CN108184866A - A kind of bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone and Flutriafol - Google Patents
A kind of bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone and Flutriafol Download PDFInfo
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- CN108184866A CN108184866A CN201810042121.0A CN201810042121A CN108184866A CN 108184866 A CN108184866 A CN 108184866A CN 201810042121 A CN201810042121 A CN 201810042121A CN 108184866 A CN108184866 A CN 108184866A
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- Prior art keywords
- flutriafol
- ethyl ketone
- pyrrole ethyl
- thiazole pyrrole
- bactericidal composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides the bactericidal composition of a kind of fluorine-containing thiazole pyrrole ethyl ketone and Flutriafol, and active constituent includes fluorine thiazole pyrrole ethyl ketone and Flutriafol, and the weight proportion of fluorine thiazole pyrrole ethyl ketone and Flutriafol is 1:40‑40:1；Prevention available for corn rust.
Description
Technical field
The invention belongs to pesticide fields, and in particular to the bactericidal composition of a kind of fluorine-containing thiazole pyrrole ethyl ketone and Flutriafol.
Background technology
Corn rust is the Common Diseases during maize production, with the expansion year by year and year after year of corn popularizing area
Plantation, corn rust have gradually risen to Major Diseases by Minor diseases in Chinese maize main producing region.The disease belongs to air-flow propagation
Disease can occur in north and south of China, in recent years in Chinese multiple corn producing regions prevalence outburst, directly contribute quality decline,
Yield reduces, and forms serious threat to maize production.Corn rust includes commonly in global occurring and damage type
Rust, southern rust, tropical rust and stem rust etc..Corn rust is mainly caused harm maize leaf and leaf sheath, is also infected when serious
Stem and bract are covered with scab on plant, hinder photosynthesis, cause quality decline, and yield is reduced.
Fluorine thiazole pyrrole ethyl ketone is the first piperidyl thiazole isoxazoline series bactericidal agent of E.I.Du Pont Company's research and development, to Oomycete disease
Opportunistic pathogen has unique action site, by reaching bactericidal effect to the inhibition of oxidation steroid binding proteins (OSBP).It is to disease
Opportunistic pathogen has prevention, treats and inhibit sporification, and fluorine thiazole pyrrole ethyl ketone is sorted out by fungicide resistance Action Committee (FRAC)
It is unique compound in the group for U15 groups, therefore it and existing fungicide no interactions resistance.But FRAC is pointed out simultaneously, fluorine thiophene
Azoles pyrrole ethyl ketone action site is single, has middle high-level resistance risk, needs to carry out resistance management.
Flutriafol is a kind of absorbability triazole bactericidal agent with protection and therapeutic effect, can be inhaled by root, stem, leaf portion
It receives, and can soon be conducted upwards in plant body, prevention sac fungus, basidiomycetes and disease caused by Fungi Imperfecti, particularly pair
Take-all, powdery mildew, rust, root rot, water rice bakanae disease, sigatoka have preferable control effect.
It is the maximally efficient means of controlling plant diseases using chemical agent.But it applies to long-term continuous high dose single
Chemical bactericide, be easy to cause the problems such as residual of medicament, environmental pollution and resistance to drug resistance fungi are developed.Rational chemistry
Bactericide compounded or mixture have expand fungicidal spectrum, improve control effect, extend the optimum period for applying fertilizer, reduce dosage, reduce poisoning,
It reduces residual, delay the positive feature such as the generation of Antifungal resistance and drug resistance and development, bactericide compounded is to solve above-mentioned ask
One of maximally efficient method of topic.
Invention content
To solve technical problem in the prior art, the object of the present invention is to provide one kind to have notable synergistic effect
Bactericidal composition, the prevention available for corn rust.
Technical solution provided by the invention is as follows：
The bactericidal composition of a kind of fluorine-containing thiazole pyrrole ethyl ketone and Flutriafol, active constituent include fluorine thiazole pyrrole ethyl ketone and powder azoles
Alcohol, and the weight proportion of fluorine thiazole pyrrole ethyl ketone and Flutriafol is 1:40-40:1.
The weight proportion of fluorine thiazole pyrrole ethyl ketone and Flutriafol described in bactericidal composition of the present invention is 1:5-10:1.
Also comprising agriculturally suitable auxiliary material in bactericidal composition of the present invention.
The weight percentage of fluorine thiazole pyrrole ethyl ketone and Flutriafol described in bactericidal composition of the present invention is 1-
95%.
The weight percentage of fluorine thiazole pyrrole ethyl ketone and Flutriafol described in bactericidal composition of the present invention is 25-
75%.
Auxiliary material of the present invention is wetting agent, dispersant, emulsifier, antifreezing agent, antifoaming agent, thickener, mould inhibitor, molten
One or more of agent, disintegrant, filler etc..
The present composition can be prepared into missible oil, microemulsion, granule, suspending agent, aqueous emulsion, wettable powder or moisture
Shot agent.
Bactericidal composition of the present invention can be used for the prevention of corps diseases.It may be preferably used for the prevention of rust.
Compared with prior art, the present invention has the advantages that：
The composition shows significant synergistic effect in certain ratio range, both improves protection effect, reduces
Mu dosage and cost, and expand fungicidal spectrum；The problem of cross resistance is not present due to active constituent each in the composition, institute
With the application of the composition can reach the occurrence and development for delaying pathogen drug resistance, help to extend the use of the medicament
Effect reduces drug resistance and generates probability；Safety is improved, influence of the mixture to environment will be lower, safer.
Specific embodiment
The specific embodiment of the present invention is described in detail with reference to embodiment, it is to be understood that the guarantor of the present invention
Shield range is not restricted by specific implementation.
Example of formulations
1 30% suspending agent of embodiment
Fluorine thiazole pyrrole ethyl ketone 15%, Flutriafol 15%, fatty alcohol polyoxyethylene ether 3%, calcium dodecyl benzene sulfonate 7%,
Triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether 3%, epoxidized soybean oil 1.5%, glycerine 1%, surplus are water.
2 24% wettable powder of embodiment
Fluorine thiazole pyrrole ethyl ketone 20%, Flutriafol 4%, pull open powder 8%, naphthalenesulfonate formaldehyde condensation compound 12%, talcum powder
10%, surplus is kaolin
3 36% water dispersible granules of embodiment
Fluorine thiazole pyrrole ethyl ketone 12%, Flutriafol 24%, lauryl sodium sulfate 8%, polycarboxylate 5%, urea 2% gather
Ethylene glycol 2.5%, soluble starch 3%, surplus are kaolin.
Assays Example one：Fluorine thiazole pyrrole ethyl ketone and Flutriafol compound the toxicity test to corn rust
Test material：Corn rust bacterium.
Reagent agent：Referring to table 1.
Assay method：It is measured using pot-culture method.The potting maize seedling for selecting two leaf phase growing ways consistent is used for experiment.Take rust
The maize leaf of sick spore maturation, adds in the water containing surfactant, washes lower spore with writing brush, is filtered through double gauze
Afterwards, spore suspension is prepared into, is uniformly sprayed on maize seedling with inoculation sprayer, the maize seedling after inoculation is put into artificial gas
It waits indoor culture, spraying treatment is carried out using medicament after 3d, classification investigation is carried out according to blank control incidence after 7d.According to
Each drug concentration and corresponding preventive effect do regression analysis, and EC50 values are obtained, and calculate the toxicity index of medicament according to the abundant methods of Sun Yun and are total to
Malicious coefficient (CTC).As CTC ＜ 80, then composition shows as antagonism, and as 80 ＜ CTC ＜ 120, then composition shows as phase
Add effect, as CTC ＞ 120, then composition shows as synergistic effect.
Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) × 100
Percentage composition+B the medicament toxicity index of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed
The percentage composition of B in agent
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100.Poison
Power measurement result is shown in Table 1.
1 fluorine thiazole pyrrole ethyl ketone of table and Flutriafol compound the toxicity test to corn rust
Table 1 the results show that fluorine thiazole pyrrole ethyl ketone and Flutriafol are used in compounding in certain ratio range to corn rust
It has significant synergies；When fluorine thiazole pyrrole ethyl ketone and Flutriafol proportioning are 1:5-10:When 1, synergistic effect is showed.Fluorine thiazole
Pyrrole ethyl ketone and Flutriafol show as summation action in other ratio ranges, antagonism do not occur.
Field efficacy embodiment one：Fluorine thiazole pyrrole ethyl ketone and Flutriafol compound the field efficacy to corn rust
Corn rust is chosen to fall ill throughout the year heavier plot.Test medicine and dosage are shown in Table 2, often handle 4 cells and repeat.
The corn rust state of an illness is investigated before medicine, corn rust disease indexs is investigated and calculates preventive effect within 7 days after state of an illness initial stage dispenser, medicine.
Grade scale：1 grade, lesion area accounts for less than 5% full wafer leaf area；3 grades, lesion area accounts for full wafer leaf area
6-10%；5 grades, lesion area accounts for the 11-25% of full wafer leaf area；7 grades, lesion area accounts for the 26-50% of full wafer leaf area；9
Grade, lesion area account for more than 50% full wafer leaf area.
2 fluorine thiazole pyrrole ethyl ketone of table and Flutriafol compound the field efficacy to corn rust
As shown in Table 2, when fluorine thiazole pyrrole ethyl ketone and Flutriafol are used in compounding, the preventive effect of corn rust is significantly improved,
Compared with single dose, have significant synergies.Field observation shows to crop safety.
The above is only the preferred embodiment of the present invention, to those skilled in the art, is not departing from this hair
It under the premise of bright raw material, can be suitably modified, these are improved also within protection scope of the present invention.
Claims (9)
1. the bactericidal composition of a kind of fluorine-containing thiazole pyrrole ethyl ketone and Flutriafol, which is characterized in that active constituent includes fluorine thiazole pyrrole
Ethyl ketone and Flutriafol, and the weight proportion of fluorine thiazole pyrrole ethyl ketone and Flutriafol is 1:40-40:1.
2. bactericidal composition according to claim 1, which is characterized in that the weight of the fluorine thiazole pyrrole ethyl ketone and Flutriafol
Match is 1:5-10:1.
3. according to claim 1-2 any one of them bactericidal compositions, which is characterized in that also include in composition and agriculturally fit
Suitable auxiliary material.
4. bactericidal composition according to claim 3, which is characterized in that the weight of the fluorine thiazole pyrrole ethyl ketone and Flutriafol
Percentage composition is 1-95%.
5. bactericidal composition according to claim 4, which is characterized in that the weight of the fluorine thiazole pyrrole ethyl ketone and Flutriafol
Percentage composition is 25-75%.
6. bactericidal composition according to claim 3, which is characterized in that the auxiliary material is wetting agent, dispersant, emulsification
One or more of agent, antifreezing agent, antifoaming agent, thickener, mould inhibitor, solvent, disintegrant, filler etc..
7. bactericidal composition according to claim 3, which is characterized in that composition can be prepared into missible oil, microemulsion, particle
Agent, suspending agent, aqueous emulsion, wettable powder or water dispersible granules.
8. it can be used for the prevention of corps diseases according to claim 1-7 any one of them bactericidal composition.
9. bactericidal composition according to claim 8 can be used for the prevention of rust.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810042121.0A CN108184866A (en) | 2018-01-16 | 2018-01-16 | A kind of bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone and Flutriafol |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810042121.0A CN108184866A (en) | 2018-01-16 | 2018-01-16 | A kind of bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone and Flutriafol |
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| CN108184866A true CN108184866A (en) | 2018-06-22 |
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| CN201810042121.0A Pending CN108184866A (en) | 2018-01-16 | 2018-01-16 | A kind of bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone and Flutriafol |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101888843A (en) * | 2006-07-27 | 2010-11-17 | 杜邦公司 | Fungicidal azocyclic amides |
| CN104663674A (en) * | 2007-10-23 | 2015-06-03 | 杜邦公司 | Fungicidal Mixtures |
-
2018
- 2018-01-16 CN CN201810042121.0A patent/CN108184866A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101888843A (en) * | 2006-07-27 | 2010-11-17 | 杜邦公司 | Fungicidal azocyclic amides |
| CN104663674A (en) * | 2007-10-23 | 2015-06-03 | 杜邦公司 | Fungicidal Mixtures |
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Application publication date: 20180622 |