CN108164394B - 一种医药化工用β-苯乙醇的制备方法 - Google Patents
一种医药化工用β-苯乙醇的制备方法 Download PDFInfo
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- CN108164394B CN108164394B CN201810060635.9A CN201810060635A CN108164394B CN 108164394 B CN108164394 B CN 108164394B CN 201810060635 A CN201810060635 A CN 201810060635A CN 108164394 B CN108164394 B CN 108164394B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
- B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
- B01J31/181—Cyclic ligands, including e.g. non-condensed polycyclic ligands, comprising at least one complexing nitrogen atom as ring member, e.g. pyridine
- B01J31/1815—Cyclic ligands, including e.g. non-condensed polycyclic ligands, comprising at least one complexing nitrogen atom as ring member, e.g. pyridine with more than one complexing nitrogen atom, e.g. bipyridyl, 2-aminopyridine
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
- B01J2531/0213—Complexes without C-metal linkages
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/827—Iridium
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Abstract
Description
实施例 | 催化剂 | 配体 | 溶剂 | 苯甲醇转化率(%) | β-苯乙醇选择性(%) |
1 | PPh<sub>3</sub>RuCl<sub>2</sub> | TPPTS | 水 | 58.2 | 79.7 |
2 | RhCl<sub>3</sub> | TPPTS | 水 | 46.6 | 82.6 |
3 | Co<sub>2</sub>(CO)<sub>8</sub> | TPPTS | 水 | 27.5 | 78.5 |
4 | IrCl<sub>3</sub> | TPPTS | 水 | 64.6 | 84.3 |
5 | [Ir(COD)Cl]<sub>2</sub> | TPPTS | 水 | 72.5 | 89.4 |
6 | Ir(OMe)(COD) | TPPTS | 水 | 63.9 | 87.6 |
7 | [Ir(COD)Cl]<sub>2</sub> | BINAPS | 水 | 71.8 | 87.3 |
8 | [Ir(COD)Cl]<sub>2</sub> | TPA | 水 | 70.4 | 84.7 |
9 | [Ir(COD)Cl]<sub>2</sub> | TPPDS | 水 | 71.8 | 88.3 |
10 | [Ir(COD)Cl]<sub>2</sub> | 2,2<sup>,</sup>-联吡啶 | 水 | 84.6 | 92.7 |
11 | [Ir(COD)Cl]<sub>2</sub> | 2,2<sup>,</sup>-联吡啶 | THF | 79.5 | 88.4 |
12 | [Ir(COD)Cl]<sub>2</sub> | 2,2<sup>,</sup>-联吡啶 | 二氯乙烷 | 78.7 | 86.7 |
13 | [Ir(COD)Cl]<sub>2</sub> | 2,2<sup>,</sup>-联吡啶 | 氯苯 | 75.4 | 89.2 |
14 | [Ir(COD)Cl]<sub>2</sub> | 2,2<sup>,</sup>-联吡啶 | THF和水(1:1) | 87.2 | 91.4 |
15 | [Ir(COD)Cl]<sub>2</sub> | 2,2<sup>,</sup>-联吡啶 | THF和水(1:3) | 91.7 | 94.6 |
16 | [Ir(COD)Cl]<sub>2</sub> | 2,2<sup>,</sup>-联吡啶 | THF和水(1:5) | 90.6 | 93.4 |
17 | [Ir(COD)Cl]<sub>2</sub> | 2,2<sup>,</sup>-联吡啶 | THF和水(3:1) | 85.7 | 93.6 |
Claims (7)
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Citations (1)
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CN107089900A (zh) * | 2017-04-28 | 2017-08-25 | 山东新和成药业有限公司 | 一种β‑苯乙醇的制备方法 |
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CN107089900A (zh) * | 2017-04-28 | 2017-08-25 | 山东新和成药业有限公司 | 一种β‑苯乙醇的制备方法 |
Non-Patent Citations (9)
Title |
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Alcohol cross-coupling reactions catalyzed by Ru and Ir terpyridine complexes;Gnanamgari, Dinakar;《Organic & Biomolecular Chemistry》;20081231;第6卷(第23期);4442-4445 * |
Alkylation of active methylene compounds with alcohols catalyzed by an iridium complex;Morita, Masao;《Chemical Communications》;20071231(第31期);3306-3310 * |
An efficient α-alkylation of aromatic ketones with primary alcohols catalyzed by [Cp*IrCl2]2 without solvent;Li, Jian;《Chinese Journal of Chemistry》;20121231;第30卷(第10期);2363-2366 * |
Direct β-Alkylation of Secondary Alcohols with Primary Alcohols Catalyzed by a CpIr Complex;Fujita, Kenichi;《Organic Letters》;20051231;第7卷(第18期);4017-4019 * |
Discovery and Mechanistic Studies of a General Air-Promoted Metal-Catalyzed Aerobic N-Alkylation Reaction of Amides and Amines with Alcohols;Liu, Chuanzhi;《Journal of Organic Chemistry》;20111231;第76卷(第14期);5759-5773 * |
Di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,-3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]diiridium;Fujita, Ken-ichi;《 e-EROS Encyclopedia of Reagents for Organic Synthesis》;20121231;1-8 * |
Iridium-Catalyzed Oxidative Methyl Esterification of Primary Alcohols and Diols with Methanol;Yamamoto, Nobuyuki;《Journal of Organic Chemistry》;20111231;第76卷(第8期);2937-2941 * |
钌、铱金属配合物的合成及在有机反应中的应用;蔡丽华;《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》;20130315(第3期);B014-75 * |
香料β-苯乙醇合成工艺研究;杜松山;《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》;20080815(第8期);B018-12 * |
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