CN108236682A - The preparation method of gout rehabilitation paste - Google Patents

The preparation method of gout rehabilitation paste Download PDF

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CN108236682A
CN108236682A CN201611211327.9A CN201611211327A CN108236682A CN 108236682 A CN108236682 A CN 108236682A CN 201611211327 A CN201611211327 A CN 201611211327A CN 108236682 A CN108236682 A CN 108236682A
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grams
gout
prepared
rehabilitation
paste
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刘双
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The present invention relates to technical field of traditional Chinese medicines more particularly to the preparation methods of gout rehabilitation paste.The gout rehabilitation paste, to improve and treat gout, provides simple, efficient, thorough, safety, devoid of risk, external curing product without side-effects, no sequel by outer patch Chinese herbal medicine.The present invention is by by Chinese herbal medicine for external use, being processed into hydrogel patch, directly acting on affected site, realize standardization, simplification, scale of mass production, be the important breakthrough of gout treatment product.

Description

The preparation method of gout rehabilitation paste
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to the preparation methods of gout rehabilitation paste.
Background technology
Gout：Gout is by monosodium urate salt（MSU）Crystal correlation arthropathy caused by deposition, with purine metabolic disturbance With（Or）Hyperuricemia caused by underexcretion is directly related, refers in particular to acute characteristic arthritis and chronic gout stone disease Disease mainly includes acute attack arthritis, tophus formation, tophaceous chornic arthritis, urate nephropathy and uric acid Lithangiuria, severe one may occur in which joint deformity and renal insufficiency.Gout is often with Central obesity, hyperlipidemia, hypertension, 2 types The performances such as diabetes and cardiovascular disease.
The traditional Chinese medical science gout belong to rheumatism and arthritis, wind-heat arthritis with fixed pain caused by dampness, blockage of phlegm and blood stasis, through vessle-Bi symptom-complex resistance etc. rheumatisms, internal cause be mainly Native endowment deficiency and healthy tendency virtual loss, external cause and place of residence are moist, work environment is clammy underwater work or take the photograph in spite of the rain water or It is overcast and rainy related, make wind, evil, wet, hot heresy intrusive body warp, stay between limbs, muscles and bones, joint, impatency is obstructed and sends out as numbness Disease.Its inducement is tired out including over fatigue, damaged by excess of seven emotions, eating and drinking without temperance, excessive drinking savoury etc., normal recurrent exerbation.Pass through Chinese herbal medicine Conditioning, clearing heat and promoting diuresis, wind expelling stagnation removing, so as to give rehabilitation.
The doctor trained in Western medicine technology for the treatment of gout at present, mainly takes the Western medicine such as non-steroid anti-inflammatory drug, colchicin to relieve pain, Only there is analgesic effect, side effect is big, very big to side effects such as stomach and intestine, kidney, livers.
Chinese traditional treatment gout method is also fewer on the market at present, and based on medicine for oral administration, slowly effect, treatment cycle It is long, dialectical medication, without the treatment product of extensive standardization.
Existing Chinese medicine treatment, is mainly taken orally by the traditional Chinese medical science come dialectical evolution, medication, will to the medical level of traditional Chinese physician Ask very high, slowly effect, treatment cycle are long, cure rate is low has certain side effect.
Invention content
The technical solution adopted by the present invention to solve the technical problems is：The preparation method of gout rehabilitation paste, step are：
（1）, by 50 grams -100 grams of betel nut, 50 grams -100 grams of rhizoma atractylodis, 50 grams -100 grams of Cortex Phellodendri, 50 grams -100 grams of the seed of jog's tears, Rhizoma Chuanxiong 50 Grams -100 grams, 50 grams -100 grams of Radix Angelicae Sinensis, 50 grams -100 grams of the root of bidentate achyranthes, 50 grams -100 grams of honeysuckle, 50 grams -100 grams of rhizoma imperatae, Radix Salviae Miltiorrhizae 50 grams -100 grams, 50 grams -100 grams of corydalis tuber, 50 grams -100 grams of the root of fangji, 50 grams -100 grams of frankincense, 50 grams -100 grams of myrrh, Rhizoma Et Radix Notopterygii 50 grams -100 grams, 50 grams -100 grams of 50 grams -100 grams of Radix Angelicae Pubescentis and asarum are crushed respectively with the broken machine of Chinese herbal medicine ultra-fine powder, are crushed to 150 It is more than mesh；Then each component medicinal powder is prepared into mixed powder after mixing with batch mixer；
（2）, by 20 grams of glycerine, 5 grams of Sodium Polyacrylate, 0.15 gram of Dihydroxyaluminium Aminoacetate, 51 grams of deionized water, 0.25 gram of tartaric acid and poly- third 4 grams of olefin(e) acid after mixing, is put into de-airing mixer and is stirred under vacuum, and mixing time was prepared at -180 minutes 30 minutes Go out rehabilitation paste matrix；
（3）, by step（1）The mixed powder and step prepared（2）The rehabilitation paste matrix of preparation is according to weight ratio 3:17 ratio Example is mixed, and de-airing mixer is put into after mixing and is stirred uniformly, mixing time prepared patent medicine at -180 minutes 30 minutes Object intermediate；
（4）, by step（3）Be prepared into pharmaceutical intermediate, be coated by water-setting rubber coating, coating thickness for 1.2 millimeters- 1.8 millimeter；
（5）, by after coating entire volume paste, cut as needed；
（6）, by the patch of well cutting, be packed into valve bag or aluminium foil bag, that is, prepare gout rehabilitation paste.
Product of the present invention, to improve and treat gout, provides simple, efficient, thorough, safety, nothing by outer patch Chinese herbal medicine Risk, external curing product without side-effects, no sequel.The present invention by by Chinese herbal medicine for external use, being processed into hydrogel patch, Affected site is directly acted on, realizes standardization, simplification, scale of mass production, is the important breakthrough of gout treatment product.
Gout rehabilitation paste of the present invention also has following remarkable advantage：
1st, it is quick：Gout rehabilitation paste of the present invention can directly be affixed on affected part, and by Transdermal absorption, drug goes directly affected part, directly sends out Drug effect is waved, effect is strong, efficacy of a drug absorption is fast, efficacy of a drug absorption is thorough, and slight person takes effect for 1-3 days, and 3-6 days take effect compared with severe one, severe patient It takes effect within 6-10 days.
2nd, uric acid reduces apparent：The slight apparent uric acid of person 10 days or so reduces, and is reduced compared with 20 days or so uric acid of severe one bright Aobvious, 30 days or so uric acid of severe patient reduce apparent.
3rd, short treating period：Slight person thorough rehabilitation in 1 month or so, compared with severe one thorough rehabilitation in 2 months or so, severe patient 3 months The thorough rehabilitation in left and right.
4th, it is significant in efficacy：Gout rehabilitation paste of the present invention not only can also can quickly reduce blood uric acid with quickly alleviating pain, After rehabilitation can with normal diet, do not need to specially aviod certain food.
5th, gout rehabilitation paste safe ready of the present invention：Chinese herbal medicine outer patch, using simple, conveniently, entirely without any medical wind Danger, without any poisonous side effect of medicine, without any sequelae.
6th, this product realizes the external application Chinese medicine standardization of gout conditioning products, simplicity, scale of mass production, does not need to appoint What advanced tcm knowledge, it is possible to use and treat.
Specific embodiment
Specific embodiment one：The preparation method of gout rehabilitation paste, step are：
（1）, by 50 grams of betel nut, 50 grams of rhizoma atractylodis, 50 grams of Cortex Phellodendri, 50 grams of the seed of jog's tears, 50 grams of Rhizoma Chuanxiong, 50 grams of Radix Angelicae Sinensis, 50 grams of the root of bidentate achyranthes, gold and silver Spend 50 grams, 50 grams of rhizoma imperatae, 50 grams of Radix Salviae Miltiorrhizae, 50 grams of corydalis tuber, 50 grams of the root of fangji, 50 grams of frankincense, 50 grams of myrrh, 50 grams of Rhizoma Et Radix Notopterygii, solely 50 grams living are crushed with 50 grams of asarum with the broken machine of Chinese herbal medicine ultra-fine powder respectively, are crushed to 160 mesh；Then with batch mixer by each component medicine Powder is prepared into mixed powder after mixing；
（2）, by 20 grams of glycerine, 5 grams of Sodium Polyacrylate, 0.15 gram of Dihydroxyaluminium Aminoacetate, 51 grams of deionized water, 0.25 gram of tartaric acid and poly- third 4 grams of olefin(e) acid after mixing, is put into de-airing mixer and is stirred under vacuum, and mixing time prepared rehabilitation paste at 60 minutes Matrix；
（3）, by step（1）The mixed powder and step prepared（2）The rehabilitation paste matrix of preparation is according to weight ratio 3:17 ratio Example is mixed, and de-airing mixer is put into after mixing and is stirred uniformly, mixing time was prepared at 60 minutes among drug Body；
（4）, by step（3）Pharmaceutical intermediate is prepared into, is coated by water-setting rubber coating, coating thickness is 1.2 millimeters；
（5）, by after coating entire volume paste, cut as needed；
（6）, by the patch of well cutting, be packed into valve bag, that is, prepare gout rehabilitation paste.
Specific embodiment two：The preparation method of gout rehabilitation paste, it is characterised in that its step is：
（1）, by 80 grams of betel nut, 80 grams of rhizoma atractylodis, 90 grams of Cortex Phellodendri, 80 grams of the seed of jog's tears, 90 grams of Rhizoma Chuanxiong, 80 grams of Radix Angelicae Sinensis, 70 grams of the root of bidentate achyranthes, gold and silver Spend 70 grams, 70 grams of rhizoma imperatae, 75 grams of Radix Salviae Miltiorrhizae, 75 grams of corydalis tuber, 75 grams of the root of fangji, 80 grams of frankincense, 80 grams of myrrh, 80 grams of Rhizoma Et Radix Notopterygii, solely 75 grams living are crushed with 75 grams of asarum with the broken machine of Chinese herbal medicine ultra-fine powder respectively, are crushed to 160 mesh；Then with batch mixer by each component medicine Powder is prepared into mixed powder after mixing；
（2）, by 20 grams of glycerine, 5 grams of Sodium Polyacrylate, 0.15 gram of Dihydroxyaluminium Aminoacetate, 51 grams of deionized water, 0.25 gram of tartaric acid and poly- third 4 grams of olefin(e) acid after mixing, is put into de-airing mixer and is stirred under vacuum, and mixing time prepared rehabilitation paste at 120 minutes Matrix；
（3）, by step（1）The mixed powder and step prepared（2）The rehabilitation paste matrix of preparation is according to weight ratio 3:17 ratio Example is mixed, and de-airing mixer is put into after mixing and is stirred uniformly, mixing time was prepared at 120 minutes among drug Body；
（4）, by step（3）Pharmaceutical intermediate is prepared into, is coated by water-setting rubber coating, coating thickness is 1.5 millimeters；
（5）, by after coating entire volume paste, cut as needed；
（6）, by the patch of well cutting, be packed into aluminium foil bag, that is, prepare gout rehabilitation paste.
Specific embodiment three：The preparation method of gout rehabilitation paste, it is characterised in that its step is：
（1）, by 100 grams of betel nut, 100 grams of rhizoma atractylodis, 100 grams of Cortex Phellodendri, 100 grams of the seed of jog's tears, 100 grams of Rhizoma Chuanxiong, 100 grams of Radix Angelicae Sinensis, the root of bidentate achyranthes 100 Gram, 100 grams of honeysuckle, 100 grams of rhizoma imperatae, 100 grams of Radix Salviae Miltiorrhizae, 100 grams of corydalis tuber, 100 grams of the root of fangji, 100 grams of frankincense, myrrh 100 Gram, 100 grams of Rhizoma Et Radix Notopterygii, 100 grams of 100 grams of Radix Angelicae Pubescentis and asarum are crushed respectively with the broken machine of Chinese herbal medicine ultra-fine powder, are crushed to 170 mesh；Then Each component medicinal powder is prepared into mixed powder after mixing with batch mixer；
（2）, by 20 grams of glycerine, 5 grams of Sodium Polyacrylate, 0.15 gram of Dihydroxyaluminium Aminoacetate, 51 grams of deionized water, 0.25 gram of tartaric acid and poly- third 4 grams of olefin(e) acid after mixing, is put into de-airing mixer and is stirred under vacuum, and mixing time prepared rehabilitation paste at 180 minutes Matrix；
（3）, by step（1）The mixed powder and step prepared（2）The rehabilitation paste matrix of preparation is according to weight ratio 3:17 ratio Example is mixed, and de-airing mixer is put into after mixing and is stirred uniformly, mixing time was prepared at 180 minutes among drug Body；
（4）, by step（3）Pharmaceutical intermediate is prepared into, is coated by water-setting rubber coating, coating thickness is 1.8 millimeters；
（5）, by after coating entire volume paste, cut as needed；
（6）, by the patch of well cutting, be packed into valve bag, that is, prepare gout rehabilitation paste.
Product of the present invention, to improve and treat gout, provides simple, efficient, thorough, safety, nothing by outer patch Chinese herbal medicine Risk, external curing product without side-effects, no sequel.The present invention by by Chinese herbal medicine for external use, being processed into hydrogel patch, Affected site is directly acted on, realizes standardization, simplification, scale of mass production, is the important breakthrough of gout treatment product.
Gout rehabilitation paste of the present invention also has following remarkable advantage：
1st, it is quick：Gout rehabilitation paste of the present invention can directly be affixed on affected part, and by Transdermal absorption, drug goes directly affected part, directly sends out Drug effect is waved, effect is strong, efficacy of a drug absorption is fast, efficacy of a drug absorption is thorough, and slight person takes effect for 1-3 days, and 3-6 days take effect compared with severe one, severe patient It takes effect within 6-10 days.
2nd, uric acid reduces apparent：The slight apparent uric acid of person 10 days or so reduces, and is reduced compared with 20 days or so uric acid of severe one bright Aobvious, 30 days or so uric acid of severe patient reduce apparent.
3rd, short treating period：Slight person thorough rehabilitation in 1 month or so, compared with severe one thorough rehabilitation in 2 months or so, severe patient 3 months The thorough rehabilitation in left and right.
4th, it is significant in efficacy：Gout rehabilitation paste of the present invention not only can also can quickly reduce blood uric acid with quickly alleviating pain, After rehabilitation can with normal diet, do not need to specially aviod certain food.
5th, gout rehabilitation paste safe ready of the present invention：Chinese herbal medicine outer patch, using simple, conveniently, entirely without any medical wind Danger, without any poisonous side effect of medicine, without any sequelae.
6th, this product realizes the external application Chinese medicine standardization of gout conditioning products, simplicity, scale of mass production, does not need to appoint What advanced tcm knowledge, it is possible to use and treat.
Obviously, the above embodiments are merely examples for clarifying the description, and is not intended to limit the embodiments.It is right For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or It changes.There is no necessity and possibility to exhaust all the enbodiments.And the obvious variation thus extended out or Among changing still in the protection domain of the invention.

Claims (1)

1. the preparation method of gout rehabilitation paste, it is characterised in that its step is：
（1）, by 50 grams -100 grams of betel nut, 50 grams -100 grams of rhizoma atractylodis, 50 grams -100 grams of Cortex Phellodendri, 50 grams -100 grams of the seed of jog's tears, Rhizoma Chuanxiong 50 Grams -100 grams, 50 grams -100 grams of Radix Angelicae Sinensis, 50 grams -100 grams of the root of bidentate achyranthes, 50 grams -100 grams of honeysuckle, 50 grams -100 grams of rhizoma imperatae, Radix Salviae Miltiorrhizae 50 grams -100 grams, 50 grams -100 grams of corydalis tuber, 50 grams -100 grams of the root of fangji, 50 grams -100 grams of frankincense, 50 grams -100 grams of myrrh, Rhizoma Et Radix Notopterygii 50 grams -100 grams, 50 grams -100 grams of 50 grams -100 grams of Radix Angelicae Pubescentis and asarum are crushed respectively with the broken machine of Chinese herbal medicine ultra-fine powder, are crushed to 150 It is more than mesh；Then each component medicinal powder is prepared into mixed powder after mixing with batch mixer；
（2）, by 20 grams of glycerine, 5 grams of Sodium Polyacrylate, 0.15 gram of Dihydroxyaluminium Aminoacetate, 51 grams of deionized water, 0.25 gram of tartaric acid and poly- third 4 grams of olefin(e) acid after mixing, is put into de-airing mixer and is stirred under vacuum, and mixing time was prepared at -180 minutes 30 minutes Go out rehabilitation paste matrix；
（3）, by step（1）The mixed powder and step prepared（2）The rehabilitation paste matrix of preparation is according to weight ratio 3:17 ratio Example is mixed, and de-airing mixer is put into after mixing and is stirred uniformly, mixing time prepared patent medicine at -180 minutes 30 minutes Object intermediate；
（4）, by step（3）Be prepared into pharmaceutical intermediate, be coated by water-setting rubber coating, coating thickness for 1.2 millimeters- 1.8 millimeter；
（5）, by after coating entire volume paste, cut as needed；
（6）, by the patch of well cutting, be packed into valve bag or aluminium foil bag, that is, prepare gout rehabilitation paste.
CN201611211327.9A 2016-12-24 2016-12-24 The preparation method of gout rehabilitation paste Pending CN108236682A (en)

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Citations (2)

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Publication number Priority date Publication date Assignee Title
CN102614422A (en) * 2012-04-06 2012-08-01 宫兆妮 Traditional Chinese medical decoction for treatment of acute gouty arthritis
CN103845662A (en) * 2012-12-07 2014-06-11 罗文礼 External-use traditional Chinese medicine composition with pain-erasing and anti-inflammatory effects

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102614422A (en) * 2012-04-06 2012-08-01 宫兆妮 Traditional Chinese medical decoction for treatment of acute gouty arthritis
CN103845662A (en) * 2012-12-07 2014-06-11 罗文礼 External-use traditional Chinese medicine composition with pain-erasing and anti-inflammatory effects

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* Cited by examiner, † Cited by third party
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张华等: "《槌果藤巴布剂基质的处方优选》", 《石河子大学学报（自然科学版）》 *
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