CN108186849A - A kind of capsule medicine and preparation method for treating menopausal syndrome - Google Patents

Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to provide a kind of capsule medicine for treating menopausal syndrome according to the understanding mechanism of Chinese traditional treatment menopausal syndrome, each component and its mass parts ratio of the drug are as follows：30~100g of Herba Epimedii, 100~250g of RADIX POLYGONI MULTIFLORI PREPARATA, 120~350g of prepared rehmannia root, Semen Cuscutae（Salt is fried）100~160g, 50~120g of wine-prepared fructus corni, 100~160g of giant knotweed, 60~100g of moutan bark, 60~160g of Radix Paeoniae Alba, 150~350g of Chinese yam, 50~120g of Rhizoma Chuanxiong, 100~160g of Poria cocos, 60~100g of rhizoma alismatis；Drug provided by the invention is a good Chinese prescription.

Description

A kind of capsule medicine and preparation method for treating menopausal syndrome

Technical field

The invention belongs to field of traditional Chinese, and in particular to a kind of capsule medicine for treating menopausal syndrome, especially It is the field of the capsule medicine and preparation method used for menopausal syndrome patient.

Background technology

It is shown according to related document：Perimenopausal syndrome is also known as menopausal syndrome（MPS）, refer to the front and rear appearance of postmenopausal women It is a series of based on function disorder of autonomic nervous system caused by sex hormone fluctuation or reduction, with one group of neuropsychological symptom Syndrome.Menopause can be divided into two kinds of natural menopause and artificial menopause.Natural menopause refers to ovarian follicle in ovary and uses up or remaining ovarian follicle Reaction is lost to promoting sexual gland hormone, estrogen is no longer developed and secreted to ovarian follicle, it is impossible to stimulate endometrial growth, cause absolutely Through.Artificial menopause refers to operation excision bilateral ovaries or stops ovarian function, such as radiotherapy and chemotherapy with other methods.It is single It solely cuts off uterus and retains side or bilateral ovaries person, not as artificial menopause.

Clinical manifestation：

Most typical symptom is hectic fever, flush in perimenopausal syndrome.45~55 years old is mostly occurred in, most of women may occur in which The symptom that weight does not wait, someone have started to occur in menopause transition symptom, continue to post menopausal 2~3 years, a few peoples are sustainable Just mitigated or disappeared to 5~10 years symptoms of post menopausal.Artificial menopause person often may occur in which climacteric in 2 weeks after surgery Syndrome, postoperative 2 months reach peak, sustainable 2 years as long as.

1. change in menstrual cycle characteristics

Change in menstrual cycle is that climacteric earliest clinical symptoms occurs, is divided into 3 types：

（1）Menstrual cycle extends, and is reduced through amount, last menopause.

（2）Menstrual cycle is irregular, and menostaxis, menorrhagia or even massive haemorrhage or bleeding dripping urine endlessly, then gradually It reduces and stops.

（3）Menstruation stops suddenly, more rare.Due to ovary No-clay weak interbed, endometrium easily occurs for estrogen level fluctuation Cancer.For abnormal bleeding person, should row diagnostic curettage, exclude canceration.

2. vasomotor symptoms

Clinical manifestation is hectic fever, perspires, and is the unstable performance of vasomotoricity, is the most prominent spy of perimenopausal syndrome Sign property symptom.Hectic fever is risen from shirtfront, is poured into incidence, is then involved whole body, a small number of women are limited to head, neck and breast. The region patient of flush feels scorching hot, rubefaction, and then explosive to perspire.Last for several seconds is differed to several minutes, breaking-out frequency Rate is daily for several times to 30~50 times.Night or stress situation easily inspire.Such vascular function is unstable to last 1 year, there is duration Up to 5 years or longer.

So, it is people in the art with regard to how to find a kind of Chinese medicine composition that can effectively treat menopausal syndrome The problem of member is urgently to be resolved.

Invention content

With the continuous development of China's traditional Chinese medicine, in treatment menopausal syndrome, during people gradually appreciate The advantages for the treatment of menopausal syndrome is cured, and good effect, the advantages such as quick, toxic side effect is small over the course for the treatment of, for existing There is the present situation of western medical treatment menopausal syndrome, the purpose of the invention is to provide a kind of capsules for treating menopausal syndrome Agent drug, to solve the problems, such as that menopausal syndrome patient gets well early.The drug is using common Chinese medicine as raw material, is led to It crosses and selects rational drug and mass parts ratio, can effectively treat above-mentioned menopausal syndrome.

To achieve the purpose that foregoing invention, the technical solution adopted in the present invention is：There is provided it is a kind of treat climacteric synthesis The capsule medicine and preparation method of sign, which is characterized in that each component and mass parts of the drug are than as follows：

30~100g of Herba Epimedii, 100~250g of RADIX POLYGONI MULTIFLORI PREPARATA, 120~350g of prepared rehmannia root, Semen Cuscutae（Salt is fried）100~160g, wine cornel 50~120g of meat, 100~160g of giant knotweed, 60~100g of moutan bark, 60~160g of Radix Paeoniae Alba, 150~350g of Chinese yam, Rhizoma Chuanxiong 50~ 120g, 100~160g of Poria cocos, 60~100g of rhizoma alismatis, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

A kind of capsule medicine and preparation method for treating menopausal syndrome, which is characterized in that the drug it is each Component and mass parts are than as follows：

36~90g of Herba Epimedii, 115~220g of RADIX POLYGONI MULTIFLORI PREPARATA, 135~310g of prepared rehmannia root, Semen Cuscutae（Salt is fried）115~140g, wine cornel 56~105g of meat, 115~140g of giant knotweed, 70~90g of moutan bark, 70~140g of Radix Paeoniae Alba, 180~310g of Chinese yam, Rhizoma Chuanxiong 56~ 105g, 115~140g of Poria cocos, 70~90g of rhizoma alismatis, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

A kind of capsule medicine and preparation method for treating menopausal syndrome, which is characterized in that the drug it is each Component and mass parts are than as follows：

Herba Epimedii 80g, RADIX POLYGONI MULTIFLORI PREPARATA 200g, prepared rehmannia root 280g, Semen Cuscutae（Salt is fried）120g, wine-prepared fructus corni 95g, giant knotweed 120g, tree peony Skin 80g, Radix Paeoniae Alba 120g, Chinese yam 280g, Rhizoma Chuanxiong 95g, Poria cocos 120g, rhizoma alismatis 80g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and shallow lake Appropriate powder.

A kind of capsule medicine and preparation method for treating menopausal syndrome, which is characterized in that the method includes such as Lower step is prepared：

A, it after above-mentioned raw materials Chinese medicine being picked impurity and dust, is ground into according to mass parts than altogether（30~50 mesh）Graininess packet It decocts；

B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and impregnates 50min, then soaked drug is put into marmite again, The cold boiling water for adding in 7~9 times of raw material Chinese medicine weight carries out first time high heat decoction, when decocting to 18min, turns slow boiling tanning 120min, leaching liquid；2. the cold boiling water for adding in 6~8 times of raw material Chinese medicine weight in the dregs of a decoction again is fried by intense fire for the second time It boils, when decocting to 15min, turns slow boiling tanning 110min, leaching liquid；3. the mixing of secondary liquid is condensed into relative density is 1.08 clear cream, it is then dry, grind with it is after disinfection to reserve；

C, the method for 1. preparing Chinese medicine capsules according to tradition after smalls sieving ground in B, adds in suitable micro mist silicon Glue, microcrystalline cellulose and starch are uniformly mixed, and are then prepared into capsule（Its capsule it is sealed after total length be 23.3mm, medicinal powder Capacity 0.4~0.5g/）, 2. then polish, sterilize, sealed packaging.

A kind of capsule medicine and preparation method for treating menopausal syndrome, which is characterized in that the instructions of taking is： By the capsule medicine prepared twice a day to take, once a dose sooner or later, dosage 3g（6）/ time, before meals or feed is same Clothes.15 days as a treatment course, 1~4 course for the treatment of of taking medicine, clinical symptoms disappear, and the disease is cured.

Each raw material Chinese medicine in prescription of the present invention has detailed in Chinese Pharmacopoeia, Chinese dictionary and its China's book on Chinese herbal medicine It records.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component：

Herba Epimedii, nature and flavor：It is acrid flavour, sweet, warm-natured, there is the effect of tonifying kidney and strengthening yang, dispelling wind and eliminating dampness, strengthening tendons key bone, for treating sun The diseases such as Chu, dyspnea and cough due to deficiency of the kidney, soreness and weakness of waist and knees, arthralgia pain due to rheumatism, hemiplegia, four limbs are meciless are lost in impotence seminal emission, empty cold infertility, frequent micturition；

RADIX POLYGONI MULTIFLORI PREPARATA, nature and flavor：Bitter, sweet, puckery, slightly warm in nature, have nourishing the blood and yin, relax bowel, preventing malaria, wind-dispelling, removing toxic substances the effect of, use In treatment deficiency of blood Light-headedness, palpitaition, insomnia, the soreness and weakness of waist and knees of the deficiency of liver-yin and kidney-yin, poliosis, tinnitus, seminal emission, dry constipation of intestines, The diseases such as chronic malaria body void, rubella itch, sore carbuncle, scrofula, hemorrhoid；

Prepared rehmannia root, nature and flavor：Sweet, tepor has the effect of nourishing yin and supplementing blood, beneficial to spirit and marrow, for treating the deficiency of liver-yin and kidney-yin, waist and knee acid Soft, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, metrostaxis, dizziness, tinnitus, Poliosis；

Semen Cuscutae（Salt is fried）, nature and flavor：It is warm, sweet, there is the effect of nourishing liver and kidney, tocolysis, improving eyesight, antidiarrheal, lost for treating impotence Essence, dripping urination, enuresis frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, spleen kidney deficiency are rushed down, externally treating leucoderma；

Wine-prepared fructus corni, nature and flavor：Sour, puckery, tepor has the effect of tonifying the liver and kidney, puckery smart prevent prolapse, for treating dizziness and tinnitus, waist and knee Ache, impotence and seminal emission, enuresis frequent micturition, under uterine bleeding band, profuse sweating collapse, Heat Diabetes；

Giant knotweed, nature and flavor：Mildly bitter flavor, cold nature, have removing dampness through diuresis and removing jaundice, clearing heat and detoxicating, removing blood stasis and analgesics, it is relieving cough and reducing sputum the effect of, use In treatment jaundice with damp-heat pathogen, stranguria with turbid discharge, band under, arthralgia pain due to rheumatism, carbuncle sore tumefacting virus, scald, Amenorrhea, abdominal mass, instep beat damage, lung heat cough It coughs；

Moutan bark, nature and flavor：It is arduous, cool, be slightly cold, have heat-clearing, promoting blood circulation to remove blood stasis the effect of, for treat warm heat disease heat invading xuefen, Hair spot, germ later stage brimful of tears hot Fu Yin distributions heat, deficiency of Yin osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhoea, carbuncle sore tumefacting virus, falls at hematemesis Flutter grieved, beriberoid pyretic arthralgia；

Radix Paeoniae Alba, nature and flavor：Hardship, is slightly cold at acid, has the effect of smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating, dizzy for treating headache The diseases such as dizzy, hypochondriac pain, abdominal pain, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat；

Chinese yam, nature and flavor：It is sweet, flat, have tonifying spleen, support lung, reinforce the kidney, strengthening the essence the effect of, for treat splenasthenic diarrhea, deficiency of food edema, Deficiency syndrome of the lung cough and asthma quenches one's thirst, passes out semen, under, kidney deficiency frequent micturition, and the diseases such as carbuncle swells, scrofula are controlled in external application；

Rhizoma Chuanxiong, nature and flavor：It is pungent, warm, there is the effect of wet promote breath and open depression, method wind-dryness, promoting blood circulation and stopping pain, for treating air-cooled headache rotation Dizzy, hypochondriac pain abdomen pain, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block pain, ulcer sores, irregular menstruation, lump in the abdomen abdominal pain, chest side of body thorn Bitterly, tumbling and swelling, arthralgia pain due to rheumatism；

Poria cocos, nature and flavor：It is sweet in flavor, light, mild-natured, there is the effect of clearing damp and promoting diuresis, invigorating the spleen, calming heart, for treating oedema oliguria, phlegm and retained fluid Feel dizzy and heart palpitations, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear；

Rhizoma alismatis, nature and flavor：It is sweet, cold, there is the effect of diuresis, clearing away damp-heat, for treating difficult urination, oedema turgor, diarrhea urine Less, the diseases such as phlegmatic vertigo, puckery pain of heat gonorrhea, hyperlipidemia.

Drug of the present invention is the principle based on Chinese traditional treatment menopausal syndrome, from the pathology machine according to menopausal syndrome System and pharmacological action are thought：With regard to menopausal syndrome, each raw material herbal medicine efficacy in drug provided by the present invention is played altogether, to upper Stating disease has good therapeutic effect.

Specific embodiment

A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned menopausal syndrome, using the formula system Standby medicine effect is good, quick, is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the present invention's Specific embodiment is described in further detail：

Embodiment 1：

A kind of capsule medicine for treating menopausal syndrome, which is characterized in that each component and the mass parts ratio of the drug It is as follows：

Herba Epimedii 80g, RADIX POLYGONI MULTIFLORI PREPARATA 200g, prepared rehmannia root 280g, Semen Cuscutae（Salt is fried）120g, wine-prepared fructus corni 95g, giant knotweed 120g, tree peony Skin 80g, Radix Paeoniae Alba 120g, Chinese yam 280g, Rhizoma Chuanxiong 95g, Poria cocos 120g, rhizoma alismatis 80g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and shallow lake Appropriate powder.

Embodiment 2：

A kind of capsule medicine for treating menopausal syndrome, which is characterized in that each component and the mass parts ratio of the drug It is as follows：

Herba Epimedii 90g, RADIX POLYGONI MULTIFLORI PREPARATA 220g, prepared rehmannia root 310g, Semen Cuscutae（Salt is fried）140g, wine-prepared fructus corni 105g, giant knotweed 140g, tree peony Skin 90g, Radix Paeoniae Alba 140g, Chinese yam 310g, Rhizoma Chuanxiong 105g, Poria cocos 140g, rhizoma alismatis 90g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and Appropriate starch.

Embodiment 3：

A kind of capsule medicine for treating menopausal syndrome, which is characterized in that each component and the mass parts ratio of the drug It is as follows：

Herba Epimedii 100g, RADIX POLYGONI MULTIFLORI PREPARATA 250g, prepared rehmannia root 350g, Semen Cuscutae（Salt is fried）It is 160g, wine-prepared fructus corni 120g, giant knotweed 160g, male Root bark of tree peony 100g, Radix Paeoniae Alba 160g, Chinese yam 350g, Rhizoma Chuanxiong 120g, Poria cocos 160g, rhizoma alismatis 100g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose Element and starch are appropriate.

Model case：

Through clinical conditions patient with gout totally 1320, the age is 680 of 46 years old or more, and only 640 are less than 46 years old. That fully recovers in 1320 patients has 1020, effective 234, invalid 66.Total effective rate is up to 95%.

Claims (3)

1. a kind of capsule medicine for treating menopausal syndrome, which is characterized in that each component and mass parts of the drug Than as follows：

30~100g of Herba Epimedii, 100~250g of RADIX POLYGONI MULTIFLORI PREPARATA, 120~350g of prepared rehmannia root, Semen Cuscutae（Salt is fried）100~160g, wine cornel 50~120g of meat, 100~160g of giant knotweed, 60~100g of moutan bark, 60~160g of Radix Paeoniae Alba, 150~350g of Chinese yam, Rhizoma Chuanxiong 50~ 120g, 100~160g of Poria cocos, 60~100g of rhizoma alismatis, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

2. it is according to claim 1 treatment menopausal syndrome capsule medicine, which is characterized in that the drug it is each A component and mass parts are than as follows：

36~90g of Herba Epimedii, 115~220g of RADIX POLYGONI MULTIFLORI PREPARATA, 135~310g of prepared rehmannia root, Semen Cuscutae（Salt is fried）115~140g, wine cornel 56~105g of meat, 115~140g of giant knotweed, 70~90g of moutan bark, 70~140g of Radix Paeoniae Alba, 180~310g of Chinese yam, Rhizoma Chuanxiong 56~ 105g, 115~140g of Poria cocos, 70~90g of rhizoma alismatis, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

3. the capsule medicine of the treatment menopausal syndrome according to claim 1 to 2, which is characterized in that the drug Each component and mass parts than as follows：

Herba Epimedii 80g, RADIX POLYGONI MULTIFLORI PREPARATA 200g, prepared rehmannia root 280g, Semen Cuscutae（Salt is fried）120g, wine-prepared fructus corni 95g, giant knotweed 120g, tree peony Skin 80g, Radix Paeoniae Alba 120g, Chinese yam 280g, Rhizoma Chuanxiong 95g, Poria cocos 120g, rhizoma alismatis 80g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and shallow lake Appropriate powder.