CN108201602A - A kind of Chinese medicine composition for having effects that assist reducing blood lipid and/or protect blood vessel and preparation method thereof and product - Google Patents
A kind of Chinese medicine composition for having effects that assist reducing blood lipid and/or protect blood vessel and preparation method thereof and product Download PDFInfo
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- CN108201602A CN108201602A CN201611187653.0A CN201611187653A CN108201602A CN 108201602 A CN108201602 A CN 108201602A CN 201611187653 A CN201611187653 A CN 201611187653A CN 108201602 A CN108201602 A CN 108201602A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition for having effects that assist reducing blood lipid and/or protect blood vessel and preparation method thereof and product.In parts by weight, which is made of the following raw material：10~100 parts of adlay, 10~100 parts of Poria cocos, 10~100 parts of dried orange peel, 10~100 parts of peach kernel, 10~100 parts of Longstamen Onion Bulb.Selected materials are medicine and food raw materials in the present composition, and safe without toxic side effect, is suitable as health products or food is taken for a long time；By invigorating the spleen for eliminating dampness, promoting blood circulation and removing blood stasis, the rules for the treatment of of temperature sun dredging collateral are arranged in pairs or groups, reasonable combination, cooperate with shared, and are verified by zoopery, and the composition has effects that preferably to assist reducing blood lipid and vascular protection, and effect is better than each single dose.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of to have effects that assist reducing blood lipid and/or protect blood vessel
Chinese medicine composition and preparation method thereof and product.
Background technology
As people's living standard improves and aging of population process, " three high " --- hypertension, hyperglycemia, hyperlipidemia disease
Disease, which has become, endangers the important killer of the mankind.Wherein, hyperlipidemia have extensive crowd basis, and with the close phase of a variety of diseases
It closes, such as atherosclerosis.The method that modern medicine has no healing to the treatment of hyperlipidemia usually selects Statins to reduce courage
The drug of sterol inhibits target spot HMG CoA (HMG-CoA) reductase activity in cholesterol biosynthesis access, this
Though class medicine can reduce cholesterol levels, disease can not be fundamentally treated, many side effects are existed simultaneously, such as to liver function
Damage, rhabdomyolysis card etc., and blood fat rebound is easily caused after being discontinued, it is impossible to it takes for a long time.There is also classes for fibrate
As problem.
Hyperlipidemia mainly occurs in Traditional Chinese Medicine in the form of disease or disease, such as dizziness, blood-arthralgia, vessle-Bi symptom-complex, blood trouble, to it
Research and record there is abundant history, from Overall View, treating both manifestation and root cause of disease, be hyperlipidemia problem effective solution.
Modern Chinese medicine generally believes that the important pathogenesis of hyperlipidemia is the dysfunction of the spleen in transport, the turbid blood stasis internal resistance of phlegm and cause, with invigorating spleen to remove dampnessization it is turbid,
Promoting blood circulation and removing blood stasis is the main rules for the treatment of.And the relevant Atherosclerosis of hyperlipidemia is eliminated with except the above-mentioned interpretation of the cause, onset and process of an illness, mostly asthenia in origin and asthenia in superficiality
Card, Han Ningxuemai, stasis life the stasis of blood, the turbid interior life of phlegm, obstruction by phlegm.
Disclosure/notification number is that the patent of invention of CN102462826A discloses a kind of Chinese medicinal composition for reducing blood fat and its preparation
Methods and applications.The Chinese medicinal composition for reducing blood fat includes following components：Rhizoma alismatis, grape pip, the fruit of glossy privet, gynostemma pentaphylla, turmeric, sea-buckthorn
And green tea.Pass through zoopery and human experiment the experimental evaluation hypolipemic function of the Chinese medicinal composition for reducing blood fat, it was demonstrated that
The Chinese medicinal composition for reducing blood fat has good hypolipemic function, and has no toxic side effect.
Disclosure/notification number is that the patent of invention of CN104258026A discloses a kind of Chinese medicinal composition for reducing blood fat and its preparation
Method.The Chinese medicinal composition for reducing blood fat includes following ingredient according to weight：2~6 parts of bush, 4~7 parts of lotus leaf, 4~9 parts of Radix Salviae Miltiorrhizae,
2~4 parts of rhodiola root, 7~12 parts of Kadsura Root-bark, 4~7 parts of fritillaria, 5~8 parts of orange peel.The Chinese medicine composition can significantly reduce blood fat
The content of middle T-CHOL and triglycerides.
At present, for have the Chinese medicine composition of notable blood fat reducing function there is still a need to.
Invention content
In view of this, the present invention provides a kind of Chinese medicine compositions for having effects that assist reducing blood lipid and/or protect blood vessel
And preparation method thereof and product.The Chinese medicine composition has effects that preferable reducing blood lipid and protection blood vessel, and effect is better than single dose.
In order to achieve the above-mentioned object of the invention, the present invention provides following technical scheme：
The present invention provides a kind of Chinese medicine compositions, and in parts by weight, which is made of the following raw material：
10~100 parts of adlay, 10~100 parts of Poria cocos, 10~100 parts of dried orange peel, 10~100 parts of peach kernel, Longstamen Onion Bulb 10~100
Part.
Adlay (Latin Semen Coicis English name Coix Seed) also known as coix seed, the seed of jog's tears, the seed of jog's tears, native corn, the heart of a lotus seed
Rice plays reality, heart of a lotus seed pearl, careless pearl, jobstears, meter Ren, maize.It is common Chinese medicine, and is food that is universal, often eating, property
Slightly sweet flavor is slightly cold, and has inducing diuresis for removing edema, invigorating spleen to remove dampness, relaxing muscles and tendons eliminating impediment, clearing away heat and eliminating pus and other effects, is common damp-clearing drug.The heart of a lotus seed
Benevolence is a kind of beauty food again, and often feeding can keep human skin gloss fine and smooth, eliminate acne, freckle, senile plaque, cyasma,
Butterfly macules have good efficacy to furfur, acne, chap, pachylosis etc..
Poria cocos is the dry sclerotia of On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf.It is sweet in flavor, light, it is mild-natured.
The thoughts of returning home, lung, spleen, kidney channel.Effect：Clearing damp and promoting diuresis, invigorating the spleen, calming heart.Major function：For oedema oliguria, phlegm retention anti-dazzle nervous, spleen deficiency food
Less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Dried orange peel is the drying and ripening fruit of rutaceae orange Citrus reticulata Blanco and its variety
Skin.It is bitter, pungent, it is warm-natured.Return lung, the spleen channel.Effect：Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.Major function：It is spat for abdominal fullness and distention, deficiency of food
It rushes down, coughing with a lot of sputum.
Peach kernel is rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunus davidiana
(Carr.) dry mature seed of Franch..It is harvested after fruit maturation, removes pulp and nucleocapsid, taken out seed, dry.The whole nation
It generally cultivates various regions.There is promoting blood circulation, relax bowel, is relieving cough and asthma.For closed dysmenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen, lung carbuncle
Acute appendicitis, injury from falling down, dry constipation of intestines, cough and asthma.
Longstamen Onion Bulb, alias Allium macrostemon, mountain garlic, bitter garlic, small garlic, small root vegetables, small root vegetables, big head, wild garlic, wild green onion, open country
Taipa.Latin literary fame Allium macrostemon Bunge belong to Liliaceae, allium.Nature and flavor are pungent, bitter, temperature.The thoughts of returning home, lung,
Stomach, large intestine channel.Function is with curing mainly：Activate yang and remove abstruction, promoting the circulation of qi lead it is stagnant, for chest impediment and cardialgia, epigastric abdominal fullness distending pain, weight after rush down dysentery.
Early period of the invention by prescription database retrieval, summarizes the classical ancient prescription and other common medicines for the treatment of angiocardiopathy
Material, the prescription medication frequency obtain multiple prescriptions that may have reducing blood lipid and alleviation atherosclerosis, are obtained by experiment sieving
Go out the composition of the present invention, be prepared by the prescription of following proportionings：Adlay, Poria cocos, dried orange peel, peach kernel, Longstamen Onion Bulb.Wherein adlay,
Poria cocos collocation strengthening the spleen and stomach, eliminating dampness and diuresis, dried orange peel regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm, peach kernel promoting blood circulation, Longstamen Onion Bulb temperature sun dredging collateral, entirely
Square reasonable combination, cooperate with shared, test proves that, there is reducing blood lipid and alleviate vascular inflammation, alleviate atherosclerosis
Effect, achievees the purpose that vascular protection, effect is better than each single dose.
All medicinal materials in patent of the present invention derive from the method prison of defending of national health State Family Planning Commission and send out [2002] No. 51 simultaneously
In file《It is both food and the article list of drug》, belong to the raw material of medicine-food two-purpose, safe without toxic side effect is suitable as
Health products or food are taken for a long time.
Preferably, in parts by weight, which is made of the following raw material：
20~60 parts of adlay, 20~60 parts of Poria cocos, 20~60 parts of dried orange peel, 40~100 parts of peach kernel, 40~100 parts of Longstamen Onion Bulb.
Preferably, in parts by weight, which is made of the following raw material：
40~60 parts of adlay, 40~60 parts of Poria cocos, 40~60 parts of dried orange peel, 40~60 parts of peach kernel, 40~60 parts of Longstamen Onion Bulb.
It is highly preferred that in parts by weight, which is made of the following raw material：
30 parts of adlay, 30 parts of Poria cocos, 30 parts of dried orange peel, 45 parts of peach kernel, 45 parts of Longstamen Onion Bulb.
Have effects that assist reducing blood lipid in preparation the present invention also provides the Chinese medicine composition and/or protect the food of blood vessel
Application in product, health food or drug.
In embodiment provided by the invention, protection blood vessel is protection vascular endothelial cell and/or alleviates Atherosclerosis
Change.But protection blood vessel is not limited to protection vascular endothelial cell and/or alleviates atherosclerosis.
The present invention also provides a kind of preparation method of the Chinese medicine composition, including：By adlay, Poria cocos, dried orange peel, peach kernel,
Longstamen Onion Bulb carries out water and carries, and obtains Chinese medicine composition.
Preferably, water carry for：In terms of g/mL, 5~15 times of water for being equivalent to raw material dosage is added in, boils extraction 1~3
It is secondary, 1~3 hour every time.
In embodiment provided by the invention, water carry for：In terms of g/mL, addition is equivalent to 9~10 times of raw material dosage
Water boils extraction 2 times, every time 2 hours.
In an embodiment provided by the invention, water carry for by adlay, Poria cocos, dried orange peel, peach kernel, Longstamen Onion Bulb mix after together into
Row water carries；In another embodiment provided by the invention, water is carried as adlay, Poria cocos, dried orange peel, peach kernel, Longstamen Onion Bulb are carried out water respectively
It carries, mixes.
Preferably, further include concentration after water carries the step of.
Preferably, the ratio of volume that the volume after concentration carries water used with water is 1：(5~15).
In embodiment provided by the invention, the ratio of volume that the volume after concentration carries water used with water is 1：(10~
12)。
In embodiment provided by the invention, the ratio of volume that the volume after concentration carries water used with water is 1：6.
The present invention also provides the preparation method of another Chinese medicine composition, including：Adlay, Poria cocos, peach kernel are carried out
Water carries, and concentrates, dry, obtains water extract；
Pericarpium Citri Reticulatae volatile oil is prepared using steam distillation, using beta-cyclodextrin as wall material, is obtained by molecular inclusion old
Skin volatile oil microcapsule；
Volatile oil is prepared using steam distillation, using beta-cyclodextrin as wall material, Chinese onion is obtained by molecular inclusion
White volatile oil microcapsule；
Water extract, Pericarpium Citri Reticulatae volatile oil microcapsules and Volatile oil microcapsules are mixed, obtain Chinese medicine composition.
The present invention also provides the preparation method of another Chinese medicine composition, including：Adlay, Poria cocos, peach kernel are carried out
Water carries, and concentration obtains water extract；
Dried orange peel is subjected to alcohol extracting, concentrates, obtains dried orange peel alcohol extract；
Longstamen Onion Bulb is subjected to alcohol extracting, concentrates, obtains Longstamen Onion Bulb alcohol extract；
Water extract, dried orange peel alcohol extract and Longstamen Onion Bulb alcohol extract are mixed, obtain Chinese medicine composition.
Preferably, in the preparation method, water carry for：In terms of g/mL, addition is equivalent to 5~15 times of raw material dosage
Water boils extraction 1~3 time, 1~3 hour every time.
In embodiment provided by the invention, water carry for：In terms of g/mL, addition is equivalent to 9~10 times of raw material dosage
Water boils extraction 2 times, every time 2 hours.
Preferably, in water extract preparation process, the ratio of volume that the volume after concentration carries water used with water is 1: (5~
15)。
In embodiment provided by the invention, the ratio of volume that the volume after concentration carries water used with water is 1：(10~
12)。
In embodiment provided by the invention, the ratio of volume that the volume after concentration carries water used with water is 1：6.
The present invention also provides the preparation method of another Chinese medicine composition, including：By adlay, Poria cocos, dried orange peel, peach
Benevolence, Longstamen Onion Bulb crush, and are uniformly mixed, obtain Chinese medicine composition.
The present invention also provides a kind of health food, including Chinese medicine composition provided by the invention.
In embodiment provided by the invention, the dosage form of health food is oral liquid, capsule, tablet, pulvis or particle
Agent.But present invention is not limited to this, and those skilled in the art think feasible dosage form within protection scope of the present invention.
The present invention also provides a kind of health food, including Chinese medicine composition provided by the invention.
The present invention also provides a kind of drug, including Chinese medicine composition provided by the invention.
The present invention also provides a kind of food, including Chinese medicine composition provided by the invention.
The present invention provides a kind of Chinese medicine composition and its preparation sides for having effects that assist reducing blood lipid and/or protect blood vessel
Method and product.In parts by weight, which is made of the following raw material：10~100 parts of adlay, 10~100 parts of Poria cocos are old
10~100 parts of skin, 10~100 parts of peach kernel, 10~100 parts of Longstamen Onion Bulb.The present invention at least has one of following advantage：
1st, selected materials are medicine and food raw materials in the present composition, and safe without toxic side effect is suitable as health care
Product or food are taken for a long time；
2nd, the present invention is arranged in pairs or groups by invigorating the spleen for eliminating dampness, promoting blood circulation and removing blood stasis, the rules for the treatment of of temperature sun dredging collateral, reasonable combination, with amounting to
With, and verified by zoopery, the composition has effects that preferably to assist reducing blood lipid and vascular protection, and effect is better than respectively
Single dose.
Description of the drawings
Fig. 1 shows that different samples represent and blank group ratio, p ＜ 0.05 the influence , ﹟ of mouse vascular plaque area；﹡ represent with
Model group ratio, p ＜ 0.05.
Specific embodiment
The invention discloses a kind of Chinese medicine composition and its preparation sides for having effects that assist reducing blood lipid and/or protect blood vessel
Method and product, those skilled in the art can use for reference present disclosure, be suitably modified technological parameter realization.In particular
It is that all similar substitutions and modifications are apparent to those skilled in the art, they are considered as being included in this
Invention.The method of the present invention and application are described by preferred embodiment, and related personnel can significantly not depart from this
Method described herein and application are modified or suitably changed with combining in invention content, spirit and scope, realizing and
Using the technology of the present invention.
Chinese medicine composition and preparation method thereof provided by the invention that there is to assist reducing blood lipid and/or protect blood vessel and
Raw materials used or auxiliary material can be bought by market in product.
With reference to embodiment, the present invention is further explained：
The preparation method of 1 Chinese medicine composition of embodiment
Adlay 30g, Poria cocos 30g, dried orange peel 30g, peach kernel 45g, Longstamen Onion Bulb 45g are taken, water 1800mL is added after merging, boils extraction,
2h, extract 2 times, merge extracting solution, be concentrated into 300mL to get.
The preparation method of 2 Chinese medicine composition of embodiment
Adlay 20g, Poria cocos 60g, dried orange peel 20g, peach kernel 100g, Longstamen Onion Bulb 40g are taken, water 2400mL is added after merging, boils extraction,
2h, extract 2 times, merge extracting solution, be concentrated into 400mL to get.
The preparation method of 3 Chinese medicine composition of embodiment
Adlay 60g, Poria cocos 20g, dried orange peel 60g, peach kernel 40g, Longstamen Onion Bulb 100g are taken, water 2800mL is added after merging, boils extraction,
2h, extract 2 times, merge extracting solution, be concentrated into 467mL to get.
The preparation method of 4 Chinese medicine composition of embodiment
Adlay 30g is taken, adds water 300mL, boils extraction, 2h, extraction twice, merges extracting solution, is concentrated into 50mL；Take Poria cocos
30g adds water 300mL, boils extraction, 2h, and extraction twice, merges extracting solution, is concentrated into 50mL；Dried orange peel 30g is taken, adds water 300mL,
Extraction, 2h are boiled, extraction twice, merges extracting solution, is concentrated into 50mL；Peach kernel 45g is taken, adds water 450mL, boils extraction, 2h is carried
It takes twice, merges extracting solution, be concentrated into 75mL；Longstamen Onion Bulb 45g is taken, adds water 450mL, boils extraction, 2h, twice, merging carries for extraction
Liquid is taken, is concentrated into 75mL；Mix above-mentioned 5 kinds of concentrates to get.
The preparation method of 5 Chinese medicine composition of embodiment
Adlay 40g, Poria cocos 40g, dried orange peel 40g, peach kernel 50g, Longstamen Onion Bulb 50g are taken, water 2400mL is added after merging, boils extraction,
2h, extract 2 times, merge extracting solution, be concentrated into 400mL to get.
1 pharmaceutical research of test example
The present invention has already passed through pharmacological testing and proves, has effects that assist reducing blood lipid and vascular protection.Experimental evidence is such as
Under：
1st, reducing blood lipid is tested
1.1 material
Experimental animal be 8 week old male SD rats, weight 180-220g.All rat adaptability are fed after a week, are started
Modeling and drug-treated.
Test specimen：
5 obtained composition of embodiment 1- embodiments；
Chinese medicine composition single dose (the preparation method is the same as that of Example 1)：
Adlay extract：Adlay 120g is taken, adds water 1200mL, boils extraction, 2h is extracted 2 times, merges extracting solution, concentration
To 200mL to get.
Tuckahoe extracts：Poria cocos 120g is taken, adds water 1200mL, boils extraction, 2h is extracted 2 times, merges extracting solution, concentration
To 200mL to get.
Dried orange peel extracts：Dried orange peel 120g is taken, adds water 1200mL, boils extraction, 2h is extracted 2 times, merges extracting solution, concentration
To 200mL to get.
Semen Persicae extract：Peach kernel 120g is taken, adds water 1200mL, boils extraction, 2h is extracted 2 times, merges extracting solution, concentration
To 200mL to get.
Longstamen onion bulb extract：Longstamen Onion Bulb 120g is taken, adds water 1200mL, boils extraction, 2h is extracted 2 times, merges extracting solution, concentration
To 200mL to get.
1.2 method
All rats are according to animal feeding feeding standard, and control room temperature is at 22 ± 2 DEG C, control day alternates with night time
(daytime-night：08:00-20:00).Above-mentioned rat is randomly divided into 12 groups by weight, every group 10, respectively blank group, model
Group, 1 processing group of embodiment~5 processing group of embodiment, each single dose group.Blank group feeds normal diet, at model group, embodiment 1
5 processing group of reason group~embodiment, single dose group feeding high glucose and high fat feed.Drug-treated is given while giving different feeds：It is empty
White group and model group feed sterile water 1.67mL/kgd, and drug-treated group feeds 1~embodiment of embodiment 5, single dose group respectively
Adlay extract, tuckahoe extracts, dried orange peel extracts, Semen Persicae extract, longstamen onion bulb extract, dosage 1.67mL/ are fed respectively
Kgd after feeding 40 days, puts to death animal, and abdominal vein takes blood, and the serum TC of rat is measured using automatic clinical chemistry analyzer
(T-CHOL), TG (triglycerides), HDL-C (high-density lipoprotein cholesterol) and LDL-C (low density lipoprotein cholesterol)
Content.Data are analyzed using mean ± standard deviation, are examined between each group using t, and when p ＜ 0.05 is statistically significant, poor
It is different notable.
1.3 result
The serum TC (T-CHOL) of each group rat, TG (triglycerides), HDL-C (high-density lipoprotein cholesterol) and
LDL-C (low density lipoprotein cholesterol) content is as shown in table 1 below.The result shows that the TC of high lipid food group rat blood serum, TG and
LDL-C concentration is all remarkably higher than chow diet group (p<0.05), HDL-C concentration is less than chow diet group, but poor in no conspicuousness
Different (p>0.05), process embodiment 1, embodiment 2, embodiment 3, embodiment 4, after the processing of embodiment 5, compared with model group,
5 serum TC of embodiment 1- embodiments, TG and LDL-C levels significantly reduce (p<0.05), illustrate that 1~embodiment of embodiment 5 is equal
The serum TC that rat is caused by high-carbonhydrate diet high in fat can be significantly reduced, TG and LDL-C levels increase, wherein, 1 effect of embodiment
It is best..
Influence of 1 Chinese medicine composition of table to rat fat
A. with blank group ratio, p ＜ 0.05；B. with model group ratio, p ＜ 0.05.
2nd, vascular protection is tested
2.1st, material
8 week old of wild type male under 8 week old ApoE gene knockouts (ApoE-/-) male mice and identical genetic background
C57BL/6 mouse.All mouse are according to animal feeding feeding standard, and control room temperature is at 22 ± 2 DEG C, and day alternates with night for control
(daytime-night time：08:00-20:00).All Animal adaptabilities start administration processing after feeding one week.
2.2nd, method
Blank group is normal C57BL/6 mouse 12, feeds arm's length basis feed, daily sterile water gavage；Model group is
ApoE-/- mouse 12 is raised with (Beijing dimension tonneau experimental animal Co., Ltd offer, containing 15% pig of ApoE mouse high lipid food
Oil, 2% cholesterol, 0.05% cholic acid), daily sterile water gavage；Administration group grouping situation is given with reference to " reducing blood lipid " test portion
Medicine group is raised for ApoE gene knockouts male mice with ApoE mouse high lipid foods, according to 6.67mL/kgd gastric infusions, daily
Once, every group 12.It is 8 weeks that processing time, which is administered, and after administration, mouse orbit veniplex takes blood, using enzyme process kit
Measure plasma TC, TG, LDL-C, HDL-C content；It is horizontal that plasma C RP is measured using enzyme-linked immunosorbent assay kit；Every group random
3 animals are taken, are anaesthetized with 1% yellow Jackets (5mL/kg).After opening thoracic cavity, quick left ventricle is carried out with isotonic physiological saline
Perfusion, washes down systemic blood.When right auricle of heart trickle is clarified, heart, blood vessel and kidney are stayed in original position.Use physiological saline
Aorta is perfused, softly detaches aortic tissue using micro-surgical instrument along backbone leading edge, carefully removes circumvascular fat
Fat tissue, isolate later whole aorta (from heart junction to bilateral arteria iliaca communis bifurcation).Use micro-scissors
It is inserted into active vessel lumen simultaneously, longitudinally cuts off whole blood vessel, the inner wall of whole blood vessel is made fully to expose.Whole blood vessel is immersed into oil red
O solutions overnights, 80% ethanol solution differentiation, then carry out image scanning and quantitative analysis.
Data are represented with average ± standard deviation.Data one-way analysis of variance (one-way ANOVA), use
Fisher PLSD carry out significant difference detection.Significance of difference level is p<0.05.
2.3 result
2.3.1 to the influence of mice plasma CRP levels
CRP is the important indicator for weighing Earlier period of inflammation.The plasma C RP levels of each group mouse are as shown in table 2 below.As a result table
Bright, for model group relative to normal group, plasma C RP is horizontal significantly to increase (p<0.05), pass through 1~embodiment of embodiment 5 and handle
Afterwards, plasma C RP levels have different degrees of reduction, significant difference.Effect is best after wherein embodiment 1 is handled, explanation
Embodiment can significantly inhibit internal inflammatory reaction (p<0.05), be conducive to delay or mitigate the inflammation of atherosclerosis
Damage delays the process of injury of blood vessel.
Influence of the 2 various dose extract of table to mice plasma CRP
| Group | CRP(pg/mL) |
| Normal group | 35±12 |
| Model group | 187±23a |
| Embodiment 1 | 81±16b |
| Embodiment 2 | 115±30b |
| Embodiment 3 | 128±24b |
| Embodiment 4 | 107±33b |
| Embodiment 5 | 115±18b |
| Adlay group | 172±31 |
| Poria cocos group | 131±21b |
| Dried orange peel group | 140±18b |
| Peach kernel group | 159±28b |
| Longstamen Onion Bulb group | 179±20 |
A. with blank group ratio, p ＜ 0.05；B. with model group ratio, p ＜ 0.05.
2.3.2 to the influence of atherosclerotic plaque in mice
The arteriosclerosis plaque of each group mouse is illustrated in fig. 1 shown below, the results show that 8 weeks ApoE-/- mouse can be formed significantly
Atherosclerotic plaque, and by embodiment 1- embodiments 5 processing after, can reduce plaque area in various degree, wherein
1 effect of embodiment is best, can substantially reduce plaque area.
The preparation method of 6 Chinese medicine composition of embodiment
Adlay 3g, Poria cocos 3g, dried orange peel 3g, peach kernel 4.5g, Longstamen Onion Bulb 4.5g are taken, is crushed, is uniformly mixed, is packed into gauze bag, i.e.,
.It is used as soup stock.
The preparation method of 7 mixture of Chinese herbal medicines of embodiment
Adlay 50g, Poria cocos 50g, dried orange peel 50g, peach kernel 50g, Longstamen Onion Bulb 50g are taken, water 2400mL is added after merging, boils extraction,
2h is extracted 2 times, merges extracting solution, concentration, it is dry to get.
The preparation method of 8 Chinese medicine composition of embodiment
Adlay 40g, Poria cocos 60g, dried orange peel 40g, peach kernel 40g, Longstamen Onion Bulb 60g are taken respectively, and water 2400mL is added after merging, boils and carries
Take, 2h, extract 2 times, merge extracting solution, concentration, it is dry to get.
The preparation method of 9 Chinese medicine composition of embodiment
Adlay 30g, Poria cocos 30g, peach kernel 30g are taken, adds water 1400mL, boils extraction, 2h is extracted 2 times, merges extracting solution,
Concentration, is dried to powdered；Dried orange peel 45g is taken, 250mL deionized waters is added in and carries out steam distillation, extract Pericarpium Citri Reticulatae volatile oil, with
Beta-cyclodextrin is wall material, and microcapsule product is prepared by molecular inclusion；Take Longstamen Onion Bulb 45g, add in 250mL deionized waters into
Row steam distillation extracts Volatile oil, using beta-cyclodextrin as wall material, microcapsules is prepared by molecular inclusion and produce
Product；Mix above-mentioned 3 kinds of powder to get.
The preparation method of 10 Chinese medicine composition of embodiment
Adlay 30g, Poria cocos 30g, peach kernel 30g are taken, adds water 1400mL, boils extraction, 2h is extracted 2 times, merges extracting solution,
Concentration；Dried orange peel 45g is taken, 30% ethyl alcohol of 500mL is added in and carries out refluxing extraction, 2h is extracted 2 times, concentration；Longstamen Onion Bulb 45g is taken, is added in
30% ethyl alcohol of 500mL carries out refluxing extraction, and 2h is extracted 2 times, concentration；Mix above-mentioned 3 kinds of extracts, it is dry to get.
The Chinese medicine composition of Example 6~10 carries out pharmacological testing, as a result test method shows implementation with test example 1
The Chinese medicine composition of example 6~10 equally has effects that assist reducing blood lipid and vascular protection.
It is prepared by 11 oral liquid of embodiment
Extract 300mL described in Example 1, filter, sterilizing, dispense to 15 bottles to get.
It is prepared by 12 capsule of embodiment
Extract 200g described in Example 6 is mixed with hydroxypropyl cellulose 60g and superfine silica gel powder 30g, with appropriate 70%
Ethyl alcohol makees wetting agent, and wet granulation is sieved after drying and adds in magnesium stearate, encapsulated after mixing, is made 800.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition, which is characterized in that in parts by weight, be made of the following raw material：
10~100 parts of adlay, 10~100 parts of Poria cocos, 10~100 parts of dried orange peel, 10~100 parts of peach kernel, 10~100 parts of Longstamen Onion Bulb.
2. Chinese medicine composition according to claim 1, which is characterized in that in parts by weight, be made of the following raw material：
20~60 parts of adlay, 20~60 parts of Poria cocos, 20~60 parts of dried orange peel, 40~100 parts of peach kernel, 40~100 parts of Longstamen Onion Bulb.
3. Chinese medicine composition according to claim 1 or 2, which is characterized in that in parts by weight, be made of the following raw material：
40~60 parts of adlay, 40~60 parts of Poria cocos, 40~60 parts of dried orange peel, 40~60 parts of peach kernel, 40~60 parts of Longstamen Onion Bulb.
4. Chinese medicine composition is being prepared with auxiliary reducing blood lipid and/or protection blood vessel work(as described in any one of claims 1 to 3
Application in the food or drug of effect.
5. the preparation method of Chinese medicine composition as described in any one of claims 1 to 3, which is characterized in that including：By adlay, Fu
Siberian cocklebur, dried orange peel, peach kernel, Longstamen Onion Bulb carry out water and carry, and obtain the Chinese medicine composition.
6. the preparation method of Chinese medicine composition as described in any one of claims 1 to 3, which is characterized in that including：By adlay, Fu
Siberian cocklebur, peach kernel carry out water and carry, and concentrate, dry, obtain water extract；
Pericarpium Citri Reticulatae volatile oil is prepared using steam distillation, using beta-cyclodextrin as wall material, dried orange peel is obtained by molecular inclusion and is waved
Hair oil microcapsules；
Volatile oil is prepared using steam distillation, using beta-cyclodextrin as wall material, Longstamen Onion Bulb is obtained by molecular inclusion and is waved
Hair oil microcapsules；
The water extract, the Pericarpium Citri Reticulatae volatile oil microcapsules and the Volatile oil microcapsules are mixed, obtain the Chinese medicine
Composition.
7. the preparation method of Chinese medicine composition as described in any one of claims 1 to 3, which is characterized in that including：By adlay, Fu
Siberian cocklebur, peach kernel carry out water and carry, and concentrate, obtain water extract；
Dried orange peel is subjected to alcohol extracting, concentrates, obtains dried orange peel alcohol extract；
Longstamen Onion Bulb is subjected to alcohol extracting, concentrates, obtains Longstamen Onion Bulb alcohol extract；
The water extract, the dried orange peel alcohol extract and the Longstamen Onion Bulb alcohol extract are mixed, obtain the Chinese medicine composition.
8. the preparation method of Chinese medicine composition as described in any one of claims 1 to 3, which is characterized in that including：By adlay, Fu
Siberian cocklebur, dried orange peel, peach kernel, Longstamen Onion Bulb crush, and are uniformly mixed, obtain the Chinese medicine composition.
9. a kind of drug, which is characterized in that including the Chinese medicine composition as described in any one of claims 1 to 3.
10. a kind of food, which is characterized in that including the Chinese medicine composition as described in any one of claims 1 to 3.
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