CN108181204A - A kind of online test method of traditional Chinese drug inspissation process Chinese medicine liquid density - Google Patents
A kind of online test method of traditional Chinese drug inspissation process Chinese medicine liquid density Download PDFInfo
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- CN108181204A CN108181204A CN201711483647.4A CN201711483647A CN108181204A CN 108181204 A CN108181204 A CN 108181204A CN 201711483647 A CN201711483647 A CN 201711483647A CN 108181204 A CN108181204 A CN 108181204A
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- liquid
- density
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- surge tank
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N9/00—Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity
- G01N9/36—Analysing materials by measuring the density or specific gravity, e.g. determining quantity of moisture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D21/00—Measuring or testing not otherwise provided for
- G01D21/02—Measuring two or more variables by means not covered by a single other subclass
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N9/00—Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity
- G01N9/002—Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity using variation of the resonant frequency of an element vibrating in contact with the material submitted to analysis
Abstract
This case is related to the online test method of traditional Chinese drug inspissation process Chinese medicine liquid density, after the liquid level in concentration tank reaches setting range, vacuum valve, the liquid valve of surge tank are opened, liquid is transferred in surge tank, liquid level gauge detection liquid level closes liquid valve and vacuum valve when reaching precalculated position；Detect the fluid temperature and pressure in surge tank；By temperature value and pressure value, to densitometer, collected data are corrected, and are established liquid density and fluid temperature, the functional relation of pressure, are calculated liquid density；After being measured, blow valve and liquid valve are opened, liquid is transferred back to concentration tank and continues to concentrate, until density reaches requirement.This case passes through the improvement to existing Chinese medicine concentration process Chinese medicine liquid Density Detection method, solves current traditional Chinese drug inspissation technical process density on-line determination problem, realize the real-time online detection of concentration process liquor strength, available for concentration technology endpoint, it realizes automated production, and improves concentration technology lot stability and product quality.
Description
Technical field
The present invention relates to pharmaceutical technology (tcd) fields, and in particular to a kind of online inspection of traditional Chinese drug inspissation process Chinese medicine liquid density
Survey method.
Background technology
Density is one of important physical parameter of liquid tcm product, and it is similar and close that measure density can distinguish chemical composition
Different liquid substances is spent, identifies the purity of fluid product and the concentration of certain solution.Therefore, it is close in tcm product detection
Degree is one of index of many liquid product mass controls.
However, in existing pharmaceutical technology (tcd) field, the Density Detection during technique progress relies primarily on people
Work samples or shuts down sampling, production efficiency will be caused to decline in this way, and influence the stability and product quality of concentration technology batch,
It is unfavorable for realizing automated production.
Invention content
For current traditional Chinese drug inspissation technical process receive cream concentration can not on-line checking and lead to problems such as to control it is inaccurate, this
Case provides a kind of online test method of traditional Chinese drug inspissation process Chinese medicine liquid density, for concentration technology endpoint, realizes
Accurate control.
To achieve the above object, technical scheme is as follows：
A kind of online test method of traditional Chinese drug inspissation process Chinese medicine liquid density, in the concentration tank connection for concentrated traditional Chinese medicine
One surge tank is integrated with liquid level gauge, densitometer, temperature detector and pressure detector in the surge tank；The surge tank with
Liquid valve is provided between concentration tank, vacuum valve and blow valve are additionally provided in the surge tank；
Online test method includes the following steps：
1) after the liquid level in concentration tank reaches setting range, the vacuum valve of surge tank is opened, liquid valve is opened, will concentrate
Liquid in tank is transferred in surge tank, and liquid level gauge detection liquid level closes liquid valve and vacuum valve when reaching precalculated position；
2) fluid temperature in surge tank is detected by temperature detector；
3) pressure in surge tank is detected by pressure detector；
4) by the temperature value measured and pressure value, to densitometer, collected data are corrected, and establish liquid density and medicine
Liquid temperature, the functional relation of pressure show the liquid density under the present situation by the functional relation；
5) after being measured, blow valve and liquid valve are opened, the liquid in surge tank is transferred in concentration tank continue it is dense
Contracting, until density reaches requirement.
Preferably, the online test method, wherein, it is additionally provided with purge valve in the surge tank.
Preferably, the online test method, wherein, the density is calculated as plug-in type on-line densimeter.
Preferably, the online test method, wherein, the density is calculated as tuning fork densitometer.
Preferably, the online test method, wherein, functional relation is：
ρ=1/S { [(F0+F1+F2)/F]2-1]}；
Wherein, ρ is liquid density, and S pitches body sensitivity, F for densitometer0The vibration frequency of body, F are pitched for densitometer1For temperature
Value, F2For pressure value, F is constant.
The beneficial effects of the invention are as follows：This case is by changing existing Chinese medicine concentration process Chinese medicine liquid Density Detection method
Into, solve current traditional Chinese drug inspissation technical process density on-line determination problem, realize concentration process liquor strength it is real-time
Line detects, and available for concentration technology endpoint, realizes automated production, and improve concentration technology lot stability and product matter
Amount.
Description of the drawings
Fig. 1 is the structure diagram of traditional Chinese drug inspissation process Chinese medicine liquid density on-line checking device therefor.
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, to enable those skilled in the art with reference to specification text
Word can be implemented according to this.
Embodiment
As shown in Figure 1, after the liquid level in concentration tank 1 reaches setting range, the vacuum valve 5 of surge tank 2 is opened, control is slow
2 vacuum degree of tank is rushed slightly larger than concentration tank 1.The liquid valve 4 of surge tank 2 is opened, liquid suck-back is entered in surge tank 2；Liquid level reaches
When predetermined high-order, liquid valve 4, vacuum valve 5 are closed successively.Temperature detector 10 measures fluid temperature, pressure detector 3 is measured and delayed
Rush pressure in tank 2, densitometer 9 is preferably plug-in type on-line densimeter, more preferably tuning fork densitometer, densitometer 9 acquires
To the vibration frequency that signal is tuning fork.Per sub-sampling, detection 8-10 groups data (remove peak, remove minimum), are averaged
Value, as an effective measurement data.Blow valve 6, liquid valve 4 are opened after being measured successively, liquid is refunded into concentration tank 1
In.
Liquid density, fluid temperature and pressure are corrected, liquid density is established and the function of fluid temperature, pressure closes
System, its functional relation is programmed, the real-time density under the present situation is shown by the functional relation.Density correction functional relation
Formula：ρ=1/S { [(F0+F1+F2)/F]2-1]}；
ρ is density in formula, S is the sensitivity of densitometer fork body, F0Vibration frequency, F for tuning fork1For temperature value, the F measured2
It is that constant, S and F carry parameter for densitometer product for the pressure value that measures, F, by densitometer, manufacturer provides.Density unit is
g/cm3。
Above-mentioned experiment is repeated, until density reaches technological requirement, measures medicinal extract density data such as following table：
Although the embodiments of the present invention have been disclosed as above, but its be not restricted in specification and embodiment it is listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, it is of the invention and unlimited
In specific details and legend shown and described herein.
Claims (5)
1. a kind of online test method of traditional Chinese drug inspissation process Chinese medicine liquid density, which is characterized in that for the dense of concentrated traditional Chinese medicine
Contracting tank connects a surge tank, and liquid level gauge, densitometer, temperature detector and pressure detector are integrated in the surge tank；It is described
Liquid valve is provided between surge tank and concentration tank, vacuum valve and blow valve are additionally provided in the surge tank；
Online test method includes the following steps：
1) after the liquid level in concentration tank reaches setting range, the vacuum valve of surge tank is opened, opens liquid valve, it will be in concentration tank
Liquid be transferred in surge tank, liquid level gauge detection liquid level closes liquid valve and vacuum valve when reaching precalculated position；
2) fluid temperature in surge tank is detected by temperature detector；
3) pressure in surge tank is detected by pressure detector；
4) by the temperature value measured and pressure value, to densitometer, collected data are corrected, and establish liquid density and liquid temperature
The functional relation of degree, pressure, the liquid density under the present situation is shown by the functional relation；
5) after being measured, blow valve and liquid valve is opened, the liquid in surge tank is transferred in concentration tank and continues to concentrate, directly
Reach requirement to density.
2. online test method as described in claim 1, which is characterized in that be additionally provided with purge valve in the surge tank.
3. online test method as described in claim 1, which is characterized in that the density is calculated as plug-in type on-line densimeter.
4. online test method as claimed in claim 3, which is characterized in that the density is calculated as tuning fork densitometer.
5. online test method as claimed in claim 4, which is characterized in that functional relation is：
ρ=1/S { [(F0+F1+F2)/F]2-1]}；
Wherein, ρ is liquid density, and S pitches body sensitivity, F for densitometer0The vibration frequency of body, F are pitched for densitometer1For temperature value,
F2For pressure value, F is constant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711483647.4A CN108181204A (en) | 2017-12-29 | 2017-12-29 | A kind of online test method of traditional Chinese drug inspissation process Chinese medicine liquid density |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711483647.4A CN108181204A (en) | 2017-12-29 | 2017-12-29 | A kind of online test method of traditional Chinese drug inspissation process Chinese medicine liquid density |
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| CN108181204A true CN108181204A (en) | 2018-06-19 |
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| CN201711483647.4A Pending CN108181204A (en) | 2017-12-29 | 2017-12-29 | A kind of online test method of traditional Chinese drug inspissation process Chinese medicine liquid density |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109632449A (en) * | 2019-01-11 | 2019-04-16 | 苏州中青宇测控技术有限公司 | A kind of traditional Chinese drug inspissation technical process medical fluid density on-line detecting system and detection method |
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| WO2005024351A3 (en) * | 2003-08-21 | 2006-05-11 | Appleton Paper Inc | Real time determination of gas solubility and related parameters in manufacturing processes |
| CN202008456U (en) * | 2011-02-24 | 2011-10-12 | 中电投远达环保工程有限公司 | Combination type slurry density measurement device |
| CN203525363U (en) * | 2013-10-18 | 2014-04-09 | 陈晓东 | Automatic control reduced pressure extraction device for preparing traditional Chinese medicines |
| CN104251874A (en) * | 2014-09-10 | 2014-12-31 | 李惠杰 | On-line measure apparatus for water content and density and measure method thereof |
| CN105251221A (en) * | 2015-09-24 | 2016-01-20 | 苏州泽达兴邦医药科技有限公司 | Traditional Chinese medicine concentration process medicine liquid density on-line detection method |
| CN105928824A (en) * | 2016-05-25 | 2016-09-07 | 江苏康缘药业股份有限公司 | Honeysuckle flower and artemisia apiacea concentrated solution vacuum concentration extract density measuring device and control method thereof |
| CN105964002A (en) * | 2016-06-16 | 2016-09-28 | 苏州浙远自动化工程技术有限公司 | Detection judgment method for traditional-Chinese-medicine double-effect-concentrator medicine-liquid transferring process |
-
2017
- 2017-12-29 CN CN201711483647.4A patent/CN108181204A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005024351A3 (en) * | 2003-08-21 | 2006-05-11 | Appleton Paper Inc | Real time determination of gas solubility and related parameters in manufacturing processes |
| CN202008456U (en) * | 2011-02-24 | 2011-10-12 | 中电投远达环保工程有限公司 | Combination type slurry density measurement device |
| CN203525363U (en) * | 2013-10-18 | 2014-04-09 | 陈晓东 | Automatic control reduced pressure extraction device for preparing traditional Chinese medicines |
| CN104251874A (en) * | 2014-09-10 | 2014-12-31 | 李惠杰 | On-line measure apparatus for water content and density and measure method thereof |
| CN105251221A (en) * | 2015-09-24 | 2016-01-20 | 苏州泽达兴邦医药科技有限公司 | Traditional Chinese medicine concentration process medicine liquid density on-line detection method |
| CN105928824A (en) * | 2016-05-25 | 2016-09-07 | 江苏康缘药业股份有限公司 | Honeysuckle flower and artemisia apiacea concentrated solution vacuum concentration extract density measuring device and control method thereof |
| CN105964002A (en) * | 2016-06-16 | 2016-09-28 | 苏州浙远自动化工程技术有限公司 | Detection judgment method for traditional-Chinese-medicine double-effect-concentrator medicine-liquid transferring process |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109632449A (en) * | 2019-01-11 | 2019-04-16 | 苏州中青宇测控技术有限公司 | A kind of traditional Chinese drug inspissation technical process medical fluid density on-line detecting system and detection method |
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Application publication date: 20180619 |