CN109675088A - A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent and preparation method thereof - Google Patents

A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent and preparation method thereof Download PDF

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CN109675088A
CN109675088A CN201910173896.6A CN201910173896A CN109675088A CN 109675088 A CN109675088 A CN 109675088A CN 201910173896 A CN201910173896 A CN 201910173896A CN 109675088 A CN109675088 A CN 109675088A
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parts
sensitive adhesive
ageing
adhesive agent
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余标
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

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Abstract

The invention discloses a kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent and preparation method thereof, it is made by following raw material: tea extract, guayule rubber extract, benzyl acrylate, konjaku glucomannan, dodecylbenzenesulfonic acid solution, pentalyn, guar gum, rosin glycerides, phenylethyl ethoxy ethyl ester, n-butyl acrylate, pure water, SEBS block copolymer emulsions, ethyl acetoacetate, pentaerythritol ester triacrylate, diethoxy acetophenone part, do not have sour third rouge of stone, nbr carboxyl terminal, isobornyl acrylate, hydroabietyl alcohol.Pressure-sensitive adhesive agent good biocompatibility disclosed by the invention, to paste good performance, antibacterial anti-inflammatory, barrier action small, gas permeability is good, penetrability is good, facilitate drug effect release, compliance is strong, it is at low cost, it is biodegradable, the characteristics of adapting to strong skin surface softness retractility and more gauffers, extend storage time.

Description

A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent and preparation method thereof
Technical field
The present invention relates to adhesive technology field, in particular to a kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent and its preparation Method.
Background technique
Application of the adhesive in medicine and hygiene fields is begun to a long time ago in fact, for example, for traumatic injury and The plaster (being commonly called as quack medicine) of inner disease outer treat just has before thousands of years in China's medicine, since the beginning of the 1970s, with medical The high score rapid development of material subject, research, exploitation and the application of medical adhesive also constantly extension, are singly with alpha-cyano third Medical adhesive based on olefin(e) acid alkyl vinegar, clinical application cases have just been more than 1,000,000, the beginning of the eighties, bio-medical glue Start to be applied to clinic.In recent years, the development of medical adhesive is more rapid, and it is polynary, function-specific that kind has been done step-by-step Series of products, it is also more and more extensive in the application medically as skin, blood vessel, internal organs and hemostasis jointing material.It is especially percutaneous Patch, also known as patch are the medicament using pressure sensitive adhesive of representative, in traumatic injury, frustrate that bone is had a pain, activating microcirculation and removing stasis medicinal, skin are recovered Various aspects, which are felt, to be widely used.With numerous patch products such as transdermal formulation, rapid development, adhesive is wanted Ask higher and higher, at present for Primary Care effect, existing adhesive is had the disadvantage that in the market: (1) not being avoided that pole For property raw material to the superinfection of patient, adhesive polarity is big, and the side effects such as infection, inflammation can be caused to patient.(2) because of adhesive Influence, drug cannot enter in vivo by scheduled speed, maintain constant treatment concentration, the peak valley for administration concentration occur is existing As toxic side effect probability of happening increases；(3) adhesive adhesion is poor, easily falls off, or because of adhesive, removes in treatment end When removing patch, there is apparent pain tearing sense, because of the influence of adhesive, drug cannot be made to enter body with constant rate of speed for a long time It is interior, it influences to extend dosing interval, reduces administration number of times, increase the effect of the compliance of patient, general oral slow (control) releases system Agent can only maintain useful effect 12-24 hours, make transdermal skin patches that the longer time then be maintained to maintain effective blood concentration；(4) by In the barrier action of adhesive, the rate that drugs through skin absorbs is very slow, and drug effect is slow, and most molecular masses are big, liposoluble The drug poor, that dosage is low of property cannot reach effective treatment concentration；(5) load performance of adhesive is poor, and release-controlled film is caused to rupture Or drug is overflowed, drug release rate can be made to sharply increase, influence therapeutic effect.
Pressure sensitive adhesive refers to that under light pressure, (such as finger pressure) can be realized industrial pharmacy one and paste while and be easily peeled off A kind of adhesive backers, played in transdermal formulation and guarantee that drug release face and skin are in close contact and medicine storage, controlled release The effects of.The selection of pressure sensitive adhesive is extremely important to transdermal formulation, and ideal pressure sensitive adhesive is preferably provided with good bio-compatible Property, it is nontoxic to skin, nonirritant, it will not cause allergic reaction；With stronger adhesive force and cohesive strength, skin is adapted to The characteristics of soft surface retractility is strong and more gauffers；Chemical property is stablized, functional to temperature and moisture (such as sweat) tolerance And have the adaptability of energy gluing different type skin, a certain amount of drug and transdermal absorption accelerator can be accommodated without influencing chemistry Stability and adhesive force.Pressure sensitive adhesive used in transdermal formulation is after being added drug agent, it is necessary to completely have to pressure-sensitive property Can, and phenomena such as while avoiding throwing off percutaneous preparation just will appear glue-line destruction, wire drawing or adhesive is caused to remain in skin surface With adhesive layer and back lining materials break-off.Currently, pressure sensitive adhesive in the market is roughly divided into three classes: polyisobutene class, acrylic acid It is esters, polysiloxane-based.
The stickiness of the pressure-sensitive colloidality substrate of polyisobutene class is weak, and pressure-sensitive acrylate cohesive force and solvent resistance are poor, Worse at high temperature, polysiloxane-based pressure sensitive adhesive is silicone resin and linearly gathers and soften and stick in skin after skin, has good Good biocompatibility, gas permeability and penetrability, it is at high price, be not suitable for marketing.
China Patent Publication No.: " CN104434542A " discloses a kind of medical antibacterial adhesive and preparation method thereof, should Medical adhesive has good bond properties, can also fast implement splicing at low temperature；Medical adhesive of the present invention has excellent Different antibiotic property；The inventive method is simple and easy, easy to implement, is suitable for a wide range of promote and apply.But its poor biocompatibility, thoroughly Gas and penetrability are bad, and adhesive has apparent barrier action, influence the effect release of drug, are unable to satisfy actual use Demand.
As those skilled in the art, it would be highly desirable to develop a kind of novel good biocompatibility, paste that performance is good, barrier is made With small, gas permeability is good, penetrability is good, facilitates drug effect release, improves the medical pressure-sensing gluing agent of the compliance of patient, comes Meet higher use demand.
Summary of the invention
The purpose of the present invention is being directed to existing problem, a kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent and its system are provided Preparation Method.
A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent, is made: tea extract 21 ~ 33 by the raw material of following parts by weight Part, 17 ~ 23 parts of guayule rubber extract, 21 ~ 33 parts of benzyl acrylate, 19 ~ 23 parts of konjaku glucomannan, dodecyl benzene sulfonic acid are molten 0.5 ~ 3.3 part of liquid, 22 ~ 35 parts of pentalyn, 5.5 ~ 7.3 parts of guar gum, 3.5 ~ 5.5 parts of rosin glycerides, acrylic acid 17 ~ 25 parts of phenyl ethoxy ethyl ester, 13 ~ 21 parts of n-butyl acrylate, 100 ~ 210 parts of pure water, SEBS block copolymer emulsions 40 ~ 57 parts, 33 ~ 47 parts of ethyl acetoacetate, 21 ~ 27 parts of pentaerythritol ester triacrylate, diethoxy acetophenone 0.6 ~ 1.3 Part there is not stone sour 0.2 ~ 0.4 part of third rouge, 17 ~ 25 parts of nbr carboxyl terminal, 37 ~ 43 parts of isobornyl acrylate, hydrogenated rosin 13 ~ 21 parts of alcohol.
Further, the SEBS block copolymer emulsions are anionic SEBS lotion, phenylethylene/butadiene block ratio It is 40/60, concentration is 18~30wt%, and the mass fraction of the dodecylbenzenesulfonic acid solution is 13% ~ 16%.
Further, the tea extract be to crush tea grounds, be added 10 ~ 35 times of tea grounds weight amount water, heating Boiling to volume is original 1/10, and the volume fractions of 35 ~ 38 times of filter residue weight amounts are added into filter residue as 68 ~ 70% in filtering Alcoholic solution, reflux extraction, all extracting solutions are merged, and being dried to water content is 5 ~ 6%, obtain tealeaf extract.
Further, the guayule rubber extract is that the weight between 106 ~ 2 × 106g/mol of guayule rubber crushing extraction is equal Molecular weight, the volatile matter content by weight percentage less than 0.5%.
A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent, preparation method includes the following steps: one, each raw material is weighed, it will Benzyl acrylate is added in reaction kettle, instills dodecylbenzenesulfonic acid solution slowly under 500 ~ 600r/min mixing speed, adds It is complete to be stirred for 3 ~ 5min, mixing speed is increased into 800 ~ 1000r/min, after continuing 6 ~ 9min of stirring, addition rosin glycerides, Guar gum, the magic sweet glycan of Portugal taro, then with ultrasonic with 200 ~ 300W ice-water bath after 3,000 3 ~ 5min of r/min high speed homogenization of homogenizer Handling 4 ~ 6min, (working time is 10 s, and interval 1 s), with ice-water bath makes temperature be no more than 5 DEG C, obtains homogeneous latex emulsion, will be newborn After liquid places 12h at room temperature, being neutralized to pH value with food buck is 7.1 ~ 7.3, is mixed into guayule rubber extract, is uniformly mixed, obtains Mixture A；Two, phenylethyl ethoxy ethyl ester, n-butyl acrylate, the mixing of pentaerythritol ester triacrylate, stirring are taken Under be heated to 50 DEG C, in 1h be added nbr carboxyl terminal and rosin pentaerythrite mixture, after addition, 50 DEG C are continued to stir Reaction 1h is mixed, being neutralized with food buck to pH value is 7.1 ~ 7.3, adds isobornyl acrylate, does not have stone sour third rouge, diethoxy Benzoylformaldoxime, after mixing evenly, then by using 4000 r/min 1.5 ~ 2min of high speed homogenization of homogenizer again, after to add SEBS embedding The lotion of section copolymer emulsion, pentalyn, hydroabietyl alcohol, ethyl acetoacetate, obtain mixture B after homogenizing；Three, By mixture A with mix B, after the mixing of 1:1 in mass ratio, tea extract is added, is made into pressure-sensitive adhesive, then through 2400 ~ 18 ~ 30s of 2500MHZ microwave treatment to get.
Beneficial effects of the present invention:
A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent provided by the invention, between adhesive and wound treatment face (or drug effect face) There is the interactions of diversified forms, such as absorb diffusate and noxious material, allow gas exchanges, to create for healing One ideal environment prevents microorganism invasion in environment, prevention surface of a wound cross-infection, inflammation etc..Make the surface dimension for creating treatment face When holding in a wet microenvironment, the migration of epithelial cell is significantly accelerated, and has the healing rate in affected part also than dry ring It is fast under border or common adhesive barrier.Wound fluid can be absorbed, obtains sufficiently drainage, and can be by diffusate all or part It is maintained in covering, thus locally causing the microenvironment for maintaining the surface of a wound wet.Since wet matrix is to cell Proliferation and epithelial cell movement have facilitation, and epithelial cell can be carried out promptly from the skin of health to the mobile of the surface of a wound.Phase Than under, after traditional adhesive is covered on wound treatment face, since moisture and drug cannot be migrated, humidity is larger, and Due to the consumption of heat, part wound treatment face face temperature is low, thereby reduces the migration velocity of drug molecule, has reduced wound treatment face Therapeutic effect.The introducing of SEBS lotion, and adhesive hardness and structure are improved, the permeability of water and oxygen is improved, The compliance and hydrophily of adhesive greatly improve, and weatherability, colour retention and the biocompatibility of adhesive are further promoted, And reduce the production cost of adhesive.
A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent provided by the invention, applies guayule rubber and tea extract, this Body has certain therapeutic effect, and guayule rubber, tea grounds property are stablized, from a wealth of sources, low in cost, can not only reduce production Cost greatly improves adhesive functionality, profit additivity, biocompatibility.The present invention is unexpectedly sent out in practice process Existing, the adhesive for being added to guayule rubber and tea extract has good anti-microbial property without adding in the case where antibacterial agent, And the two has synergetic antibacterial effect, adhesive does not have to add additional antibacterial agent, reduces production cost, and be added and glue can be improved The adhesive property of glutinous agent.
The present invention has the advantage that compared with prior art
Pressure-sensitive adhesive agent of the present invention has excellent adhesion and resistance to ag(e)ing, and long-term storage has not significant impact pressure-sensitive, Using natural material tea extract, rosin glycerides, guayule rubber extract, guar gum, there is good degradability and life Object compatibility.Feed change composition and ratio, obtain good biocompatibility, paste that performance is good, barrier action is small, gas permeability It is good, penetrability is good, facilitate drug effect release, the strong medical pressure-sensing gluing agent of the compliance of patient.To various membrane materials have compared with Good coating performance and adhesion property, peel strength and original viscosity are also fine, but its cohesive force and solvent resistance are good, high temperature resistant, It is at low cost, the characteristics of adapting to strong skin surface softness retractility and more gauffers；Chemical property is stablized, (such as to temperature and moisture Sweat) tolerance is functional and has the adaptability of energy gluing different type skin, a certain amount of drug and percutaneous absorbtion can be accommodated Promotor has gently contacted good cementability, feel at pressure sensitive adhesive and wound treatment without influencing chemical stability and adhesive force Stickiness is good, and gluing power is strong, there is good pressure-sensitive performance, would not will appear glue-line when throwing off and destroy and wire drawing or gluing Agent remains in phenomena such as skin surface.
Specific embodiment
Illustrate the present invention with specific embodiment below, but is not limitation of the present invention.
Embodiment 1
A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent, is made by the raw material of following parts by weight: 21 parts of tea extract, guayule rubber 17 parts of extract, 21 parts of benzyl acrylate, 23 parts of konjaku glucomannan, 2.3 parts of dodecylbenzenesulfonic acid solution, rosin Ji Wusi 22 ~ 35 parts of alcohol ester, 7.3 parts of guar gum, 3.5 parts of rosin glycerides, 25 parts of phenylethyl ethoxy ethyl ester, n-butyl acrylate 18 parts, 190 parts of pure water, 57 parts of SEBS block copolymer emulsions, 39 parts of ethyl acetoacetate, pentaerythritol ester triacrylate 27 parts, 1.2 parts of diethoxy acetophenone, do not have stone sour 0.4 part of third rouge, 17 ~ 25 parts of nbr carboxyl terminal, isobomyl acrylate 43 parts of ester, 21 parts of hydroabietyl alcohol.
Further, the SEBS block copolymer emulsions are anionic SEBS lotion, phenylethylene/butadiene block ratio It is 40/60, concentration 28wt%, the mass fraction of the dodecylbenzenesulfonic acid solution is 16%.
Further, the tea extract be to crush tea grounds, be added 10 ~ 35 times of tea grounds weight amount water, heating Boiling to volume is original 1/10, and the volume fractions of 35 ~ 38 times of filter residue weight amounts are added into filter residue as 68 ~ 70% in filtering Alcoholic solution, reflux extraction, all extracting solutions are merged, and being dried to water content is 5 ~ 6%, obtain tealeaf extract.
Further, the guayule rubber extract is to crush guayule rubber to extract 106~2×106Dividing equally between g/mol again Son amount, the volatile matter content by weight percentage less than 0.5%.
A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent, preparation method includes the following steps: one, each raw material is weighed, it will Benzyl acrylate is added in reaction kettle, instills dodecylbenzenesulfonic acid solution slowly under 500 ~ 600r/min mixing speed, adds It is complete to be stirred for 3 ~ 5min, mixing speed is increased into 800 ~ 1000r/min, continues after stirring 9min, rosin glycerides, melon is added That glue, the sweet glycan of magic Portugal taro, then be ultrasonically treated with after 3000 r/min high speed homogenization 5min of homogenizer with 200 ~ 300W ice-water bath (working time is 10 s to 6min, and interval 1 s), with ice-water bath makes temperature be no more than 5 DEG C, homogeneous latex emulsion obtained, by lotion in room After the lower placement 12h of temperature, being neutralized to pH value with food buck is 7.3, is mixed into guayule rubber extract, is uniformly mixed, obtains mixture A；Two, Phenylethyl ethoxy ethyl ester, n-butyl acrylate, the mixing of pentaerythritol ester triacrylate are taken, is heated to 50 under stirring DEG C, the mixture of nbr carboxyl terminal and rosin pentaerythrite is added in 1h, after addition, 50 DEG C are continued to be stirred to react 1h, Being neutralized with food buck to pH value is 7.3, adds isobornyl acrylate, does not have stone sour third rouge, diethoxy acetophenone, stirring Uniformly after, then by again use 4000 r/min 1.5 ~ 2min of high speed homogenization of homogenizer, after add SEBS block copolymer emulsions Lotion, pentalyn, hydroabietyl alcohol, ethyl acetoacetate, after homogenizing mixture B；Three, by mixture A with It mixes B tea extract is added, is made into pressure-sensitive adhesive after the mixing of 1:1 in mass ratio, then through 2500MHZ microwave treatment 30s, To obtain the final product.
Embodiment 2
A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent, is made by the raw material of following parts by weight: 21 ~ 33 parts of tea extract, silver 23 parts of glue chrysanthemum extract, 33 parts of benzyl acrylate, 19 parts of konjaku glucomannan, 3.3 parts of dodecylbenzenesulfonic acid solution, rosin season 22 ~ 35 parts of Doutrate, 5.5 ~ 7.3 parts of guar gum, 5.5 parts of rosin glycerides, 25 parts of phenylethyl ethoxy ethyl ester, propylene 21 parts of sour N-butyl, 210 parts of pure water, 57 parts of SEBS block copolymer emulsions, 33 ~ 47 parts of ethyl acetoacetate, pentaerythrite 23 parts of ester triacrylate, 1.3 parts of diethoxy acetophenone do not have stone sour 0.4 part of third rouge, 25 parts of nbr carboxyl terminal, third 43 parts of olefin(e) acid isobornyl thiocyanoacetate, 21 parts of hydroabietyl alcohol.
Further, the SEBS block copolymer emulsions are anionic SEBS lotion, phenylethylene/butadiene block ratio It is 40/60, concentration 30wt%, the mass fraction of the dodecylbenzenesulfonic acid solution is 13%.
Further, the tea extract be to crush tea grounds, be added 10 ~ 35 times of tea grounds weight amount water, heating Boiling to volume is original 1/10, and the volume fractions of 35 ~ 38 times of filter residue weight amounts are added into filter residue as 68 ~ 70% in filtering Alcoholic solution, reflux extraction, all extracting solutions are merged, and being dried to water content is 5 ~ 6%, obtain tealeaf extract.
Further, the guayule rubber extract is to crush guayule rubber to extract 106~2×106Dividing equally between g/mol again Son amount, the volatile matter content by weight percentage less than 0.5%.
A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent, preparation method includes the following steps: one, each raw material is weighed, it will Benzyl acrylate is added in reaction kettle, instills dodecylbenzenesulfonic acid solution slowly under 500 ~ 600r/min mixing speed, adds It is complete to be stirred for 3min, mixing speed is increased into 800 ~ 1000r/min, continues after stirring 6min, rosin glycerides, Guar is added Glue, the sweet glycan of magic Portugal taro, then be ultrasonically treated with after 3000 r/min high speed homogenization 3min of homogenizer with 200 ~ 300W ice-water bath (working time is 10 s to 4min, and interval 1 s), with ice-water bath makes temperature be no more than 5 DEG C, homogeneous latex emulsion obtained, by lotion in room After the lower placement 12h of temperature, being neutralized to pH value with food buck is 7.1, is mixed into guayule rubber extract, is uniformly mixed, obtains mixture A；Two, Phenylethyl ethoxy ethyl ester, n-butyl acrylate, the mixing of pentaerythritol ester triacrylate are taken, is heated to 50 under stirring DEG C, the mixture of nbr carboxyl terminal and rosin pentaerythrite is added in 1h, after addition, 50 DEG C are continued to be stirred to react 1h, Being neutralized with food buck to pH value is 7.1, adds isobornyl acrylate, does not have stone sour third rouge, diethoxy acetophenone, stirring After uniformly, then by using 4000 r/min high speed homogenization 2min of homogenizer again, after add the creams of SEBS block copolymer emulsions Liquid, pentalyn, hydroabietyl alcohol, ethyl acetoacetate obtain mixture B after homogenizing；Three, by mixture A with mix After B, in mass ratio 1:1 mixing, tea extract is added, is made into pressure-sensitive adhesive, then through 2450MHZ microwave treatment 30s, i.e., ?.
Comparative example 1
This comparative example compared with Example 2, weighs in step in raw material, saves benzyl acrylate ingredient, method step in addition to this It is rapid all the same.
Comparative example 2
This comparative example compared with Example 2, weighs in step in raw material, saves tea extract ingredient, method step in addition to this It is rapid all the same.
Comparative example 3
This comparative example compared with Example 2, weighs in step in raw material, saves guayule rubber extract component, method in addition to this Step is all the same.
Comparative example 4
This comparative example compared with Example 2, weighs in step in raw material, saves rosin glycerides ingredient, method step in addition to this It is rapid all the same.
Comparative example 5
This comparative example compared with Example 2, weighs in step in raw material, saves phenylethyl ethoxy ethyl ester ingredient, removes this Outer method and step is all the same.
The performance test results of 1 embodiment and comparative example adhesive of table
Project Embodiment 1 Embodiment 2 Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 Comparative example 5
Stretching It is qualified It is qualified It is qualified It is qualified It is qualified It is qualified It is qualified
Peel strength It is qualified It is qualified It is qualified It is qualified It is qualified It is qualified It is qualified
Hold viscosity It is qualified It is qualified It is qualified It is qualified It is qualified It is qualified It is qualified
Water vapo(u)r transmission g/m2 643 638 610 621 618 634 623
Water resistance It is excellent It is excellent It is excellent It is excellent It is excellent It is good It is excellent
Biocompatibility It is qualified It is qualified It is qualified It is qualified It is qualified It is qualified It is qualified
Bond strength KPa 264 258 251 248 243 249 245
Note: stretching, waterproofness, peel strength, holds viscosity, water vapo(u)r transmission with reference to YY/T 0148- at biocompatibility 2006 medical adhesive tape General Requirements, water resistance are tested according to GB/T18103-2000, and each finished product is first spread evenly across PBT Sample plate surface, two pieces of PBT sample boards is bonded, is placed in 80 DEG C of water and impregnates 3h, it is water-fast to detect its afterwards by 2 μm of coating layer thickness Property, wherein, excellent is two pieces of sample board bonding jails, adhesive cracking of the difference between two pieces of sample boards.Bond stress detection, specifically Method is as follows: purchase fresh porcine skin is cut into the similar pigskin sheet of size, fresh porcine skin is placed in pH7.0,0.0lmol/ 60min is cultivated in LPBS buffer in 37 DEG C of incubators, watery blood is removed, 2h is dried at room temperature, at room temperature by adhesive adhesive tape It is uniformly covered on pigskin with stress, pigskin is placed in 25 DEG C, 48h is cultivated in the constant incubator of RH50%, in universal material testing The drawing force F of the adhesive tape of bonding is tested on machine, records gluing area S, each adhesive of bond stress o=F/S, and bond stress is put down Mean value computation and obtain.

Claims (5)

1. a kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent, which is characterized in that be made by the raw material of following parts by weight: tealeaves extracts 21 ~ 33 parts of object, 17 ~ 23 parts of guayule rubber extract, 21 ~ 33 parts of benzyl acrylate, 19 ~ 23 parts of konjaku glucomannan, dodecyl 0.5 ~ 3.3 part of benzene sulfonic acid solution, 22 ~ 35 parts of pentalyn, 5.5 ~ 7.3 parts of guar gum, rosin glycerides 3.5 ~ 5.5 Part, 17 ~ 25 parts of phenylethyl ethoxy ethyl ester, 13 ~ 21 parts of n-butyl acrylate, 100 ~ 210 parts of pure water, SEBS block are total 40 ~ 57 parts of copolymer emulsion, 33 ~ 47 parts of ethyl acetoacetate, 21 ~ 27 parts of pentaerythritol ester triacrylate, diethoxybenzene second 0.6 ~ 1.3 part of ketone does not have stone sour 0.2 ~ 0.4 part of third rouge, 17 ~ 25 parts of nbr carboxyl terminal, isobornyl acrylate 37 ~ 43 Part, 13 ~ 21 parts of hydroabietyl alcohol.
2. a kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent according to claim 1, which is characterized in that the SEBS block Copolymer emulsion is anionic SEBS lotion, and phenylethylene/butadiene block ratio is 40/60, and concentration is 18~30wt%, described The mass fraction of dodecylbenzenesulfonic acid solution is 13% ~ 16%.
3. a kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent according to claim 1, which is characterized in that the tealeaves extracts Object be to crush tea grounds, be added the water of 10 ~ 35 times of tea grounds weight amounts, it is original 1/10 that heating, which is boiled to volume, filtering, The alcoholic solution that the volume fraction of 35 ~ 38 times of filter residue weight amounts is 68 ~ 70%, reflux extraction, by all extractions are added into filter residue Liquid merges, and being dried to water content is 5 ~ 6%, obtains tealeaf extract.
4. a kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent according to claim 1, which is characterized in that the guayule rubber mentions Taking object is to crush guayule rubber to extract 106~2×106Weight average molecular weight between g/mol, by weight percentage less than 0.5% Volatile matter content.
5. the preparation method of ageing-resistant antibacterial medical pressure-sensitive adhesive agent described in a kind of claim 1-3, which is characterized in that including Following steps: one, weighing each raw material, and benzyl acrylate is added in reaction kettle, under 500 ~ 600r/min mixing speed slowly Dodecylbenzenesulfonic acid solution is instilled, adds and is stirred for 3 ~ 5min, mixing speed is increased into 800 ~ 1000r/min, continue to stir After mixing 6 ~ 9min, be added rosin glycerides, guar gum, the magic sweet glycan of Portugal taro, then with 3000 r/min high speed homogenization 3 of homogenizer ~ With 200 ~ 300W ice-water bath ultrasonic treatment, 4 ~ 6min, (working time is 10 s, and interval 1 s), makes temperature not with ice-water bath after 5min More than 5 DEG C, homogeneous latex emulsion is obtained, after lotion is placed 12h at room temperature, being neutralized to pH value with food buck is 7.1 ~ 7.3, is mixed Enter guayule rubber extract, is uniformly mixed, obtains mixture A；Two, phenylethyl ethoxy ethyl ester, n-butyl acrylate, season penta are taken The mixing of four alcohol ester triacrylates, is heated to 50 DEG C under stirring, nbr carboxyl terminal and rosin pentaerythrite are added in 1h Mixture, after addition, 50 DEG C are continued to be stirred to react 1h, with food buck neutralize to pH value be 7.1 ~ 7.3, it is different to add acrylic acid Norbornene ester does not have stone sour third rouge, diethoxy acetophenone, after mixing evenly, then by again with 4000 r/min of homogenizer high speed 1.5 ~ 2min of homogeneous, after add lotion, the pentalyn, hydroabietyl alcohol, acetyl of SEBS block copolymer emulsions Ethyl acetate obtains mixture B after homogenizing；Three, by mixture A with mix B, after the mixing of 1:1 in mass ratio, tealeaves is added and extracts Object, is made into pressure-sensitive adhesive, then through 2400 ~ 2500MHZ microwave treatment, 18 ~ 30s to get.
CN201910173896.6A 2019-03-08 2019-03-08 A kind of ageing-resistant antibacterial medical pressure-sensitive adhesive agent and preparation method thereof Withdrawn CN109675088A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111525136A (en) * 2020-04-30 2020-08-11 青岛科技大学 Composite binder and application thereof in silicon cathode of lithium ion battery

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111525136A (en) * 2020-04-30 2020-08-11 青岛科技大学 Composite binder and application thereof in silicon cathode of lithium ion battery

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