CN108135849A - 多维生素挤出物 - Google Patents
多维生素挤出物 Download PDFInfo
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- CN108135849A CN108135849A CN201680055630.6A CN201680055630A CN108135849A CN 108135849 A CN108135849 A CN 108135849A CN 201680055630 A CN201680055630 A CN 201680055630A CN 108135849 A CN108135849 A CN 108135849A
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- Prior art keywords
- vitamin
- extrudate
- weight
- ester
- acid
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Abstract
本发明大体上涉及多维生素挤出物、其生产及其用途。
Description
本发明大体上涉及多维生素挤出物、其生产及其用途。
挤出是一种众所周知的用于生产多种配制物的方法。挤出还用于多种技术领域中。事实上,挤出是一种用途非常广泛的方法。
挤出是一种用于产生具有固定横截面轮廓的物体的方法。
原则上,可以区分热挤出(hot extrusion)、冷挤出(cold extrusion)和温挤出(warm extrusion)。
热挤出是一种热加工方法,这意味着其在材料的熔融温度以上进行,以防止材料硬化并使推动材料穿过模具更加容易。大多数热挤出在230-11000公吨的水平液压机上进行(压力范围为30-700MPa)。
冷挤出在室温或接近室温下进行。
温挤出在高于室温但低于材料的熔融温度下进行。温度范围为100-975℃。其通常用于实现所需力量、延展性和最终挤出性能的适当平衡。
为了配制含脂溶性维生素的配制物,还存在其他常用的技术,例如喷雾干燥、喷雾冷却等。
本发明的目标是找到以简单且经改进的方式生产多维生素配制物的方法。
目标是这些多维生素配制物可以原样使用或在包含多种维生素的任何其他组合物中使用。
如今,当例如生产多维生素片剂时,会生产各种维生素的预混物。这是通过将期望量的不同维生素或维生素配制物混合在一起来进行的,然后如此使用。通常,每种维生素配制物都是单独生产的(通常通过喷雾干燥)。这种通常实施的工作方式需要大量处理且总是与污染风险相关。此外,粉末的处理通常与粉尘问题有关。
现在,我们找到了一种以挤出物形式递送配制物的方法,其中所有维生素(所需的和所期望的)均以其应用所需的量存在。利用这种挤出物时,不需要混合和生产不同的维生素配制物。
此外,本发明的挤出物可以包含,基于所述挤出物的总重量,高总量的维生素(至少8重量%(wt-%))。
此外,挤出物可以包含各种水溶性维生素的混合物或各种油溶性维生素的混合物或水溶性维生素和油溶性维生素的混合物。
另外,根据本发明的配制物是自由流动的(没有灰尘问题!)。
因此,本发明涉及挤出物(E),基于所述挤出物的总重量,其包含至少8重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
维生素在挤出物中的分布极好,这意味着所有挤出物(颗粒)中各种维生素的比例(w/w)基本相同。
根据本发明的挤出物可以具有任何常见的形式和尺寸。这很大程度上取决于挤出物会被进一步用于何种组合物。通常,根据本发明的挤出物是直径(颗粒的最大维度)最大为1000μm的颗粒。
优选地,颗粒具有球状形式。挤出物在原样使用时(至多1mm)通常比在配制物中使用时(通常为100-600μm)更大。如上所述,获得的挤出物呈自由流动形式(粉末)。
颗粒尺寸和形状可以通过公知的方法来控制,通常通过模具形状和直径的选择来控制。
此外,根据本发明的挤出物可以包含,基于所述挤出物的总重量,至多95重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
因此,本发明涉及挤出物(E1),其是这样的挤出物(E),基于挤出物的总重量,其包含至多95重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
一个优选的范围是:基于挤出物的总重量,8重量%-95重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
另一个优选的范围是:基于挤出物的总重量,8重量%-80重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
另一个优选的范围是:基于挤出物的总重量,8重量%-60重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
另一个优选的范围是:基于挤出物的总重量,8重量%-50重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
因此,本发明涉及挤出物(E2),其是这样的挤出物(E)或(E1),基于挤出物总重量,其包含8重量%-95重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
因此,本发明涉及挤出物(E3),其是这样的挤出物(E)或(E1),基于挤出物总重量,其包含8重量%-80重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
因此,本发明涉及挤出物(E4),其是这样的挤出物(E)或(E1),基于挤出物总重量,其包含8重量%-60重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
因此,本发明涉及挤出物(E5),其是这样的挤出物(E)或(E1),基于挤出物总重量,其包含8重量%-50重量%的多于一种水溶性维生素和/或多于一种油溶性维生素。
掺入根据本发明的挤出物中的脂溶性维生素是维生素A或其酯(例如维生素A乙酸酯和维生素A棕榈酸酯)、维生素E或其酯(例如维生素E乙酸酯)、维生素K(植物甲萘醌(phytomenadione))和维生素D3(胆钙化醇)。
掺入根据本发明的挤出物中的水溶性维生素是维生素B1(硫胺素)、维生素B2(核黄素)、维生素B3(烟酸、烟酰胺)、维生素B5(泛酸)、维生素B6(吡哆醇、吡哆胺、吡哆醛)、维生素B7(生物素)、维生素B9(叶酸、亚叶酸)、维生素B12(氰钴维生素、羟钴胺素、甲基钴胺素)和维生素C(抗坏血酸)。
这些维生素容易从商业来源获得。而且,它们可以由技术人员通过常规方法制备。
根据本发明的挤出物包含多于一种维生素,所述维生素选自维生素A或其酯(例如维生素A乙酸酯和维生素A棕榈酸酯)、维生素E或其酯(例如维生素E乙酸酯)、维生素K(植物甲萘醌)、维生素D3(胆钙化醇)、维生素B1(硫胺素)、维生素B2(核黄素)、维生素B3(烟酸、烟酰胺)、维生素B5(泛酸)、维生素B6(吡哆醇、吡哆胺、吡哆醛)、维生素B7(生物素)、维生素B9(叶酸、亚叶酸)、维生素B12(氰钴维生素、羟钴胺素、甲基钴胺素)和维生素C(抗坏血酸)。
因此,本发明涉及挤出物(E6),其是这样的挤出物(E)、(E1)、(E2)、(E3)、(E4)或(E5),其包含多于一种维生素,所述维生素选自维生素A或其酯(例如维生素A乙酸酯和维生素A棕榈酸酯)、维生素E或其酯(例如维生素E乙酸酯)、维生素K(植物甲萘醌)、维生素D3(胆钙化醇)、维生素B1(硫胺素)、维生素B2(核黄素)、维生素B3(烟酸、烟酰胺)、维生素B5(泛酸)、维生素B6(吡哆醇、吡哆胺、吡哆醛)、维生素B7(生物素)、维生素B9(叶酸、亚叶酸)、维生素B12(氰钴维生素、羟钴胺素、甲基钴胺素)和维生素C(抗坏血酸)。
根据本发明的挤出物可以是仅包含水溶性维生素的挤出物(这意味着挤出物中不存在油溶性维生素)。在这种情况下,维生素的含量可以非常高。基于挤出物的总重量,至多95重量%的水溶性维生素是可能且合适的。优选地,基于挤出物的总重量,至多60重量%的水溶性维生素是优选的。更优选地,基于挤出物的总重量,至多50重量%的水溶性维生素是优选的。
基于挤出物的总重量,一个常用且优选的范围是8重量%-60重量%的一种或更多种水溶性维生素,其中所述挤出物不含任何油溶性维生素。
水溶性维生素选自维生素B1、维生素B2、维生素B3、维生素B5、维生素B6、维生素B7、维生素B9、维生素B12和维生素C。
基于挤出物的总重量,另一常用且优选的范围是8重量%-50重量%的一种或更多种水溶性维生素,所述水溶性维生素选自维生素B1、维生素B2、维生素B3、维生素B5、维生素B6、维生素B7、维生素B9、维生素B12和维生素C,其中所述挤出物不含任何油溶性维生素。
根据本发明的挤出物可以是仅包含油溶性维生素的挤出物(这意味着挤出物中不存在水溶性维生素)。
脂溶性维生素选自维生素A或其酯、维生素E或其酯、维生素K和维生素D3。
在这种情况下,维生素的含量不如针对水溶性维生素时那么高。通常挤出物中有至多40重量%的油溶性维生素。
另一常用且优选的范围是:基于挤出物的总重量,8重量%-30重量%的一种或更多种水溶性维生素,所述水溶性维生素选自维生素A或其酯、维生素E或其酯、维生素K和维生素D3,其中所述挤出物不含任何水溶性维生素。
另一常用且优选的范围是:基于挤出物的总重量,8重量%-20重量%的一种或更多种水溶性维生素,所述水溶性维生素选自维生素A或其酯、维生素E或其酯、维生素K和维生素D3,其中所述挤出物不含任何水溶性维生素。
根据本发明的挤出物可以是这样的挤出物,其包含一种或多种水溶性维生素和一种或多种油溶性维生素的混合物。
因此,本发明涉及挤出物(E7),其是这样的挤出物(E)、(E1)、(E2)、(E3)、(E4)、(E5)或(E6),其仅包含水溶性维生素,所述水溶性维生素选自维生素B1、维生素B2、维生素B3、维生素B5、维生素B6、维生素B7、维生素B9、维生素B12和维生素C(不含任何油溶性维生素)。
对于这些挤出物,基于挤出物的总重量,含量优选介于8重量%-60重量%之间。
对于这些挤出物,基于挤出物的总重量,含量优选介于8重量%-50重量%之间。
因此,本发明涉及挤出物(E7’),其是这样的挤出物(E7),其中基于挤出物的总重量,水溶性维生素的含量为至多95重量%,其中所述挤出物不含任何油溶性维生素。
因此,本发明涉及挤出物(E7”),其是这样的挤出物(E7),其中基于挤出物的总重量,水溶性维生素的含量为8重量%-60重量%。
因此,本发明涉及挤出物(E7”’),其是这样的挤出物(E7),其中基于挤出物的总重量,水溶性维生素的含量为8重量%-50重量%。
因此,本发明涉及挤出物(E8),其是这样的挤出物(E)、(E1)、(E2)、(E3)、(E4)、(E5)或(E6),其仅包含选自维生素A或其酯、维生素E或其酯、维生素K和维生素D3的油溶性维生素,其中所述挤出物不含任何水溶性维生素。
因此,本发明涉及挤出物(E8’),其是这样的挤出物(E8),其中基于挤出物的总重量,维生素的含量为至多40重量%。
因此,本发明涉及挤出物(E8”),其是这样的挤出物(E8),其中基于挤出物的总重量,维生素的含量为8重量%-30重量%。
根据本发明的挤出物包含至少两种维生素(水溶性的和/或油溶性的)。
本发明的另一实施方式涉及包含至少三种维生素(水溶性的和/或油溶性的)的挤出物。
本发明的另一实施方式涉及包含至少四种维生素(水溶性的和/或油溶性的)的挤出物。
因此,本发明涉及挤出物(E9),其是这样的挤出物(E)、(E1)、(E2)、(E3)、(E4)、(E5)或(E6)、(E7)、(E7’)、(E7”)、(E7”’)、(E8)、(E8’)或(E8”),其中所述挤出物包含至少三种维生素。
因此,本发明涉及挤出物(E9’),其是这样的挤出物(E)、(E1)、(E2)、(E3)、(E4)、(E5)、(E6)、(E7)、(E7’)、(E7”)、(E7”’)、(E8)、(E8’)或(E8”),其中所述挤出物包含至少四种维生素。
如上所述,根据本发明的挤出物可以是这样的挤出物,其包含一种或多种水溶性维生素和一种或多种油溶性维生素的混合物。
因此,本发明涉及挤出物(E10),其是这样的挤出物(E)、(E1)、(E2)、(E3)、(E4)、(E5)、(E6)、(E9)或(E9’),其包含至少一种水溶性维生素和至少一种油溶性维生素的混合物。
本发明涉及挤出物(E10’),其是这样的挤出物(E10),其包含至少两种水溶性维生素和至少一种油溶性维生素。
本发明涉及挤出物(E10”),其是这样的挤出物(E10),其包含至少三种水溶性维生素和至少一种油溶性维生素。
本发明涉及挤出物(E10”’),其是这样的挤出物(E10),其包含至少两种水溶性维生素和至少一种油溶性维生素。
本发明涉及挤出物(E10””),其是这样的挤出物(E10),其包含2、3、4、5、6或7种(不同的)水溶性维生素和2、3或4种(不同的)油溶性维生素。
如果使用油溶性维生素来形成根据本发明的挤出物,那么根据本发明的挤出物包含至少一种通常已知和使用的乳化剂。
也可以将至少一种乳化剂加入仅包含水溶性维生素的挤出物中。
根据本发明的挤出物中的至少一种乳化剂的含量为基于所述挤出物的总重量10重量%-92重量%、优选15重量-92重量%、更优选20重量%-92重量%。
很明显,百分比加起来决不超过100,并且关于挤出物的百分比加起来总是100。该要求对于本专利申请中描述的所有挤出物都是有效的。
如上所述,当使用至少一种油溶性维生素时,在根据本发明的方法中使用至少一种乳化剂。可以使用任何通常已知和使用的乳化剂。可以根据之后挤出物的最终用途来选择乳化剂。这意味着:如果通过根据本发明的方法获得的挤出物被用于食品或饲料产品中,则乳化剂必须是食品级或饲料级的。
合适的乳化剂即改性(食物)淀粉、果胶、藻酸盐、卡拉胶、红藻胶、壳聚糖、麦芽糖糊精、糊精衍生物、纤维素和纤维素衍生物(例如乙酸纤维素、甲基纤维素、羟丙基甲基纤维素)、木质素磺酸盐、多糖胶(例如金合欢胶、阿拉伯胶、亚麻子胶、茄替胶、罗望子胶和阿拉伯半乳聚糖)、明胶(牛、鱼、猪肉、家禽)、植物蛋白(例如豌豆、大豆、蓖麻子、棉花、土豆、甘薯、木薯、油菜籽、向日葵、芝麻、亚麻子、红花、扁豆、坚果、小麦、水稻、玉米、大麦、黑麦、燕麦、羽扇豆和高粱)、动物蛋白包括乳或乳清蛋白、卵磷脂、脂肪酸聚甘油酯、脂肪酸单甘油酯、脂肪酸双甘油酯、山梨聚糖酯、丙二醇(PG)酯和糖酯(及其衍生物)。
可以对淀粉进行物理改性和化学改性。预胶化淀粉是物理改性淀粉的例子。酸改性淀粉、氧化淀粉、交联淀粉、淀粉酯、淀粉醚和阳离子淀粉是化学改性淀粉的例子。
因此,本发明涉及挤出物(E11),其是这样的挤出物(E)、(E1)、(E2)、(E3)、(E4)、(E5)、(E6)、(E8)、(E8’)、(E8”)、(E9)、(E9’)、(E10)、(E10”)、(E10”’)或(E10””),其包含至少一种乳化剂。
因此,本发明涉及挤出物(E11’),其是这样的挤出物(E)、(E1)、(E2)、(E3)、(E4)、(E5)、(E6)、(E7)、(E7’)、(E7”)、(E7”’)、(E7””)、(E8)、(E8’)、(E8”)、(E9)、(E9’)、(E10)、(E10”)、(E10”’)或(E10””),其包含至少一种乳化剂。
因此,本发明涉及挤出物(E11”),其是这样的挤出物(E11)或(E11’),基于挤出物的总重量,其包含15重量%-92重量%(优选20重量%-92重量%)的至少一种乳化剂。
如上所述,百分比加起来决不超过100,并且关于挤出物的百分比加起来总是100。
因此,本发明涉及挤出物(E11”’),其是这样的挤出物(E11)、(E11’)或(E11”’),其中所述乳化剂选自改性(食物)淀粉、果胶、藻酸盐、卡拉胶、红藻胶、壳聚糖、麦芽糖糊精、糊精衍生物、纤维素和纤维素衍生物(例如乙酸纤维素、甲基纤维素、羟丙基甲基纤维素)、木质素磺酸盐、多糖胶(例如金合欢胶、阿拉伯胶、亚麻子胶、茄替胶、罗望子胶和阿拉伯半乳聚糖)、明胶(牛、鱼、猪肉、家禽)、植物蛋白(例如豌豆、大豆、蓖麻子、棉花、土豆、甘薯、木薯、油菜籽、向日葵、芝麻、亚麻子、红花、扁豆、坚果、小麦、水稻、玉米、大麦、黑麦、燕麦、羽扇豆和高粱)、动物蛋白包括乳或乳清蛋白、卵磷脂、脂肪酸聚甘油酯、脂肪酸单甘油酯、脂肪酸双甘油酯、山梨聚糖酯、PG酯和糖酯(及其衍生物)。
挤出物还可以包含成分(ingredients)(助剂)。这种助剂可用于挤出方法和/或挤出物和/或产品(或应用),其中随后使用挤出物。
这种助剂有例如抗氧化剂(例如抗坏血酸或其盐、生育酚(合成的或天然的);丁羟甲苯(BHT);丁羟茴醚(BHA);没食子酸丙酯;叔丁基羟基喹啉和/或脂肪酸的抗坏血酸酯);乙氧喹;塑化剂;稳定剂;湿润剂(例如甘油、山梨醇、聚乙二醇);保护胶体;染料,芳香剂;矿物质(例如葡萄糖酸锌、葡萄糖酸铜(II)、碘化钾、亚硒酸钠、富马酸亚铁、磷酸三钙、硫酸亚铁、硫酸锌);填充剂(例如微晶纤维素)和缓冲剂。
这些助剂是任选添加的。当添加时,基于挤出物的总重量,助剂的量为0.1重量%-92重量%(当使用时,优选为20重量%-60重量%)。
因此,本发明涉及挤出物(E12),其是这样的挤出物(E)、(E1)、(E2)、(E3)、(E4)、(E5)、(E6)、(E7)、(E7’)、(E7”)、(E7”’)、(E7””)、(E8)、(E8’)、(E8”)、(E9)、(E9’)、(E10)、(E10”)、(E10”’)、(E10””)、(E11)、(E11”)或(E10”’),其包含至少一种助剂。
因此,本发明涉及挤出物(E12’),其是这样的挤出物(E12),基于挤出物的总重量,其包含0.1重量%-92重量%的至少一种助剂。
因此,本发明涉及挤出物(E12”),其是这样的挤出物(E12),基于挤出物的总重量,其包含20重量%-60重量%的至少一种助剂。
根据本发明的挤出物(E1)、(E2)、(E3)、(E4)、(E5)、(E6)、(E7)、(E7’)、(E7”)、(E7”’)、(E7””)、(E8)、(E8’)、(E8”)、(E9)、(E9’)、(E10)、(E10”)、(E10”’)、(E10””)、(E11)、(E10”)、(E11”)、(E12)、(E12’)和(E12”)是通过使用公知的挤出条件以及设备生产的。
挤出机内的温度通常介于20℃-220℃之间。优选地,离开挤出机的挤出物的温度<100℃。成分在挤出机中的总停留时间通常介于1-400秒之间。
根据本发明的挤出方法的剪切量(amount of shear)通常为200-80000单位。
此外,还可以泵送惰性气体通过挤出机。通常在进入挤出机时泵入惰性气体。但也可以在挤出方法的任何阶段泵入惰性气体(也通过位于不同位置的若干入口)。惰性气体可有助于保护敏感成分。
挤出机通常包含一个或多个螺旋轴,其中多个输送或捏合型螺纹元件安装在所述螺旋轴上。
这些元件运输材料通过挤出机(任选地在压力和提高的温度下)。在挤出机的末端(出口),可以存在模具,挤出的材料通过该模具被挤压。之后,干燥并切割(或者反之)挤出的材料。挤出机可具有若个入口,通过所述入口可加入材料。
在挤出过程结束时(当挤出股线(strand)离开挤出机时),股线会被切割、成型并干燥以获得具有期望的形状和尺寸的颗粒。
根据本发明的挤出物可以原样使用以及在其它配制物中使用。
当挤出物被原样使用时,它们可以被消费者(人和/或动物)原样消费或与其它成分混合在一起。根据本发明的挤出物还可以用在食物、饲料、药物和/或个人护理配制物,以及用于食物、饲料、药物和/或个人护理配制物的预混物中。
本发明还涉及至少一种挤出物(E1)、(E2)、(E3)、(E4)、(E5)、(E6)、(E7)、(E7’)、(E7”)、(E7”’)、(E7””)、(E8)、(E8’)、(E8”)、(E9)、(E9’)、(E10)、(E10”)、(E10”’)、(E10””)、(E11)、(E10”)、(E11”)、(E12)、(E12’)和(E12”)作为营养组合物的用途。
本发明还涉及至少一种挤出物(E1)、(E2)、(E3)、(E4)、(E5)、(E6)、(E7)、(E7’)、(E7”)、(E7”’)、(E7””)、(E8)、(E8’)、(E8”)、(E9)、(E9’)、(E10)、(E10”)、(E10”’)、(E10””)、(E11)、(E10”)、(E11”)、(E12)、(E12’)和(E12”)用于生产食物、饲料、药物和/或个人护理配制物的用途。
本发明还涉及预混物,其包含至少一种(E1)、(E2)、(E3)、(E4)、(E5)、(E6)、(E7)、(E7’)、(E7”)、(E7”’)、(E7””)、(E8)、(E8’)、(E8”)、(E9)、(E9’)、(E10)、(E10”)、(E10”’)、(E10””)、(E11)、(E10”)、(E11”)、(E12)、(E12’)和(E12”)。
本发明还涉及食物、饲料、药物和/或个人护理配制物,其包含至少一种挤出物(E1)、(E2)、(E3)、(E4)、(E5)、(E6)、(E7)、(E7’)、(E7”)、(E7”’)、(E7””)、(E8)、(E8’)、(E8”)、(E9)、(E9’)、(E10)、(E10”)、(E10”’)、(E10””)、(E11)、(E10”)、(E11”)、(E12)、(E12’)和(E12”)。
以下实施例用于阐释本发明。温度以℃给出,百分比总是与重量相关。
实施例
实施例1:包含所有B族维生素的挤出多组分颗粒
本实施例描述了包含所有B族维生素(硫胺素、核黄素、吡哆醇、尼克酸、叶酸和钴胺素)的固体挤出颗粒的生产。将包含B族维生素以及小麦淀粉和硬质小麦粗粉(作为载体材料)的粉末预混物通过重力法(gravimetrically)进料(Brabender Technologie)到实验室规模的同向旋转双螺杆挤出机(Thermo Fisher Scientific,HAAKE Polylab OS和PTW16/40OS双螺杆挤出机)的第一桶中。挤出机由10个(电加热和水冷却的)桶和模头(12或)组成,螺杆直径为16mm,长径比为40。将脱矿质水注入第二桶中。将桶2-10和模头的温度设定为20℃。以500g/h进料粉末预混物并加入60g/h水。在模头处通过两个旋转刀直接模面切割含有B族维生素的挤出物股线。模面切割之后,将固体颗粒在实验室规模的流化床干燥器(Retsch TG 200)中在50℃下干燥60分钟以获得6重量%的最终含水量。
干挤出物颗粒的含量示于表1中。通过新制备挤出物的HPLC来测量维生素B2-5-磷酸盐的含量,发现回收率为93%。
表1.含有所有B族维生素的干挤出物的组成。
成分 | 在干挤出物中的含量,wt% |
硝酸硫胺素(B1) | 0.829 |
核黄素5'-磷酸钠(B2) | 0.96 |
盐酸吡哆醇(B6) | 0.74 |
烟酰胺(B3) | 7.28 |
叶酸(B9) | 0.19 |
维生素B12晶体 | 0.001 |
小麦淀粉 | 45.00 |
硬质小麦粗粉 | 45.00 |
实施例2:包含油溶性维生素和水溶性维生素的挤出多组分颗粒
本实施例描述了包含油溶性维生素(维生素A乙酸酯、维生素D3、维生素E乙酸酯)和水溶性维生素(维生素C、硫胺素、核黄素、吡多醇、烟酸、叶酸和钴胺素)的固体挤出颗粒的生产。在实施例1中所述的实验室规模的同向旋转双螺杆挤出机上进行包含乳化的油溶性维生素以及水溶性维生素的固体挤出颗粒的生产。将乳化剂(改性食物淀粉)以及填充物(微晶纤维素)与水溶性维生素预混合,如表2中所示。将该粉末预混物通过重力法进料到双螺杆挤出机的第一桶中。将脱矿质水注入第二桶中。将桶2-10和模头的温度设定为50℃。将油溶性维生素维生素A乙酸酯、维生素D3晶体、d,1-α-生育酚乙酸酯(任选地,和添加的抗氧化剂例如d,1-α-生育酚或丁羟甲苯(BHT))熔化并在70℃下预混合(表3)。将这种油质熔体注入桶5中并与下游桶中的其他组分混合。以750g/h进料粉末预混物,以40g/h进料油质预混物并加入210g/h水。收集含有油溶性维生素和水溶性维生素的挤出物股线,冷却至室温,随后用造粒机(Thermo Fisher Scientific)切割。将切割的固体颗粒在实验室规模的流化床干燥器(Retsch TG 200)中在50℃下干燥60分钟以获得5重量%的最终含水量。
表2.用于挤出水溶性维生素和油溶性维生素的粉末预混物的组成。
成分 | 在粉末预混物中的含量,wt% |
硝酸硫胺素(B1) | 0.51 |
核黄素5'-磷酸钠(B2) | 0.61 |
盐酸吡哆醇(B6) | 0.47 |
烟酰胺(B3) | 4.61 |
叶酸(B9) | 0.12 |
维生素B12晶体 | 0.001 |
抗坏血酸细粉(C) | 20.39 |
改性食物淀粉 | 29.32 |
微晶纤维素 | 43.969 |
表3.用于挤出水溶性维生素和油溶性维生素的油质熔体的组成。
成分 | 在油质熔体中的含量,wt% |
维生素A乙酸酯晶体 | 7.30 |
维生素D3晶体 | 0.08 |
d,l-α-生育酚乙酸酯(E) | 91.62 |
d,l-α-生育酚 | 1.00 |
干挤出物颗粒的含量示于表4中。通过新制备挤出物的HPLC来测量维生素B2-5-磷酸盐、维生素A乙酸酯以及维生素D3的含量,发现回收率分别为94%、89%和100%。
表4.含有油溶性维生素和水溶性维生素的干挤出物的组成。
实施例3:包含油溶性维生素的挤出多组分颗粒
本实施例描述了包含油溶性维生素(维生素A乙酸酯、维生素D3、维生素E乙酸酯)的固体挤出颗粒的生产。在实施例1中所述的实验室规模的同向双螺杆挤出机上进行包含乳化的油溶性维生素的固体挤出颗粒的生产。将乳化剂(改性食物淀粉)和填充物(微晶纤维素)以2:3的比例预混合。将该粉末预混物通过重力法进料到双螺杆挤出机的第一桶中。将脱矿质水注入第二桶中。将桶2-10和模头的温度设定为50℃。将油溶性维生素维生素A乙酸酯、维生素D3晶体、d,1-α-生育酚乙酸酯(任选地,和添加的抗氧化剂例如d,1-α-生育酚或丁羟甲苯(BHT))熔化并在70℃下预混合(表5)。将这种油质熔体注入桶5中并与下游桶中的其他组分混合。以500g/h进料粉末预混物,以73g/h进料油质预混物并加入300g/h水。收集含有油溶性维生素和水溶性维生素的挤出物股线,随后以每批250g在1900rpm下球化(spheronized)15分钟(Gabler R-250)。将球化的固体颗粒在实验室规模的流化床干燥器(Retsch TG 200)中在50℃下干燥60分钟以获得4重量%的最终含水量。
干挤出物颗粒的含量示于表6中。通过新制备挤出物的HPLC来测量维生素A乙酸酯以及维生素D3的含量,发现回收率分别为88%和92%。
表5.用于挤出油溶性维生素的油质熔体的组成。
成分 | 在油质熔体中的含量,wt% |
维生素A乙酸酯晶体 | 7.30 |
维生素D3晶体 | 0.08 |
d,l-α-生育酚乙酸酯(E) | 91.63 |
d,l-α-生育酚 | 0.99 |
表6.含油溶性维生素的干挤出物的组成。
成分 | 在干挤出物中的含量,wt% |
维生素A乙酸酯晶体 | 0.94 |
维生素D3晶体 | 0.01 |
d,l-α-生育酚乙酸酯(E) | 11.73 |
d,l-α-生育酚 | 0.13 |
改性食物淀粉 | 34.87 |
微晶纤维素 | 52.32 |
Claims (15)
1.一种挤出物,基于所述挤出物的总重量,其包含至少8重量%的多于一种水溶性维生素和/或一种或更多种油溶性维生素。
2.根据权利要求1所述的挤出物,基于所述挤出物的总重量,其包含至多95重量%的多于一种维生素。
3.根据权利要求1所述的挤出物,基于所述挤出物的总重量,其包含8重量%-80重量%的多于一种维生素。
4.根据权利要求3所述的挤出物,其包含至少三种维生素。
5.根据前述权利要求中任一项所述的挤出物,其包含多于一种维生素,所述维生素选自维生素A或其酯(例如维生素A乙酸酯和维生素A棕榈酸酯)、维生素E或其酯(例如维生素E乙酸酯)、维生素K(植物甲萘醌)、维生素D3(胆钙化醇)、维生素B1(硫胺素)、维生素B2(核黄素)、维生素B3(烟酸、烟酰胺)、维生素B5(泛酸)、维生素B6(吡哆醇、吡哆胺、吡哆醛)、维生素B7(生物素)、维生素B9(叶酸、亚叶酸)、维生素B12(氰钴维生素、羟钴胺素、甲基钴胺素)和维生素C(抗坏血酸)。
6.根据前述权利要求中任一项所述的挤出物,其中所述挤出物仅包含水溶性维生素。
7.根据前述权利要求1-5中任一项所述的挤出物,其中所述挤出物仅包含脂溶性维生素。
8.根据前述权利要求中任一项所述的挤出物,其包含至少一种乳化剂。
9.根据权利要求8所述的挤出物,基于所述挤出物的总重量,其包含10-92重量%、优选15-92重量%、更优选20-92重量%的至少一种乳化剂。
10.根据权利要求8或9所述的挤出物,其中所述乳化剂选自改性(食物)淀粉、果胶、藻酸盐、卡拉胶、红藻胶、壳聚糖、麦芽糖糊精、糊精衍生物、纤维素和纤维素衍生物(例如乙酸纤维素、甲基纤维素、羟丙基甲基纤维素)、木质素磺酸盐、多糖胶(例如金合欢胶、阿拉伯胶、亚麻子胶、茄替胶、罗望子胶和阿拉伯半乳聚糖)、明胶(牛、鱼、猪肉、家禽)、植物蛋白(例如豌豆、大豆、蓖麻子、棉花、土豆、甘薯、木薯、油菜籽、向日葵、芝麻、亚麻子、红花、扁豆、坚果、小麦、水稻、玉米、大麦、黑麦、燕麦、羽扇豆和高粱)、动物蛋白包括乳或乳清蛋白、卵磷脂、脂肪酸聚甘油酯、脂肪酸单甘油酯、脂肪酸双甘油酯、山梨聚糖酯、PG酯和糖酯(及其衍生物)。
11.根据前述权利要求中任一项所述的挤出物,其包含至少一种助剂。
12.根据权利要求11所述的挤出物,其包含至少一种助剂,所述助剂选自抗氧化剂(例如抗坏血酸或其盐、生育酚(合成的或天然的));丁羟甲苯(BHT);丁羟茴醚(BHA);没食子酸丙酯;叔丁基羟基喹啉和/或脂肪酸的抗坏血酸酯);乙氧喹;塑化剂;稳定剂;湿润剂(例如甘油、山梨醇、聚乙二醇);保护胶体;染料,芳香剂;矿物质(例如葡萄糖酸锌、葡萄糖酸铜(II)、碘化钾、亚硒酸钠、富马酸亚铁、磷酸三钙、硫酸亚铁、硫酸锌);填充剂(例如微晶纤维素)和缓冲剂。
13.根据权利要求11或权利要求12所述的挤出物,其中基于所述挤出物的总重量,所述助剂的量为0.1-92重量%。
14.至少一种根据权利要求1-13中任一项所述的挤出物在生产食物、饲料、药物和/或个人护理配制物以及用于食物、饲料、药物和/或个人护理配制物的预混物中的用途。
15.食物、饲料、药物和/或个人护理配制物或者用于食物、饲料、药物和/或个人护理配制物的预混物,其包含至少一种根据权利要求1-13中任一项所述的挤出物。
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CN112955024A (zh) * | 2018-10-30 | 2021-06-11 | 帝斯曼知识产权资产管理有限公司 | 包含维生素b9的挤出物 |
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EP3764820A1 (en) * | 2018-03-15 | 2021-01-20 | DSM IP Assets B.V. | Manufacturing of extrudates having improved microbial quality |
CN112912067A (zh) * | 2018-08-31 | 2021-06-04 | 欧普科爱尔兰环球控股有限公司 | 儿童剂型、制造和使用方法 |
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