CN108181297A - A kind of drug batch mixing mixture homogeneity detection device - Google Patents
A kind of drug batch mixing mixture homogeneity detection device Download PDFInfo
- Publication number
- CN108181297A CN108181297A CN201810245719.XA CN201810245719A CN108181297A CN 108181297 A CN108181297 A CN 108181297A CN 201810245719 A CN201810245719 A CN 201810245719A CN 108181297 A CN108181297 A CN 108181297A
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- Prior art keywords
- mixing tank
- detection device
- raman
- mixture homogeneity
- batch mixing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
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- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
This application provides a kind of drug batch mixing mixture homogeneity detection devices, the detection device includes mixing tank, an agitating device is provided on the mixing tank, the agitating device includes the stirring rod set along the vertical direction, the multiple stirring blades being arranged in the stirring rod, be arranged on outside the mixing tank for driving motor that the stirring rod is driven to rotate, multiple sample points are evenly distributed on the side wall of the mixing tank, the sample point is connected respectively with a raman laser detection module, multiple raman laser detection modules are connect with a PC end signals.A kind of drug batch mixing mixture homogeneity detection device of the application can detect the strength of fluid of each sample point in mixing tank in real time, so as to when the concentration of each sample point reaches consistent, stop stirring.
Description
Technical field
This application involves a kind of drug batch mixing mixture homogeneity detection devices.
Background technology
In the prior art, batch mixing uniformity quality directly influences the drug effect of finished medicines, at this stage, the mixing of drug batch mixing
The general way of detection be to be shut down at the time of thinking that batch mixing is uniform, then in mixing tank the different parts of material sample into
Row laboratory assay is analyzed, and if the content value of wherein certain ingredient is consistent, that is, thinks that batch mixing reaches uniform, but due to
The poor in timeliness of the way, it is time-consuming, laborious, production efficiency is reduced, the uniformity of last batch mixing can not be completely secured.
Apply for content
The application technical problems to be solved are to provide a kind of drug batch mixing mixture homogeneity detection device.
In order to solve the above-mentioned technical problem, it is described this application provides a kind of drug batch mixing mixture homogeneity detection device
Detection device include mixing tank, an agitating device is provided on the mixing tank, the agitating device is included vertically
The stirring rod of direction setting, the multiple stirring blades being arranged in the stirring rod, the use being arranged on outside the mixing tank
In being evenly distributed with multiple sample points, institute on the driving motor of the driving stirring rod rotation, the side wall of the mixing tank
The sample point stated is connected respectively with a raman laser detection module, and multiple raman laser detection modules and a PC ends are believed
Number connection.
Preferably, multiple damping sheets, the first end of the damping sheet are additionally provided on the inner wall of the mixing tank
It is fixed on the inner wall of the mixing tank, the other end is free end, and the damping sheet is from first end to free end
It tilts gradually downward.
Preferably, a charge door is additionally provided at the top of the mixing tank, one is additionally provided at the charge door and is added
Material lid and a strainer.
Preferably, the bottom of the mixing tank is a pars infundibularis, and the bottom of the pars infundibularis is provided with a discharge gate,
The first valve that the discharge gate described in a control opens or closes is provided at the discharge gate.
Preferably, the raman laser detection module includes sample cell, and the sample cell is connected respectively with sample point
Logical, the raman laser detection module further includes excites one or more checking matters to generate swashing for Raman diffused light for exporting
Luminous laser, Raman probe, spectrometer, the Raman probe is for guiding exciting light to multiple positions of sample cell
It puts, and Raman diffused light is sent back to the spectrometer.
Preferably, the spectrometer is connect with the PC end signals, and the PC is sent to for that will analyze spectrum
End.
Preferably, the sample cell is provided with liquid detecting channel, intersecting with the liquid detecting channel connects
Optical fiber duct, the optical fiber duct includes positioned at the incident optical slot of liquid detecting channel side and another positioned at liquid detecting channel
The output optical fiber slot of side is provided with incident optical in the incident optical slot, is provided with out in the output optical fiber slot
Optical fiber is penetrated, the incident optical and the output optical fiber are connected with the Raman probe.
Preferably, the light that the laser is sent out passes through Raman probe, incident optical, liquid detecting channel, goes out successively
Penetrate optical fiber, Raman probe is transferred to spectrometer and forms light path, in the light path and the liquid detecting channel
The testing liquid intersection flowed through forms strength of fluid detection zone.
A kind of drug batch mixing mixture homogeneity detection device of the application, can detect each sample point in mixing tank in real time
Strength of fluid, so as to when the concentration of each sample point reaches consistent, stop stirring.Improve the efficiency of batch mixing with it is accurate
Rate.Accuracy rate is up to more than 95%, and accuracy of detection can be realized within 0.01.
Description of the drawings
Fig. 1 is a kind of structure diagram of drug batch mixing mixture homogeneity detection device；
Fig. 2 is the structure diagram of raman laser detection module,
Wherein：1st, mixing tank；11st, damping sheet；2nd, feeding cover；21st, strainer；3rd, stirring rod；31st, stirring blade；4th, discharge
Mouthful；41st, the first valve；5th, sample point；6th, raman laser detection module；7th, PC ends；61st, sample cell；62nd, laser；63rd, Raman
Probe；64th, spectrometer.
Specific embodiment
The application is described further in the following with reference to the drawings and specific embodiments, so that those skilled in the art can be with
It more fully understands the application and can be practiced, but illustrated embodiment is not as the restriction to the application.
As shown in the figure, this application provides a kind of drug batch mixing mixture homogeneity detection device, the detection device packet
Mixing tank 1 is included, an agitating device is provided on the mixing tank 1, the agitating device includes what is set along the vertical direction
Stirring rod 3, the multiple stirring blades 31 being arranged in the stirring rod 3, be arranged on outside the mixing tank 1 for driving
The driving motor that the stirring rod 3 rotates is evenly distributed with multiple sample points 5 on the side wall of the mixing tank 1, described
Sample point 5 is connected respectively with a raman laser detection module 6, and multiple raman laser detection modules 6 are believed with a PC ends 7
Number connection.Multiple damping sheets 11 are additionally provided on the inner wall of the mixing tank 1, the first end of the damping sheet 11 is fixed
On the inner wall of the mixing tank 1, the other end is free end, the damping sheet 11 from first end to free end by
Gradually tilt down.The top of the mixing tank 1 is additionally provided with a charge door, and a feeding cover is additionally provided at the charge door
2 and a strainer 21.The bottom of the mixing tank 1 is a pars infundibularis, and the bottom of the pars infundibularis is provided with a discharge gate 4,
The first valve 41 that the discharge gate 4 described in a control opens or closes is provided at the discharge gate 4.The raman laser
Detection module 6 includes sample cell 61, and the sample cell 61 is connected respectively with sample point, the raman laser detection module
6 further include laser 62, the Raman probe for exporting the exciting light that one or more checking matters is excited to generate Raman diffused light
63rd, spectrometer 64, the Raman probe 63 is for guiding exciting light to multiple positions of sample cell 61, and by Raman scattering
Light sends back the spectrometer 64.The spectrometer 64 is connect with 7 signal of PC ends, for that will analyze spectrum transmission
To the PC ends 7.The sample cell 61 is provided with liquid detecting channel, intersecting with the liquid detecting channel connects
Optical fiber duct, the optical fiber duct includes positioned at the incident optical slot of liquid detecting channel side and another positioned at liquid detecting channel
The output optical fiber slot of side is provided with incident optical in the incident optical slot, is provided with out in the output optical fiber slot
Optical fiber, the incident optical and the output optical fiber is penetrated with the Raman probe 63 to be connected.The laser 62 is sent out
The light gone out is transferred to light by Raman probe 63, incident optical, liquid detecting channel, the output optical fiber, Raman probe 63 successively
Spectrometer 64 forms light path, the testing liquid intersection shape flowed through in the light path and the liquid detecting channel
Into strength of fluid detection zone.
A kind of drug batch mixing mixture homogeneity detection device of the application, can detect each sampling in mixing tank 1 in real time
The strength of fluid of point 5, so as to when the concentration of each sample point 5 reaches consistent, stop stirring.Improve the efficiency and standard of batch mixing
True rate.Accuracy rate is up to more than 95%, and accuracy of detection can be realized within 0.01.
Embodiment described above is only the preferred embodiment lifted to absolutely prove the application, the protection model of the application
It encloses without being limited thereto.The equivalent substitute or transformation that those skilled in the art are made on the basis of the application, in the application
Protection domain within.The protection domain of the application is subject to claims.
Claims (8)
1. a kind of drug batch mixing mixture homogeneity detection device, which is characterized in that the detection device includes mixing tank, described
Mixing tank on be provided with an agitating device, the agitating device includes the stirring rod set along the vertical direction, is arranged on institute
Multiple stirring blades in the stirring rod stated, be arranged on outside the mixing tank for drive that the stirring rod is driven to rotate
Dynamic motor, is evenly distributed with multiple sample points on the side wall of the mixing tank, the sample point respectively with a raman laser
Detection module is connected, and multiple raman laser detection modules are connect with a PC end signals.
A kind of 2. drug batch mixing mixture homogeneity detection device as described in claim 1, which is characterized in that the mixing tank
Inner wall on be additionally provided with multiple damping sheets, the first end of the damping sheet is fixed on the inner wall of the mixing tank,
The other end is free end, and the damping sheet tilts gradually downward from first end to free end.
A kind of 3. drug batch mixing mixture homogeneity detection device as claimed in claim 2, which is characterized in that the mixing tank
Top be additionally provided with a charge door, a feeding cover and a strainer are additionally provided at the charge door.
A kind of 4. drug batch mixing mixture homogeneity detection device as claimed in claim 3, which is characterized in that the mixing tank
Bottom for a pars infundibularis, the bottom of the pars infundibularis is provided with a discharge gate, a control is provided at the discharge gate
The first valve that the discharge gate opens or closes.
5. a kind of drug batch mixing mixture homogeneity detection device as claimed in claim 4, which is characterized in that the Raman swashs
Light detection module includes sample cell, and the sample cell is connected respectively with sample point, and the raman laser detection module is also
Laser, Raman probe, spectrum including being used to export the exciting light that the one or more checking matters of excitation generate Raman diffused light
Instrument, the Raman probe are sent back Raman diffused light described for guiding exciting light to multiple positions of sample cell
Spectrometer.
A kind of 6. drug batch mixing mixture homogeneity detection device as claimed in claim 5, which is characterized in that the spectrometer
It is connect with the PC end signals, the PC ends is sent to for spectrum will to be analyzed.
A kind of 7. drug batch mixing mixture homogeneity detection device as claimed in claim 6, which is characterized in that the sample cell
Be provided with liquid detecting channel, intersect the optical fiber duct connected with the liquid detecting channel, the optical fiber duct include position
Incident optical slot in liquid detecting channel side and the output optical fiber slot positioned at liquid detecting channel opposite side, the incidence
Incident optical is provided in optical fiber duct, is provided with the output optical fiber in the output optical fiber slot, the incident optical and described
The output optical fiber be connected with the Raman probe.
A kind of 8. drug batch mixing mixture homogeneity detection device as claimed in claim 7, which is characterized in that the laser hair
The light gone out is transferred to spectrometer by Raman probe, incident optical, liquid detecting channel, the output optical fiber, Raman probe successively
Light path is formed, the testing liquid intersection flowed through in the light path and the liquid detecting channel forms liquid
Concentration detecting area.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810245719.XA CN108181297A (en) | 2018-03-23 | 2018-03-23 | A kind of drug batch mixing mixture homogeneity detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810245719.XA CN108181297A (en) | 2018-03-23 | 2018-03-23 | A kind of drug batch mixing mixture homogeneity detection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108181297A true CN108181297A (en) | 2018-06-19 |
Family
ID=62553966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810245719.XA Withdrawn CN108181297A (en) | 2018-03-23 | 2018-03-23 | A kind of drug batch mixing mixture homogeneity detection device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108181297A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108872088A (en) * | 2018-08-14 | 2018-11-23 | 南京唯诺尔科技项目管理有限公司 | One kind being used for detection of drug concentration device |
| CN114047030A (en) * | 2021-11-02 | 2022-02-15 | 江苏三沃电子科技有限公司 | Scaling powder sampling method and system |
-
2018
- 2018-03-23 CN CN201810245719.XA patent/CN108181297A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108872088A (en) * | 2018-08-14 | 2018-11-23 | 南京唯诺尔科技项目管理有限公司 | One kind being used for detection of drug concentration device |
| CN114047030A (en) * | 2021-11-02 | 2022-02-15 | 江苏三沃电子科技有限公司 | Scaling powder sampling method and system |
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Application publication date: 20180619 |