CN108195822A - A kind of drug concentration real-time detection apparatus - Google Patents
A kind of drug concentration real-time detection apparatus Download PDFInfo
- Publication number
- CN108195822A CN108195822A CN201810246519.6A CN201810246519A CN108195822A CN 108195822 A CN108195822 A CN 108195822A CN 201810246519 A CN201810246519 A CN 201810246519A CN 108195822 A CN108195822 A CN 108195822A
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- Prior art keywords
- mixing tank
- channel
- drug concentration
- optical fiber
- detection apparatus
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1418—Depression, aspiration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
- G01N2001/386—Other diluting or mixing processes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hydrology & Water Resources (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
This application provides a kind of drug concentration real-time detection apparatus,Including mixing tank,An agitating device is provided on the mixing tank,The agitating device includes the stirring rod set along the vertical direction,The multiple stirring blades being arranged in the stirring rod,Be arranged on outside the mixing tank for driving motor that the stirring rod is driven to rotate,The sampling channel that a upper and lower directions runs through stirring rod is provided in the stirring rod,The bottom of the sampling channel forms sample point,The bottom of the mixing tank is additionally provided with an aerator,The aerator includes the aeration tube being arranged in the mixing tank,The aeration tube upper surface is uniformly provided with multiple solarization air caps,The aerator further includes one and is arranged on the air pump that the mixing tank is outer and is connected with the aeration tube,The sampling channel is connected with a raman laser detection module,The raman laser detection module is connect with a PC end signals.
Description
Technical field
This application involves a kind of drug concentration real-time detection apparatus.
Background technology
In the prior art, batch mixing uniformity quality directly influences the drug effect of finished medicines, at this stage, the mixing of drug batch mixing
The general way of detection be to be shut down at the time of thinking that batch mixing is uniform, then in mixing tank the different parts of material sample into
Row laboratory assay is analyzed, and if the content value of wherein certain ingredient is consistent, that is, thinks that batch mixing reaches uniform, but due to
The poor in timeliness of the way, it is time-consuming, laborious, production efficiency is reduced, the uniformity of last batch mixing can not be completely secured.
Apply for content
The application technical problems to be solved are to provide a kind of drug concentration real-time detection apparatus.
In order to solve the above-mentioned technical problem, this application provides a kind of drug concentration real-time detection apparatus, the detections
Device includes mixing tank, and an agitating device is provided on the mixing tank, and the agitating device includes setting along the vertical direction
The stirring rod put, the multiple stirring blades being arranged in the stirring rod, be arranged on outside the mixing tank for driving
The driving motor of the stirring rod rotation, the interior upper and lower directions that is provided with of the stirring rod are led to through the sampling of stirring rod
Road, the bottom of the sampling channel form sample point, and the bottom of the mixing tank is additionally provided with an aerator, described
Aerator include the aeration tube being arranged in the mixing tank, the aeration tube upper surface is uniformly provided with multiple
Solarization air cap, the aerator further include one and are arranged on the gas that the mixing tank is outer and is connected with the aeration tube
Pump, the sampling channel are connected with a raman laser detection module, and the raman laser detection module and a PC ends are believed
Number connection, is additionally provided with a bottom screen in the mixing tank, the bottom screen be located on the upside of the aeration tube and
Positioned at the downside of the agitating device.
Preferably, the sampling channel on the interface channel of the raman laser detection module with being also equipped with a use
The water pump of detection sample is extracted in interval, the PC ends are used to control the extraction frequency of the water pump.
Preferably, the raman laser detection module includes sample cell, and the sample cell is connected respectively with sample point
Logical, the raman laser detection module further includes excites one or more checking matters to generate swashing for Raman diffused light for exporting
Luminous laser, Raman probe, spectrometer, the Raman probe is for guiding exciting light to multiple positions of sample cell
It puts, and Raman diffused light is sent back to the spectrometer.
Preferably, a charge door is additionally provided at the top of the mixing tank, one is additionally provided at the charge door and is added
Material lid and a top screen.
Preferably, the bottom of the mixing tank is a pars infundibularis, and the bottom of the pars infundibularis is provided with a discharge gate,
The valve that the discharge gate described in a control opens or closes is provided at the discharge gate.
Preferably, the spectrometer is connect with the PC end signals, and the PC is sent to for that will analyze spectrum
End, the PC ends are additionally operable to that the motor stopping is controlled to stir when the variance of the testing result of continuous n times is less than setting value
It mixes.
Preferably, the sample cell is provided with liquid detecting channel, intersecting with the liquid detecting channel connects
Optical fiber duct, the optical fiber duct includes positioned at the incident optical slot of liquid detecting channel side and another positioned at liquid detecting channel
The output optical fiber slot of side is provided with incident optical in the incident optical slot, is provided with out in the output optical fiber slot
Optical fiber is penetrated, the incident optical and the output optical fiber are connected with the Raman probe.
Preferably, the optical fiber duct is mutually perpendicular to intersect with the liquid detecting channel.
Preferably, the light that the laser is sent out passes through Raman probe, incident optical, liquid detecting channel, goes out successively
Penetrate optical fiber, Raman probe is transferred to spectrometer and forms light path, in the light path and the liquid detecting channel
The testing liquid intersection flowed through forms strength of fluid detection zone.
Preferably, the incident optical is close to the end face of one end of liquid detecting channel and the side wall of liquid detecting channel
It overlaps；The output optical fiber is overlapped close to the end face of one end of liquid detecting channel with another side wall of liquid detecting channel,
The end face that the incident optical and the output optical fiber coincides with liquid detecting channel side wall is mutually parallel.
A kind of drug concentration real-time detection apparatus of the application can realize that the drug batch mixing uniformity detects, without modeling,
Quickly, efficiently.Testing result is more intuitive, very clear to the batch mixing uniformity situation in mixing process, grasps in real time, improves
The efficiency and accuracy rate of batch mixing.Accuracy rate is up to more than 95%, and accuracy of detection can be realized within 0.01.
Description of the drawings
Fig. 1 is a kind of structure diagram of drug concentration real-time detection apparatus described herein；
Fig. 2 is the structure diagram of raman laser detection module,
Wherein：1st, mixing tank；2nd, feeding cover；21st, top screen；3rd, stirring rod；31st, stirring blade；4th, discharge gate；41、
Valve；5th, sample point；6th, raman laser detection module；7th, PC ends；61st, sample cell；62nd, laser；63rd, Raman probe；64th, light
Spectrometer；81st, air pump；82nd, aeration tube；83rd, solarization air cap；9th, bottom screen；10th, water pump.
Specific embodiment
The application is described further in the following with reference to the drawings and specific embodiments, so that those skilled in the art can be with
It more fully understands the application and can be practiced, but illustrated embodiment is not as the restriction to the application.
As shown in the figure, this application provides a kind of drug concentration real-time detection apparatus, the detection device includes batch mixing
Tank 1, an agitating device is provided on the mixing tank 1, and the agitating device includes the stirring rod set along the vertical direction
3rd, multiple stirring blades 31 for being arranged in the stirring rod 3, be arranged on it is described for driving outside the mixing tank 1
The driving motor that stirring rod 3 rotates, the interior sampling channel for being provided with a upper and lower directions and running through stirring rod 3 of the stirring rod 3,
The bottom of the sampling channel forms sample point 5, and the bottom of the mixing tank 1 is additionally provided with an aerator, described
Aerator include the aeration tube 82 being arranged in the mixing tank 1,82 upper surface of aeration tube is uniformly set
Have multiple solarization air caps 83, the aerator further include one be arranged on the mixing tank 1 it is outer and with the aeration tube 82
The air pump 81 being connected, the sampling channel are connected with a raman laser detection module 6, raman laser detection mould
Block 6 is connect with 7 signal of a PC ends, and a bottom screen 9 is additionally provided in the mixing tank 1, and the bottom screen 9 is located at institute
On the upside of the aeration tube 82 stated and positioned at the downside of the agitating device.The sampling channel is detected with the raman laser
Be also equipped on the interface channel of module 6 one for interval extract detection sample water pump 10, the PC ends 7 be used for control institute
The extraction frequency for the water pump 10 stated.The raman laser detection module 6 include sample cell 61, the sample cell 61 respectively with
Sample point 5 is connected, and the raman laser detection module 6 further includes generates drawing for exporting the one or more checking matters of excitation
Laser 62, Raman probe 63, the spectrometer 64 of the exciting light of graceful scattering light, the Raman probe 63 are used to draw exciting light
Multiple positions of sample cell 61 are directed at, and Raman diffused light is sent back to the spectrometer 64.The top of the mixing tank 1
A charge door is additionally provided with, a feeding cover 2 and a top screen 21 are additionally provided at the charge door.The mixing tank 1
Bottom for a pars infundibularis, the bottom of the pars infundibularis is provided with a discharge gate 4, a control is provided at the discharge gate 4
The valve 41 that the system discharge gate 4 opens or closes.The spectrometer 64 is connect with 7 signal of PC ends, for inciting somebody to action
Analysis spectrum is sent to the PC ends 7, and the PC ends 7 are additionally operable to be less than setting when the variance of the testing result of continuous n times
The motor is controlled to stop stirring during value.The sample cell 61 is provided with liquid detecting channel and the liquid detecting
Channel intersects the optical fiber duct of connection, the optical fiber duct include positioned at liquid detecting channel side incident optical slot and be located at
The output optical fiber slot of liquid detecting channel opposite side is provided with incident optical, the emergent light in the incident optical slot
The output optical fiber, the incident optical and the output optical fiber is provided in fine slot with the Raman probe 63 to be connected.
The optical fiber duct is mutually perpendicular to intersect with the liquid detecting channel.The light that the laser 62 is sent out is successively by drawing
Graceful probe 63, incident optical, liquid detecting channel, the output optical fiber, Raman probe 63 are transferred to spectrometer 64 and form light path,
The light path forms strength of fluid detection zone with the testing liquid intersection flowed through in the liquid detecting channel.
The incident optical is overlapped close to the end face of one end of liquid detecting channel with the side wall of liquid detecting channel；The outgoing
Optical fiber is overlapped close to the end face of one end of liquid detecting channel with another side wall of liquid detecting channel, the incident optical and
The end face that the output optical fiber coincides with liquid detecting channel side wall is mutually parallel.A kind of drug concentration of the application detects dress in real time
It puts, can realize that the drug batch mixing uniformity detects, it is quick, efficient without modeling.Testing result is more intuitive, to mixing process
In batch mixing uniformity situation it is very clear, grasp in real time, improve the efficiency and accuracy rate of batch mixing.Accuracy rate be up to 95% with
On, accuracy of detection can be realized within 0.01.
Embodiment described above is only the preferred embodiment lifted to absolutely prove the application, the protection model of the application
It encloses without being limited thereto.The equivalent substitute or transformation that those skilled in the art are made on the basis of the application, in the application
Protection domain within.The protection domain of the application is subject to claims.
Claims (10)
1. a kind of drug concentration real-time detection apparatus, which is characterized in that the detection device includes mixing tank, the batch mixing
An agitating device is provided on tank, the agitating device includes the stirring rod set along the vertical direction, is arranged on described stir
The driving for being used to that the stirring rod to be driven to rotate for mix multiple stirring blades on stick, being arranged on outside the mixing tank is electric
Machine, the stirring rod in be provided with a upper and lower directions run through stirring rod sampling channel, the sampling channel it is most lower
End forms sample point, and the bottom of the mixing tank is additionally provided with an aerator, and the aerator includes being arranged on institute
The aeration tube in mixing tank stated, the aeration tube upper surface are uniformly provided with multiple solarization air caps, the aerator
It further includes one and is arranged on the air pump that the mixing tank is outer and is connected with the aeration tube, the sampling channel and one draw
Graceful laser detection module is connected, and the raman laser detection module is connect with a PC end signals, in the mixing tank also
A bottom screen is provided with, the bottom screen is located on the upside of the aeration tube and under the agitating device
Side.
2. a kind of drug concentration real-time detection apparatus as described in claim 1, which is characterized in that the sampling channel and institute
Be also equipped on the interface channel of raman laser detection module stated one for interval extract detect sample water pump, the PC
Hold the extraction frequency for controlling the water pump.
A kind of 3. drug concentration real-time detection apparatus as claimed in claim 2, which is characterized in that the raman laser detection
Module includes sample cell, and the sample cell is connected respectively with sample point, and the raman laser detection module further includes use
Laser, Raman probe, the spectrometer of the exciting light of one or more checking matters generation Raman diffused lights are excited in output, it is described
Raman probe for guiding exciting light to multiple positions of sample cell, and Raman diffused light is sent back to the spectrum
Instrument.
A kind of 4. drug concentration real-time detection apparatus as claimed in claim 3, which is characterized in that the top of the mixing tank
A charge door is additionally provided with, a feeding cover and a top screen are additionally provided at the charge door.
A kind of 5. drug concentration real-time detection apparatus as claimed in claim 4, which is characterized in that the bottom of the mixing tank
For a pars infundibularis, the bottom of the pars infundibularis is provided with a discharge gate, is provided at the discharge gate described in a control
The valve that discharge gate opens or closes.
6. a kind of drug concentration real-time detection apparatus as claimed in claim 5, which is characterized in that the spectrometer with it is described
The connection of PC end signals, be sent to the PC ends for that will analyze spectrum, the PC ends are additionally operable to the detection for working as continuous n times
As a result the control motor stops stirring when variance is less than setting value.
7. a kind of drug concentration real-time detection apparatus as claimed in claim 6, which is characterized in that the sample cell is provided with
Liquid detecting channel, intersect the optical fiber duct connected with the liquid detecting channel, and the optical fiber duct includes being located at liquid
The incident optical slot of sense channel side and the output optical fiber slot positioned at liquid detecting channel opposite side, the incident optical slot
Incident optical is inside provided with, the output optical fiber, the incident optical and the outgoing are provided in the output optical fiber slot
Optical fiber is connected with the Raman probe.
8. a kind of drug concentration real-time detection apparatus as claimed in claim 7, which is characterized in that the optical fiber duct with it is described
Liquid detecting channel be mutually perpendicular to intersect.
A kind of 9. drug concentration real-time detection apparatus as claimed in claim 8, which is characterized in that the light that the laser is sent out
Line is transferred to spectrometer by Raman probe, incident optical, liquid detecting channel, the output optical fiber, Raman probe successively and forms inspection
Light path is surveyed, the testing liquid intersection flowed through in the light path and the liquid detecting channel forms strength of fluid inspection
Survey region.
10. a kind of drug concentration real-time detection apparatus as claimed in claim 9, which is characterized in that the incident optical leans on
The end face of one end of nearly liquid detecting channel is overlapped with the side wall of liquid detecting channel；The output optical fiber is close to liquid detecting
The end face of one end of channel is overlapped with another side wall of liquid detecting channel, and the incident optical and the output optical fiber are examined with liquid
The end face that channel side wall coincides is surveyed to be mutually parallel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810246519.6A CN108195822A (en) | 2018-03-23 | 2018-03-23 | A kind of drug concentration real-time detection apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810246519.6A CN108195822A (en) | 2018-03-23 | 2018-03-23 | A kind of drug concentration real-time detection apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108195822A true CN108195822A (en) | 2018-06-22 |
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ID=62595862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810246519.6A Withdrawn CN108195822A (en) | 2018-03-23 | 2018-03-23 | A kind of drug concentration real-time detection apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108195822A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110672810A (en) * | 2019-11-12 | 2020-01-10 | 深圳市科荣软件股份有限公司 | Water quality detection device for water laboratory |
-
2018
- 2018-03-23 CN CN201810246519.6A patent/CN108195822A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110672810A (en) * | 2019-11-12 | 2020-01-10 | 深圳市科荣软件股份有限公司 | Water quality detection device for water laboratory |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180622 |
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| WW01 | Invention patent application withdrawn after publication |