promotion tumour knurl according to claim 1,2,3 or 4 is withered away:It is characterized in that granule Preparation method is:
1):It is weighed by above-mentioned formula:Tribulus terrestris, Chinese herbaceous peony, the tuber of dwarf lilyturf, radix rehmanniae recen, gypsum, radix achyranthis bidentatae, pangolin, Radix Glycyrrhizae addition weight 2 times of water of amount, which boils with strong fire to change, to be cooked by slow fire 30 minutes, then add Radix Astragali, Rhizoma Atractylodis Macrocephalae, Fructus Aurantii, Rhizoma Chuanxiong, Chinese cassia tree, radix scutellariae, Fructus Forsythiae, light The leaf of bamboo, Bulbus Allii Fistulosi mixing decoct 10 minutes and filter to obtain filtrate;
2):It is spare to weigh the dry finely ground powder of oxhide gelatin toast;
3):Spare ginger juice is taken to be added in step 1 gained filtrate, the dry finely ground powder of oxhide gelatin toast for adding corresponding weight is condensed into phase To density 1.35 or so (80 DEG C of heat are surveyed) thick medicinal extract, it is dried in vacuo, crushes, add in appropriate pharmaceutical carrier mixing, 75% alcohol Grain, it is dry, it packs to obtain the final product.
7. the Chinese medicine that a kind of promotion tumour knurl according to claim 1,2,3 or 4 is withered away:It is characterized in that the Chinese medicine Application in gastric cancer medicament is treated.
8. the Chinese medicine that a kind of promotion tumour knurl according to claim 1,2,3 or 4 is withered away:It is characterized in that the Chinese medicine Application in gastric cancer medicament is treated.
CN201810097535.3A 2018-01-31 2018-01-31 A kind of Chinese medicine that tumour knurl is promoted to wither away and preparation method thereof Pending CN108261534A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1695731A (en) * 2005-04-18 2005-11-16 上海方心科技研究所 Preparation of Chinese traditional medicine for treating trmor in alimentary canal
US20070082072A1 (en) * 2005-10-06 2007-04-12 Sheng Foong Pharmaceutical Co., Ltd. Herbal Composition for Treating Cancer
CN107375815A (en) * 2017-07-31 2017-11-24 新乡医学院第附属医院 A kind of Chinese medicine for treating tumor in digestive tract

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1695731A (en) * 2005-04-18 2005-11-16 上海方心科技研究所 Preparation of Chinese traditional medicine for treating trmor in alimentary canal
US20070082072A1 (en) * 2005-10-06 2007-04-12 Sheng Foong Pharmaceutical Co., Ltd. Herbal Composition for Treating Cancer
CN107375815A (en) * 2017-07-31 2017-11-24 新乡医学院第附属医院 A kind of Chinese medicine for treating tumor in digestive tract

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刘毅等: "中西医结合治疗晚期胃癌30例", 《山东中医杂志》 *
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Application publication date: 20180710