CN108126052A - A kind of preparation process for nourishing refreshing particle - Google Patents

A kind of preparation process for nourishing refreshing particle Download PDF

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Publication number
CN108126052A
CN108126052A CN201611085132.4A CN201611085132A CN108126052A CN 108126052 A CN108126052 A CN 108126052A CN 201611085132 A CN201611085132 A CN 201611085132A CN 108126052 A CN108126052 A CN 108126052A
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component
particle
prepare
extraction
preparation process
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林祥宇
辛奇
许莹
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to drug extraction and processing technique field, a kind of preparation process for nourishing refreshing particle includes the following steps：Step 1）Weigh raw material, step 2）Prepare component A, step 3）Prepare component B, step 4）Prepare component C, step 5）Prepare particle.Animal experiment shows that chin or cheek god's particle sleeping effect prepared by preparation process of the present invention is better than existing preparation, and each effective active composition also greatly improves in drug.

Description

A kind of preparation process for nourishing refreshing particle
Technical field
The invention belongs to drug extraction and processing technique fields, and in particular to a kind of preparation process for nourishing refreshing particle.
Background technology
The refreshing particle of chin or cheek is made of fermentation cordyceps, ganoderma lucidum and three taste Chinese medicine of the fruit of Chinese wolfberry, by famous medical expert, advanced work Cheng Shi Mr.s Qiu Chenbo design, and are manufactured experimently at the beginning of 92 and obtain Guangdong Province's inspection for food hygiene into health food and be approved as formally marking Standard, name of product are east god grass.Due to the product to lassitude hypodynamia, neurasthenia, soreness and weakness of waist and knees, enuresis nocturna, impotence, menstruation not Tune etc. is relieved effect, the ground such as situation of selling well port, Australia, new, Thailand.Animal drugs are carried out through Guangzhou Traditional Chinese Medicine College, Hubei College Of Traditional Chinese Medicine Reason research, it was demonstrated that this product has the humoral immunity and cellular immune function that immune suppressed cell is remarkably reinforced, and can promote buck The development of accessory sex organ improves the multiple pharmacological effects such as internal Serum Testosterone Levels, ratifies to produce in 1994 Nian Huo Department of Public Health of Shanxi Province. After product puts goods on the market, preferable economic benefit and social benefit are produced.Company is according to national drug supervision and management within 2001 Office system summary and has organized the related production about the reform to Chinese patent drug health medicine and adjustment rectification policy and pertinent regulations The data such as a series of pharmacology of product and clinic upgrade to the technology requirement of quasi-font size drug according to Chinese patent drug health medicine, by this Product declares Chinese medicines quasi-word drug, and National Drug Administration's quasi-font size drug approval production text was obtained in 2002 Number.Existing technology transfer gives me company.
Particle of the refreshing particle of chin or cheek for brown color, mildly bitter flavor.Major function：It tonifies the liver and kidney, replenishes qi to invigorate the spleen, antitoxic heart-soothing and sedative.With In kidney deficiency and liver, deficiency-weakness of spleen-QI is shown in there is soreness and weakness of waist and knees, and the tired body of god is tired, dizzy margins of eyelids, palpitation and insomnia etc., and put available for cancer, The auxiliary treatment of chemotherapy.Clinic is chiefly used in treatment of insomnia patients, and material composition is relatively easy, and effect is good, and toxic side effect is small, Receive patient's favor.Applicant has found that there are the defects of effective ingredients from lossing in the drug extraction process in pharmacy procedure.And And known drug is improved, the R＆D costs of enterprise's early period can be saved, are the hot spots of business research in recent years.How to lead to Modified technique is crossed, to improve drug effect using raw material to greatest extent, is the problem of we need research.
Invention content
The defects of in order to overcome the prior art, the present invention propose a kind of preparation process for nourishing refreshing particle, this it is simple for process can Row, the active ingredient for being extracted raw material to greatest extent, improve drug effect, save raw material.
The present invention is achieved by the following technical solution：
A kind of preparation process for nourishing refreshing particle, includes the following steps：Step 1）Weigh raw material, step 2）Prepare component A, step 3）Prepare component B, step 4）Prepare component C, step 5）Prepare particle.
Specifically, the preparation process includes the following steps：
Step 1）Weigh raw material：Weigh fermentation cordyceps 250g, ganoderma lucidum 250g, fruit of Chinese wolfberry 50g；
Step 2）Prepare component A：Fermentation cordyceps are taken, add the water of 5 times of weight, are impregnated 30 minutes, is extracted and volatilized with the way of distillation Oil extracts 3 hours, collects volatile oil, and the absolute ethyl alcohol for accounting for raffinate two volumes, refluxing extraction two are then added into raffinate Secondary, extraction 2 hours, second of extraction 1 hour for the first time controlled at 50 DEG C, microwave power 500W in extraction process, divides It does not filter, merging filtrate, rotary evaporation in vacuo recycling ethyl alcohol is further concentrated to the medicinal extract of 1.35-1.40g/ml, finally and volatile oil Mixing is to get component A；
Step 3）Prepare component B：Ganoderma lucidum is crushed, then is ground into fine powder, crosses 200 mesh sieve, is then paved into the flat bed of 3mm thickness, Intensity is placed in as 2000-3000 uW/cm220min is irradiated under ultraviolet light, powder is collected and is placed in ultrasonic extraction tank, add in treble The purified water of amount, control Extracting temperature is 80 DEG C, with frequency 50KHz ultrasonic extraction 60min, cross molecular cut off be 20,000 it is super Filter membrane collects concentrate, and concentrate then is crossed the ultrafiltration membrane that molecular cut off is 100,000, collects permeate centrifugation, filters, will Filtrate decompression is concentrated into the clear cream of 1.1 ~ 1.2g/ml of density to get component B；
Step 4）Prepare component C：Into the fruit of Chinese wolfberry plus the water boiling and extraction of 5 times of weight twice, 3 hours for the first time, second 2 is small When, merge extracting solution twice, add in the absolute ethyl alcohol with extracting solution same volume, 3000rpm centrifugation 5min remove supernatant, so Into precipitation, addition accounts for the 75% of extracting solution half volume afterwards（Volume ratio）Ethyl alcohol, mixing, 3000rpm centrifugation 3min, go Except supernatant, precipitation is collected to get component C；
Step 5）Prepare particle：Component A, component B and component C are merged, mixing adds Steviosin 1.5g, is uniformly mixed so as to obtain mixing Object.Take 1 part of said mixture, particle is made in 4 parts of lactose, dry, be made 1000g to get.
The present invention also provides the particles prepared according to above-mentioned preparation process.
The present invention also provides purposes of the above-mentioned particle in treatment is had a sleepless night.
The present invention has relative to the prior art but is not limited to following advantage and effect：
Animal experiment shows that chin or cheek god's particle sleeping effect prepared by the present invention is each effective better than existing preparation, and in drug Active constituent also greatly improves；Cordyceps sinensis is handled using alcohol extracting mode so that volatile oil substance is lost, and the present invention uses the way of distillation Extraction, assisted microwave synthesis alcohol extracting avoid the loss of active ingredient；Traditional boiling or alcohol are avoided in present invention extraction ganoderma lucidum technique Mode is put forward, in a manner that ultraviolet irradiation, ultrasonic wave added water carry, a variety of effective ingredients in ganoderma lucidum is enable directly to be precipitated, significantly The effective component content of extract is improved, efficiency greatly improves, and energy consumption also accordingly reduces, and avoids traditional extraction process and causes spirit A large amount of losses of sesame active ingredient；The present invention handles the receipts that matrimony vine causes polysaccharides by the way of boiling and ethanol purification Rate can reach more than 12%, and prior art preparation yield by the way of alcohol extracting is only 10% or so.The present invention is successfully to existing Prescription is improved, and can carry out the clinical experimental study of next step.
Specific embodiment
In order to make those skilled in the art better understand the technical solutions in the application, have below in conjunction with the application Body embodiment more clearly and completely describes the present invention, it is clear that described embodiment is only the application one Divide embodiment, instead of all the embodiments.Based on the embodiment in the application, those of ordinary skill in the art are not making All other embodiments obtained under the premise of creative work should all belong to the scope of protection of the invention.
Embodiment 1
A kind of preparation process for nourishing refreshing particle, includes the following steps：
Take fermentation cordyceps 250g, ganoderma lucidum 250g, fruit of Chinese wolfberry 50g；
Fermentation cordyceps are taken, add the water of 5 times of weight, are impregnated 30 minutes, volatile oil is extracted with the way of distillation, extracts 3 hours, collect Then volatile oil adds the absolute ethyl alcohol for accounting for raffinate two volumes into raffinate, refluxing extraction is secondary, for the first time extraction 2 hours, Second of extraction 1 hour, filters, merging filtrate, very respectively in extraction process controlled at 50 DEG C, microwave power 500W Empty rotary evaporation recycles ethyl alcohol, is further concentrated to the medicinal extract of 1.35-1.40g/ml, is finally mixed with volatile oil to get component A；
Ganoderma lucidum is crushed, then is ground into fine powder, crosses 200 mesh sieve, is then paved into the flat bed of 3mm thickness, is placed in intensity as 2000- 3000 uW/cm220min is irradiated under ultraviolet light, powder is collected and is placed in ultrasonic extraction tank, adds in the purified water of three times weight, control Extracting temperature is 80 DEG C, with frequency 50KHz ultrasonic extraction 60min, crosses the ultrafiltration membrane that molecular cut off is 20,000, collects concentrate, Then concentrate is crossed into the ultrafiltration membrane that molecular cut off is 100,000, collects permeate centrifugation, filtering concentrates filtrate to close The clear cream of 1.1 ~ 1.2g/ml is spent to get component B；
The water boiling and extraction for adding 5 times of weight into the fruit of Chinese wolfberry twice, 3 hours for the first time, second 2 hours, merges and extracts twice Liquid, adds in the absolute ethyl alcohol with extracting solution same volume, and 3000rpm centrifugation 5min remove supernatant, then add accounting for into precipitation The 75% of extracting solution half volume（Volume ratio）Ethyl alcohol, mixing, 3000rpm centrifugation 3min, remove supernatant, collect precipitation, Up to component C；
Component A, component B and component C are merged, mixing adds Steviosin 1.5g, is uniformly mixed so as to obtain mixture.Take said mixture 1 Part, particle is made in 4 parts of lactose, dry, be made 1000g to get.
Usage and dosage：Boiling water is taken after mixing it with water, a 4g, 2 times a day.
Embodiment 2
A kind of preparation process for nourishing refreshing particle, includes the following steps：
Take fermentation cordyceps 250g, ganoderma lucidum 250g, fruit of Chinese wolfberry 50g；
Fermentation cordyceps add 60% alcohol steep twice, and every time plus 8 times of 60% ethyl alcohol is measured, and 12 hours every time, merges leaching liquor, filter It crosses, after decompression filtrate recycling ethanol, is concentrated under reduced pressure into the clear cream of 1.20 ~ 1.25g/ml of density；Ganoderma lucidum adds water to cook twice, every time Add 8 times of amounts of water, decoct 2 hours, decoct 1.5 hours for the second time, collecting decoction for the first time, filtration, filtrate decompression is concentrated into density The clear cream of 1.05 ~ 1.10g/ml；The fruit of Chinese wolfberry adds 70% alcohol steep twice, and every time plus 5 times of 70% ethyl alcohol is measured, and 48 hours every time, is closed And filtrate, it filters, after decompression filtrate recycling ethanol, is concentrated under reduced pressure into the clear cream of 1.20 ~ 1.25g/ml of density, is closed with above-mentioned clear cream And mixing, add Steviosin 1.5g, be uniformly mixed so as to obtain mixture.1 part of said mixture is taken, particle is made in 4 parts of lactose, dry, system Into 1000g to get.
Usage and dosage：Boiling water is taken after mixing it with water, a 4g, 2 times a day.
Embodiment 3
The extraction process of comparing embodiment 1-2：Compared with Example 2, the adenosine content in 1 product of embodiment improves 11.3%, Mannitol improves 6.7%, and polysaccharides improves 23.9%, the active principles such as sterol, saponin(e, amino acid and fritillaria alkaloids Also it greatly improves；By detection, the content of ganoderma lucidum polysaccharide is 913.4mg in the component B of embodiment 1, and the ganoderma lucidum of embodiment 2 is extracted The content of ganoderma lucidum polysaccharide is 607.2mg in clear cream, improves 50%.
Embodiment 4
1. animal acute toxicity is studied：
The healthy kunming mice 20 of selection, half male and half female, weight is 19.3 ± 2.1g, 20 mouse is randomly divided into two groups, often Group half male and half female, wherein 10 as control group, fills with ordinary water；Other 10 mouse give the particle of 1 technique of embodiment preparation Preparation, for 4mg/ only, 2 times a day, Application mouse carries out acute toxicity testing and shows dosage：Compared with the control group, it is small after administration Mouse has no notable difference, and experiment is observed continuously two weeks, mouse systemic situation, ingest, drink water, body weight increase it is normal.Administration is worked as After it and administration in two weeks, have no animal dead, prompt the medicine acute toxicity low, clinical application safety.
2. effect experiment：Influence to the sleeping time of yellow Jackets
Animal：Healthy kunming mice, half male and half female, are randomly divided into 3 groups, every group 30 by totally 90.
Experimental method：1 group of embodiment, 2 groups of embodiment, blank control group（Physiological saline）, drug is before experiment with distillation Water is configured, gastric infusion.Successive administration 7d, each 1 time daily morning and evening, for 2mg/ only, 1h's dosage weighs and abdominal cavity after the last administration 0.3% yellow Jackets 0.15ml/10g is injected, records drug of the present invention to mouse yellow Jackets sub-threshold dose syngignoscism Influence, be shown in Table 1：
Table 1
Group Number of cases Sleeping time
1 group of embodiment 30 73.5±19.1
2 groups of embodiment 30 56.4±15.9
Blank control group 30 30.2±14.7
The result shows that：1 group of the embodiment of the present invention can obviously reduce mouse autonomic activities number, significantly extend sleeping time, effect It is substantially better than 2 groups of embodiment.
Finally, it should also be noted that it is listed above be only the present invention several specific embodiments.Obviously, the present invention not It is limited to above example, acceptable there are many deform.Those of ordinary skill in the art can be direct from present disclosure All deformations for exporting or associating, are considered as protection scope of the present invention.

Claims (4)

1. a kind of preparation process for nourishing refreshing particle, includes the following steps：Step 1）Weigh raw material, step 2）Prepare component A, step Rapid 3）Prepare component B, step 4）Prepare component C, step 5）Prepare particle.
2. preparation process according to claim 1, which is characterized in that the preparation process includes the following steps：
Step 1）Weigh raw material：Weigh fermentation cordyceps 250g, ganoderma lucidum 250g, fruit of Chinese wolfberry 50g；
Step 2）Prepare component A：Fermentation cordyceps are taken, add the water of 5 times of weight, are impregnated 30 minutes, is extracted and volatilized with the way of distillation Oil extracts 3 hours, collects volatile oil, and the absolute ethyl alcohol for accounting for raffinate two volumes, refluxing extraction two are then added into raffinate Secondary, extraction 2 hours, second of extraction 1 hour for the first time controlled at 50 DEG C, microwave power 500W in extraction process, divides It does not filter, merging filtrate, rotary evaporation in vacuo recycling ethyl alcohol is further concentrated to the medicinal extract of 1.35-1.40g/ml, finally and volatile oil Mixing is to get component A；
Step 3）Prepare component B：Ganoderma lucidum is crushed, then is ground into fine powder, crosses 200 mesh sieve, is then paved into the flat bed of 3mm thickness, Intensity is placed in as 2000-3000 uW/cm220min is irradiated under ultraviolet light, powder is collected and is placed in ultrasonic extraction tank, add in treble The purified water of amount, control Extracting temperature is 80 DEG C, with frequency 50KHz ultrasonic extraction 60min, cross molecular cut off be 20,000 it is super Filter membrane collects concentrate, and concentrate then is crossed the ultrafiltration membrane that molecular cut off is 100,000, collects permeate centrifugation, filters, will Filtrate decompression is concentrated into the clear cream of density 1.1-1.2g/ml to get component B；
Step 4）Prepare component C：Into the fruit of Chinese wolfberry plus the water boiling and extraction of 5 times of weight twice, 3 hours for the first time, second 2 is small When, merge extracting solution twice, add in the absolute ethyl alcohol with extracting solution same volume, 3000rpm centrifugation 5min remove supernatant, so Into precipitation, addition accounts for the 75% of extracting solution half volume afterwards（Volume ratio）Ethyl alcohol, mixing, 3000rpm centrifugation 3min, go Except supernatant, precipitation is collected to get component C；
Step 5）Prepare particle：Component A, component B and component C are merged, mixing adds Steviosin 1.5g, is uniformly mixed so as to obtain mixing Object takes 1 part of said mixture, and particle is made in 4 parts of lactose, dry, be made 1000g to get.
3. the particle prepared according to claim 1-2 preparation processes.
4. purposes of the particle of claim 3 in treatment is had a sleepless night.
CN201611085132.4A 2016-12-01 2016-12-01 A kind of preparation process for nourishing refreshing particle Pending CN108126052A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112237602A (en) * 2020-08-11 2021-01-19 翔宇药业股份有限公司 Yisheng medicinal granule and its preparation method
CN112274486A (en) * 2020-08-11 2021-01-29 翔宇药业股份有限公司 Yishen granule and its application
CN113577240A (en) * 2021-09-02 2021-11-02 翔宇药业股份有限公司 Pharmaceutical composition, preparation method and application thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112237602A (en) * 2020-08-11 2021-01-19 翔宇药业股份有限公司 Yisheng medicinal granule and its preparation method
CN112274486A (en) * 2020-08-11 2021-01-29 翔宇药业股份有限公司 Yishen granule and its application
CN113577240A (en) * 2021-09-02 2021-11-02 翔宇药业股份有限公司 Pharmaceutical composition, preparation method and application thereof
CN113577240B (en) * 2021-09-02 2024-01-30 翔宇药业股份有限公司 Pharmaceutical composition, preparation method and application thereof

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