CN108186558B - It is a kind of to treat infant eczema emulsifiable paste and preparation method thereof - Google Patents
It is a kind of to treat infant eczema emulsifiable paste and preparation method thereof Download PDFInfo
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- CN108186558B CN108186558B CN201810228351.6A CN201810228351A CN108186558B CN 108186558 B CN108186558 B CN 108186558B CN 201810228351 A CN201810228351 A CN 201810228351A CN 108186558 B CN108186558 B CN 108186558B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to disinfectant field, provides and a kind of treat infant eczema emulsifiable paste and preparation method thereof.Main component is stearic acid 3-5 parts, 8-12 parts of pegoxol 7 stearate, 10-14 parts of light liquid petrolatum, 0.08-0.12 parts of ethyl hydroxy benzoate, 0.8-1.5 parts of vitamin E, 0.08-0.12 parts of natrium adetate, 4-6 parts of 1,2- propylene glycol, 1.5-2.5 parts of matrine, 60-70 parts of deionized water.Eczema Creams prepared by the present invention have uniform and smooth, and stickiness is suitable for being easy to absorb, and have the characteristics that anti-inflammatory, sterilization, non-stimulated to skin；It is particularly suitable for infant eczema etc., total effective rate 91.1%.
Description
Technical field
The present invention relates to disinfectant technical fields, and in particular to a kind of infant eczema emulsifiable paste and preparation method thereof.
Background technique
Eczema is a kind of common skin disease for having substantial connection with allergy as caused by a variety of internal and external factors.It is clinical
On mostly not equal with weight itch, the skin lesion of variform, when have the characteristics of exudation and recurrent exerbation.Children's period with
Infantile eczema is most commonly seen, followed by childhood eczema.Onset 1~March after life mostly, gradually mitigate after 6 months, 1 years old half
Later most of infants gradually self-healing.A part of infant be extended down to child or childhood.The state of an illness differs in weight.Fash is more common in head
Portion, such as forehead, cheeks, overhead, from the beginning of when to distribute or the small red pimple of cluster or erythema, gradually increase, and visible phlysis,
The yellow-white scales of skin that peel off and crust can have exudation, erosion and secondary infection.Because itch infant is had the fidgets, night cries and screams, influences to sleep
It sleeps.
The drug for the treatment of eczema includes antihistamine, corticosteroid hormone etc. at present, and treatment is easy to appear biggish pair
Effect；Common treatment method generates biggish stimulation to skin, it is therefore desirable to develop that a kind of pair of skin irritation be small, nontoxic pair
It acts on, effect is obvious, infant eczema emulsifiable paste easy to use.
Summary of the invention
The purpose of the present invention is to provide a kind of emulsifiable pastes with treatment infant eczema, and it is another object of the present invention to mention
For the preparation method of above-mentioned infant eczema emulsifiable paste, the third object of the present invention is to provide above-mentioned infant eczema emulsifiable paste and exists
Skin sterilization, disinfection, the application in infant eczema.
The first aspect of the present invention is to provide a kind of emulsifiable paste for treating infant eczema.
A kind of infant eczema emulsifiable paste, in parts by weight, main component are as follows:
3-5 parts of stearic acid
8-12 parts of pegoxol 7 stearate
10-14 parts of light liquid petrolatum
0.08-0.12 parts of ethyl hydroxy benzoate
0.8-1.5 parts of vitamin E
0.08-0.12 parts of natrium adetate
1,2 4-6 parts of propylene glycol
1.5-2.5 parts of matrine
60-70 parts of deionized water
The infant eczema emulsifiable paste the preparation method is as follows:
1) stearic acid, pegoxol 7 stearate, light liquid petrolatum, ethyl hydroxy benzoate, which, are heated to 70-80 DEG C, makes
Melting is liquid, constitutes oily phase；
2), by natrium adetate, 1,2-PD, deionized water heating water bath to 70-80 DEG C, water phase is constituted；
3), water is dispersed by kuh-seng alkali soluble；
4), oil is mutually slowly added into water phase while stirring, continues stirring 10-20 minutes after adding oily phase, stops water-bath,
When naturally cooling to 40 DEG C or less, C is added, continues stirring 10-20 minute, it is cooling, dispense to get.
The application of infant eczema cream of the invention in skin sterilization, disinfection, infant eczema: 80 infants are chosen
Eczema patients, the month at age 1-6, mean random are divided into 2 groups, every group 40, are used continuously 7 days；Eczema subsides substantially, total effective rate
91.1%。
Infant eczema emulsifiable paste prepared by the present invention has uniform and smooth, and stickiness is suitable for being easy to absorb, non-stimulated to skin
The features such as.
Specific embodiment
Embodiment 1:
1, take 3 parts of stearic acid, 10 parts of pegoxol 7 stearate, 12 parts of light liquid petrolatum, 0.1 part of ethyl hydroxy benzoate,
For 0.8 part of heating water bath of vitamin E to 70-80 DEG C, making melting is liquid, constitutes oily phase；
2,0.1 part of natrium adetate, 5 parts of 1,2-PD, 60 parts of deionized water are weighed, heating water bath is to 70-80 DEG C, structure
At water phase；
3,2 parts of matrine are weighed, is dispersed in water, matrine water is constituted；
4, oil is mutually slowly added into water phase while stirring, after adding oily phase and continuing stirring 15 minutes, is naturally cooled to
Matrine water is added at 40 DEG C or less, continues stirring 15 minutes, it is cooling, packing to get.
Embodiment 2:
1, take 5 parts of stearic acid, 12 parts of pegoxol 7 stearate, 10 parts of light liquid petrolatum, 0.1 part of ethyl hydroxy benzoate,
For .0 parts of heating water baths of vitamin e1 to 70-80 DEG C, making melting is liquid, constitutes oily phase；
2,0.1 part of natrium adetate, 5 parts of 1,2-PD, 70 parts of deionized water are weighed, heating water bath is to 70-80 DEG C, structure
At water phase；
3,2 parts of matrine are weighed, is dispersed in water, matrine water is constituted；
4, oil is mutually slowly added into water phase while stirring, after adding oily phase and continuing stirring 15 minutes, is naturally cooled to
Matrine water is added at 40 DEG C or less, continues stirring 15 minutes, it is cooling, packing to get.
Embodiment 3: thermal stability experiment
Infant eczema emulsifiable paste prepared by example 1 or embodiment 2 is placed in 24 h in 55 DEG C of insulating boxs, finds preparation
Emulsifiable paste keeps uniform, stablizes, no lamination.Illustrate that the infant eczema emulsifiable paste of the invention patent preparation has thermal stability.
Embodiment 4: centrefuge experiment
Infant eczema emulsifiable paste prepared by example 1 is placed in centrifuge tube, is centrifuged 30 minutes under the conditions of 3000 rpm, is sent out
The emulsifiable paste now prepared keeps uniform, stablizes, no lamination.Illustrate the invention patent preparation infant eczema emulsifiable paste have compared with
Good stability.
Embodiment 5: to the effect experiment of infant eczema
The invention patent emulsifiable paste is verified to infant eczema therapeutic effect by emulsifiable paste prepared by clinic trial embodiment 1,
80 tested volunteers of infant eczema, the month at age 1-6 are chosen, mean random is divided into 2 groups, every group 40.One group: using daily
Emulsifiable paste prepared by embodiment 1 is used continuously 7 days；Two groups: using commercially available eczema product daily, be used continuously 7 days.Comparison makes
With front and back therapeutic effect, 1 the results are shown in Table.
Invalid: eczema is not improved situation, or even aggravates；
Slightly effectively: eczema color is thin out, sleep quality improves；
Effective: eczema subsides substantially.
Therapeutic effect of 1 embodiment 1 of table to infant eczema
| Slightly effectively | Effectively | In vain | Total effective rate | |
| Embodiment 1 | 9 | 73 | 8 | 91.1% |
| Commercial product | 18 | 57 | 15 | 83.3% |
The results showed that this product rationally application can be treated effectively and seek infant eczema, and have no adverse reaction, has safely
Effect.
Each ingredient of the invention is as follows:
Matrine: matrine is extracted and is made through organic solvents such as ethyl alcohol by the dry root of leguminous plant kuh-seng, plant, fruit
At.With antiallergy, anti-inflammatory effect, it is adjustable immune and increasing leukocyte, inhibits the release of inflammatory mediator.To certain common
Dermatophyte has different degrees of inhibiting effect, while having heat-clearing, diuresis, desinsection, clearing damp and other effects.
Vitamin E: prevention of inflammation dermatoses reduce the deposition of scar and pigment, accelerate the healing of eczema.
1,2-PD: propylene glycol has the problem of wetting agent, moisturizer effect, have dry skin after adjustment eczema.
The preferred embodiment of the present invention has been described in detail above, but the invention be not limited to it is described
Embodiment, those skilled in the art can also make various equivalent on the premise of not violating the inventive spirit of the present invention
Variation or replacement, these equivalent variation or replacement are all included in the scope defined by the claims of the present application.
Claims (3)
1. a kind of treat infant eczema emulsifiable paste, by weight, it is characterised in that: be made of the following components: stearic acid 3-5
Part, 8-12 parts of pegoxol 7 stearate, 10-14 parts of light liquid petrolatum, 0.08-0.12 parts of ethyl hydroxy benzoate, vitamin E
0.8-1.5 parts, 0.08-0.12 parts of natrium adetate, 4-6 parts of 1,2- propylene glycol, 1.5-2.5 parts of matrine, deionized water 60-70
Part.
2. a kind of preparation method for the treatment of infant eczema emulsifiable paste as described in claim 1, comprising the following steps:
1), by 3-5 parts of stearic acid, 8-12 parts of pegoxol 7 stearates, 10-14 parts of light liquid petrolatums, 0.08-0.12
Part ethyl hydroxy benzoate, 0.8-1.5 parts of vitamin Es, which are heated to 70-80 DEG C, makes melting be liquid, constitutes oily phase；
2), by 0.08-0.12 parts of natrium adetates, 1,2 propylene glycol of 4-6 part, 60-70 parts of deionized water heating water baths to 70-80
DEG C, constitute water phase；
3), 1.5-2.5 parts of matrines are dispersed in water；
4), the oil in step 1) is mutually added slowly in the water phase of step 2 while stirring, continues to stir 10- after adding oily phase
20 minutes, stop water-bath, when naturally cooling to 40 DEG C or less, the matrine water of step 3) be added, continues stirring 10-20 minutes,
It is cooling, packing to get.
3. it is a kind of as claimed in claim 2 preparation treatment for skin sterilization, disinfection, infant eczema emulsifiable paste use
On the way, it is characterised in that: be to choose 80 tested volunteers, the month at age 1-6, mean random is divided into 2 groups, every group 40, continuously makes
With 7 days；Eczema subsides substantially, total effective rate 91.1%.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810228351.6A CN108186558B (en) | 2018-03-20 | 2018-03-20 | It is a kind of to treat infant eczema emulsifiable paste and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810228351.6A CN108186558B (en) | 2018-03-20 | 2018-03-20 | It is a kind of to treat infant eczema emulsifiable paste and preparation method thereof |
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| Publication Number | Publication Date |
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| CN108186558A CN108186558A (en) | 2018-06-22 |
| CN108186558B true CN108186558B (en) | 2019-07-23 |
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| CN201810228351.6A Active CN108186558B (en) | 2018-03-20 | 2018-03-20 | It is a kind of to treat infant eczema emulsifiable paste and preparation method thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116159005A (en) * | 2023-02-22 | 2023-05-26 | 北京中研创科医疗科技有限公司 | Infant eczema nursing milk and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973560A (en) * | 2012-12-03 | 2013-03-20 | 施惠娟 | Novel method of applying matrine to treating eczematous dermatitis |
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2018
- 2018-03-20 CN CN201810228351.6A patent/CN108186558B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973560A (en) * | 2012-12-03 | 2013-03-20 | 施惠娟 | Novel method of applying matrine to treating eczematous dermatitis |
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