CN108143985A - A kind of medical more skin biology film forming spray and preparation method thereof - Google Patents

A kind of medical more skin biology film forming spray and preparation method thereof Download PDF

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CN108143985A
CN108143985A CN201810165624.7A CN201810165624A CN108143985A CN 108143985 A CN108143985 A CN 108143985A CN 201810165624 A CN201810165624 A CN 201810165624A CN 108143985 A CN108143985 A CN 108143985A
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herb
preparation
film forming
medical
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王鹤明
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Suzhou New Materials Co Ltd
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Suzhou New Materials Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/55—Liquid-liquid separation; Phase separation

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Abstract

The present invention provides a kind of medical more skin biology film forming sprays and preparation method thereof.Preparation method is as follows：（1）Scarlet pimpernel herb, conical conocephalum herb, cymbalaria halerpestes herb, water speedwell are cleaned, air-dries and squeezes the juice, thick slag is removed in filtering, obtains filtrate, and macroporous resin adsorption separation with ethanol elution, collects eluent；（2）Crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng are weighed by weight, coarse powder is broken into, adds in ethyl alcohol, are carried out room temperature texture and are crushed extraction, extracting solution is filtered, carry out flash concentration, concentrate repeatedly；（3）By step（1）The eluent of preparation,（2）The extracting solution of preparation is added in ethyl alcohol, sequentially adds chitosan, polyethylene pyrrole network alkanone, cellulose hydroxypropyl methyl ether, pearl powder, propolis stir evenly, sterilization packaging.The medical more skin biology film forming spray of the present invention has the function of to remove necrosis and promote granulation, and is conducive to the healing of wound, greatly reduces bleeding stopping period, plays the role of significantly promoting wound healing.

Description

A kind of medical more skin biology film forming spray and preparation method thereof
Technical field
The present invention relates to field of medical materials, and in particular to a kind of medical more skin biology film forming spray and preparation method thereof.
Background technology
The spray that forms a film is a kind of novel form with reference to made of film, spray point, easy to use, and can be by creating Hinder the absorbable biofilm of surface shape, play the protection surface of a wound, wound healing and other effects.Form a film spray development mainly according to By the development of filmogen, antibacterial biological filmogen is the new functional quickly grown in recent years, have inhibit or The function of bacterium, the Main way of antibacterial filmogen future development are killed, and chitosan and its derivative is the hot spot of research. Chitosan is a kind of good biological filmogen of water solubility, and solution viscosity is low, and the effective concentration of liquid dressing is high, during pH value is in Property and irritation is small, anti-inflammatory sterilization, hemostasis and pain-relieving after film forming, and good biocompatibility, the features such as being reuptaked by tissue, Make that there is significant advantage in its development and application in water-soluble liquid dressing.The spray film that forms a film is playing chitosan self-acting Meanwhile often add some analgesic chemical compositions and antibiotic.Antibiotic has bactericidal antiphlogistic, mainly by interfering bacterium The synthesis of cell wall changes the modes such as bacterium inner metabolism to realize, meanwhile, it can also damage not guilty normal structure.And it plants Natural antibiotics in object are usually the juice and volatile materials of plant, including alkaloids, flavonoids, it is protein-based, have Machine acids and phenolic compound etc., can kill or inhibit certain germs, and human body is not injured substantially.
Invention content
Technical problems to be solved：The object of the present invention is to provide a kind of medical more skin biology film forming spray, without antibiosis Element has anti-inflammatory, hemostasis, the effect for promoting skin healing.
Technical solution：A kind of medical more skin biology film forming spray, is prepared by weight by following component：Chitosan 1- 5 parts, 0.1-1 parts of polyethylene pyrrole network alkanone, 1-8 parts of cellulose hydroxypropyl methyl ether, 85-100 parts of ethyl alcohol, 0.1-2 parts of pearl powder, 0.1-10 parts of propolis, 3-10 parts of scarlet pimpernel herb, 3-10 parts of conical conocephalum herb, 2-5 parts of crownofhorns euphorbia flower, 2-5 parts of common maidenhair spleenwort herb with root, trilliaceae 2- 5 parts, native 2-5 parts of pseudo-ginseng, 5-15 parts of cymbalaria halerpestes herb, 5-15 parts of water speedwell.
It is further preferred that the medical more skin biology film forming spray of described one kind, prepared by weight by following component and Into：2-4 parts of chitosan, 0.1-0.5 parts of polyethylene pyrrole network alkanone, 2-4 parts of cellulose hydroxypropyl methyl ether, 90-100 parts of ethyl alcohol, 0.5-1.5 parts of pearl powder, 2-6 parts of propolis, 3-7 parts of scarlet pimpernel herb, 3-7 parts of conical conocephalum herb, 3-4 parts of crownofhorns euphorbia flower, common maidenhair spleenwort herb with root 3-4 Part, 3-4 parts of trilliaceae, native 3-4 parts of pseudo-ginseng, 8-12 parts of cymbalaria halerpestes herb, 8-12 parts of water speedwell.
Further, the medical more skin biology film forming spray of described one kind, a concentration of 20-40wt% of the ethyl alcohol.
The preparation method of above-mentioned medical more skin biology film forming spray, includes the following steps：
（1）Scarlet pimpernel herb, conical conocephalum herb, cymbalaria halerpestes herb, water speedwell are cleaned, air-dries and squeezes the juice, thick slag is removed in filtering, obtains filtrate, greatly Hole resin adsorption separation, with 35-45wt% ethanol elutions, elution speed collects eluent for 1-4BV/h；
（2）Crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng are weighed by weight, are broken into 40-80 mesh sieve Coarse powder, it is 1 to add in solid-liquid ratio:5-1:10, the ethyl alcohol of a concentration of 30-50wt% carries out room temperature texture and crushes extraction 1-3 times, extraction Time is 2-5min, and extracting solution is filtered, and at 50-80 DEG C, vacuum degree uses Reduced Pressure Concentration Device under the conditions of being 0.1Mpa Flash concentration is carried out, is concentrated into the 1/5-10 of original volume repeatedly；
（3）By step（1）The eluent of preparation,（2）The extracting solution of preparation is added in ethyl alcohol, sequentially adds chitosan, poly- second Alkene pyrrole network alkanone, cellulose hydroxypropyl methyl ether, pearl powder, propolis stir evenly, sterilization packaging.
Further, the preparation method of a kind of medical more skin biology film forming spray, the step（1）Middle ethyl alcohol is dense It spends for 40wt%, elution flow rate 2BV/h.
Further, the preparation method of a kind of medical more skin biology film forming spray, the step（2）Middle coarse powder is thin It spends for 60 mesh, solid-liquid ratio 1:6-1:8, concentration of alcohol 40wt%, extraction time are 2-3 times, extraction time 3-5min.
Further, the preparation method of a kind of medical more skin biology film forming spray, the step（2）Middle thickening temperature is 60-70 DEG C, it is concentrated into original volume 1/7-9.
Advantageous effect：Scarlet pimpernel herb, the conical conocephalum herb ingredient contained in the medical more skin biology film forming spray of the present invention, there is corruption The effect of myogenic is conducive to the healing of wound, add crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng extracting solution it Afterwards, bleeding stopping period is greatly reduced, while the medication of embodiment group is after a week, Wound exudate is reduced, and comparative example group wound healing It is in confused situation aobvious, show that this film forming spray plays the role of significantly promoting wound healing.
Specific embodiment
Embodiment 1
A kind of medical more skin biology film forming spray, is prepared by weight by following component：1 part of chitosan, polyethylene pyrrole network 0.1 part of alkanone, 1 part of cellulose hydroxypropyl methyl ether, 85 parts of ethyl alcohol, 2 parts of pearl powder, 0.1 part of propolis, 3 parts of scarlet pimpernel herb, conical conocephalum herb 10 parts, 2 parts of crownofhorns euphorbia flower, 2 parts of common maidenhair spleenwort herb with root, 2 parts of trilliaceae, native 5 parts of pseudo-ginseng, 5 parts of cymbalaria halerpestes herb, 15 parts of water speedwell.
It is above-mentioned it is medical more skin biology film forming spray preparation method be：（1）Scarlet pimpernel herb, conical conocephalum herb, cymbalaria halerpestes herb, water is bitter Mai is cleaned, and is air-dried and is squeezed the juice, and thick slag is removed in filtering, obtains filtrate, macroporous resin adsorption separation, with 45wt% ethanol elutions, elution speed It spends and collects eluent for 4BV/h；（2）Crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng are weighed by weight, are smashed Into the coarse powder for crossing 40 mesh sieve, it is 1 to add in solid-liquid ratio:5, the ethyl alcohol of a concentration of 30wt% carries out room temperature texture and crushes extraction 1 time, carries The time is taken to filter extracting solution for 5min, at 50 DEG C, vacuum degree is carried out under the conditions of being 0.1Mpa using Reduced Pressure Concentration Device Flash concentration is concentrated into the 1/5 of original volume repeatedly；（3）By step（1）The eluent of preparation,（2）The extracting solution of preparation adds in second In alcohol, chitosan, polyethylene pyrrole network alkanone are sequentially added, cellulose hydroxypropyl methyl ether, pearl powder, propolis stir evenly, Sterilization packaging.
Embodiment 2
A kind of medical more skin biology film forming spray, is prepared by weight by following component：5 parts of chitosan, polyethylene pyrrole network 1 part of alkanone, 8 parts of cellulose hydroxypropyl methyl ether, 100 parts of ethyl alcohol, 0.1 part of pearl powder, 10 parts of propolis, 10 parts of scarlet pimpernel herb, snake 3 parts of money, 5 parts of crownofhorns euphorbia flower, 5 parts of common maidenhair spleenwort herb with root, 5 parts of trilliaceae, native 2 parts of pseudo-ginseng, 15 parts of cymbalaria halerpestes herb, 5 parts of water speedwell.
It is above-mentioned it is medical more skin biology film forming spray preparation method be：（1）Scarlet pimpernel herb, conical conocephalum herb, cymbalaria halerpestes herb, water is bitter Mai is cleaned, and is air-dried and is squeezed the juice, and thick slag is removed in filtering, obtains filtrate, macroporous resin adsorption separation, with 35wt% ethanol elutions, elution speed It spends and collects eluent for 4BV/h；（2）Crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng are weighed by weight, are smashed Into the coarse powder for crossing 80 mesh sieve, it is 1 to add in solid-liquid ratio:10, the ethyl alcohol of a concentration of 50wt% carries out room temperature texture and crushes extraction 3 times, Extraction time is 2min, and extracting solution is filtered, at 80 DEG C, vacuum degree be 0.1Mpa under the conditions of using Reduced Pressure Concentration Device into Row flash concentration is concentrated into the 1/10 of original volume repeatedly；（3）By step（1）The eluent of preparation,（2）The extracting solution of preparation adds Enter in ethyl alcohol, sequentially add chitosan, polyethylene pyrrole network alkanone, cellulose hydroxypropyl methyl ether, pearl powder, propolis, stirring Uniformly, sterilization packaging.
Embodiment 3
A kind of medical more skin biology film forming spray, is prepared by weight by following component：2 parts of chitosan, polyethylene pyrrole network 0.1 part of alkanone, 2 parts of cellulose hydroxypropyl methyl ether, 90 parts of ethyl alcohol, 0.5 part of pearl powder, 6 parts of propolis, 3 parts of scarlet pimpernel herb, conical conocephalum herb 7 parts, 3 parts of crownofhorns euphorbia flower, 4 parts of common maidenhair spleenwort herb with root, 3 parts of trilliaceae, native 3 parts of pseudo-ginseng, 8 parts of cymbalaria halerpestes herb, 12 parts of water speedwell.
It is above-mentioned it is medical more skin biology film forming spray preparation method be：（1）Scarlet pimpernel herb, conical conocephalum herb, cymbalaria halerpestes herb, water is bitter Mai is cleaned, and is air-dried and is squeezed the juice, and thick slag is removed in filtering, obtains filtrate, macroporous resin adsorption separation, with 40wt% ethanol elutions, elution speed It spends and collects eluent for 2BV/h；（2）Crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng are weighed by weight, are smashed Into the coarse powder for crossing 60 mesh sieve, it is 1 to add in solid-liquid ratio:6, the ethyl alcohol of a concentration of 40wt% carries out room temperature texture and crushes extraction 2 times, carries The time is taken to filter extracting solution for 3min, at 60 DEG C, vacuum degree is carried out under the conditions of being 0.1Mpa using Reduced Pressure Concentration Device Flash concentration is concentrated into the 1/7 of original volume repeatedly；（3）By step（1）The eluent of preparation,（2）The extracting solution of preparation adds in second In alcohol, chitosan, polyethylene pyrrole network alkanone are sequentially added, cellulose hydroxypropyl methyl ether, pearl powder, propolis stir evenly, Sterilization packaging.
Embodiment 4
A kind of medical more skin biology film forming spray, is prepared by weight by following component：4 parts of chitosan, polyethylene pyrrole network 0.5 part of alkanone, 4 parts of cellulose hydroxypropyl methyl ether, 100 parts of ethyl alcohol, 0.5 part of pearl powder, 6 parts of propolis, 7 parts of scarlet pimpernel herb, snake 3 parts of money, 4 parts of crownofhorns euphorbia flower, 3 parts of common maidenhair spleenwort herb with root, 4 parts of trilliaceae, native 4 parts of pseudo-ginseng, 12 parts of cymbalaria halerpestes herb, 8 parts of water speedwell.
It is above-mentioned it is medical more skin biology film forming spray preparation method be：（1）Scarlet pimpernel herb, conical conocephalum herb, cymbalaria halerpestes herb, water is bitter Mai is cleaned, and is air-dried and is squeezed the juice, and thick slag is removed in filtering, obtains filtrate, macroporous resin adsorption separation, with 40wt% ethanol elutions, elution speed It spends and collects eluent for 2BV/h；（2）Crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng are weighed by weight, are smashed Into the coarse powder for crossing 60 mesh sieve, it is 1 to add in solid-liquid ratio:8, the ethyl alcohol of a concentration of 40wt% carries out room temperature texture and crushes extraction 3 times, carries The time is taken to filter extracting solution for 5min, at 70 DEG C, vacuum degree is carried out under the conditions of being 0.1Mpa using Reduced Pressure Concentration Device Flash concentration is concentrated into the 1/9 of original volume repeatedly；（3）By step（1）The eluent of preparation,（2）The extracting solution of preparation adds in second In alcohol, chitosan, polyethylene pyrrole network alkanone are sequentially added, cellulose hydroxypropyl methyl ether, pearl powder, propolis stir evenly, Sterilization packaging.
Embodiment 5
A kind of medical more skin biology film forming spray, is prepared by weight by following component：3 parts of chitosan, polyethylene pyrrole network 0.3 part of alkanone, 3 parts of cellulose hydroxypropyl methyl ether, 94 parts of ethyl alcohol, 1 part of pearl powder, 4 parts of propolis, 5 parts of scarlet pimpernel herb, conical conocephalum herb 5 Part, 4 parts of crownofhorns euphorbia flower, 4 parts of common maidenhair spleenwort herb with root, 4 parts of trilliaceae, native 4 parts of pseudo-ginseng, 10 parts of cymbalaria halerpestes herb, 10 parts of water speedwell.
It is above-mentioned it is medical more skin biology film forming spray preparation method be：（1）Scarlet pimpernel herb, conical conocephalum herb, cymbalaria halerpestes herb, water is bitter Mai is cleaned, and is air-dried and is squeezed the juice, and thick slag is removed in filtering, obtains filtrate, macroporous resin adsorption separation, with 40wt% ethanol elutions, elution speed It spends and collects eluent for 2BV/h；（2）Crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng are weighed by weight, are smashed Into the coarse powder for crossing 60 mesh sieve, it is 1 to add in solid-liquid ratio:7, the ethyl alcohol of a concentration of 40wt% carries out room temperature texture and crushes extraction 3 times, carries The time is taken to filter extracting solution for 4min, at 65 DEG C, vacuum degree is carried out under the conditions of being 0.1Mpa using Reduced Pressure Concentration Device Flash concentration is concentrated into the 1/7 of original volume repeatedly；（3）By step（1）The eluent of preparation,（2）The extracting solution of preparation adds in second In alcohol, chitosan, polyethylene pyrrole network alkanone are sequentially added, cellulose hydroxypropyl methyl ether, pearl powder, propolis stir evenly, Sterilization packaging.
Comparative example 1
A kind of medical more skin biology film forming spray, is prepared by weight by following component：1 part of chitosan, polyethylene pyrrole network 0.1 part of alkanone, 1 part of cellulose hydroxypropyl methyl ether, 85 parts of ethyl alcohol, 2 parts of pearl powder, 0.1 part of propolis, 2 parts of crownofhorns euphorbia flower, iron angle 2 parts of phoenix-tail fern, 2 parts of trilliaceae, native 5 parts of pseudo-ginseng, 5 parts of cymbalaria halerpestes herb, 15 parts of water speedwell.
It is above-mentioned it is medical more skin biology film forming spray preparation method be：（1）Cymbalaria halerpestes herb, water speedwell are cleaned, air-dries and squeezes Thick slag is removed in juice, filtering, obtains filtrate, macroporous resin adsorption separation, with 45wt% ethanol elutions, elution speed is collected for 4BV/h Eluent；（2）Crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng are weighed by weight, are broken into 40 mesh sieve Coarse powder, it is 1 to add in solid-liquid ratio:5, the ethyl alcohol of a concentration of 30wt% carries out room temperature texture and crushes extraction 1 time, and extraction time is 5min filters extracting solution, and at 50 DEG C, vacuum degree using Reduced Pressure Concentration Device flash dense under the conditions of being 0.1Mpa Contracting, is concentrated into the 1/5 of original volume repeatedly；（3）By step（1）The eluent of preparation,（2）The extracting solution of preparation is added in ethyl alcohol, Chitosan, polyethylene pyrrole network alkanone are sequentially added, cellulose hydroxypropyl methyl ether, pearl powder, propolis stir evenly, sterilization Packaging.
Comparative example 2
A kind of medical more skin biology film forming spray, is prepared by weight by following component：5 parts of chitosan, polyethylene pyrrole network 1 part of alkanone, 8 parts of cellulose hydroxypropyl methyl ether, 100 parts of ethyl alcohol, 0.1 part of pearl powder, 10 parts of propolis, 10 parts of scarlet pimpernel herb, snake 3 parts of money, 15 parts of cymbalaria halerpestes herb, 5 parts of water speedwell.
It is above-mentioned it is medical more skin biology film forming spray preparation method be：（1）Scarlet pimpernel herb, conical conocephalum herb, cymbalaria halerpestes herb, water is bitter Mai is cleaned, and is air-dried and is squeezed the juice, and thick slag is removed in filtering, obtains filtrate, macroporous resin adsorption separation, with 35wt% ethanol elutions, elution speed It spends and collects eluent for 4BV/h；（2）By step（1）The eluent of preparation is added in ethyl alcohol, sequentially adds chitosan, poly- second Alkene pyrrole network alkanone, cellulose hydroxypropyl methyl ether, pearl powder, propolis stir evenly, sterilization packaging.
Comparative example 3
A kind of medical more skin biology film forming spray, is prepared by weight by following component：5 parts of chitosan, polyethylene pyrrole network 1 part of alkanone, 8 parts of cellulose hydroxypropyl methyl ether, 100 parts of ethyl alcohol, 0.1 part of pearl powder, 10 parts of propolis, 10 parts of scarlet pimpernel herb, snake 3 parts of money, 5 parts of crownofhorns euphorbia flower, 5 parts of common maidenhair spleenwort herb with root, 5 parts of trilliaceae, native 2 parts of pseudo-ginseng.
It is above-mentioned it is medical more skin biology film forming spray preparation method be：（1）Scarlet pimpernel herb, conical conocephalum herb are cleaned, air-dries and squeezes the juice, Thick slag is removed in filtering, obtains filtrate, macroporous resin adsorption separation, with 35wt% ethanol elutions, elution speed is washed for 4BV/h collections De- liquid；（2）Crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng are weighed by weight, are broken into the thick of 80 mesh sieve Powder, it is 1 to add in solid-liquid ratio:10, the ethyl alcohol of a concentration of 50wt% carries out room temperature texture and crushes extraction 3 times, extraction time 2min, Extracting solution is filtered, at 80 DEG C, vacuum degree uses Reduced Pressure Concentration Device to carry out flash concentration under the conditions of being 0.1Mpa, repeatedly It is concentrated into the 1/10 of original volume；（3）By step（1）The eluent of preparation,（2）The extracting solution of preparation is added in ethyl alcohol, then successively Chitosan, polyethylene pyrrole network alkanone are added in, cellulose hydroxypropyl methyl ether, pearl powder, propolis stir evenly, and sterilization packaging is It can.
1-5 and comparative example 1-3 in conjunction with the embodiments carries out the film forming spray following test.
Anti-inflammatory is tested：SD rats 80 are chosen, half male and half female, weight is divided into embodiment and reference examples at 200 grams or so Group, totally 7 groups, every group 10.Two sides is respectively coated dimethylbenzene 0.03mL before and after mouse right ear, and left ear is without any processing. Each group 30min auris dextras sprinkling corresponding product equivalent after causing scorching preceding and cause scorching.4h cervical dislocations put to death animal after causing inflammation, cut Ears lay round auricle in ear same area respectively with 9mm diameters card punch, weigh, using the weight difference of left and right ear as swelling Degree, and swelling inhibiting rate is calculated, comparing embodiment group and reference examples group difference condition.
Swelling inhibiting rate (%)=(physiological saline group be averaged swelling-administration group be averaged swelling)/physiological saline group is average Swelling × 100%
Hemostasis experiment：80 Japan large ear rabbits are chosen, are divided into 7 groups, every rabbit cuts off auris dextra ear edge artery, free bleeding The film forming spray obtained by embodiment and comparative example is sprayed into wound respectively after 5s, 5s.
Wound healing is tested：Healthy adult ICR mouse 80,20 ± 2g of weight are taken, half male and half female is randomly divided into 7 groups. 3% yellow Jackets 30mg/kg intraperitoneal injections are anaesthetized, and mouse back backbone both sides hair is taken off, depilation area 4cm2, use Boiling water scalds hair removal section, and by embodiment group, reference examples group mouse scald area carries out sprinkling drug, and daily dressing is primary.
The property indices of material of the present invention see the table below, it may be seen that containing in this medical more skin biology film forming spray Some scarlet pimpernel herbs, conical conocephalum herb ingredient, remove necrosis and promote granulation, and are conducive to the healing of wound, add crownofhorns euphorbia flower, iron angle phoenix After tail grass, trilliaceae, native pseudo-ginseng extracting solution, bleeding stopping period is greatly reduced, while the medication of embodiment group is after a week, wound exudation Object is reduced, and comparative example group wound healing is in confused situation aobvious, shows that this film forming spray plays the role of significantly promoting wound healing.
The property indices of the medical more skin biology film forming spray of table 1
Name of product The average healing（My god） Bleeding stopping period（s） Swelling rate（%）
Embodiment 1 13.6 10 23.0
Embodiment 2 13.2 9 22.2
Embodiment 3 12.5 8 24.4
Embodiment 4 12.2 8 23.8
Embodiment 5 11.5 7 27.1
Comparative example 1 17.3 10 22.6
Comparative example 2 13.5 25 22.0
Comparative example 3 13.6 9 15.6

Claims (7)

1. a kind of medical more skin biology film forming spray, which is characterized in that be prepared by weight by following component：Chitosan 1- 5 parts, 0.1-1 parts of polyethylene pyrrole network alkanone, 1-8 parts of cellulose hydroxypropyl methyl ether, 85-100 parts of ethyl alcohol, 0.1-2 parts of pearl powder, 0.1-10 parts of propolis, 3-10 parts of scarlet pimpernel herb, 3-10 parts of conical conocephalum herb, 2-5 parts of crownofhorns euphorbia flower, 2-5 parts of common maidenhair spleenwort herb with root, trilliaceae 2- 5 parts, native 2-5 parts of pseudo-ginseng, 5-15 parts of cymbalaria halerpestes herb, 5-15 parts of water speedwell.
2. the medical more skin biology film forming spray of one kind according to claim 1, which is characterized in that by following component by weight Part is prepared：2-4 parts of chitosan, 0.1-0.5 parts of polyethylene pyrrole network alkanone, 2-4 parts of cellulose hydroxypropyl methyl ether, ethyl alcohol 90-100 parts, 0.5-1.5 parts of pearl powder, 2-6 parts of propolis, 3-7 parts of scarlet pimpernel herb, 3-7 parts of conical conocephalum herb, 3-4 parts of crownofhorns euphorbia flower, iron angle 3-4 parts of phoenix-tail fern, 3-4 parts of trilliaceae, native 3-4 parts of pseudo-ginseng, 8-12 parts of cymbalaria halerpestes herb, 8-12 parts of water speedwell.
3. the medical more skin biology film forming spray of one kind according to claim 1 and 2, it is characterised in that：The ethyl alcohol A concentration of 20-40wt%.
4. a kind of preparation method of medical more skin biology film forming spray, which is characterized in that include the following steps：
（1）Scarlet pimpernel herb, conical conocephalum herb, cymbalaria halerpestes herb, water speedwell are cleaned, air-dries and squeezes the juice, thick slag is removed in filtering, obtains filtrate, greatly Hole resin adsorption separation, with 35-45wt% ethanol elutions, elution speed collects eluent for 1-4BV/h；
（2）Crownofhorns euphorbia flower, common maidenhair spleenwort herb with root, trilliaceae, native pseudo-ginseng are weighed by weight, are broken into 40-80 mesh sieve Coarse powder, it is 1 to add in solid-liquid ratio:5-1:10, the ethyl alcohol of a concentration of 30-50wt% carries out room temperature texture and crushes extraction 1-3 times, extraction Time is 2-5min, and extracting solution is filtered, and at 50-80 DEG C, vacuum degree uses Reduced Pressure Concentration Device under the conditions of being 0.1Mpa Flash concentration is carried out, is concentrated into the 1/5-10 of original volume repeatedly；
（3）By step（1）The eluent of preparation,（2）The extracting solution of preparation is added in ethyl alcohol, sequentially adds chitosan, poly- second Alkene pyrrole network alkanone, cellulose hydroxypropyl methyl ether, pearl powder, propolis stir evenly, sterilization packaging.
5. a kind of preparation method of medical more skin biology film forming spray according to claim 4, it is characterised in that：The step Suddenly（1）Middle concentration of alcohol is 40wt%, elution flow rate 2BV/h.
6. a kind of preparation method of medical more skin biology film forming spray according to claim 4, it is characterised in that：The step Suddenly（2）Middle coarse powder fineness be 60 mesh, solid-liquid ratio 1:6-1:8, concentration of alcohol 40wt%, extraction time is 2-3 times, during extraction Between be 3-5min.
7. a kind of preparation method of medical more skin biology film forming spray according to claim 4, it is characterised in that：The step Suddenly（2）Middle thickening temperature is 60-70 DEG C, is concentrated into original volume 1/7-9.
CN201810165624.7A 2018-02-28 2018-02-28 A kind of medical more skin biology film forming spray and preparation method thereof Pending CN108143985A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006013084A1 (en) * 2004-08-03 2006-02-09 Royal College Of Surgeons In Ireland Phenytoin formulations, and uses thereof in wound healing
CN105432676A (en) * 2015-12-22 2016-03-30 湖南农业大学 Preparation method of antibacterial spraying agent
CN106109517A (en) * 2016-08-24 2016-11-16 广东工业大学 A kind of white externally used antimicrobial spray-filming agent and preparation method thereof
CN106361816A (en) * 2016-08-27 2017-02-01 广东罗浮山国药股份有限公司 Wound disinfecting spraying film agent and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006013084A1 (en) * 2004-08-03 2006-02-09 Royal College Of Surgeons In Ireland Phenytoin formulations, and uses thereof in wound healing
CN105432676A (en) * 2015-12-22 2016-03-30 湖南农业大学 Preparation method of antibacterial spraying agent
CN106109517A (en) * 2016-08-24 2016-11-16 广东工业大学 A kind of white externally used antimicrobial spray-filming agent and preparation method thereof
CN106361816A (en) * 2016-08-27 2017-02-01 广东罗浮山国药股份有限公司 Wound disinfecting spraying film agent and preparation method thereof

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