CN108124452A - 感染溶瘤性单纯疱疹病毒的细胞 - Google Patents
感染溶瘤性单纯疱疹病毒的细胞 Download PDFInfo
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Applications Claiming Priority (3)
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| GB201504251A GB201504251D0 (en) | 2015-03-13 | 2015-03-13 | Oncolytic herpes simplex virus infected cells |
| GB1504251.8 | 2015-03-13 | ||
| PCT/EP2016/055325 WO2016146535A1 (fr) | 2015-03-13 | 2016-03-11 | Cellules infectées par le virus de l'herpès simplex oncolytique |
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| CN (1) | CN108124452A (fr) |
| GB (1) | GB201504251D0 (fr) |
| WO (1) | WO2016146535A1 (fr) |
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| JP7490365B2 (ja) * | 2017-03-09 | 2024-05-27 | シァメン・ユニヴァーシティ | 組み換え単純ヘルペスウイルス及びその使用 |
| EP3594328A4 (fr) * | 2017-03-09 | 2021-03-31 | Xiamen University | Virus de l'herpès simplex recombinant et utilisation correspondante |
| US10761162B2 (en) * | 2018-09-18 | 2020-09-01 | General Electric Company | Gradient coil cooling systems |
| TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
| KR102315868B1 (ko) * | 2019-02-25 | 2021-10-22 | 한양대학교 산학협력단 | 생체 내 이식 신경세포 추적 플랫폼 |
| WO2024015332A1 (fr) * | 2022-07-11 | 2024-01-18 | Sokolich Max | Manipulation cellulaire par microrobots et systèmes, procédés et appareil de commande associés |
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| CN101376893A (zh) * | 2007-08-28 | 2009-03-04 | 李小鹏 | 单纯疱疹病毒载体和重组病毒及宿主细胞及其药物组合物 |
| US20090180994A1 (en) * | 2001-05-11 | 2009-07-16 | Wellstat Biologics Corporation | Oncolytic virus therapy |
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|---|---|---|---|---|
| GB9102126D0 (en) | 1991-01-31 | 1991-03-13 | Smithkline Beecham Biolog | Novel vaccine |
| US20020068048A1 (en) * | 1997-09-05 | 2002-06-06 | Patrick A. Dreyfus | Method for the treatment or diagnosis of human pathologies with disseminated or difficult to access cells or tissues |
| JP2005521398A (ja) * | 2002-03-27 | 2005-07-21 | ベイラー カレッジ オブ メディスン | 癌治療用の強力な腫瘍溶解性単純ヘルペスウイルス |
| JP2004099584A (ja) * | 2002-05-02 | 2004-04-02 | Keio Gijuku | Ｈｓｖを用いた抗腫瘍剤 |
| CA2621127C (fr) | 2005-08-31 | 2014-02-25 | Oncolytics Biotech Inc. | Traitement utilisant un virus oncolytique et un immunostimulant destine a renforcer in vivo la reconnaissance de neoplasmes par le systeme immunitaire |
| US20090123366A1 (en) * | 2006-04-03 | 2009-05-14 | Keele University | Targeted Therapy |
| WO2008156655A2 (fr) * | 2007-06-15 | 2008-12-24 | Genelux Corporation | Microorganismes pour une imagerie et/ou un traitement de tumeurs |
| US8313896B2 (en) | 2008-04-04 | 2012-11-20 | The General Hospital Corporation | Oncolytic herpes simplex virus immunotherapy in the treatment of brain cancer |
| WO2010025322A2 (fr) | 2008-08-28 | 2010-03-04 | The Florida International University Board Of Trustees | Nanodistribution magnétique d'agents thérapeutiques à travers la barrière hémato-encéphalique |
| EP2248903A1 (fr) * | 2009-04-29 | 2010-11-10 | Universitat Autònoma De Barcelona | Procédés et réactifs pour le transfert génétique efficace et ciblé vers des monocytes et macrophages |
| WO2013071015A1 (fr) | 2011-11-11 | 2013-05-16 | The Children's Hospital Of Philadelphia | Monocytes modifiés ex-vivo comme excipients de distribution locale pour traiter les artères malades |
| WO2014047318A1 (fr) * | 2012-09-21 | 2014-03-27 | Memorial Sloan-Kettering Cancer Center | Administration de composés thérapeutiques à l'aide de nanoparticules d'oxyde de fer |
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2015
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2016
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090180994A1 (en) * | 2001-05-11 | 2009-07-16 | Wellstat Biologics Corporation | Oncolytic virus therapy |
| CN101376893A (zh) * | 2007-08-28 | 2009-03-04 | 李小鹏 | 单纯疱疹病毒载体和重组病毒及宿主细胞及其药物组合物 |
Non-Patent Citations (6)
| Title |
|---|
| J CONNER, ET AL.: ""A strategy for systemic delivery of the oncolytic herpes virus HSV1716-redirected tropism by antibody-binding sites incorporated on the virion surface as a glycoprotein D fusion protein"", 《GENE THER.》 * |
| MUNITTA MUTHANA, ET AL.: ""A novel magnetic approach to enhance the efficacy of cell-based gene therapies"", 《GENE THER.》 * |
| MUNITTA MUTHANA, ET AL.: ""Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting"", 《NATURE COMMUNICATIONS》 * |
| MUNITTA MUTHANA, ET AL.: ""Macrophage delivery of an oncolytic virus abolishes tumor regrowth and metastasis after chemotherapy or irradiation"", 《CANCER RESEARCH》 * |
| 向近敏等主编: "《分子生态学》", 29 February 1996 * |
| 季晓辉 等: ""单纯疱疹病毒感染单核-巨噬细胞"", 《国外医学（微生物学分册）》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180071348A1 (en) | 2018-03-15 |
| US10596210B2 (en) | 2020-03-24 |
| JP7266648B2 (ja) | 2023-04-28 |
| KR102657640B1 (ko) | 2024-04-17 |
| EP3268466A1 (fr) | 2018-01-17 |
| KR20180033446A (ko) | 2018-04-03 |
| US11612626B2 (en) | 2023-03-28 |
| GB201504251D0 (en) | 2015-04-29 |
| EP3268466B1 (fr) | 2019-03-06 |
| WO2016146535A1 (fr) | 2016-09-22 |
| JP2018509181A (ja) | 2018-04-05 |
| JP6937702B2 (ja) | 2021-09-22 |
| US20200289590A1 (en) | 2020-09-17 |
| JP2021184755A (ja) | 2021-12-09 |
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