CN108135797B - 具有杀微生物性的基于醇的皮肤消毒剂 - Google Patents
具有杀微生物性的基于醇的皮肤消毒剂 Download PDFInfo
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- CN108135797B CN108135797B CN201680057200.8A CN201680057200A CN108135797B CN 108135797 B CN108135797 B CN 108135797B CN 201680057200 A CN201680057200 A CN 201680057200A CN 108135797 B CN108135797 B CN 108135797B
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Abstract
一种皮肤消毒组合物，其含有脂肪族醇(0.1‑90％w/w)、螯合剂(0.1‑5％)、助水溶物(0.1‑5.0％)、用于调节pH的酸(0.01‑5％)、C10至C16烷基苯磺酸盐(0.1‑1.0％)、离液剂(0.01‑10％)、类倍半萜烯(0.01‑1％)、皮肤保湿、调理和/或润肤剂(0.01‑10％)和用于平衡的水。所述组合物可以是液体、发泡的或其可以是增稠凝胶。
Description
技术领域
本发明涉及用于皮肤的快速消毒的基于醇的制剂。
背景技术
在针对与护理相关的感染以及病原体传播的抗争中，手部卫生方面非常重要。然而，在医院，对于用水和肥皂清洗手部的依从性不如它应当的那样重要，因为存在太多限制(要求手部清洗、冲洗和干燥，然后手部消毒)。这是为什么行业中开始开发一些水醇制剂的原因。
在90年代上市的这些产品首先不被当时推崇手部清洗依从性的卫生学者所欣赏。由于相当多的研究已经证实在使用温和肥皂之后，接着使用基于醇的消毒洗手液减少了职业性手部皮炎的发病率。如今，作为肥皂的补充，基于醇的消毒洗手液是用于手部卫生和术前手部消毒的优选方法。
基于醇的消毒洗手液通常由20-30％的水(其对于细菌蛋白的变性是绝对必需的)、60-80％的醇(乙醇和/或异丙醇和/或正丙醇)组成，并且它们有时含有一些额外的杀生物剂(例如，洗必泰、季铵盐、酚醛树脂…)，以便强化它们的初始抗微生物谱的功效。当长期使用时，这些额外的杀生物剂可能具有皮肤角质分离和/或刺激性(过敏症的一些情形也在专业文献中有描述)；因此，从纯粹毒理学观点出发，它们不适合于免洗类产品。
在没有杀生物添加剂的情况下，醇类对于植物性革兰氏阳性和革兰氏阴性细菌、分枝杆菌、酵母型真菌(yeast)和包膜病毒具有广谱活性。它们对于真菌是慢活性的(要求接触≥5分钟)，并且在用于可接受接触时间内的快速皮肤卫生消毒(1分钟以下)时，它们也可以被认为对于无包膜病毒(也称为亲水性或裸病毒)是无活性的。为了获得在一分钟以内或更少时间内对裸病毒的功效，一些当前上市的消毒洗手液包括80至90％w/w的乙醇和/或正丙醇和/或异丙醇以及一些杀伤增效剂如脂肪醇、表面活性剂或二醇。然而，将醇的浓度增大至高于80％会导致杀细菌功效的损失；20至30％的水对于使醇渗透到细菌细胞中并使其胞浆蛋白凝结来说是必需的。而且，就皮肤耐受性而言，高浓度的醇是不适合的，因为它增大经皮肤的失水量和相关的皮肤脱水。由于皮肤刺激和/或过敏的风险，额外的杀生物添加剂如季铵盐、洗必泰、三氯生、对氯间二甲苯酚、碘等是不适合的；对于在医疗和食品部门工作的职员来说，这些添加剂整天并且每天保持在皮肤上。
发明内容
本发明的一个目的是提供一种用作消毒洗手液的基于醇的组合物或制剂，其优选地含有约60至约70％w/w醇，并且对大多数的病原性微生物(包括无包膜病毒)族具有功效。
典型地，除了醇之外，所述制剂不含任何共杀生物剂。这减少皮肤刺激或过敏症的风险。
为了改善本发明对于细菌、酵母型真菌和无包膜病毒的体外功效以及对细菌的体内功效，制剂策略基于在组合物的成分可以不包括杀生物共活性物的情况下增加其能够靶向的细胞成分的数量。获得的最终组合物将醇与上述成分在复配增效制剂中组合，该复配增效制剂具有合适的皮肤相容性、不具有或有很少的本征抗微生物性和增大活性谱的潜力，以及增大制剂对于微生物细胞成分的化学作用所致的细菌杀灭率。
本发明的一个目的是提供低或高醇含量组合物，具有高水平的抗微生物功效，其含有表面活性剂/润湿剂以及消毒剂/溶剂/载体，并且其基本不引起使用者的皮肤或手部干燥，并且能够作为液体、凝胶、泡沫取用，或从加压系统取用。
相应地，本发明的一个方面提供了用于个人卫生的液体组合物。该组合物可以是发泡制剂。该组合物可以是增稠的制剂。
本发明的一个方面是一种皮肤消毒组合物或制剂，包含：
(a)一种或多种C2至C5脂肪族醇，其以所述组合物的约0.1至约90％w/w的量存在；
(b)一种或多种螯合剂，其以所述组合物的约0.1至约5％w/w的量存在；
(c)一种或多种助水溶物，其以所述组合的约0.1至5.0％w/w的量存在；
(d)被选取以在约pH 2至约pH 6的范围内调节所述组合物的pH的一种或多种无机酸和/或一种或多种有机酸，其以所述组合物的约0.01至约5％w/w的量存在，；
(e)一种或多种C10至C16烷基苯磺酸盐，其以所述组合物的约0.1至1.0％w/w的量存在；
(f)一种或多种离液剂，其以所述组合物的约0.01至约10％w/w的量存在；
(g)一种或多种类倍半萜烯，其以所述组合物的约0.01至约1％w/w的量存在；
(h)一种或多种皮肤保湿、调理和润肤剂，其以所述组合物的约0.01至约10％w/w的量存在；和
(i)水，其以将整个组合物平衡至100％w/w的量存在。
本发明的一个方面是配制作为发泡组合物的组合物。这样的发泡制剂包含表面活性剂，其以所述组合物的约1至5％w/w的量存在。
本发明的另一个方面是这样的组合物，其中该组合物通过流变改性剂增稠，所述流变改性剂以所述组合物的约0.01至约10％w/w的量存在。
在另一个实施方案中，提供了一种对皮肤，特别是手部进行清洗或清洁的方法，其包括将本发明的组合物施用至所述皮肤。
附图说明
下文将参考附图描述实施方案，所述附图不是必需地按比例绘出。
图1示意性地示出了利用体外试验获得的细菌结果，其中接触时间为15秒并且在产品中的浓度为80％vol/vol。图(a)示出了杀细菌试验的结果：对于大肠杆菌(Escherichia coli)ATCC 11229的ASTM E2315-03时间-杀灭试验。图(b)示出了利用金黄色葡萄球菌(Staphylococcus aureus)ATCC 6538获得的试验结果；
图2示意性地示出了利用体外杀真菌试验获得的结果：对于白色念珠菌(Candidaalbicans)ATCC 10231的EN13624标准(norm)，其中接触时间为15秒，并且在产品中的浓度为80％vol/vol；
图3示意性地示出了利用体外杀病毒试验获得的结果：对于脊髓灰质炎病毒(Poliovirus)的EN14476标准，其中接触时间为30秒，并且在产品中的浓度为80％vol/vol；以及
图4示意性地示出了活体内杀细菌试验：对于大肠杆菌K12的EN1500标准，涉及5个对象，接触时间为30秒，并且产品的体积为3ml。
具体实施方式
在一个方面，本发明提供了一种包含至少一种C2至C5脂肪族醇的快速作用的水醇皮肤消毒(杀细菌、杀真菌和杀病毒)溶液。所述醇可以是这样的一种醇组分，其可以是单一的醇或醇的混合物，尤其是乙醇、正丙醇和/或异丙醇中的一种或多种。醇组分的浓度为所述溶液的约0.1至约90％w/w的量，优选地所述醇为60至70％w/w的乙醇，并且更优选地以所述组合物的约70％w/w的浓度存在。
该组合物包含至少一种螯合剂，其以约0.1至约5％w/w的浓度存在。螯合剂组分可以是一种或多种螯合剂，其选自谷氨酸，磷酸，具有1至5个膦酸基团的膦酸，例如1-羟基亚乙基-1,1,-二膦酸、氨基三(亚甲基膦酸)、二亚乙基三胺五(亚甲基膦酸)、2-羟基乙基亚氨基二(亚甲基膦酸)和乙二胺四(亚甲基膦酸)，三聚磷酸钠、乙二胺四乙酸(EDTA)、二乙烯三胺五乙酸(DTPA)、N-(羟乙基)-乙二胺-三乙酸(HEDTA)、2-羟乙基亚氨基二乙酸(HEIDA)、亚氨基二琥珀酸、聚天冬氨酸、谷氨酸二乙酸四钠，并且因此可以是任何前述中的任意组合。优选的螯合剂是谷氨酸二乙酸四钠，并且优选地，所述组合物的螯合剂组分以所述组合物的约0.4％w/w的量存在。
该组合物包含作为至少一种助水溶物的组分，其以所述组合物或制剂的约0.1至约5.0％w/w的量存在。所述一种或多种助水溶物可以选自二甲苯磺酸、二甲苯磺酸钠、二甲苯磺酸铵、二甲苯磺酸钙、二甲苯磺酸钾、甲苯磺酸、甲苯磺酸钠、甲苯磺酸铵、异丙苯磺酸、异丙苯磺酸钠、异丙苯磺酸铵、磷酸聚醚酯、烷基二苯醚二磺酸盐和任何前述中的任意组合。优选的助水溶物是异丙苯磺酸或其盐。助水溶物组分的优选量为约0.5％w/w。
该组合物包含至少一种酸。所述酸可以是无机和/或有机酸。酸组分以所述组合物的约0.01至约5wt/wt％的量存在，并且一种或多种酸被选取用于将制剂的pH调节在约pH 2至约pH 6的范围内。酸可以选自α-羟基-酸(例如柠檬酸、乳酸、酒石酸、苹果酸、乙醇酸)、马来酸、丙酸、丁酸、戊酸、己酸、庚酸、一辛酸、二辛酸和三辛酸、β-羟基-酸、磷酸及其任意组合。优选的酸是磷酸，并且优选地，所述制剂具有约4.5的pH。
该组合物包含一种或多种烷基苯磺酸盐，其选自那些具有10至16个碳的烷基苯磺酸盐，并以所述组合物的约0.1至约1.0％w/w的量存在。所述一种或多种烷基苯磺酸盐可以选自癸基苯磺酸钠、十二烷基苯磺酸钠、十三烷基苯磺酸钠，并且因此可以是这些的任意组合。优选的烷基苯磺酸盐是烷基苯磺酸盐，并且优选地，烷基苯磺酸盐的浓度为0.1％w/w。
该组合物包含一种或多种离液剂，其以所述组合物的约0.01至约10％w/w的浓度存在。优选的离液剂是变性剂尿素，并且离液剂组分的优选浓度为所述组合物的约0.1至约5％w/w，更优选为所述组合物的约1％w/w。
本发明的组合物还包含一种或多种类倍半萜烯，这种组分以所述组合物的约0.01至约1％w/w存在。在一个实施方案中，所述至少一种类倍半萜烯选自橙花叔醇、法呢醇、没药醇和2-(3,7-二甲基-2,6-辛二烯)环戊酮(apritone)，并且可以是这些中的任意的组合。类倍半萜烯组分的优选浓度为所述组合物的约0.1％w/w。
组合物还包含至少一种皮肤保湿和/或调理和/或润肤剂，其浓度为所述制剂的约0.01至约10％w/w。这样的成分可以选自多元醇和二醇，例如丙三醇、聚丙三醇、山梨糖醇、甘露醇、赤藻糖醇、木糖醇、阿糖醇、核糖醇、卫矛醇、乳糖醇、麦芽糖醇、丙二醇、聚乙二醇、己二醇、丁二醇、尿囊素、磷脂，如大豆卵磷脂、神经酰胺、必需脂肪酸，例如亚麻酸、γ-亚麻酸、亚油酸和γ-亚油酸、维生素，如d-泛酰醇和生育酚、阳离子剂(cationics)，如季铵化胶、季铵化瓜尔胶、二羟基丙基PEG-5亚油基氯化铵、山萮基三甲基氯化铵和聚季铵盐、糖衍生物如葡萄糖-醚如甲基葡糖醇聚醚-20、甘油酯，如油酸甘油酯、棕榈酸甘油酯、椰酸甘油酯和十一烯酸甘油酯，以及植物提取物，如母菊(Matricaria chamomilla)、芦荟(Aloevera)和光果甘草(Glycyrrhiza glabra L.)。优选的保湿剂是d-泛酰醇，并且优选的浓度在所述组合物的约0.01至1％w/w的范围内。一种或多种的皮肤保湿和/或调理和/或润肤剂的优选浓度为所述组合物的约0.5％w/w。
如之前提及的，水以使整个组合物平衡至100％w/w的量存在。
本发明的组合物还可以作为含有至少一种表面活性剂的泡沫进行制备。对于这样的发泡形式，一种或多种表面活性剂可以选自具有"梳状结构"(即具有位于该分子的内部位置处的官能团)或"末端结构"(其中该官能团位于分子的端部处)的乙氧基化聚二甲基硅氧烷。实例是3-(3-羟丙基)-七甲基三硅氧烷、聚醚改性的聚硅氧烷或聚硅氧烷甜菜碱、磺基琥珀酸的烯基酯或二酯(其中该烷基或烯基独立地含有六至十八个碳原子)，以及碱金属、三乙醇胺、钠、铵、钙或镁、C8至C18烷基醚硫酸盐、或C8-C18烷基胺氧化物、或烷基聚葡萄糖苷、或水溶性树脂，如分子量为100,000至4000,000道尔顿的环氧乙烷的非离子聚合物。优选的表面活性剂是处于上升组合物的1至5％w/w的Bis-PEG-12聚二甲基硅氧烷，并且优选的浓度为约1.00％w/w。优选的水溶性树脂是具有1000,000分子量的聚环氧乙烷，其处于所述组合物的0.05％w/w的优选浓度。
本发明的组合物可以被增稠，含有为所述组合物的约0.01至约10％w/w的浓度的至少一种流变改性剂。一种或多种流变改性剂可以选自丙烯酸酯/C10-30丙烯酸烷基酯交联聚合物、卡波姆、黄原胶、瓜尔胶、纤维素醚、季铵化瓜尔胶、海藻酸盐和膨润土，及其组合。优选的范围为组合物的约0.1至约10％w/w。优选的增稠剂是为凝胶制剂的0.1和1％w/w的丙烯酸酯/C10-30丙烯酸烷基酯交联聚合物或卡波姆。
优选的添加剂在以下更详细地描述。
异丙苯磺酸
异丙苯磺酸，也称为苯磺酸，(1-甲基乙基)异丙苯磺酸(CAS：16066-35-6)，是一种助水溶物；本身它应有助于使微生物的疏水性膜和包膜增溶。因此，在本发明中，认为异丙苯磺酸改善所涉及醇的杀细菌性和杀真菌性。
谷氨酸二乙酸四钠
谷氨酸二乙酸四钠，也称为N,N-双(羧甲基)-L-谷氨酸四钠(CAS：51981-21-6)，是一种可生物降解且安全的化妆品螯合剂。其是EDTA的替代品。
细菌要求金属离子满足金属酶和细胞壁结构组分的特定要求。螯合剂能够通过螯合必要的金属(特别是Fe2+)来增加细菌细胞壁的渗透性。它们还可以捕获金属离子(特别是Mg2+)，其充当DNA合成过程中的辅助因子且涉及脂多糖内聚力。
在本发明中，认为谷氨酸二乙酸四钠主要改善对于革兰氏阴性菌的杀灭率。
橙花叔醇
一种天然倍半萜烯，也称为苦橙花醇或3,7,11-三甲基-1,6,10-十二烷三烯-3-醇(CAS：7212-44-4)，橙花叔醇存在于许多种类型的植物和花的精油中，并且具有潜在的杀细菌性和杀真菌性。
橙花叔醇的杀微生物活性已在多个研究中有文献记载。一个研究(1)包括评价三种萜烯-醇(法呢醇、橙花叔醇和普劳诺托)对金黄色葡萄球菌的杀细菌作用，着重于K+离子的泄漏和随时间的毒性，表明萜烯醇可能对细胞膜起作用。抗菌活性反映K+离子泄漏的初始速率，表明对细胞膜的损害可能是这些萜烯醇的主要作用模式之一。结果还证实泄漏的初始速率和泄漏的K+离子的量可用作疏水性化合物的抗菌活性的指标。
在另一个研究(2)中，对类倍半萜烯橙花叔醇、法呢醇、没药醇和2-(3,7-二甲基-2,6-辛二烯)环戊酮，考察了它们增强细菌渗透性的能力和对外源抗微生物化合物的易感性。开始，通过流式细胞仪观察到，这些类倍半萜烯促进膜不通透性核酸染色剂溴化乙锭在发酵乳杆菌(Lactobacillus fermentum)的细胞内累积，表明由于细胞质膜的破坏导致增强渗透性。在纸片扩散测定中，利用低浓度(0.5至2mM)的橙花叔醇、没药醇或2-(3,7-二甲基-2,6-辛二烯)环戊酮处理，增强金黄色葡萄球菌对环丙沙星、克林霉素、红霉素、庆大霉素、四环素和万古霉素的易感性。橙花叔醇和法呢醇还使大肠杆菌对多粘菌素B敏感。
一个更近的研究(3)阐明了从日本柏油(Japanese cypress oil)中分离的丁香酚和橙花叔醇在被石膏样小孢子菌(Microsporum gypseum)感染的豚鼠模型中的抗真菌活性。通过最低抑菌浓度(MIC)、皮肤病变评分、毛发培养和皮肤组织的组织病理学检查以评价这些油的抗真菌作用。丁香酚、橙花叔醇和益康唑(阳性对照)的MIC分别为0.01-0.03％和0.5-2％和4-16μg/ml。基于这些MIC，将丁香酚和橙花叔醇用
凡士林基质调节至10％浓度，并且每天局部地施用至被石膏样小孢子菌(M.gypseum)感染的皮肤病变，持续3周。根据皮肤病变评分确定，丁香酚和橙花叔醇二者在施用的第一周期间在改善病变方面都是临床有效的。根据毛发培养试验确定，橙花叔醇改善被石膏样小孢子菌感染的皮肤病变，但丁香酚不会。病理组织学检查揭示，相比于阳性对照，丁香酚和橙花叔醇处理的组具有更低程度的皮肤角化病和炎性细胞浸润。综合来看，这些结果表明丁香酚和橙花叔醇可以施加辅助抗真菌药。
在本发明中，认为橙花叔醇提高对革兰氏阴性菌的杀灭率。
尿素
尿素，也称为脲、碳酰二胺、羰基二胺、二氨基甲醛或二氨基甲酮(CAS：57-13-6)，是用于使蛋白质变性的强大离液剂；其具有破坏细菌、真菌和病毒的细胞蛋白质和酶的二级和三级结构的非共价键的潜力；变性的蛋白质将展开成长的多肽链同时不涉及肽键的水解或破坏。
在本发明中，认为尿素提高对革兰氏阴性细菌、酵母型真菌和无包膜病毒的杀灭率。
十二烷基苯磺酸
十二烷基苯磺酸也称为烷基-芳基磺酸；烷基-苯-磺酸；4-十二烷基-苯磺酸；对十二烷基-苯磺酸(CAS：121-65-3)。该类阴离子化合物的选择基于理论研究法：构成病毒衣壳的蛋白质的大多数氨基酸具有约5-6的等电点，因此在酸性pH下，这些氨基酸变为阳离子的。在pH<5并且在阴离子化合物存在下，氨基酸应沉淀，因为它们已达到最小水溶性点。
阴离子表面活性剂也应破坏蛋白质的分子内离子键，并且使细菌、真菌和病毒脂质膜或包膜增溶。
在本发明中，认为十二烷基苯磺酸提高对革兰氏阴性细菌、酵母型真菌和包膜及无包膜病毒的杀灭率。
除非明确指明，在本说明书中指示材料的量或比率、反应的条件；材料的物理性质和/或用途；尺寸和尺寸比率的所有数值都应理解为通过词语“约”修饰。
术语"包含"意指但不限于任何随后所陈述的要素，而是涵盖主要或次要功能重要性的未具体说明要素。换句话说，所列出的步骤、要素或选项不是穷尽的。无论何时使用词语“包括”或“具有”，这些术语意指等同于如上所定义的“包含”。应当注意，在具体说明浓度或量的任何范围中，任何具体的较高浓度或量可以与任何具体的较低浓度或量相关联。报道的范围包括它们的端点值。
除非另有指明，在本说明书(包括权利要求书)中提及的所有份、百分比、比率和比例都是按重量计的。
以下实施例将更充分地举例说明本发明的实施方案。这些实施例不意图以任何方式限制本发明的范围。
实施例
杀微生物功效的评价
所有上述制剂经过初步体外和体内测试以预评价它们对革兰氏阳性细菌和革兰氏阴性细菌、以及真菌和无包膜病毒的杀微生物功效水平。
所有制剂针对一种参照70％w/w乙醇水溶液和一种市场上的含有乙醇65％w/w和正丙醇10％w/w的基于醇的消毒洗手液进行测试。
试验结果
体外杀细菌试验：针对大肠杆菌ATCC 11229和金黄色葡萄球菌ATCC 6538的ASTME2315-03时间-杀灭试验，其中接触时间为15秒，并且在产品中的浓度为80％vol/vol。参见图1。
体外杀酵母型真菌试验：针对白色念珠菌ATCC 10231的EN13624标准，其中接触时间为15秒，并且在产品中的浓度为80％vol/vol。参见图2。
体外杀病毒试验：针对脊髓灰质炎病毒的EN14476标准，其中接触时间为30秒，并且在产品中的浓度为80％vol/vol。参见图3。
对于体内杀细菌试验：针对大肠杆菌K12的EN1500标准，涉及5个对象，接触时间为30秒，并且产品的体积为3ml。参见图4。
对于所有的上述试验，相比于参照70°乙醇溶液和参照市场上的消毒洗手液，试验-试剂对于细菌(大肠杆菌和金黄色葡萄球菌)、酵母型真菌(白色念珠菌)和无包膜病毒(脊髓灰质炎病毒)是更有效的。这支持这样的主张，即所述添加剂增大了醇(70％w/w的乙醇)的杀微生物性。
皮肤刺激潜力的初步评估
在进行体内或体外皮肤刺激试验之前，依据1999年5月31日的欧洲议会和理事会(European Parliament and of the Council)的指令1999/45/EC(‘危险制剂的分类、包装和标记’(‘Classification,Packaging and Labelling of Dangerous Preparations’))，计算皮肤刺激评分。
根据该指令，上述制剂都没有被归类为《刺激皮肤》(限值为'1')，并且由于计算的评分极低(全部<0.1)，所以它们可以被认为对皮肤是非常温和的。
还对11个对象并且使用48-小时半密闭贴片试验方法进行了急性皮肤相容性的体内研究。仅测试了最浓的制剂(#8)，并且其被归类为"对皮肤无刺激"，因为所获得的平均刺激指数(M.I.I.)为零。
参考文献
(1)Yoshihiro Inouea,Akiko Shiraishia,Toshiko Hadaa,Kazuma Hirosea,Hajime Hamashimaa,Jingoro Shimada,"The antibacterial effects of terpenealcohols on Staphylococcus aureus and their mode of action(萜烯醇对于金黄色葡萄球菌的抗菌作用及其作用模式)",FEMS microbiology letters(FEMSmicrobiol.lett.)2004,237(2),pp.325-331。
(2)Byron F.Brehm-Stecher和Eric A.Johnson,"Sensitization of S.aureusand E.coli to Antibiotics by the Sesquiterpenoids Nerolidol,Farnesol,Bisabolol,and Apritone(通过类倍半萜烯橙花叔醇,法呢醇,没药醇和2-(3,7-二甲基-2,6-辛二烯)环戊酮使金黄色葡萄球菌和大肠杆菌对抗生素敏化)",Antimicrob AgentsChemother.2003October；47(10),pp 3357–3360。
(3)Sook-Jin Lee,Je-Ik Han,Geun-Shik Lee,Mi-Jin Park,In-Gyu Choi,Ki-Jeong Na,Eui-Bae Jeung,"Antifungal Effect of Eugenol and Nerolidol againstMicrosporum gypseum in a Guinea Pig Model(在豚鼠模型中丁香酚和橙花叔醇对于石膏样小孢子菌的抗真菌作用)",Biological&Pharmaceutical Bulletin,Vol.30(2007),No.1,p 184。
Claims (45)
1.一种皮肤消毒组合物，包含：
(a) 一种或多种C2至C5脂肪族醇，以所述组合物的60至70%w/w的量存在，其中所述C2至C5脂肪族醇选自乙醇、丙醇和/或异丙醇、或其混合物；
(b) 一种或多种螯合剂，以所述组合物的0.1至5% w/w的量存在；
(c) 一种或多种助水溶物，以所述组合物的0.1至5.0% w/w的量存在；
(d) 被选取用于在pH 2至pH 6的范围内调节所述组合物的pH的一种或多种无机酸和/或一种或多种有机酸，以所述组合物的0.01至5% w/w的量存在；
(e) 一种或多种C10至C16烷基苯磺酸盐，以所述组合物的0.1至1.0% w/w的量存在；
(f) 一种或多种离液剂，以所述组合物的0.01至10% w/w的量存在；其中所述一种或多种离液剂为尿素、硫酸铵或其组合；
(g) 一种或多种类倍半萜烯，以所述组合物的0.01至1% w/w的量存在；
(h) 一种或多种皮肤保湿、调理和润肤剂，以所述组合物的0.01至10% w/w的量存在；和
(i) 水，以将整个组合物平衡至100% w/w的量存在。
2.根据权利要求1所述的组合物，其中所述一种或多种C2至C5脂肪族醇是乙醇。
3.根据权利要求2所述的组合物，其中所述乙醇以所述组合物的70% w/w的量存在。
4.根据权利要求1所述的组合物，其中所述一种或多种螯合剂为谷氨酸、一种或多种具有1至5个膦酸基团的膦酸、或者前述中的任意的混合物。
5.根据权利要求1所述的组合物，其中所述一种或多种螯合剂为1-羟基亚乙基-1,1-二膦酸、氨基三(亚甲基膦酸)、二亚乙基三胺五(亚甲基膦酸)、2-羟基乙基亚氨基二(亚甲基膦酸)（2-hydroxy ethyliminobis (methylene phosphonic acid)）、乙二胺四(亚甲基膦酸)、三聚磷酸钠、乙二胺四乙酸(EDTA)、二乙烯三胺五乙酸(DTPA)、N-(羟乙基)-乙二胺-三乙酸(HEDTA)、2-羟乙基亚氨基二乙酸(HEIDA)、亚氨基二琥珀酸、聚天冬氨酸、谷氨酸二乙酸四钠或者前述中的任意的混合物。
6.根据权利要求5所述的组合物，其中所述一种或多种螯合剂为谷氨酸二乙酸四钠。
7.根据权利要求1所述的组合物，其中所述一种或多种螯合剂以所述组合物的0.4%w/w的量存在。
8.根据权利要求1所述的组合物，其中所述一种或多种助水溶物为二甲苯磺酸、二甲苯磺酸钠、二甲苯磺酸铵、二甲苯磺酸钙、二甲苯磺酸钾、甲苯磺酸、甲苯磺酸钠、甲苯磺酸铵、异丙苯磺酸、异丙苯磺酸钠、异丙苯磺酸铵、磷酸聚醚酯、烷基二苯醚二磺酸盐、或者前述中的任意的混合物。
9.根据权利要求8所述的组合物，其中所述一种或多种助水溶物为异丙苯磺酸或其盐。
10.根据权利要求1所述的组合物，其中所述一种或多种助水溶物以所述组合物的0.5%w/w的量存在。
11.根据权利要求1所述的组合物，其中所述一种或多种无机酸和/或一种或多种有机酸被选取用于将所述组合物的pH调节为4.5。
12.根据权利要求1所述的组合物，其中所述一种或多种无机酸和/或一种或多种有机酸为一种或多种α-羟基-酸、马来酸、丙酸、丁酸、戊酸、己酸、庚酸、一辛酸、二辛酸、三辛酸、一种或多种β-羟基-酸、磷酸或者前述中的任意的组合。
13.根据权利要求12所述的组合物，其中所述一种或多种α-羟基-酸为柠檬酸、乳酸、酒石酸、苹果酸、乙醇酸或者前述中的任意的组合。
14.根据权利要求13所述的组合物，其中所述一种或多种无机酸和/或一种或多种有机酸为磷酸。
15.根据权利要求1所述的组合物，其中所述一种或多种无机酸和/或一种或多种有机酸以所述组合物的0.1至0.5%w/w的量存在。
16.根据权利要求1所述的组合物，其中所述组合物被调节至pH为4.5。
17.根据权利要求1所述的组合物，其中所述一种或多种C10至C16烷基苯磺酸盐为癸基苯磺酸钠、十二烷基苯磺酸钠、十三烷基苯磺酸钠或者前述中的任意的组合。
18.根据权利要求1所述的组合物，其中所述一种或多种C10至C16烷基苯磺酸盐以所述组合物的0.1%w/w的量存在。
19.根据权利要求1所述的组合物，其中所述一种或多种离液剂为尿素。
20.根据权利要求1所述的组合物，其中所述一种或多种离液剂以所述组合物的0.1至5%w/w的量存在。
21.根据权利要求20所述的组合物，其中所述一种或多种离液剂以所述组合物的1%w/w的量存在。
22.根据权利要求1所述的组合物，其中所述一种或多种类倍半萜烯为橙花叔醇、法呢醇、没药醇、2-(3,7-二甲基-2,6-辛二烯)环戊酮（apritone）或者前述中的任意的组合。
23.根据权利要求22所述的组合物，其中所述一种或多种类倍半萜烯为橙花叔醇。
24.根据权利要求1所述的组合物，其中所述一种或多种类倍半萜烯以所述组合物的0.1%w/w的量存在。
25.根据权利要求1所述的组合物，其中所述一种或多种皮肤保湿、调理和润肤剂为一种或多种多元醇、一种或多种磷脂、一种或多种必需脂肪酸、一种或多种维生素、一种或多种阳离子化合物、一种或多种糖衍生物、一种或多种植物提取物或者前述中的任意的组合。
26.根据权利要求25所述的组合物，其中所述一种或多种磷脂为大豆卵磷脂、神经酰胺或其组合。
27.根据权利要求25或26所述的组合物，其中所述一种或多种必需脂肪酸为亚麻酸、γ-亚麻酸、亚油酸、γ-亚油酸或者前述中的任意的组合。
28.根据权利要求25或26所述的组合物，其中所述一种或多种维生素为d-泛酰醇、生育酚或其组合。
29.根据权利要求25或26所述的组合物，其中所述一种或多种阳离子化合物为季铵化胶、二羟基丙基PEG-5亚油基氯化铵、山萮基三甲基氯化铵、聚季铵盐或者前述中的任意的组合。
30.根据权利要求25或26所述的组合物，其中所述一种或多种糖衍生物为一种或多种葡萄糖-醚、一种或多种甘油酯或其组合。
31.根据权利要求30所述的组合物，其中所述一种或多种葡萄糖-醚为甲基葡糖醇聚醚-20。
32.根据权利要求30所述的组合物，其中所述一种或多种甘油酯为油酸甘油酯、棕榈酸甘油酯、椰酸甘油酯、十一烯酸甘油酯或者前述中的任意的组合。
33.根据权利要求25或26所述的组合物，其中所述一种或多种植物提取物为Matricaria chamomilla、Aloe vera、Glycyrrhiza glabra L.或者前述中的任意的组合。
34.根据权利要求1所述的组合物，其中所述一种或多种皮肤保湿、调理和润肤剂以所述组合物的0.01至1%w/w的量存在。
35.根据权利要求34所述的组合物，其中所述一种或多种皮肤保湿、调理和润肤剂以所述组合物的0.5%w/w的量存在。
36.根据权利要求1所述的组合物，其中所述组合物为发泡组合物，并且所述组合物还包含表面活性剂，所述表面活性剂以所述组合物的1至5%w/w的量存在。
37.根据权利要求36所述的组合物，其中所述表面活性剂为具有梳状结构或末端结构或其组合的乙氧基化聚二甲基硅氧烷。
38.根据权利要求36所述的组合物，其中所述表面活性剂为3-(3-羟丙基)-七甲基三硅氧烷；聚醚改性的聚硅氧烷；聚硅氧烷甜菜碱；磺基琥珀酸的烯基酯或二酯，其中烷基或烯基独立地含有六至十八个碳原子；碱金属、三乙醇胺、钠、铵、钙或镁、C8至C18烷基醚硫酸盐；C8-C18烷基胺氧化物；烷基聚葡萄糖苷；水溶性树脂或者前述中的任意的组合。
39.根据权利要求38所述的组合物，其中所述水溶性树脂为具有100,000至4,000,000道尔顿的分子量的环氧乙烷的非离子聚合物。
40.根据权利要求39所述的组合物，其中所述环氧乙烷的聚合物具有1,000,000的分子量，并且以所述组合物的0.05%w/w的量存在。
41.根据权利要求38所述的组合物，其中所述表面活性剂为以所述组合物的1.00%w/w的量存在的Bis-PEG-12聚二甲基硅氧烷。
42.根据权利要求1所述的组合物，其中所述组合物通过流变改性剂增稠，所述流变改性剂以所述组合物的0.01至10%w/w的量存在。
43.根据权利要求42所述的组合物，其中所述流变改性剂为丙烯酸酯/C10-30丙烯酸烷基酯交联聚合物、卡波姆、黄原胶、瓜尔胶、纤维素醚、海藻酸盐、膨润土或者前述中的任意的组合。
44.根据权利要求43所述的组合物，其中所述流变改性剂以所述组合物的0.1至10%w/w的量存在。
45.根据权利要求42所述的组合物，其中所述流变改性剂为丙酸酯/C10-30丙烯酸烷基酯交联聚合物或卡波姆，以所述组合物的0.1至1%w/w的量存在。
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| WO2019214838A1 (en) * | 2018-05-09 | 2019-11-14 | Eviderm Institute Ab | Use of an alcohol-containing composition for improving the skin barrier function |
| CA3099887A1 (en) | 2018-05-10 | 2019-11-14 | Protair-X Health Solutions Inc. | Foam sanitizer composition |
| CN109248336B (zh) * | 2018-11-08 | 2021-06-18 | 广州润虹医药科技股份有限公司 | 一种抑菌促愈合泡沫敷料及其制备方法和应用 |
| CN113710331B (zh) * | 2019-03-12 | 2024-03-22 | 西姆莱斯股份公司 | 一种抗微生物混合物 |
| GR1009978B (el) * | 2019-12-20 | 2021-04-22 | Ossino, Maurizio Vittorio | Σκευασμα (γελη) τοπικης εφαρμογης για αντισηψια, απολυμανση και προστασια απο ιους, βακτηρια, μυκητες |
| WO2021219622A1 (en) * | 2020-04-30 | 2021-11-04 | Dsm Ip Assets B.V. | Hand sanitiser composition |
| CN114733334A (zh) * | 2022-03-18 | 2022-07-12 | 南阳迎盈环保科技有限公司 | 一种液体生物质除臭剂 |
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| US8450378B2 (en) * | 2006-02-09 | 2013-05-28 | Gojo Industries, Inc. | Antiviral method |
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| CN101466265A (zh) * | 2006-05-31 | 2009-06-24 | 日晷公司 | 具有改进效果的含醇抗微生物组合物 |
| WO2007142967A2 (en) * | 2006-05-31 | 2007-12-13 | The Dial Corporation | Alcohol-containing antimicrobial compositions having improved efficacy |
| US8840911B2 (en) * | 2008-03-07 | 2014-09-23 | Kimberly-Clark Worldwide, Inc. | Moisturizing hand sanitizer |
| US20090285886A1 (en) * | 2008-05-14 | 2009-11-19 | Van Beek Ronald R | Enhanced antimicrobial activity of plant essential oils |
| US8911801B2 (en) * | 2008-10-06 | 2014-12-16 | Woodcliff Skincare Solutions, Inc. | Natural preservative alternatives and compositions containing same |
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| JP2015529213A (ja) * | 2012-09-07 | 2015-10-05 | ピベド リミテッド | 界面活性剤及び溶媒を含まない強力皮膚洗浄剤 |
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