CN108159474A - A kind of preparation method for the dressing for being suitable for burn - Google Patents
A kind of preparation method for the dressing for being suitable for burn Download PDFInfo
- Publication number
- CN108159474A CN108159474A CN201810120343.XA CN201810120343A CN108159474A CN 108159474 A CN108159474 A CN 108159474A CN 201810120343 A CN201810120343 A CN 201810120343A CN 108159474 A CN108159474 A CN 108159474A
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- CN
- China
- Prior art keywords
- dressing
- burn
- preparation
- freeze
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The present invention provides a kind of preparation method for the dressing for being suitable for burn, and porous material is obtained, and the bio-absorbable film of the porous material and film-form is compound in a manner that natural polymer is handled with foamable.The preparation method of the present invention is easy to operate, solve the problems, such as that dressing of the prior art is not suitable for burning or scald, the bleeding-stopping dressing being prepared has good biocompatibility, good with the stickiness of the surface of a wound, external bacterium can be isolated, preferably promote burn or scalding healing.
Description
Technical field
The present invention relates to medicine and hygiene fields, and in particular to a kind of preparation method for the dressing for being suitable for burn.
Background technology
Scald or burn are referred to as " burning ", are a kind of common wounds, not only cause the damage of skin, but also can cause
The burn of serious general reaction, especially large area, general reaction is very violent, such as liquid exudation, infection, toxin absorption
Deng may occur in which each system, organ metabolic disorder, functional disturbance, the death rate is high.Meanwhile such as burn wound is dealt with improperly (as outside
Apply mercurochrome, toothpaste, dog oil and some special prescription of Chinese herbal medicine etc.), it easily causes trauma surface infestation, depth down, wound healing time and prolongs
Pain that is long etc. and increasing patient and formation scar or scar hyperplasia, contracture etc. cause deformity, dysfunction and influence beautiful
Etc. sequelae etc..
For the Wound treatment of burn or scald, principle is cleaning and the protection surface of a wound, mitigates pain, reduces exudation and water
Swell, prevent and prevent infection from deepening, wound healing.Wound treatment method have wrapping, exposure, half exposure (opening), soak,
Immersion therapy etc..It should be depending on the property of the surface of a wound, the drug of selection and covering etc..In the case of need to use covering
Under, the performance of dressing plays an important role the healing of the surface of a wound.
The wound healing time of scald or burn is long, and current dressing there are wound by tissue fluid is impregnated and swollen for a long time
Swollen, antibacterial bacteriostatic energy force difference, the deficiencies of biocompatibility is undesirable part are unfavorable for wound healing.
In consideration of it, urgently proposing a kind of preparation method at present, being prepared can prevent tissue fluid from impregnating the surface of a wound, antibacterial bacteriostatic
Ability is high, the dressing for being suitable for burn of good biocompatibility.
Invention content
The technical problems to be solved by the invention be that medical dressing preparation method of the prior art is prepared only
Blood dressing is unsuitable for burn wound, is unfavorable for the problem of wound healing, antibacterial bacteriostatic energy force difference, and then provides a kind of suitable for burn
Or the preparation method of the high dressing of scald, be conducive to wound healing, antibacterial bacteriostatic ability.
For this purpose, the present invention provides a kind of preparation method for the dressing for being suitable for burn, include the following steps：
(1) high molecular material is taken, is added it in water, is stirred to being completely dissolved, after mixing, in vacuum condition
Under, controlled at 100-300 DEG C, foamable processing is carried out, obtains porous material；
(2) high molecular material is taken, is dissolved in water, after stirring evenly, is toppled in the plane, casting film-forming is to get thin
Membranaceous bio-absorbable film；
It (3) will foaming treated the porous material in the bio-absorbable film that obtained in step (2) and step (1)
Crimping is integrated, then is placed it under vacuum condition and be freeze-dried, control temperature -20~-80 DEG C, freeze-drying 1-2h to get
To the dressing for being suitable for burn.
Preferably, the high molecular material is one kind in ossein, gelatin.
Preferably, in step (1), when carrying out foamable processing, hydroxypropyl methyl cellulose is additionally added as foaming
Agent.
Preferably, the mass ratio of the high molecular material and the foaming agent is 100：(0.1~2).
Preferably, in step (1), the molding time of foamable processing is 0.5-2h.
Preferably, in step (3), in temperature -20~-80 DEG C, after being freeze-dried 1-2h, then it is -10~-20 to adjust temperature
DEG C, it is freeze-dried 3-5h.
The present invention also provides the dressing for being suitable for burn that a kind of preparation method of the present invention is prepared.
Technical solution provided by the invention, has the following advantages that：
The preparation method of absorbable hemostasia dressing of the present invention is handled using natural polymer foamable
Mode obtains porous material, and the bio-absorbable film of the porous material and film-form is compound.The preparation method behaviour of the present invention
Make simply, solve the problems, such as that dressing of the prior art is not suitable for burning or scald, the bleeding-stopping dressing being prepared has
Good biocompatibility, it is good with the stickiness of the surface of a wound, external bacterium can be isolated, preferably promote burn or scalding healing.
Specific embodiment
Embodiment 1
The preparation method of the dressing for being suitable for burn of the present embodiment, step are as follows：
(1) high molecular material is taken, is added it in water, is stirred to being completely dissolved, after mixing, in vacuum condition
Under, controlled at 300 DEG C, foamable processing is carried out, obtains porous material；
(2) weigh 20g osseins particulate abrasive to powdered, be dissolved in water, be made into mass fraction for 0.5%~
10% colloidal liquid adds in 5g sodium alginates, is poured over after stirring evenly on glass or stainless steel plate, casting film-forming, room temperature
Dry the bio-absorbable film up to film-form；
It (3) will foaming treated the porous material in the bio-absorbable film that obtained in step (2) and step (1)
Crimping is integrated, then is placed it under vacuum condition and be freeze-dried, and controls -80 DEG C of temperature, and freeze-drying 2h fits to get to described
For the dressing of burn.
Embodiment 2
The preparation method of the dressing for being suitable for burn of the present embodiment, step are as follows：
(1) gelatin 20g is taken, is added it in water, adds hydroxypropyl methyl cellulose 0.02g, is stirred to completely molten
Solution after mixing, under vacuum, controlled at 100 DEG C, carries out foamable processing, molding 2h is to get to porous
Material；
(2) 20g gelatin particles are weighed and are ground to powdered, are dissolved in water, it is 0.5%~10% to be made into mass fraction
Colloidal liquid, add in 5g sodium alginates, be poured over after stirring evenly on glass or stainless steel plate, casting film-forming, room temperature is dried
Up to the bio-absorbable film of film-form；
It (3) will foaming treated the porous material in the bio-absorbable film that obtained in step (2) and step (1)
Crimping is integrated, then is placed it under vacuum condition and be freeze-dried, and controls -80 DEG C of temperature, and freeze-drying 2h fits to get to described
For the dressing of burn.
Embodiment 3
The preparation method of the dressing for being suitable for burn of the present embodiment, step are as follows：
(1) ossein 20g is taken, is added it in water, adds hydroxypropyl methyl cellulose 0.08g, is stirred to complete
Dissolving after mixing, under vacuum, controlled at 100 DEG C, carries out foamable processing, molding 2h is to get to more
Porous materials；
(2) 20g gelatin particles are weighed and are ground to powdered, are dissolved in water, it is 0.5%~10% to be made into mass fraction
Colloidal liquid, add in 5g sodium alginates, be poured over after stirring evenly on glass or stainless steel plate, casting film-forming, room temperature is dried
Up to the bio-absorbable film of film-form；
It (3) will foaming treated the porous material in the bio-absorbable film that obtained in step (2) and step (1)
Crimping is integrated, then is placed it under vacuum condition and be freeze-dried, and controls -20 DEG C of temperature, is freeze-dried 2h, then adjust temperature
It is -10 DEG C, is freeze-dried 3-5h.Obtain the dressing for being suitable for burn.
Experimental example
Technique effect for the preparation method for verifying the dressing of the present invention for being suitable for burn, carries out following wound
Healing Experiments：
15 adult SD rats are taken, are divided into 3 groups, every group 5, number is 1 group of embodiment, 2 groups of embodiment, embodiment respectively
3 groups, respectively then 15 rats, are rejected by the hair of rat back, carried out standby using 10% chloraldurate intraperitoneal injection of anesthesia
Prepared by skin, disinfection, scald, two sizes, burning are manufactured in every rat back backbone both sides antimere with thermostatic type electric pressing instrument
Hinder the consistent burn wound of depth.The surface of a wound be 85 DEG C at it is for 10 seconds caused by burn.After burn is formed, carry out disinfection processing
Afterwards, the dressing being prepared in embodiment 1-3 is respectively adopted to bind up a wound, observes wound situation.
Experiment obtains following result：7 days after tested animal wrapping, it is suitable for applying for burn using what the present invention was prepared
Material, during for tested animal, tested animal wound healing is good.
Obviously, the above embodiments are merely examples for clarifying the description, and is not intended to limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And the obvious variation thus extended out or
Among changing still in the protection domain of the invention.
Claims (7)
1. a kind of preparation method for the dressing for being suitable for burn, which is characterized in that include the following steps：
(1) high molecular material is taken, is added it in water, is stirred to being completely dissolved, after mixing, under vacuum, control
Temperature processed is 100-300 DEG C, carries out foamable processing, obtains porous material；
(2) high molecular material is taken, is dissolved in water, after stirring evenly, is toppled in the plane, casting film-forming is to get film-form
Bio-absorbable film；
(3) by foaming in the bio-absorbable film obtained in step (2) and step (1), treated that the porous material crimps
It is integrated, then places it under vacuum condition and be freeze-dried, control temperature -20~-80 DEG C, freeze-drying 1-2h is to get to institute
State the dressing suitable for burn.
2. according to the preparation method of the dressing for being suitable for burn described in claim 1, which is characterized in that the macromolecule material
Expect for one kind in ossein, gelatin.
3. according to the preparation method of the dressing for being suitable for burn described in claim 2, which is characterized in that in step (1),
When carrying out foamable processing, hydroxypropyl methyl cellulose is additionally added as foaming agent.
4. according to the preparation method of the dressing for being suitable for burn described in claim 3, which is characterized in that in step (1), institute
The mass ratio for stating high molecular material and the foaming agent is 100：(0.1~2).
5. according to the preparation method of the dressing for being suitable for burn described in claim 4, which is characterized in that in step (1), add
The molding time of heat foamable processing is 0.5-2h.
6. the preparation method of the dressing for being suitable for burn according to any one in claim 1-5, which is characterized in that step
Suddenly in (3), in temperature -20~-80 DEG C, after being freeze-dried 1-2h, then it is -10~-20 DEG C to adjust temperature, is freeze-dried 3-5h.
7. the dressing for being suitable for burn that the preparation method in a kind of 1-6 as claim described in any one is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810120343.XA CN108159474A (en) | 2018-02-07 | 2018-02-07 | A kind of preparation method for the dressing for being suitable for burn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810120343.XA CN108159474A (en) | 2018-02-07 | 2018-02-07 | A kind of preparation method for the dressing for being suitable for burn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108159474A true CN108159474A (en) | 2018-06-15 |
Family
ID=62513542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810120343.XA Pending CN108159474A (en) | 2018-02-07 | 2018-02-07 | A kind of preparation method for the dressing for being suitable for burn |
Country Status (1)
| Country | Link |
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| CN (1) | CN108159474A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1458568A1 (en) * | 2001-12-21 | 2004-09-22 | Avery Dennison Corporation | Process for the manufacture of multi-layered wound dressings |
| US20070122463A1 (en) * | 2005-11-25 | 2007-05-31 | Feng Chia University | Antimicrobial compositions and wound dressings |
| CN103239326A (en) * | 2006-07-06 | 2013-08-14 | 株式会社瑞光 | Wound dressing |
| CN103550816A (en) * | 2013-11-15 | 2014-02-05 | 南通大学 | Preparation method for chitosan-based electrostatic spinning combined wound dressing |
| US20140046236A1 (en) * | 2010-06-04 | 2014-02-13 | University Of Liege | Chitosan biomimetic scaffolds and methods for preparing the same |
| CN104414772A (en) * | 2013-09-06 | 2015-03-18 | 山东百多安医疗器械有限公司 | In-vivo degradable and absorbable artificial medical tissue repairing film |
| CN104491914A (en) * | 2014-12-25 | 2015-04-08 | 中国人民解放军第四军医大学 | Porous complex gel-nanofiber oxygen permeation dressing and preparation method thereof |
| CN104758977A (en) * | 2014-10-11 | 2015-07-08 | 河南亚都实业有限公司 | An alginate dressing for treating bedsore and a preparing method thereof |
| CN107625582A (en) * | 2017-10-18 | 2018-01-26 | 佛山市优特医疗科技有限公司 | Wound dressing, its preparation method and its application with sandwich construction |
-
2018
- 2018-02-07 CN CN201810120343.XA patent/CN108159474A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1458568A1 (en) * | 2001-12-21 | 2004-09-22 | Avery Dennison Corporation | Process for the manufacture of multi-layered wound dressings |
| US20070122463A1 (en) * | 2005-11-25 | 2007-05-31 | Feng Chia University | Antimicrobial compositions and wound dressings |
| CN103239326A (en) * | 2006-07-06 | 2013-08-14 | 株式会社瑞光 | Wound dressing |
| US20140046236A1 (en) * | 2010-06-04 | 2014-02-13 | University Of Liege | Chitosan biomimetic scaffolds and methods for preparing the same |
| CN104414772A (en) * | 2013-09-06 | 2015-03-18 | 山东百多安医疗器械有限公司 | In-vivo degradable and absorbable artificial medical tissue repairing film |
| CN103550816A (en) * | 2013-11-15 | 2014-02-05 | 南通大学 | Preparation method for chitosan-based electrostatic spinning combined wound dressing |
| CN104758977A (en) * | 2014-10-11 | 2015-07-08 | 河南亚都实业有限公司 | An alginate dressing for treating bedsore and a preparing method thereof |
| CN104491914A (en) * | 2014-12-25 | 2015-04-08 | 中国人民解放军第四军医大学 | Porous complex gel-nanofiber oxygen permeation dressing and preparation method thereof |
| CN107625582A (en) * | 2017-10-18 | 2018-01-26 | 佛山市优特医疗科技有限公司 | Wound dressing, its preparation method and its application with sandwich construction |
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|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180615 |