CN108236670A - Qi-blood tonifying preparation - Google Patents

Qi-blood tonifying preparation Download PDF

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Publication number
CN108236670A
CN108236670A CN201611201832.5A CN201611201832A CN108236670A CN 108236670 A CN108236670 A CN 108236670A CN 201611201832 A CN201611201832 A CN 201611201832A CN 108236670 A CN108236670 A CN 108236670A
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grams
radix
chinese medicine
mutual
polycythemia vera
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赵巧云
王德伍
赵青朝
赵青团
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Zhengzhou Tiandiren Agricultural And Sideline Products Co Ltd
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Zhengzhou Tiandiren Agricultural And Sideline Products Co Ltd
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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Abstract

The invention discloses one kind for treating polycythemia vera innerwear Chinese medicine preparation, which is characterized in that the Chinese medicine material and parts by weight of selection be respectively：12 grams of aster, 24 grams of Radix Astragali, 9 grams of pueraria lobata, 9 grams of Radix Polygalae, 12 grams of Chinese yam, 3 grams of cimicifugae foetidae, 6 grams of radix bupleuri, 12 grams of lily, 15 grams of radix polygonati officinalis, 15 grams of oldenlandia diffusa, 12 grams of semen brassicae, 19 grams of Caulis Spatholobi, 15 grams of the fruit of glossy privet, 6 grams of Radix Notoginseng.Raw medicinal material pharmacological property effect selected by the present invention is complementary, evaded the mutual inhibition of compatibility between drug, mutual restraint between two drugs, the mutual-detoxication choosing, make drug mutual reinforcement between, mutually make effect notable, there is resolving sputum enriching yin, promoting blood circulation and removing obstruction in channels.Orally taken for curing polycythemia vera has definite curative effect.

Description

Qi-blood tonifying preparation
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of qi-blood tonifying preparation, for treating polycythemia vera Innerwear Chinese medicine preparation has effects that resolving sputum enriching yin, promoting blood circulation and removing obstruction in channels.
Background technology
Polycythemia vera is a kind of Clonal Chronic Myeloid proliferative diseases of candidate stem cell.PV onsets are hidden It attacks, makes slow progress, be usually subjected to following two advance stages：1. often there are erythremia in proliferation period or erythremia phase；② Show as that whole blood trace elements, extramedullary hematopoiesis, hepatosplenomegaly, spleen be high and myelofibrosis the erythremia later stage.Bleeding and blood Bolt is two main clinical manifestations of PV, and small number of patients can progress to acute leukemia.
Invention content
The present invention relates to the field of Chinese medicines, and in particular to and one kind is used to treat polycythemia vera innerwear Chinese medicine preparation, There is resolving sputum enriching yin, promoting blood circulation and removing obstruction in channels.It is for oral administration, it can be used for polycythemia vera treatment, there is definite curative effect.
Present invention employs following technical solutions to achieve the above object：The medicinal material of Chinese medicine preparation selection of the present invention And parts by weight are respectively：12 grams of aster, 24 grams of Radix Astragali, 9 grams of pueraria lobata, 9 grams of Radix Polygalae, 12 grams of Chinese yam, 3 grams of cimicifugae foetidae, 6 grams of radix bupleuri, hundred 12 grams of conjunction, 15 grams of radix polygonati officinalis, 15 grams of oldenlandia diffusa, 12 grams of semen brassicae, 19 grams of Caulis Spatholobi, 15 grams of the fruit of glossy privet, 6 grams of Radix Notoginseng.
In the Chinese medicine material that the present invention selects：Aster：Nature and flavor：Hardship, temperature.Major function：Warm lung, lower gas, dissolving phlegm, cough-relieving. Control cough due to wind-cold evil's asthma, consumptive disease cough vomiting of pus and blood, larynx numbness, difficult urination.
Radix Astragali：With 1, exterior deficiency spontaneous perspiration, it is chiefly used in the weak caused spontaneous perspiration of physically weak table.2nd, night sweat due to yin deficiency；3rd, acute nephritis water It is swollen, for the void oedema caused by YANG QI deficiency；4th, oedema due to chronic nephritis, spleen kidney deficiency person；5th, yang-energy is weak, long for sore Not diabrosis and invaginate, have promote diabrosis and limitation effect.6th, sore bursts be not cured long, after sore diabrosis, does not close up long, there is life The effect of flesh closing in；7th, syndrome of deficiency of spleen qi, weak burnout, diarrhea, the sinking of qi of middle-jiao, internal organs prolapsus, the indigestion and loss of appetite all diseases of deficiency of food.8th, Lung Qi deficiency Card.With the passing of time, shortness of breath and tired spirit, phlegm harmony is brought up in lung is powerless cough and asthma.9th, hidrosis and edema.10th, it is weak for the deficiency of vital energy, lassitude hypodynamia, Or the sinking of qi of middle-jiao, rectal prolapse, the prolapse of uterus.Nature and flavor：It is sweet, tepor.Channel tropism：Return lung, spleen, liver and kidney channel；There is enhancing immunity of organism work( Energy, liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial action.
Pueraria lobata：With fitness, anti-aging, decompression, hypoglycemic, lipid-loweringing, increase skin elasticity, moisturizing and other effects.Pueraria lobata Middle institute's isoflavone-containing has the function of to moisturize the skin, restores skin elasticity, can also slow down the aging of skeletal tissue's cell, help In calcareous absorption, reduce bone calcium and lose, increase bone density and prevent bone it is hollow disappear it is molten, so as to far from osteoporosis.Pueraria lobota Active constituent in root can prevent cardio-cerebrovascular diseases and effectively alleviate climacteric syndrome, and can promote longevity, increase Into health, the ideal chose for be female middle-aged daily health caring, improving the quality of living.Most it will be appreciated that women often eats pueraria lobata, Breast development can be promoted to increase, this is exactly mainly the contribution of isoflavones.Chemical composition：The pueraria lobata of the main isoflavone-containing class of pueraria lobata The ingredients such as element and triterpenes Pueraria lobota soap alcohol.
Radix Polygalae：It is warm-natured, it is bitter, pungent, there is tranquilize the mind and promote the intelligence, eliminating the phlegm, detumescence, for insomnia caused by breakdown of the normal physiological coordination between the heart and the kidney Dreaminess, forgetful palpitation with fear, wandering, expectoration is not well, sore swollen toxin, mastosis.
Chinese yam：Have nourish it is strong, it is aid digestion, hold back abnormal sweating, the effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes It quenches one's thirst, oliguria frequency, road essence, women is with lower and dyspeptic chronic enteritis.Nature and flavor：It is sweet, flat, nontoxic.Channel tropism：Returns spleen, lung, Kidney channel.Function：Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, Under band, frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, diarrhea loose stool, leukorrhea.
Cimicifugae foetidae：Rising Yang is delivered, promoting eruption, removing toxic substances.【Major function】When gas plague, fever and chills of having a headache, prickly heat heat itches, and has sore throat, and dashes forward It swells poison, stomach energy toothache, dispute sore, macula is impermeable；The sinking of qi of middle-jiao, protracted dysentery and diarrhea, rectal prolapse, women is collapsed, band, uterus tenesmus；Carbuncle Swollen sore gas is micro-, mildly bitter flavor and it is puckery.
Radix bupleuri：Clearind deficient heat Chinese medicine, for cold, fever, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, rectal prolapse, son Palace comes off, irregular menstruation.Meridian distribution of property and flavor：Cold nature, bitter, pungent, return liver warp, lung channel, the spleen channel.Function：Saturating table expels the heat-evil, soothing the liver solution It is strongly fragrant, it rises and lifts yang-energy.It cures mainly：Cold, fever, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, rectal prolapse, uterus come off, menstruation It is uncomfortable.
Lily：Pick impurity, black valve, ash disposal of winnowing with a dustpan bits.Nature and flavor：It is sweet；Slight bitter；It is slightly cold.Channel tropism：The heart；Lung channel.Major function： Yin nourishing and lung moistening；Clearing away the heart fire and tranquillizing.The main deficiency of Yin is coughed long；Blood-stained sputum；The pyreticosis later stage；Waste heat is not clear or feelings will it is unsuccessful caused by dysphoria It is palpitation with fear, insomnia and dreamful sleep, absent-minded；Carbuncle swells；Wet sore.
Radix polygonati officinalis：Major function：Yin-nourishing is moisturized, and relieving restlessness is quenched the thirst.Control pyreticosis impairment of yin, polydipsia of coughing, deficient fever, the paddy that disappears is easy The diseases such as famine, frequent urination, heart disease, diabetes, tuberculosis；Tool yin-nourishing is moisturized, heat-clearing, is promoted the production of body fluid, cough-relieving and other effects.
Oldenlandia diffusa：Chemical composition：Herb contains asperuloside, and asperuloside acid removes acetic acid, base asperuloside acid, all Square rafter glucoside acid, Chinese Fevervine Herb time glucoside, Chinese Fevervine Herb time glucoside methyl esters, 6-O- p- hydroxyl cinnamyl Chinese Fevervine Herb time glucoside methyl esters, the p- first of 6-O- Oxygroup cinnamyl Chinese Fevervine Herb time glucoside methyl esters, 6-O- asafoetide acyls Chinese Fevervine Herb time glucoside methyl esters, 2- methyl -3- hydroxy-anthraquiones, 2- methyl -3- Methoxy anthraquinone, 2- methyl -3- hydroxyl -4- methoxy anthraquinones etc. and ursolic acid, cupreol, hentriacontane, stigmasterol, Oleanolic acid, cupreol-β-glycoside, p-coumaric acid etc..It cures mainly：Dyspnea and cough due to lung-heat；Abscess of throat；Acute appendicitis；Furuncle sore Ulcer；Venomous snake bite；Puckery pain of heat gonorrhea；Oedema；Dysentery；Enteritis；Jaundice with damp-heat pathogen；It is good at a variety of cancerous swellings for the treatment of.Nature and flavor：Bitter, light, property It is cold.
Semen brassicae：Function：Warm lung slit phlegm profit gas, dissipating bind are removed obstruction in channels to relieve pain.It cures mainly：For phlegm asthma cough of trembling with fear, distending pain in the chest and hypochondrium, phlegm is stagnant Channels and collaterals, joint numbness, pain, phlegm-damp oozing in the body, cloudy subcutaneous ulcer pyogenic infections.Mustard seed contains potassium myronate, and glucoside has no stimulation in itself, but meets water warp The effect generation volatile oil of myrosase, main component is allyl isothiocyanate, there is pungent acid and stimulation.It is applied to Skin has warm feeling and is allowed to rubescent or even causes bubble, warts.Mustard is made after mustard flour usually is removed fat song Sub- plaster uses, as counter-stimulus（Dripping of irritant drugs is used in local skin, and effect is not limited only to agents area, and lead Relate to other positions, when generating therapeutic effect, referred to as anti-irritant effect）, treatment neuralgia, rheumatalgia, pleurisy and strain etc.. It is first moistened using preceding with the water of tepor, to strengthen the effect of myrosase（Boiling water then inhibits the effect of myrosase）.
Caulis Spatholobi：Rattan contains epifriedelanol, Daucosterol, cupreol, 7- ketone groups-cupreol（7-oxo-β- sitosterol）, formoononetin, ononin, prunetin, afromosin, daidzein, 3,7- dihydroxy -6- methoxyl groups Flavanonol, epicatechin, Isoliquiritigenin 3,4,2 ', 4 '-tetrahydroxy chalcone, Licochalcone A, lucerne pig phenol, former youngster Boheic acid, 9- methoxyl group coumestrols, pigeonpea isoflavones.Bitter but slightly sweet taste, warm-natured, Return liver, the heart, kidney channel；Color it is red enter blood, matter profit row It dissipates；With activating blood and relaxing tendons, the effect of nourishing blood for regulating menstruation；Cure mainly arthralgia pain due to rheumatism, numb in every limb, quadriplegia, irregular menstruation, through it is capable not Freely, dysmenorrhoea, Amenorrhea, leukopenia.
The fruit of glossy privet：Nature and flavor：It is sweet, it is bitter, it puts down.Channel tropism：Liver；Kidney channel；Effect is classified：Tonic.Effect：It tonifies the liver and kidney, it is clear empty Heat, strong waist and knee, bright knowledge, black beard and hair.It cures mainly：Light-headedness；Soreness and weakness of waist and knees；Seminal emission；Tinnitus；Poliosis, osteopyrexia and fever.
Radix Notoginseng：[meridian distribution of property and flavor]：Warm-natured, sweet in flavor, slight bitter, nontoxic, Return liver, stomach.Function：Hemostasis；Dissipate blood；Analgesic therapy. It cures mainly：Fall and flutter the stasis of blood and swell, obstruction of qi in the chest angina, abdominal mass；Blood stasis；Dysmenorrhoea；Postpartum stasis of blood the moon abdominal pain；Sore, carbuncle and painful swelling.
Raw medicinal material pharmacological property effect selected by the present invention is complementary, evaded the mutual inhibition of compatibility between drug, mutual restraint between two drugs, the mutual-detoxication it Choosing, make drug mutual reinforcement between, mutually make effect notable, have improve immunity, resolving sputum enriching yin, it is promoting blood circulation and removing obstruction in channels the effect of.Orally taken for curing is true Property polycythemia, have definite curative effect.
Using of the present invention for treating polycythemia vera innerwear Chinese medicine preparation, by clinical practice, obtain Unexpected promising result；
Drug therapy polycythemia vera clinical observation of the present invention：
1. general information
Accept out-patient totally 30 for medical treatment, 20 ~ 30 years old age 2,31 ~ 40 years old 8,41 ~ 50 years old 15,50 years old or more 5.
It is as follows that 2. case is embodied：Mr. Wang, female, 55 years old.Suffering from sexual polycythemia 2 years, tosses about each hospital, once with Clearing heat and cooling blood, the broken silt of promoting blood circulation, dispersing stagnated hepatoqi Chinese medicine take daily 1 dose, admire that more than 1 year disease of Radix Et Rhizoma Rhei et Eupolyphaga Seu Steleophaga Pilulae slightly subtracts, but laboratory indexes occupy It is high not under.See that its figure is plump, and complexion is secretly stagnant, there is the dark violet spot of coin sample in cheek.It states dizzy feeling dazed.Tiredness is weak, dynamic then shortness of breath, Limbs are heavy, sleepy, two xerophtalmias, blurred vision, and mesh is not intended to open, and face is micro- to itch, and belch is not smooth, evil of vomitting from morning, soreness and weakness of waist and knees, Mouth parched and tongue scorched, dysphoria in chestpalms-soles, irritability enrages, and erythema by ridge, frequent urination, tongue is secretly tender, deep-slow pulse.With throwing prescription 15 of the present invention Agent, takes daily 1 dose, divides 2 times sooner or later and warmly takes, empty stomach boiling water is taken after mixing it with water.With examining later, the symptoms such as dizzy, sleepy, blurred vision are equal It gets better and turns, face is polished thoroughly, and tongue is dark, deep thready pulse.Blood picture laboratory indexes are improved.35 courses for the treatment of of following the service, all diseases are all removed.It enjoins It, one course for the treatment of of continual cure consolidates curative effect.Take several doses i.e. more.
Specific embodiment
It is described for treating polycythemia vera innerwear Chinese medicine preparation, which is characterized in that the Chinese medicine material of selection and Parts by weight are respectively：12 grams of aster, 24 grams of Radix Astragali, 9 grams of pueraria lobata, 9 grams of Radix Polygalae, 12 grams of Chinese yam, 3 grams of cimicifugae foetidae, 6 grams of radix bupleuri, lily 12 grams, 15 grams of radix polygonati officinalis, 15 grams of oldenlandia diffusa, 12 grams of semen brassicae, 19 grams of Caulis Spatholobi, 15 grams of the fruit of glossy privet, 6 grams of Radix Notoginseng；
Preparation method：12 grams of aster, 24 grams of Radix Astragali, 9 grams of pueraria lobata, 9 grams of Radix Polygalae, 12 grams of Chinese yam, 3 grams of cimicifugae foetidae, 6 grams of radix bupleuri, lily 12 grams, 15 grams of radix polygonati officinalis, 15 grams of oldenlandia diffusa, 12 grams of semen brassicae, 19 grams of Caulis Spatholobi, 15 grams of the fruit of glossy privet, 6 grams of Radix Notoginseng；It makes respectively Into medicine materical crude slice, by pressure cooker cooking disinfection 50-70 minutes, dry, obtain aseptic raw material, be sealed packaging, acquisition commodity Chinese medicine preparation drink.

Claims (2)

1. for treating polycythemia vera innerwear Chinese medicine preparation, which is characterized in that the Chinese medicine material and parts by weight of selection It is respectively：12 grams of aster, 24 grams of Radix Astragali, 9 grams of pueraria lobata, 9 grams of Radix Polygalae, 12 grams of Chinese yam, 3 grams of cimicifugae foetidae, 6 grams of radix bupleuri, 12 grams of lily, jade 15 grams of bamboo, 15 grams of oldenlandia diffusa, 12 grams of semen brassicae, 19 grams of Caulis Spatholobi, 15 grams of the fruit of glossy privet, 6 grams of Radix Notoginseng.
2. treatment polycythemia vera innerwear Chinese medicine preparation according to claim 1, it is characterised in that：Its preparation side Method is following steps：Step 1）Weigh raw medicinal material：12 grams of aster, 24 grams of Radix Astragali, 9 grams of pueraria lobata, 9 grams of Radix Polygalae, 12 grams of Chinese yam, 3 grams of cimicifugae foetidae, 6 grams of radix bupleuri, 12 grams of lily, 15 grams of radix polygonati officinalis, 15 grams of oldenlandia diffusa, 12 grams of semen brassicae, 19 grams of Caulis Spatholobi, the fruit of glossy privet 15 grams, 6 grams of Radix Notoginseng；
Step 2：The medicine materical crude slice that will be obtained by pressure cooker cooking disinfection 50-70 minutes, dries, and obtains aseptic raw material；
Step 3：The aseptic raw material that will be obtained is sealed packaging, obtains commodity Chinese medicine preparation drink.
CN201611201832.5A 2016-12-23 2016-12-23 Qi-blood tonifying preparation Pending CN108236670A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104258222A (en) * 2014-10-20 2015-01-07 侯云珍 Traditional Chinese medicine composition for treating polycythemia vera

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104258222A (en) * 2014-10-20 2015-01-07 侯云珍 Traditional Chinese medicine composition for treating polycythemia vera

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赵珍品等: "活血养阴法为主治疗真性红细胞增多症10例临床观察", 《新中医》 *
郑翠娥等: "血府逐瘀汤合益气养阴方治疗真性红细胞增多症15例", 《山东中医杂志》 *
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Application publication date: 20180703