CN108143772A - A kind of transdermal patch for alleviating nasal obstruction - Google Patents
A kind of transdermal patch for alleviating nasal obstruction Download PDFInfo
- Publication number
- CN108143772A CN108143772A CN201810049700.8A CN201810049700A CN108143772A CN 108143772 A CN108143772 A CN 108143772A CN 201810049700 A CN201810049700 A CN 201810049700A CN 108143772 A CN108143772 A CN 108143772A
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- CN
- China
- Prior art keywords
- eucalyptus oil
- menthol
- ethyl alcohol
- coating
- back sheet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to the transdermal patches for alleviating nasal obstruction, it can effectively solve the problems, such as to cause that uncomfortable and external use plaster action time is short, it is too small, caducous to paste viscosity using U-shaped inhalant, its solve technical solution be, nose patch of feeling well is made of adherent layer 1, adhesive layer 2, back sheet 3, adhesive layer 2 is using menthol, eucalyptus oil, ethyl alcohol as raw material, using acrylic adhesive as matrix, through mix, be coated with, be die cut made of externally applied product；Specifically by following weight percent meter：Eucalyptus oil 4 6%, menthol 1.5 2.5%, acrylic adhesive 70 76% and ethyl alcohol 18 22% are made, and the present invention is safe and non-toxic, fragrant pleasant, easy to use, no sense of discomfort；The viscosity of acrylate glue-line is stronger, pastes securely, not easily to fall off, while energy rapid recovery nasal obstruction symptom, and action time is lasting, is a big innovation of nose patch class product.
Description
Technical field
The present invention relates to external use plaster, particularly a kind of transdermal patch for alleviating nasal obstruction.
Background technology
The externally applied product of nasal obstruction is caused to have inhalant and external use plaster for rhinitis or flu currently on the market, inhalant leads to
Cross in U-shaped suction line and place effective ingredient and reach improvement nasal obstruction phenomenon, the drawback is that be placed in nostril foreign matter cause it is uncomfortable；Mesh
Preceding external use plaster is product to be pasted onto on the clothes of front or novel high polymer aqueous gel type is pasted on skin surface, is pasted
Product on the clothes of front works slowly, and the duration is short, and polymer waterborne gel type products viscosity is not strong, action time
It is short.Therefore, the problem of improvement on the externally applied product of nasal obstruction and innovation being caused to be current urgent need to resolve for rhinitis or flu.
Invention content
For the above situation, to solve the defect of the prior art, the purpose of the present invention is just to provide a kind of alleviation nasal obstruction
Transdermal patch, can effectively solve to cause that uncomfortable and external use plaster action time is short, it is too small, easy to paste viscosity using U-shaped inhalant
The problem of coming off.
The technical solution that the present invention solves is, nose patch of feeling well is made of adherent layer 1, adhesive layer 2, back sheet 3, adhesive layer
2 be using menthol, eucalyptus oil, ethyl alcohol as raw material, using acrylic adhesive as matrix, through mix, be coated with, be die cut made of external application produce
Product；Specifically by following weight percent meter：Eucalyptus oil 4-6%, menthol 1.5-2.5%, acrylic adhesive 70-76% and ethyl alcohol
18-22% is made, and eucalyptus oil, menthol, ethyl alcohol are mixed, stirred evenly, and obtains eucalyptus oil mixed liquor, then by eucalyptus oil mixed liquor
It adds in acrylic adhesive, stirring obtains intermediate products rubber cement（That is adhesive layer）；Adherent layer 1 and back sheet 3 are fixed on coating machine
On, and 100-200 μm of coating thickness is adjusted, intermediate products rubber cement is coated on adherent layer, upper back sheet is then covered, containing cream
Amount control is in 120-160mg/9.8cm2In the range of/patch, coating complete to obtain cream volume, by cream volume cross cutting to get.
The present invention is safe and non-toxic, fragrant pleasant, easy to use, no sense of discomfort；The viscosity of acrylate glue-line is stronger, pastes
Securely, it is not easily to fall off, while energy rapid recovery nasal obstruction symptom, action time is lasting, is a big innovation of nose patch class product.
Description of the drawings
Fig. 1 is the structural diagram of the present invention.
Specific embodiment
The specific embodiment of the present invention is described in further detail below in conjunction with drawings and examples.
Embodiment 1
The present invention in the specific implementation, can be by following weight percent meter：Eucalyptus oil 5%, menthol 2%, 73% and of acrylic adhesive
Ethyl alcohol 20% is made, and eucalyptus oil, menthol, ethyl alcohol are mixed, stirred evenly, and obtains eucalyptus oil mixed liquor, then by eucalyptus oil mixed liquor
It adds in acrylic adhesive, stirring obtains intermediate products rubber cement；Adherent layer and back sheet are fixed on coating machine, and adjust painting
150 μm of cloth thickness, intermediate products rubber cement is coated on adherent layer, then covers upper back sheet, and paste containing amount is controlled in 140mg/
9.8cm2In the range of/patch, coating complete to obtain cream volume, by cream volume cross cutting to get.
Embodiment 2
The present invention in the specific implementation, can also be by following weight percent meter：Eucalyptus oil 4.5%, menthol 2.5%, acrylate
Glue 74% and ethyl alcohol 19% are made, and eucalyptus oil, menthol, ethyl alcohol are mixed, stirred evenly, and obtain eucalyptus oil mixed liquor, then by eucalyptus
Oily mixed liquor is added in acrylic adhesive, and stirring obtains intermediate products rubber cement；Adherent layer and back sheet are fixed on coating machine,
And 100 μm of coating thickness is adjusted, intermediate products rubber cement is coated on adherent layer, then covers upper back sheet, paste containing amount control
In 120mg/9.8cm2In the range of/patch, coating complete to obtain cream volume, by cream volume cross cutting to get.
Embodiment 3
The present invention in the specific implementation, can also be by following weight percent meter：Eucalyptus oil 6%, menthol 1.5%, acrylic adhesive
72% and ethyl alcohol 20.5% be made, eucalyptus oil, menthol, ethyl alcohol are mixed, stirred evenly, obtains eucalyptus oil mixed liquor, then by eucalyptus
Oily mixed liquor is added in acrylic adhesive, and stirring obtains intermediate products rubber cement；Adherent layer and back sheet are fixed on coating machine,
And 200 μm of coating thickness is adjusted, intermediate products rubber cement is coated on adherent layer, then covers upper back sheet, paste containing amount control
In 160mg/9.8cm2In the range of/patch, coating complete to obtain cream volume, by cream volume cross cutting to get.
Embodiment 4
The present invention in the specific implementation, can also be by following weight meter：Eucalyptus oil 7.5mg, menthol 2.5mg, acrylic adhesive
100mg and ethyl alcohol 30mg are made, and eucalyptus oil, menthol, ethyl alcohol are mixed, stirred evenly, and obtain eucalyptus oil mixed liquor, then by eucalyptus
Oily mixed liquor is added in acrylic adhesive, and stirring obtains intermediate products rubber cement；Adherent layer and back sheet are fixed on coating machine,
And 200 μm of coating thickness is adjusted, intermediate products rubber cement is coated on adherent layer, then covers upper back sheet, paste containing amount control
In 160mg/9.8cm2In the range of/patch, coating complete to obtain cream volume, by cream volume cross cutting to get.
The present invention to nasal obstruction crowd carry out examination patch experiment, and with existing nose exchange premium row Contrast on effect, counted product respectively
Onset time, function and effect hold time, product is sticky and comfort level problem, and carries out Macro or mass analysis to statistical result, as a result
It is shown in Table 1.
The table compared with similar products of the invention of table 1
| Nose pastes title | Manufacturer | Onset time （min） | Duration (h） | It is viscous Property | Comfort level | Effect Effect |
| Pendant madam | Hong Kong pendant madam | 20-30 | 6-8 | It is weak | Well | Generally |
| Contac | Contac | 10-15 | 8-12 | It is good It is good | Nose foreign body sensation is stronger | Well |
| U inhales | Shanghai Yi Kang rivers health section Skill Co., Ltd | 20-30 | 3-5 | / | Nasal cavity is put into, it is different Object sense is stronger | Generally |
| Product of the present invention | Self-control | 3-5 | 8-12 | It is good It is good | Well | Well |
Show significant effect of the present invention by the above results, function and effect fast and stable just can be apparent after 3-5 minutes using this product
Improve nasal obstruction phenomenon, it is 8-12 hours sustainable, using comfortable.This product includes eucalyptus oil, menthol natural plant extracts, non-stimulated
Property.Available for alleviating the nasal obstruction as caused by rhinitis, flu etc..
The present invention has the following advantages compared with the prior art：
1st, the present invention is by back sheet（Medical backing film）, adhesive layer and adherent layer（Medical stick film）Composition.Adhesive layer uses third
Olefin(e) acid ester material, adhesive layer, can various discomforts caused by rapid recovery nasal obstruction containing ingredients such as eucalyptus oil, menthols.
2nd, drying of the present invention（Form stable matrix type structure）, cross cutting, packaging.Patch smell is pleasant.Product quality
Stablize, for menthol as traditional Chinese medicine, it is turbid that dirtyization is warded off in external application, with good antibacterial, antiviral and health-care effect.
3rd, the apish nose shape of shape of the present invention, when use, throw off protective layer, and the one side containing adhesive layer is pasted
In on nose, easy to use, no sense of discomfort is sticky moderate（Pain will not be caused when will not come off, take off naturally）, action time holds
Long.
4th, raw material of the present invention selection science and of low cost, it is nontoxic, light it is compact, paste freely, fragrant odour
The features such as.
The present invention efficiently solves the existing viscosity for being directed to rhinitis or the external use plaster for causing nasal obstruction of catching a cold currently on the market
The problem of bad and duration is short and inhalant, which are put into nostril, makes human body have strong foreign body sensation, the problem of influencing comfort level,
It is safe and non-toxic, it is easy to use, it is of low cost, improve nasal obstruction phenomenon stable and durable effect, be that the one of nose patch class product innovates greatly, tool
There is good economic and social benefit.
Claims (5)
1. a kind of transdermal patch for alleviating nasal obstruction, which is characterized in that nose patch of feeling well is by adherent layer（1）, adhesive layer（2）, backing
Layer（3）It forms, adhesive layer（2）Be using menthol, eucalyptus oil, ethyl alcohol as raw material, using acrylic adhesive as matrix, through mixing, being coated with,
Externally applied product made of cross cutting；Specifically by following weight percent meter：Eucalyptus oil 4-6%, menthol 1.5-2.5%, acrylic acid
Ester gum 70-76% and ethyl alcohol 18-22% are made, and eucalyptus oil, menthol, ethyl alcohol are mixed, stirred evenly, and obtain eucalyptus oil mixing
Liquid, then eucalyptus oil mixed liquor is added in acrylic adhesive, stirring obtains intermediate products rubber cement；By adherent layer（1）With back sheet（3）
It is fixed on coating machine, and adjusts 100-200 μm of coating thickness, intermediate products rubber cement is coated on adherent layer, is then covered
Upper back sheet, paste containing amount are controlled in 120-160mg/9.8cm2In the range of/patch, cream volume is completed to obtain in coating, and cream is rolled up and is die cut, i.e.,
.
2. the transdermal patch according to claim 1 for alleviating nasal obstruction, which is characterized in that by following weight percent meter：
Eucalyptus oil 5%, menthol 2%, acrylic adhesive 73% and ethyl alcohol 20% are made, and eucalyptus oil, menthol, ethyl alcohol are mixed, stirring
Uniformly, eucalyptus oil mixed liquor is obtained, then eucalyptus oil mixed liquor is added in acrylic adhesive, stirring obtains intermediate products rubber cement；By adherent layer
It is fixed on coating machine with back sheet, and adjusts 150 μm of coating thickness, intermediate products rubber cement is coated on adherent layer, then
Back sheet in covering, paste containing amount are controlled in 140mg/9.8cm2In the range of/patch, cream volume is completed to obtain in coating, and cream is rolled up and is die cut, i.e.,
.
3. the transdermal patch according to claim 1 for alleviating nasal obstruction, which is characterized in that by following weight percent meter：
Eucalyptus oil 4.5%, menthol 2.5%, acrylic adhesive 74% and ethyl alcohol 19% are made, and eucalyptus oil, menthol, ethyl alcohol are mixed,
It stirs evenly, obtains eucalyptus oil mixed liquor, then eucalyptus oil mixed liquor is added in acrylic adhesive, stirring obtains intermediate products rubber cement；It will be anti-
Adhesion coating is fixed on coating machine, and adjust 100 μm of coating thickness with back sheet, and intermediate products rubber cement is coated on adherent layer,
Then upper back sheet is covered, paste containing amount is controlled in 120mg/9.8cm2In the range of/patch, cream volume is completed to obtain in coating, and cream is rolled up mould
Cut to get.
4. the transdermal patch according to claim 1 for alleviating nasal obstruction, which is characterized in that by following weight percent meter：
Eucalyptus oil 6%, menthol 1.5%, acrylic adhesive 72% and ethyl alcohol 20.5% are made, and eucalyptus oil, menthol, ethyl alcohol are mixed,
It stirs evenly, obtains eucalyptus oil mixed liquor, then eucalyptus oil mixed liquor is added in acrylic adhesive, stirring obtains intermediate products rubber cement；It will be anti-
Adhesion coating is fixed on coating machine, and adjust 200 μm of coating thickness with back sheet, and intermediate products rubber cement is coated on adherent layer,
Then upper back sheet is covered, paste containing amount is controlled in 160mg/9.8cm2In the range of/patch, cream volume is completed to obtain in coating, and cream is rolled up mould
Cut to get.
5. the transdermal patch according to claim 1 for alleviating nasal obstruction, which is characterized in that by following weight meter：Eucalyptus oil
7.5mg, menthol 2.5mg, acrylic adhesive 100mg and ethyl alcohol 30mg are made, and eucalyptus oil, menthol, ethyl alcohol are mixed,
It stirs evenly, obtains eucalyptus oil mixed liquor, then eucalyptus oil mixed liquor is added in acrylic adhesive, stirring obtains intermediate products rubber cement；It will be anti-
Adhesion coating is fixed on coating machine, and adjust 200 μm of coating thickness with back sheet, and intermediate products rubber cement is coated on adherent layer,
Then upper back sheet is covered, paste containing amount is controlled in 160mg/9.8cm2In the range of/patch, cream volume is completed to obtain in coating, and cream is rolled up mould
Cut to get.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810049700.8A CN108143772A (en) | 2018-01-18 | 2018-01-18 | A kind of transdermal patch for alleviating nasal obstruction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810049700.8A CN108143772A (en) | 2018-01-18 | 2018-01-18 | A kind of transdermal patch for alleviating nasal obstruction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108143772A true CN108143772A (en) | 2018-06-12 |
Family
ID=62461907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810049700.8A Pending CN108143772A (en) | 2018-01-18 | 2018-01-18 | A kind of transdermal patch for alleviating nasal obstruction |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108143772A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110420259A (en) * | 2019-09-04 | 2019-11-08 | 东莞市辛济生物科技有限公司 | One kind refresh the mind patch and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000043A (en) * | 2010-11-19 | 2011-04-06 | 沈阳药科大学 | Flurbiprofen salt transdermal patch and preparation method thereof |
-
2018
- 2018-01-18 CN CN201810049700.8A patent/CN108143772A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000043A (en) * | 2010-11-19 | 2011-04-06 | 沈阳药科大学 | Flurbiprofen salt transdermal patch and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 涟漪: "植物药数据库", 《国外医药 植物药分册》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110420259A (en) * | 2019-09-04 | 2019-11-08 | 东莞市辛济生物科技有限公司 | One kind refresh the mind patch and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 465550 No. 666 General Road, Xinxian County, Xinyang City, Henan Province Applicant after: Henan Lingrui Pharmaceutical Co., Ltd. Address before: 465550 No. 232 Xiangyang Road, Xinxian County, Xinyang City, Henan Province Applicant before: Henan Lingrui Pharmaceutical Co., Ltd. |
|
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180612 |