CN108204907B

CN108204907B - Sample extractor for pharmaceutical experiment

Info

Publication number: CN108204907B
Application number: CN201711482093.6A
Authority: CN
Inventors: 孙丽敏
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-12-29
Filing date: 2017-12-29
Publication date: 2020-07-03
Anticipated expiration: 2037-12-29
Also published as: CN108204907A

Abstract

The invention discloses a pharmaceutical experiment sample extractor, which belongs to the field of equipment for pharmaceutical experiments and comprises a main transparent cylinder and an auxiliary transparent cylinder, wherein central shafts of the main transparent cylinder and the auxiliary transparent cylinder are positioned on the same axis; the gear rack fixing mechanism is used for fixing the position of the main piston, limiting tooth grooves which correspond to the scale marks on the main scale one by one are arranged on the rack, and a plurality of transition tooth grooves with included angles of groove bottoms larger than the limiting tooth grooves are connected between every two adjacent limiting tooth grooves. The invention determines the amount of the absorbed liquid medicine by measuring the two stages of graduated scales, has higher accuracy and adopts a fixing mechanism to ensure the application accuracy of the device; the device is also beneficial to preventing samples from being polluted, is convenient to operate, and greatly reduces the working difficulty of medical staff.

Description

Sample extractor for pharmaceutical experiment

Technical Field

The invention relates to the field of equipment for pharmaceutical experiments, in particular to a novel pharmaceutical experiment sampler.

Background

Pharmacy, the healthcare industry linking health sciences and chemical sciences, bears the responsibility of ensuring safe and effective use of drugs. Pharmacy mainly researches the source, processing, properties, effects, analysis, identification, blending, production, storage and searching (including synthesis) of new drugs and the like of the drugs. The main task is to continuously provide more effective medicines, improve the quality of the medicines, ensure the safety of the medicines and enable human beings to better fight against diseases.

At present in pharmacy experiment, mostly use ordinary sample straw to draw the sample, this kind of sample straw structure of carrying is very simple, is exactly a hollow body that has the scale, inserts the body during the operation in the sample, with the help of atmospheric pressure with the sample suction tube in back, the finger blocks up body top opening, the sample is stayed inside the body promptly, moves the liquid to corresponding container according to the experiment requirement again in. The traditional operation mode requires a certain operation experience and skilled operation skill of experimenters, and the working difficulty of medical staff is high; the risk of easily polluting the sample exists; the dosage of the absorbed liquid medicine is determined only by the primary scale, and the accuracy is not high enough.

Disclosure of Invention

1. Technical problem to be solved

The invention aims to solve the technical problem of providing a novel pharmaceutical experiment sampler, which measures and determines the amount of liquid medicine to be sucked through two stages of graduated scales, has higher accuracy and adopts a fixing mechanism to ensure the application accuracy of the device; the device is also beneficial to preventing samples from being polluted, is convenient to operate, and greatly reduces the working difficulty of medical staff.

2. Technical scheme

In order to solve the problems, the invention adopts the following technical scheme:

a novel pharmaceutical experiment sampler comprises a transparent main cylinder body and an auxiliary cylinder body, wherein the central axes of the main cylinder body and the auxiliary cylinder body are positioned on the same axis, the lower end of the main cylinder body is provided with a medicine suction port, the main cylinder body and the auxiliary cylinder body are respectively internally provided with a main piston and an auxiliary piston, the auxiliary cylinder body is arranged in the main piston in a penetrating way, the lower end of the auxiliary cylinder is opened and is positioned on the lower end surface of the main piston, the main piston comprises a first piston head with the side surface attached to the inner wall of the main cylinder, the upper surface of the piston head I is fixedly connected with a piston rod I, the other end of the piston rod I extends to the outer side of the main cylinder body, the end part of the piston rod I is fixedly connected with a push-pull handle I, the auxiliary piston comprises a second piston head with the side surface attached to the inner wall of the auxiliary cylinder body, the upper surface of the second piston head is fixedly connected with the second piston rod, the other end of the piston rod II extends to the outer side of the auxiliary cylinder body and penetrates through the first push-pull handle, and the other end of the piston rod II is fixedly connected with the second push-pull handle; the outer surfaces of the main cylinder body and the auxiliary cylinder body are respectively provided with a main graduated scale and an auxiliary graduated scale along the length direction;

a rack parallel to the side wall of the main cylinder is fixed on the cylinder wall of the upper end of the main cylinder, a notch for the rack to pass through is arranged on the corresponding side of the first push-pull handle, limiting tooth grooves corresponding to the scale marks on the main scale one by one are arranged on the rack, a plurality of transition tooth grooves with included angles of groove bottoms larger than the limiting tooth grooves are connected between every two adjacent limiting tooth grooves, a gear matched with the limiting tooth grooves is arranged on the outer side of the rack, a pushing shaft is penetrated in the center of the gear, two ends of the pushing shaft are respectively inserted into two opposite side surfaces of the notch, moving grooves for the pushing shaft to horizontally move are arranged on the corresponding two side surfaces of the notch, the length of each moving groove is equal to the horizontal distance between the gear when the gear is meshed in the limiting tooth grooves and the gear in the transition tooth grooves under two states when the gear is in clearance, and an annular permanent magnet II which is magnetically attracted with the permanent magnet I is fixed on the gear.

Further, the section radius of the main cylinder and the auxiliary cylinder meets the formula:

wherein r is₁The radius of the cross section of the main cylinder is shown,r₂represents the section radius of the auxiliary cylinder, a represents an integer between 2 and 10, and the interval ratio of the graduation lines of the main graduated scale and the auxiliary graduated scale is

According to the formula V ═ pi R for calculating the volume of the cylinder²H (where V denotes the volume of the liquid medicine within h height, R denotes the radius of the cross section of the cylinder, and h denotes the height of the liquid medicine within the cylinder) is obtained, and the volume ratio of the main cylinder to the sub cylinder at the same scale is 10: 1, the reading precision of the auxiliary scale can be accurate to 0.1 of the reading precision of the main scale. Thereby effectively improving the accuracy of the dosage of the medicine taken by the device.

Further, a is 10, and the distance ratio of the graduation lines of the main graduated scale and the auxiliary graduated scale is 1: 1. the distance between the scale marks of the main scale and the auxiliary scale is set to be consistent, so that the human eyes can check whether the liquid medicine reaches the scales or not.

Further, the thickness of the first piston head is 10 times of the distance between two adjacent scale marks on the auxiliary scale. Because the first piston head is generally black, the scales of the auxiliary cylinder in the first piston head cannot be read, the thickness of the first piston head is 10 times of the distance between two adjacent scale marks on the auxiliary scale, the reading precision based on the auxiliary scale can be accurate to 0.1 of the reading precision of the main scale, the volume of the auxiliary cylinder in the first piston head is equal to the volume of the distance between one scale mark in the main cylinder, and when the liquid medicine volume in the main cylinder is used, the corresponding scale of the liquid medicine volume in the main cylinder is determined as the next scale mark of the actually needed volume scale, so that the liquid level of the medicine in the auxiliary cylinder is positioned above the first piston head, and the reading is facilitated.

3. Advantageous effects

(1) The invention comprises a transparent main cylinder and an auxiliary cylinder, wherein the central shafts of the main cylinder and the auxiliary cylinder are positioned on the same axis, a main piston and an auxiliary piston are respectively arranged in the main cylinder and the auxiliary cylinder, the auxiliary cylinder penetrates through the main piston, the lower end of the auxiliary cylinder is opened and is positioned on the lower end surface of the main piston, and a main graduated scale and an auxiliary graduated scale are respectively arranged on the outer surfaces of the main cylinder and the auxiliary cylinder along the length direction of the main cylinder and the auxiliary cylinder. During manufacturing, the relation of the section radius of the auxiliary cylinder and the main cylinder and the distance ratio of the scale marks of the main scale and the auxiliary scale can be set, so that the precision relation between the main scale and the auxiliary scale can be determined. When the liquid level control device is used, the main piston is firstly actuated, the liquid level of the liquid medicine in the main cylinder is controlled to be an integer numerical value close to the volume of the liquid medicine actually needed, then the auxiliary piston is driven, and when the liquid level of the liquid medicine in the main cylinder is controlled to be a certain scale of the auxiliary scale, the liquid level control device is a decimal numerical value relative to the main scale of the main cylinder, so that the accurate liquid medicine suction amount can be obtained.

(2) The operation process of the invention is that the main piston is moved first, and the auxiliary piston is moved after the main piston stops moving, and the movement of the auxiliary piston is relative to the movement of the main piston, so that the invention is also provided with a gear rack fixing mechanism for fixing the position of the main piston in order to prevent the main piston from moving accidentally. When the gear fixing device is applied, in the process of pulling the first push-pull handle or rotating the gear, the gear moves along the rack, the permanent magnet II on the gear is attracted by the permanent magnet I, but in a short time, the moving gear cannot be completely meshed in the limiting tooth groove, when the push-pull handle is stopped to be pulled, the gear stops rotating, at the moment, under the magnetic attraction effect of the permanent magnet, the gear approaches to the permanent magnet I until the gear is completely meshed in the limiting tooth groove, namely, the gear is fixed, and the position of the main piston is stably fixed. According to the invention, through the special setting of the tooth grooves on the rack, the movement along the rack is not influenced, the locking of the gear position can be realized, the position of the locking gear corresponds to the scale marks on the main scale one by one, the requirements are met, the lower end surface of the main piston can be ensured to be stably positioned on a certain scale mark of the main scale, and the accuracy of the device is further ensured.

(3) The main piston and the auxiliary piston respectively comprise a piston head I attached to the inner wall of the main cylinder and a piston head II attached to the inner wall of the auxiliary cylinder, and the auxiliary cylinder is arranged in the main piston in a penetrating manner, so that liquid medicines in the main cylinder and the auxiliary cylinder are in relatively sealed environments, and the pollution to samples is favorably prevented; in addition, as can be seen from the above, the device only needs to push and pull the main piston and the auxiliary piston in sequence when in use, does not need certain operation experience and skilled operation skill, is convenient to operate, and greatly reduces the work difficulty of medical staff.

In conclusion, the device measures and determines the amount of the liquid medicine to be sucked through the two stages of graduated scales, has higher accuracy, and adopts the fixing mechanism to ensure the application accuracy of the device; the device is also beneficial to preventing samples from being polluted, is convenient to operate, and greatly reduces the working difficulty of medical staff.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is an enlarged view of the structure of the region B in FIG. 1;

FIG. 3 is a schematic view of the structure of section A-A in FIG. 1;

fig. 4 is an enlarged schematic view of the structure of the region C in fig. 3.

Reference numerals: 1-main cylinder body, 2-auxiliary cylinder body, 3-medicine suction port, 4-main piston, 41-first piston head, 42-first piston rod, 43-first push-pull handle, 5-auxiliary piston, 51-second piston head, 52-second piston rod, 53-second push-pull handle, 6-main graduated scale, 7-auxiliary graduated scale, 8-rack, 81-limit tooth groove, 82-transition tooth groove, 9-notch, 10-gear, 11-pushing shaft, 12-moving groove, 13-first permanent magnet, 14-second permanent magnet.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings and examples.

Example 1

The novel pharmaceutical experiment sampler as shown in fig. 1 and 3 comprises a transparent main cylinder 1 and an auxiliary cylinder 2, wherein the central shaft of the main cylinder 1 is positioned on the same axis, the lower end of the main cylinder 1 is provided with a drug suction port 3, a main piston 4 and an auxiliary piston 5 are respectively arranged in the main cylinder 1 and the auxiliary cylinder 2, the auxiliary cylinder 2 penetrates through the main piston 4, the lower end of the auxiliary cylinder 2 is open and is positioned on the lower end face of the main piston 4, the main piston 4 comprises a first piston head 41 attached to the inner wall of the main cylinder 1 on the side face, a first piston rod 42 is fixedly connected to the upper surface of the first piston head 41, the other end of the first piston rod 42 extends to the outer side of the main cylinder 1 and is fixedly connected with a first push-pull handle 43 at the end, the auxiliary piston 5 comprises a second piston head 51 attached to the inner wall of the auxiliary cylinder 2 on the side face, a second piston rod 52 is fixedly connected to the upper surface of the second piston head 51, the other, the other end of the piston rod II 52 is fixedly connected with a push-pull handle II 53; the outer surfaces of the main cylinder body 1 and the auxiliary cylinder body 2 are respectively provided with a main graduated scale 6 and an auxiliary graduated scale 7 along the length direction;

as shown in fig. 2 and 4, a rack 8 parallel to the side wall of the main cylinder 1 is fixed on the cylinder wall of the upper end of the main cylinder 1, a notch 9 for the rack 8 to pass through is arranged on the corresponding side of the first push-pull handle 43, a limit tooth groove 81 corresponding to the scale mark on the main scale 6 one by one is arranged on the rack 8, a plurality of transition tooth grooves 82 with included angles of the groove bottoms larger than the limit tooth groove 81 are connected between every two adjacent limit tooth grooves 81, a gear 10 matched with the limit tooth groove 81 is arranged on the outer side of the rack 8, a pushing shaft 11 is arranged in the center of the gear 10, two ends of the pushing shaft 11 are respectively arranged on the two opposite side surfaces of the notch 9 in an inserting manner, moving grooves 12 for the pushing shaft 11 to move horizontally are arranged on the two corresponding side surfaces of the notch 9, the length of the moving grooves 12 is equal to the horizontal distance between the gear 10 engaged in the limit tooth groove 81 and the gear 10 in the transition, a first permanent magnet 13 is fixed on the side wall of the notch 9 on the inner side of the rack 8, and a second annular permanent magnet 14 which is magnetically attracted with the first permanent magnet 13 is fixed on the gear 10.

Specifically, the section radii of the main cylinder 1 and the auxiliary cylinder 2 satisfy the formula:

wherein r is₁Represents the cross-sectional radius, r, of the main cylinder 1₂Represents the section radius of the auxiliary cylinder 2, a represents an integer between two and ten, and the distance ratio of the graduation lines of the main graduated scale 6 and the auxiliary graduated scale 7 is

According to the formula V ═ pi R for calculating the volume of the cylinder²H (where V denotes the volume of the liquid medicine within h height, R denotes the radius of the cross section of the cylinder, and h denotes the height of the liquid medicine within the cylinder) is obtained, and the volume ratio of the main cylinder 1 to the sub cylinder 2 between the same scales is 10: 1, the reading precision of the auxiliary graduated scale 7 can be accurate to the main scaleThe reading precision of the measuring scale 6 is 0.1, and the measuring scale conforms to the common conventional decimal reading habit. Thereby effectively improving the accuracy of the dosage of the medicine taken by the device.

In this embodiment, a is ten, and the pitch ratio of the scale lines of the main scale 6 and the sub scale 7 is 1: 1. the distance between the scale marks of the main scale 6 and the auxiliary scale 7 is set to be consistent, so that the human eyes can check whether the liquid medicine reaches the scales or not conveniently.

In this embodiment, the thickness of the first piston head 41 is ten times the distance between two adjacent graduation marks on the secondary scale 7. Because the first piston head 41 is generally black, the scales of the auxiliary cylinder 2 in the first piston head 41 cannot be read, the thickness of the first piston head 41 is ten times of the distance between two adjacent scale marks on the auxiliary scale 7, and the reading precision of the auxiliary scale 7 can be accurate to 0.1 of the reading precision of the main scale 6, so that the volume of the auxiliary cylinder 2 in the first piston head 41 is equal to the volume of one scale space in the main cylinder 1, and when the liquid medicine volume corresponding to the scales in the main cylinder 1 is determined to be the next scale of the actually required volume scales (for example, the actually required liquid medicine volume is 14.4ml, the liquid medicine level in the main cylinder 1 is controlled to be 13ml), so that the liquid medicine level in the auxiliary cylinder 2 is positioned above the first piston head 41, and the reading is facilitated.

The specific application process of the novel pharmaceutical experiment sampler comprises the following steps:

in an initial state, the main piston 4 and the auxiliary piston 5 are respectively positioned at the lower ends of the main cylinder 1 and the auxiliary cylinder 2, the medicine suction port 3 is inserted into medicine liquid to be taken, the first pull handle 43 (or the rotating gear 10) is pulled and pushed successively to drive the first piston head 41 to move towards the rear side together with the auxiliary cylinder 2 and the auxiliary piston 5, the medicine liquid is sucked into the main cylinder 1, when the liquid level of the medicine liquid in the main cylinder 1 reaches an actually required medicine liquid volume (for example, the actually required medicine liquid volume is 14.4ml, the liquid level of the medicine liquid in the main cylinder 1 is controlled to be 13ml, namely 13 th scale mark, as shown in figure 1), the first pull handle 43 is stopped, the gear 10 moves upwards along the rack 8 in the process of pulling the first pull handle 43, the second permanent magnet 14 on the gear 10 is magnetically attracted by the first permanent magnet 13 in a short time, but the moving gear 10 cannot be completely engaged in the limit tooth groove 81, when the first push-pull handle 43 stops being pulled, the gear 10 stops rotating, at the moment, under the magnetic attraction effect of the permanent magnet, the gear 10 approaches to the first permanent magnet 13 and is completely meshed in the limiting tooth groove 81, the gear 10 is fixed, and therefore the position of the main piston 4 is stably fixed; then, the second push-pull handle 53 is pulled backwards to drive the second piston head 51 to move backwards, the liquid medicine is pumped into the auxiliary cylinder 2, when the liquid level of the liquid medicine in the auxiliary cylinder 2 reaches the actually required liquid medicine volume (for example, the actually required liquid medicine volume is 14.4ml, the liquid level of the liquid medicine in the main cylinder 1 is controlled to be 13ml, and the liquid level of the liquid medicine in the auxiliary cylinder 2 is controlled to be 1.4ml, namely the 14 th scale mark, as shown in fig. 1), the second push-pull handle 53 is stopped to be pulled, namely, the liquid medicine with the actually required dosage is obtained more accurately; and finally, taking the medicine suction port 3 out of the medicine taking liquid, extending the medicine suction port into an experimental utensil, firstly pushing the second push-pull handle 53 forwards, injecting the medicine liquid in the auxiliary cylinder body 2 into the experimental utensil, then pressing the first push-pull handle 43 (or reversely rotating the gear 10), and injecting the medicine liquid in the main cylinder body 1 into the experimental utensil, thus finishing the sample extraction of the medicine in the pharmaceutical experiment.

Therefore, the liquid medicine suction device has the advantages that the dosage of the sucked liquid medicine is measured and determined through the two stages of graduated scales, the accuracy is high, and the application accuracy of the device is guaranteed by adopting the fixing mechanism; the device is also beneficial to preventing samples from being polluted, is convenient to operate, and greatly reduces the working difficulty of medical staff.

It should be understood by those skilled in the art that the above embodiments are only for illustrating the present invention and are not to be used as a limitation of the present invention, and that changes and modifications to the above embodiments are within the scope of the claims of the present invention as long as they are within the spirit and scope of the present invention.

Claims

1. The pharmaceutical experiment sampler is characterized by comprising a transparent main cylinder body (1) and an auxiliary cylinder body (2) of which the central shafts are positioned on the same axis, wherein the lower end of the main cylinder body (1) is provided with a medicine suction port (3), a main piston (4) and an auxiliary piston (5) are respectively arranged in the main cylinder body (1) and the auxiliary cylinder body (2), the auxiliary cylinder body (2) penetrates through the main piston (4), the lower end of the auxiliary cylinder body (2) is opened and is positioned on the lower end face of the main piston (4), the main piston (4) comprises a first piston head (41) of which the side face is attached to the inner wall of the main cylinder body (1), a first piston rod (42) is fixedly connected to the upper surface of the first piston head (41), the other end of the first piston rod (42) extends to the outer side of the main cylinder body (1) and is fixedly connected with a first push-pull handle (43) at the end, the auxiliary piston (5) comprises a second piston head (51), the upper surface of the piston head II (51) is fixedly connected to one end of the piston rod II (52), the other end of the piston rod II (52) extends to the outer side of the auxiliary cylinder body (2) and penetrates through the push-pull handle I (43), the piston rod II (52) penetrates through one end of the push-pull handle I (43), and the end part of the piston rod II (52) is fixedly connected with the push-pull handle II (53); the outer surfaces of the main cylinder body (1) and the auxiliary cylinder body (2) are respectively provided with a main graduated scale (6) and an auxiliary graduated scale (7) along the length direction;

the rack is characterized in that a rack (8) parallel to the side wall of the main barrel body (1) is fixed on the barrel wall of the upper end of the main barrel body (1), notches (9) for the rack (8) to penetrate through are formed in the corresponding side of the first push-pull handle (43), limiting tooth grooves (81) corresponding to scale marks on the main scale (6) one by one are formed in the rack (8), a plurality of transition tooth grooves (82) with included angles of groove bottoms larger than the limiting tooth grooves (81) are connected between every two adjacent limiting tooth grooves (81), gears (10) matched with the limiting tooth grooves (81) are arranged on the outer side of the rack (8), a push shaft (11) penetrates through the center of each gear (10), two ends of the push shaft (11) are respectively arranged on two side faces opposite to the notches (9), moving grooves (12) for the push shaft (11) to horizontally move are formed in the two corresponding side faces of the notches (9), and the length of each moving groove (12) is equal to that the length of each gear (10) 10) The horizontal distance of the center of the gear (10) under two states when the gear is meshed in the transition tooth groove (82) in a clearance mode, a first permanent magnet (13) is fixed on the side wall of a notch (9) on the inner side of the rack (8), and a second permanent magnet (14) which is annular and magnetically attracted with the first permanent magnet (13) is fixed on the gear (10).

2. The pharmaceutical experiment sampler according to claim 1, characterized in that the section radius of the main cylinder (1) and the sub-cylinder (2) satisfies the formula:

wherein r is₁Represents the section radius r of the main cylinder (1)₂Represents the section radius of the auxiliary cylinder (2), a represents an integer between 2 and 10, and the distance ratio of the graduation lines of the main graduated scale (6) and the auxiliary graduated scale (7) is

3. The pharmaceutical laboratory sample injector according to claim 2, characterized in that a is 10, the distance ratio between the graduation lines of the main graduated scale (6) and the auxiliary graduated scale (7) is 1: 1.

4. the pharmaceutical laboratory sampler according to claim 3, characterized in that the thickness of the first piston head (41) is 10 times the distance between two adjacent graduation marks on the secondary scale (7).