CN108187034A - Cordyceps sinensis composite fungi amylose piece - Google Patents
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- CN108187034A CN108187034A CN201810171716.6A CN201810171716A CN108187034A CN 108187034 A CN108187034 A CN 108187034A CN 201810171716 A CN201810171716 A CN 201810171716A CN 108187034 A CN108187034 A CN 108187034A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21062—Subtilisin (3.4.21.62)
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Abstract
The invention discloses cordyceps sinensis composite fungi amylose pieces, include the ingredient of following weight ratio：20 55 parts of Cordyceps sinensis polysaccharide, 15 25 parts of Agaricus Blazei Murrill polysaccharide, 8 12 parts of grifolan, 7 13 parts of phytosterol, 46 parts of Nattokinase, 46 parts of astaxanthin, 12 parts of Taraxacum Polysaccharides, 38 parts of Barley Greeg.The present invention realizes Agaricus Blazei Murrill polysaccharide, grifolan, phytosterol, Nattokinase, astaxanthin, Taraxacum Polysaccharides, Barley Greeg effect further enhances by the particularity of Cordyceps sinensis polysaccharide compound；Realize better repair cell, it is antitumor, the effect of anti-gene mutation.And the present invention uses the raw material of integration of drinking and medicinal herbs, using security level highest, you can reasonable compatibility is carried out not limit the foodstuff raw material of dosage, has both effect and safety, it is without side-effects, and without dose limit.
Description
Technical field
The present invention relates to a kind of cordyceps sinensis composite fungi amylose pieces.
Background technology
Contained Cordyceps sinensis polysaccharide is that cordyceps sinensis in-vivo content is most abundant, one of most important bioactive substance in cordyceps sinensis,
With extensive pharmacological action.Resource increasingly failure in recent years, people attempt culture cordyceps mycelia, fructification makees natural cs
It substitutes, has obtained different degrees of accreditation.First class national new drug cordyceps are to use to isolate cordyceps sinensis from natural cs
Strain, the fermentation of artificial medium body and solid culture are made.
Cordyceps militaris is Ascomycota, meat seat mesh, cordyceps sinensis Cordycepps, the type sepecies of Cordyceps also known as northern Chinese caterpillar Fungus, Cordceps militaris
Deng.Cordyceps militaris has realized artificial cultivation at present.Cordycepin, cordycepic acid and Cordyceps sinensis polysaccharide compound are the distinctive objects of aweto
Matter is the leading indicator of cordyceps sinensis special efficacy.And exactly these indexs, the north grown under the conditions of artificial environment is affluent
Cordyceps sinensis content can be grown higher than life under natural endowment.The protein for the northern Chinese caterpillar Fungus manually cultivated, amino acid, dimension
Raw element equal size meets or exceeds the level of natural cordyceps.Although indivedual nutrition in the northern Chinese caterpillar Fungus manually cultivated
Ingredient is slightly below natural cordyceps level, but these nutritional ingredients can be improved by research.
As cordyceps sinensis tradition effect is constantly excavated, particularly the corresponding pharmacological research of cordyceps sinensis composition and clinical efficacy fruit be all
The affirmative of consumer has been obtained, as the drug of raw material and food has been protected using cordyceps sinensis, health products are gradually developed and enters market.According to state
Food and medicine Surveillance Authority of family data query as a result, domestic health-care food contg. Chinese caterpillar fungus is largely former grass or to cultivate cordyceps sinensis direct
It sells or carries out to play the roughing such as powder, tabletting sale, two drawbacks are supplied with health food made of simple cordyceps sinensis.
One to allow for cordyceps sinensis expensive, and single product reach that effect same day taking dose is larger, and product price is higher, and
Ordinary consumer is enabled to be difficult to bear；
Second is that being not based on Basic Theories of Chinese Medicine, its maximum efficiency is played by Chinese medicine monarch, minister compatibility, and makes health care efficiency
It is more prominent.
It is mostly sold currently on the market with simple cordyceps sinensis fresh grass, hay raw material, cordyceps sinensis deep processed product kind analogy
Few compared with single and quantity, cordyceps sinensis composition market is largely moved towards based on high-end medical product, seriously constrains the attached of cordyceps sinensis combination
Price markup value and economic benefit.And existing cordyceps sinensis beverage formulation production technology is not reasonable so that active constituent is destroyed, nutrients
Matter loss is excessive, unbalanced nutrition, health-care effect unobvious；In addition excessive auxiliary material is added in process of producing product, as sucrose,
Preservative, artificial color etc. damage consumer's health, can not meet the needs of consumer's nourishing and health preserving.
Invention content
The present invention in view of the above-mentioned problems, propose a kind of Cordyceps sinensis polysaccharide, Agaricus Blazei Murrill polysaccharide, grifolan, phytosterol,
Nattokinase, astaxanthin, Taraxacum Polysaccharides, the compatibility of Barley Greeg, to solve the defects of prior art worm grass product, reach with
The purpose for the effect of synergy, better repair cell is antitumor, anti-gene mutation.
The technical solution that the present invention takes is as follows：
The present invention provides a kind of cordyceps sinensis composite fungi amylose piece, includes the ingredient of following parts by weight：
20-55 parts of Cordyceps sinensis polysaccharide, 15-25 parts of Agaricus Blazei Murrill polysaccharide, 8-12 parts of grifolan, 7-13 parts of phytosterol are received
4-6 parts of beans kinases, 4-6 parts of astaxanthin, 1-2 parts of Taraxacum Polysaccharides, 3-8 parts of Barley Greeg.
Further, the cordyceps sinensis is Cordyceps militaris.
Further, the Cordyceps sinensis polysaccharide utilizes the polysaccharide or liquid fermentation and culture cordyceps mycelium of Cordyceps militaris extraction,
Then Cordyceps sinensis polysaccharide is extracted from zymotic fluid to be purified.
Further, the astaxanthin is extracted from haematococcus pluvialis and is obtained.
Further, the Barley Greeg is extracted from barley seedling and is obtained.
Further, the cordyceps sinensis composite fungi amylose piece by following parts by weight into being grouped as：35 parts of Cordyceps sinensis polysaccharide, a Ji
20 parts of blazei polysaccharide, 10 parts of grifolan, 10 parts of phytosterol, 5 parts of Nattokinase, 5 parts of astaxanthin, 1 part of Taraxacum Polysaccharides,
5 parts of Barley Greeg.
Further, tablet is made in the cordyceps sinensis composite fungi amylose piece.
Compared with prior art, the beneficial effects of the invention are as follows：
Polysaccharide compound is widely present in the cell wall of animal cell membrane and plant, microorganism, is by aldehyde radical and ketone
One of high molecular polymer that base is connected by glycosidic bond and the four big base substances for forming life.Cordyceps sinensis polysaccharide inhibits tumour
Gene reduces micronuclear rates and induction tumor cell differentiation, inhibits growth of tumour cell by immunological regulation.Cordyceps sinensis polysaccharide is mainly
By the activated immune factor and cell, the approach such as cell factor generation is promoted to play dual regulation to immune system, currently
One of extraordinary immunopotentiating agent in the world.
Agaricus Blazei Murrill polysaccharide is the effective active composition extracted from Agricus blazei fructification, and fragrant odour, effect is notable, is had
The effect of energy is enhanced to human body, and the growth of tumour cell can be inhibited, there is antitumor action, have to carcinogen absorption,
Excretion.It also has the function of hypoglycemic, improvement diabetes, norcholesterol, improves artery sclerosis.
Grifolan is a kind of effective biological immunomodulator, and different component is containing β -1,3-, β -1,6- Portugals
The structure of glycan, can greatly active cell immune function, so as to improve immunity of organisms；By activate body immune system come
Normal cell canceration is prevented, inhibits growth and metastasis of tumours；By the synergistic effect with chemicotherapy, therapeutic effect is improved, is reduced
The toxicity of chemicotherapy.
Phytosterol is similar to animality sterol such as cholesterol in structure, and the fine or not courage in its energy " identification " blood
Sterol.Phytosterol can seize position of the bad cholesterol in enteron aisle, and it is promoted to excrete, so as to reduce total courage in blood
The content of sterol and bad cholesterol, while had no effect on the content of cholesterol.And promote the katabolism of cholesterol, inhibit
The effects that biochemical synthesis of cholesterol.
Astaxanthin i.e. 3,3 '-dihydroxy -4,4 '-diketo-β, β '-carrotene are terpenes unsaturated compounds, change
Credit minor is C40H52O4, and there are two alpha, beta-lonone ring, 11 conjugated double bonds in molecular structure.Astaxanthin is widely present in
Nature, as in most of shellfish and salmon fishes body, the leaf of plant, flower, fruit and the feather of flamingo are medium.
Astaxanthin has a variety of physiological functions, such as in inoxidizability, antitumor, pre- anti-cancer, strengthen immunity, improvement eyesight etc.
There is certain effect.It is and best from natural safe haematococcus pluvialis extraction natural astaxanthin effect.
Nattokinase is a kind of Proteinkinase, is to be generated in soybean isoflavone by natto strain by Bacillus subtilis natto from Traditional Japanese Food
A kind of serine protease.With thrombus, blood viscosity is reduced, improves blood circulation, the works such as softening and increase blood vessel elasticity
With.
Dandelion is clearing heat and detoxicating, diuresis dissipating bind.Control acute mastitis, adenolymphitis, scrofula, boil poisonous soreness, acute conjunctiva
Inflammation, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infections.It is carried from dandelion
The Taraxacum Polysaccharides taken have antitumor, anti-mutation, anti-oxidant, antifatigue and improve the bioactivity such as immune.
The nutrient that Barley Greeg is needed rich in more than 200 kinds of human body：70 several mineral materials, 18 kinds of amino acid (high-quality small molecules
Protein), more than 100 kinds of enzyme, various vitamins, plant flavone, soluble dietary fiber, natural chlorophyll, 26 such as SOD enzymes
Alkanol etc. can adjust body acid-base value with general equilibrium cytotrophy.It makes cell dynamic, accelerates self-regeneration speed, increase
Strong immunity consolidates positive source, rehabilitation disease.To the inferior healths disease such as digestive discomfort, constipation, gastritis, prostatitis, insomnia, gout
Shape has good improvement.
The present invention is dominated using Cordyceps sinensis polysaccharide, Agaricus Blazei Murrill polysaccharide, grifolan, phytosterol as monarch part, Nattokinase, shrimp
Green element, Taraxacum Polysaccharides, Barley Greeg are helped for minister part paving and are composed；Realize cooperative synergism effect.Cordyceps sinensis polysaccharide can enhance people
Body is to the assimilation effects of other substances, the effect of so as to promote other compositions.The present invention is special by Cordyceps sinensis polysaccharide compound
Property, realize Agaricus Blazei Murrill polysaccharide, grifolan, phytosterol, Nattokinase, astaxanthin, Taraxacum Polysaccharides, Barley Greeg effect
It further enhances；Realize better repair cell, it is antitumor, the effect of anti-gene mutation.And the present invention uses integration of drinking and medicinal herbs
Raw material, using security level highest, you can with do not limit the foodstuff raw material of dosage carry out reasonable compatibility, have both effect and peace
Quan Xing, it is without side-effects, and without dose limit.
Specific embodiment：
With reference to specific embodiment, the present invention is described in detail.
Embodiment 1
Cordyceps sinensis composite fungi amylose piece
Cordyceps mycelia is taken, liquid fermentation method is cultivated, and after cultivating 5 days, extracts the Cordyceps sinensis polysaccharide in culture, extraction
Method uses the prior art, obtains cordyceps sinensis Thick many candies.Then cordyceps sinensis Thick many candies are purified, obtains purity and be more than 90%
Cordyceps sinensis polysaccharide.
The present invention is to Agaricus Blazei Murrill polysaccharide, grifolan, phytosterol, Nattokinase, astaxanthin, Taraxacum Polysaccharides, wheat
The extracting mode of green element has no particular/special requirement, it is only necessary to ensure that purity is more than 90%.Above-mentioned each raw material can directly be bought.
Cordyceps sinensis composite fungi amylose piece is configured by following mass fraction：
20 parts of Cordyceps sinensis polysaccharide, 15 parts of Agaricus Blazei Murrill polysaccharide, 8 parts of grifolan, 7 parts of phytosterol, 4 parts of Nattokinase, shrimp
Green element 4 parts, 1 part of Taraxacum Polysaccharides, 3 parts of Barley Greeg obtain cordyceps sinensis composite fungi amylose piece.
Embodiment 6
Cordyceps sinensis composite fungi amylose piece
Cordyceps mycelium is taken, liquid fermentation method is cultivated, and after cultivating 8 days, is extracted the Cordyceps sinensis polysaccharide in culture, is carried
Method is taken to use the prior art.The present embodiment selection is extracted with water extraction, obtains cordyceps sinensis Thick many candies.Then it is slightly more to cordyceps sinensis
Sugar is purified, and obtains the Cordyceps sinensis polysaccharide that purity is more than 95%.
Cordyceps sinensis composite fungi amylose piece is configured by following mass fraction：
55 parts of worm Cordyceps sinensis polysaccharide, 25 parts of Agaricus Blazei Murrill polysaccharide, 12 parts of grifolan, 13 parts of phytosterol, Nattokinase 6
Part, 6 parts of astaxanthin, 2 parts of Taraxacum Polysaccharides, 8 parts of Barley Greeg obtain cordyceps sinensis composite fungi amylose piece.
Embodiment 7
Cordyceps sinensis composite fungi amylose piece
Cordyceps mycelium is taken, liquid fermentation method is cultivated, and after cultivating 10 days, is extracted in culture
Cordyceps sinensis polysaccharide, extracting method use the prior art.The present embodiment selection is extracted with water extraction, and it is thick to obtain cordyceps sinensis
Polysaccharide.Then cordyceps sinensis Thick many candies are purified, obtains Cordyceps sinensis polysaccharide of the purity more than 99% and answer.
Cordyceps sinensis composite fungi amylose piece is configured by following mass fraction：
35 parts of Cordyceps sinensis polysaccharide, 20 parts of Agaricus Blazei Murrill polysaccharide, 10 parts of grifolan, 10 parts of phytosterol, 5 parts of Nattokinase,
5 parts of astaxanthin, 1 part of Taraxacum Polysaccharides, 5 parts of Barley Greeg.
The foregoing is merely the preferred embodiment of the present invention, not thereby limit the scope of patent protection of the present invention, all
It is the equivalent transformation made with present specification, is directly or indirectly used in other related technical areas, together
Reason includes within the scope of the present invention.
Claims (7)
1. cordyceps sinensis composite fungi amylose piece, which is characterized in that the cordyceps sinensis composite fungi amylose piece includes following parts by weight
Ingredient：
20-55 parts of Cordyceps sinensis polysaccharide, 15-25 parts of Agaricus Blazei Murrill polysaccharide, 8-12 parts of grifolan, 7-13 parts of phytosterol, natto swash
4-6 parts of enzyme, 4-6 parts of astaxanthin, 1-2 parts of Taraxacum Polysaccharides, 3-8 parts of Barley Greeg.
2. cordyceps sinensis composite fungi amylose piece as described in claim 1, which is characterized in that the cordyceps sinensis is Cordyceps militaris.
3. cordyceps sinensis composite fungi amylose piece as claimed in claim 2, which is characterized in that the Cordyceps sinensis polysaccharide is carried using Cordyceps militaris
Then the polysaccharide or liquid fermentation and culture cordyceps mycelium taken extracts Cordyceps sinensis polysaccharide from zymotic fluid and is purified.
4. cordyceps sinensis composite fungi amylose piece as described in claim 1, which is characterized in that the astaxanthin is from haematococcus pluvialis
Extraction obtains.
5. cordyceps sinensis composite fungi amylose piece as described in claim 1, which is characterized in that the Barley Greeg is carried from barley seedling
It obtains.
6. cordyceps sinensis composite fungi amylose piece as described in claim 1, which is characterized in that the cordyceps sinensis composite fungi amylose piece by
Following parts by weight into being grouped as：35 parts of Cordyceps sinensis polysaccharide, 20 parts of Agaricus Blazei Murrill polysaccharide, 10 parts of grifolan, phytosterol 10
Part, 5 parts of Nattokinase, 5 parts of astaxanthin, 1 part of Taraxacum Polysaccharides, 5 parts of Barley Greeg.
7. cordyceps sinensis composite fungi amylose piece as claimed in any one of claims 1 to 6, which is characterized in that the cordyceps sinensis is compound true
Tablet is made in granulose piece.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710631749X | 2017-07-28 | ||
| CN201710631749 | 2017-07-28 |
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| CN108187034A true CN108187034A (en) | 2018-06-22 |
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| CN201810171716.6A Pending CN108187034A (en) | 2017-07-28 | 2018-03-01 | Cordyceps sinensis composite fungi amylose piece |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006134409A2 (en) * | 2005-06-13 | 2006-12-21 | Jaszberenyi Csaba Jozsef | Synergistic prebiotic compositions |
| CN104840481A (en) * | 2015-04-15 | 2015-08-19 | 威海御膳坊生物科技有限公司 | Composite fungal polysaccharide product |
| CN106913854A (en) * | 2017-01-22 | 2017-07-04 | 楼良水 | Cordyceps sinensis polysaccharide albumen peptide complexes and its application |
-
2018
- 2018-03-01 CN CN201810171716.6A patent/CN108187034A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006134409A2 (en) * | 2005-06-13 | 2006-12-21 | Jaszberenyi Csaba Jozsef | Synergistic prebiotic compositions |
| CN104840481A (en) * | 2015-04-15 | 2015-08-19 | 威海御膳坊生物科技有限公司 | Composite fungal polysaccharide product |
| CN106913854A (en) * | 2017-01-22 | 2017-07-04 | 楼良水 | Cordyceps sinensis polysaccharide albumen peptide complexes and its application |
Non-Patent Citations (5)
| Title |
|---|
| 张小洁等: "蒲公英多糖的药理作用研究进展", 《吉林医药学院学报》 * |
| 戴稼禾: "《健康隐性杀手》", 30 April 2011, 复旦大学出版社 * |
| 毛光明等: "麦绿素的安全性毒理学研究", 《疾病控制杂志》 * |
| 汪勇等: "《粮油副产物加工技术》", 31 July 2016, 暨南大学出版社 * |
| 汪多仁: "《绿色医药化学品》", 31 July 2008, 科学技术文献出版社 * |
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