CN108213719A - A kind of laser production method of multi-electrode blood sugar test paper - Google Patents
A kind of laser production method of multi-electrode blood sugar test paper Download PDFInfo
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- CN108213719A CN108213719A CN201810013276.1A CN201810013276A CN108213719A CN 108213719 A CN108213719 A CN 108213719A CN 201810013276 A CN201810013276 A CN 201810013276A CN 108213719 A CN108213719 A CN 108213719A
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- laser
- electrode
- electrode pattern
- blood sugar
- test paper
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/36—Removing material
- B23K26/361—Removing material for deburring or mechanical trimming
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/36—Removing material
- B23K26/38—Removing material by boring or cutting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
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- Chemical Kinetics & Catalysis (AREA)
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- General Health & Medical Sciences (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of laser production methods of multi-electrode blood sugar test paper, are as follows：A designs electrode pattern in computer CAD, carries out positive typesetting, electrode pattern is converted into laser trace-diagram；B laser etching machines realize the processing of electrode pattern using vibration mirror scanning mode, and product is positioned；C sets laser processing parameter；Material is placed on the workbench of laser etching machine by d, and CCD captures default target and calculates differential location automatically, and laser is opened and carries out laser-induced thermal etching along CAD approach, is machined to the large stretch of of electrode pattern and is completed；E laser cutting machines cut into monomer small pieces；Enzyme layer is coated in electrode enzyme layer conversion zone by f, then cover film is bonded the multi-electrode blood sugar test paper that completes with glue special.The present invention simplifies processing step, and high precision machining is high-quality；Reduce process equipment, improving the production efficiency of product simultaneously can flexibly carry out Technological adaptability making, have preferable practical function.
Description
Technical field
Present invention relates to a kind of laser production methods for detecting class test paper；More particularly to a kind of blood glucose monitoring system
The laser production method of mating test paper belongs to the processing method field of biosensor technique product.
Background technology
Diabetes are a kind of common metabolism endocrine system diseases, are by lacking insulin or its receptor abnormality institute in human body
It causes, is a kind of worldwide pandemic using hyperglycemia as main feature.Its morbidity is in notable ascendant trend in recent years,
At present the whole world there are about 10% adult to suffer from this disease.In China, there are about 40,000,000 people, current treatment sides by diabetic
Formula mainly regulates and controls glucose metabolism in patient body, and the important evidence of clinical treatment administration is the blood glucose of patient
Sugared content.Therefore, by self-monitoring of blood glucose instrument come to track, assess the control of diabetes be critically important.On domestic and international market
The blood glucose meter of supply is substantially using electrochemical process blood sugar test system, the wink that when glucose response in enzyme and blood generates
When electronics captured by electron mediator, electronically form electric current under the action of voltage, blood glucose meter detection electric current simultaneously turns electric current
Blood glucose value in chemical conversion blood shows that therefore, the accuracy of blood glucose test result is largely and blood sugar test paper
On electrode material it is related.Major part blood sugar test paper is worked electrode using carbon ink material at present, uses silver or silver chloride material
Do reference electrode.With graphite work electrode when, sweat or cosmetics easily corrode electrode, influence the accurate of blood sugar test
Property.
Two kinds nothing more than of the electrode structure of traditional blood sugar test paper, one kind is two electrode structures, another is exactly three electricity
Pole structure.Two electrode structures are made of a working electrode and a reference electrode.Three-electrode system includes, working electrode
(WE), reference electrode (RE) and to electrode (CE).Reference electrode is used for pinpointing a zero, and electric current flows through working electrode and to electricity
Pole, working electrode and reference electrode form a system that is obstructed or being powered less substantially, utilize the stability of reference electrode current potential
To measure the electrode potential of working electrode.Working electrode and the system that an energization is formed to electrode, for measuring working electrode
By electric current.Only there are one working electrodes for two electrode structures and three-electrode structure, and a data, nothing can only be generated every time by measuring
Method judges the accuracy of test data.
The production method of the electrode of the blood sugar test paper of above-mentioned two electrode structure and three-electrode structure, generally using silk-screen printing
Technology.This traditional manufacturing process needs silk-screen template process, and production process is more complicated；The precision of electrode fabrication is not
Height, simple coarse are easy to cause blood sugar test data inaccuracy, test crash and the problems such as not easy to control.
With the development of technology, multielectrode blood sugar test paper product, the structural configuration of product continuously emerge currently on the market
New variation has occurred in formula.General this kind of multielectrode blood sugar test paper product, substantially by substrate layer, electrode layer, enzyme layer and covering
Layer composition；Multiple electrodes are to form uniform metallic diaphragm in substrate surface by vacuum magnetic-control sputtering method in electrode layer therein
Machine-shaping；Metallic diaphragm can be used metallic copper, silver, Jin, Palladium billon and do electrode, corrosion-resistant, against weather, it is not easy to by outer
The influence of boundary's environment can prevent the interference of the various radiation such as mobile phone, electric appliance, performance from stablizing, good conductivity, and accuracy is high.
It is different according to the multielectrode layout pattern of the product design of blood sugar test paper, it needs to different electrode lay-out patterns
Carry out the making of fast and high quality.The processing methods such as the making for this kind of new product, traditional screen printing technique can not expire
The full high-precision processing request in border, processing quality is not high, and efficiency is low, and the processing that can not adapt to Different electrodes layout pattern will
It asks, needs of production can not be met.
Invention content
Goal of the invention：For the above situation, to overcome the defect of the prior art, the object of the present invention is to provide a kind of processing
High-quality, efficient, the flexible multi-electrode blood sugar test paper of Technological adaptability laser production method.
Technical solution：For achieving the above object, the technical solution adopted by the present invention is
A kind of production method of the laser-induced thermal etching of multi-electrode blood sugar test paper, is as follows：
A designs electrode pattern in computer CAD, carries out positive typesetting, and typesetting breadth is less than sizes of substrate；According to schematic diagram
Electrode pattern is converted into laser trace-diagram；
B laser etching machines realize the processing of electrode pattern using vibration mirror scanning mode, and product is determined with CCD industrial cameras
Position；
C sets laser processing parameter:Optical maser wavelength is 1064nm, 20-30 microns of laser focal beam spot, galvanometer after light path shaping
Sweep speed 1000mm/s-3500mm/s, laser output power 8W-16W, laser repetition rate 100-400KHz, processing times 1
It is secondary；
The substrate of one and the rapidoprint of metallic diaphragm are placed on the workbench of laser etching machine by d, CCD to default target into
Row captures and calculates differential location automatically, and laser is opened and carries out laser-induced thermal etching along CAD approach, is machined to the sheet of electrode pattern
It completes；
The sheet of electrode pattern is cut into monomer small pieces by e laser cutting machines；
Enzyme layer is coated in electrode enzyme layer conversion zone, then is fitted in cover film and electrode monomer small pieces with glue special by f
Together, multi-electrode blood sugar test paper completes.
Advantageous effect：Compared with prior art, the present invention carries out electrode pattern etching using laser production method, and cuts
Point, laser-induced thermal etching processing technology is expanded in the production field of bioelectrode, production method enormously simplifies production technology step
Suddenly, the electrode pattern precision high quality of processing is good, improves the stability and accuracy of blood sugar test paper test；Reduce processing to set
It is standby, be conducive to large-scale production, improve the production efficiency of product；Different electrode lay-out patterns can also be directed to, is carried out
Technological adaptability flexibly makes, and has preferable practical function.
Description of the drawings
Fig. 1 is the laser production method flow chart of steps of the present invention；
Fig. 2 is the product structure schematic diagram of multi-electrode blood sugar test paper in the embodiment of the present invention；
Fig. 3 is electrode layer electrode pattern schematic diagram in the embodiment of the present invention.
Fig. 4 is that machined parameters and design sketch represent to be intended in the embodiment of the present invention；
Fig. 5 is the processing effect picture enlarged drawing of product in the embodiment of the present invention；
Fig. 6 is the processing effect picture enlarged drawing of product in the embodiment of the present invention；
Fig. 7 is the processing effect picture enlarged drawing of product in the embodiment of the present invention.
Wherein：1 substrate, 2 electrode layers, 3 enzyme layer, 4 coatings；5 reference electrodes, 6 working electrode A, 7 working electrode B, 8 connect
Energization pole, 9 trigger electrodes.
Specific embodiment
In the following with reference to the drawings and specific embodiments, the present invention is furture elucidated, it should be understood that these embodiments are merely to illustrate
It the present invention rather than limits the scope of the invention, after the present invention has been read, those skilled in the art are to of the invention each
The modification of kind equivalent form falls within the application range as defined in the appended claims.
As shown in Fig. 2 Fig. 3, illustratively the structure of multi-electrode blood sugar test paper this kind of product of making involved in the present invention is special
Point and electrode pattern example.
As shown in Fig. 2, the multi-electrode blood sugar test paper that a kind of structure novel, measuring stability are high, including substrate layer 1, electrode
Layer 2, enzyme layer 3 and coating 4；Layout relationship between each functional layer is：Substrate layer 1 is arranged on one layer of bottommost, on substrate layer 1
Face is electrode layer 2, is provided with enzyme layer 3 on electrode layer central area, and coating 4 is placed in top, and with outside substrate layer 1
Profile is corresponding, by 3 layers of cladding of electrode layer 2 and enzyme therebetween；Part on coating 4 corresponding to enzyme layer 3 is arranged for ease of
The fenestration of test, rest part are covered on electrode layer 3；
Wherein substrate layer 1 selects polyethylene terephthalate（PET）Or polyvinyl chloride（PVC）Or polypropylene（PP）Or
Makrolon（PC）In one of which material be made.
As shown in figure 3, electrode layer 2 is by reference electrode 5, working electrode A6, working electrode B7, electrode 8 and triggering are connected
The multi-electrode layer that electrode 9 forms；Above-mentioned multi-electrode can be to take copper or the electrode layer material of silver or gold, Huo Palladium billons
Electrode made of a kind of material.The multi-electrode is to form uniform metal film in substrate layer surface by vacuum magnetic-control sputtering method
Layer, and electrode pattern is etched using the production method of laser-induced thermal etching on the metal layer.
As shown in Fig. 2, enzyme layer is reaction zone；Coating：For covering a part for electrode layer.
For the product structure feature of multi-electrode blood sugar test paper, electrode layer is metallic diaphragm, and requirement on machining accuracy is high, etching
Graphic feature is straight line, and regional area needs are emptied, and etching line width will ensure in the range of 30-40um, and etching line width sawtooth will
In the 10% of line width, and require lines uniform；Specific production method step is as follows：
As shown in Figure 1：
A kind of laser production method of multi-electrode blood sugar test paper, step are as follows：
A designs electrode pattern in computer CAD, carries out positive typesetting, and typesetting breadth is less than sizes of substrate；According to schematic diagram
Electrode pattern is converted into laser trace-diagram；
B laser etching machines realize the processing of electrode pattern using vibration mirror scanning mode, and product is determined with CCD industrial cameras
Position；
C sets laser processing parameter:Optical maser wavelength is 1064nm, 20-30 microns of laser focal beam spot, galvanometer after light path shaping
Sweep speed 1000mm/s-3500mm/s, laser output power 8W-16W, laser repetition rate 100-400KHz, processing times 1
It is secondary；
The substrate of one and the rapidoprint of metallic diaphragm are placed on the workbench of laser etching machine by d, CCD to default target into
Row captures and calculates differential location automatically, and laser is opened and carries out laser-induced thermal etching along CAD approach, is machined to the sheet of electrode pattern
It completes；
The sheet of electrode pattern is cut into monomer small pieces by e laser cutting machines；
Enzyme layer is coated in electrode enzyme layer conversion zone, then is fitted in cover film and electrode monomer small pieces with glue special by f
Together, multi-electrode blood sugar test paper completes.
Specifically, in the laser production method step c of multi-electrode blood sugar test paper, the setting of suitable laser processing parameter
There is direct influence to the processing quality of product.
Multi-electrode blood sugar test paper using metallic diaphragm as copper film layer does examples of implementation, is described as follows：
In the step c of production method of the present invention:Laser processing parameter is set:Optical maser wavelength is 1064nm, is swashed after light path shaping
20-30 microns, scan rate of vibrating mirror 3000mm/s, laser output power 8W-16W of light focal beam spot, laser repetition rate
260KHz, processing times 1 time；
In the case where remaining step is identical, the chart institute of preferable processing effect, machined parameters and effect such as Fig. 4 is obtained
Show, process time is short, and straightness can reach well ± 3um, and the uniformity can reach the precision of ± 5um, and without broken string notch；Such as figure
5th, shown in Fig. 6, Fig. 7, in terms of the micro- amplification effect picture of processing effect（Amplify 220 multiples）, etch line width and maintain 0.031
Mm, 0.033 mm, it in 0.030 mm 0.029mm numerical value width ranges, substantially can be controlled in the range of 31 ± 2um, ensure that
Preferable machining accuracy.
Raw material are processed for the blood sugar test paper of different metal film layer, it, can be according to specific processing feelings during actual fabrication
Condition, selection confirm that the parameter value of above-mentioned parameter range is combined, are optimal the processing effect of matter.Different groups of more than parameter
It is within the scope of the present invention to close the technical solution formed.
The invention provide a kind of multi-electrode blood sugar test paper laser production method, using laser-induced thermal etching production method into
Row electrode pattern etches, and cutting, laser-induced thermal etching processing technology is expanded in the production field of bioelectrode, production method is big
Simplify production craft step greatly, the electrode pattern precision high quality of processing is good, improve blood sugar test paper test stability and
Accuracy；Reduce process equipment, be conducive to large-scale production, improve the production efficiency of product；Difference can also be directed to
Electrode lay-out pattern, carry out Technological adaptability flexibly make, have preferable practical function.
The multi-electrode blood sugar test paper made of laser production method of the present invention：The design of more working electrodes passes through test
Multiple blood glucose values as a result, multiple measurement results are compared automatically for instrument, in error range then average by comparison result,
The error of blood glucose measurement can be reduced in this way, improve the accuracy of measurement.
Claims (1)
1. a kind of laser production method of multi-electrode blood sugar test paper, it is characterised in that：
It is as follows：
A designs electrode pattern in computer CAD, carries out positive typesetting, and typesetting breadth is less than sizes of substrate；It will according to schematic diagram
Electrode pattern is converted into laser trace-diagram；
B laser etching machines realize the processing of electrode pattern using vibration mirror scanning mode, and product is determined with CCD industrial cameras
Position；
C sets laser processing parameter:Optical maser wavelength is 1064nm, and 20-30 microns of laser focal beam spot after light path shaping, galvanometer is swept
Retouch speed 1000mm/s-3500mm/s, laser output power 8W-16W, laser repetition rate 100-400KHz, processing times 1
It is secondary；
The substrate of one and the rapidoprint of metallic diaphragm are placed on the workbench of laser etching machine by d, CCD to default target into
Row captures and calculates differential location automatically, and laser is opened and carries out laser-induced thermal etching along CAD approach, is machined to the sheet of electrode pattern
It completes；
The sheet of electrode pattern is cut into monomer small pieces by e laser cutting machines；
Enzyme layer is coated in electrode enzyme layer conversion zone, then is fitted in cover film and electrode monomer small pieces with glue special by f
Together, multi-electrode blood sugar test paper completes.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810013276.1A CN108213719A (en) | 2018-01-06 | 2018-01-06 | A kind of laser production method of multi-electrode blood sugar test paper |
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|---|---|---|---|
| CN201810013276.1A CN108213719A (en) | 2018-01-06 | 2018-01-06 | A kind of laser production method of multi-electrode blood sugar test paper |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109877461A (en) * | 2019-01-30 | 2019-06-14 | 大族激光科技产业集团股份有限公司 | A kind of light transmission negative film making method and device |
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| US20120251708A1 (en) * | 1999-11-15 | 2012-10-04 | Shoji Miyazaki | Biosensor, thin film electrode forming method, quantification apparatus, and quantification method |
| EP2034301A2 (en) * | 2007-09-04 | 2009-03-11 | Lifescan, Inc. | Analyte test strip with improved reagent deposition |
| CN101303324A (en) * | 2008-07-03 | 2008-11-12 | 宗小林 | Method for manufacturing fast detecting test strip electrode |
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| CN109877461A (en) * | 2019-01-30 | 2019-06-14 | 大族激光科技产业集团股份有限公司 | A kind of light transmission negative film making method and device |
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Application publication date: 20180629 |