CN108129383B - 一种治疗高血压光学纯盐酸马尼地平的制备工艺 - Google Patents
一种治疗高血压光学纯盐酸马尼地平的制备工艺 Download PDFInfo
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- CN108129383B CN108129383B CN201711402742.7A CN201711402742A CN108129383B CN 108129383 B CN108129383 B CN 108129383B CN 201711402742 A CN201711402742 A CN 201711402742A CN 108129383 B CN108129383 B CN 108129383B
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- CN
- China
- Prior art keywords
- manidipine
- reaction
- optically pure
- preparation process
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711402742.7A CN108129383B (zh) | 2017-12-22 | 2017-12-22 | 一种治疗高血压光学纯盐酸马尼地平的制备工艺 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201711402742.7A CN108129383B (zh) | 2017-12-22 | 2017-12-22 | 一种治疗高血压光学纯盐酸马尼地平的制备工艺 |
Publications (2)
Publication Number | Publication Date |
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CN108129383A CN108129383A (zh) | 2018-06-08 |
CN108129383B true CN108129383B (zh) | 2021-02-12 |
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Family Applications (1)
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CN201711402742.7A Expired - Fee Related CN108129383B (zh) | 2017-12-22 | 2017-12-22 | 一种治疗高血压光学纯盐酸马尼地平的制备工艺 |
Country Status (1)
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CN (1) | CN108129383B (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102875451A (zh) * | 2012-04-05 | 2013-01-16 | 常州制药厂有限公司 | 一种盐酸马尼地平合成工艺的改进方法 |
CN104292150A (zh) * | 2013-07-19 | 2015-01-21 | 许昌恒生制药有限公司 | 一种盐酸马尼地平的合成工艺 |
CN105439942A (zh) * | 2015-12-02 | 2016-03-30 | 扬子江药业集团北京海燕药业有限公司 | 一种(s)-马尼地平的制备方法 |
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2017
- 2017-12-22 CN CN201711402742.7A patent/CN108129383B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102875451A (zh) * | 2012-04-05 | 2013-01-16 | 常州制药厂有限公司 | 一种盐酸马尼地平合成工艺的改进方法 |
CN104292150A (zh) * | 2013-07-19 | 2015-01-21 | 许昌恒生制药有限公司 | 一种盐酸马尼地平的合成工艺 |
CN105439942A (zh) * | 2015-12-02 | 2016-03-30 | 扬子江药业集团北京海燕药业有限公司 | 一种(s)-马尼地平的制备方法 |
Non-Patent Citations (2)
Title |
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Enantioselective determination of R-(-)-manidipine and S-(+)-manidipine in human plasma by a sensitive and selective chiral LC–MS/MS assay;Vinayender Adireddy等;《Biomedical Chromatography.》;20170613;第31卷;e4027 * |
盐酸马尼地平的合成;肖方青等;《中国医药工业杂志》;20041231;第35卷(第2期);65-66 * |
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Publication number | Publication date |
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CN108129383A (zh) | 2018-06-08 |
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CB03 | Change of inventor or designer information |
Inventor after: Wang Bin Inventor after: Xue Kezeng Inventor after: Shi Jingli Inventor after: Sun Yidong Inventor before: Shi Jingli Inventor before: Sun Yidong |
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CB03 | Change of inventor or designer information | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20210120 Address after: Qingdao Municipal Hospital, No.1 Jiaozhou Road, Shibei District, Qingdao, Shandong Province (Headquarters) Applicant after: QINGDAO MUNICIPAL Hospital Address before: 276017 biomedical industrial park, high tech Zone, Luozhuang District, Linyi City, Shandong Province Applicant before: LINYI QIZE MEDICINE TECHNOLOGY Co.,Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee |
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