CN108124088A - The method of micro-fluidic chip camera arrangement and shooting micro-fluidic chip based on smart mobile phone and simple light pipe - Google Patents
The method of micro-fluidic chip camera arrangement and shooting micro-fluidic chip based on smart mobile phone and simple light pipe Download PDFInfo
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- CN108124088A CN108124088A CN201711400194.4A CN201711400194A CN108124088A CN 108124088 A CN108124088 A CN 108124088A CN 201711400194 A CN201711400194 A CN 201711400194A CN 108124088 A CN108124088 A CN 108124088A
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- 230000000007 visual effect Effects 0.000 claims description 9
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- 238000004458 analytical method Methods 0.000 abstract description 6
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- 238000002965 ELISA Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
- H04N23/50—Constructional details
- H04N23/51—Housings
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B15/00—Special procedures for taking photographs; Apparatus therefor
- G03B15/02—Illuminating scene
- G03B15/03—Combinations of cameras with lighting apparatus; Flash units
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- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B15/00—Special procedures for taking photographs; Apparatus therefor
- G03B15/02—Illuminating scene
- G03B15/06—Special arrangements of screening, diffusing, or reflecting devices, e.g. in studio
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
- H04N23/40—Circuit details for pick-up tubes
- H04N23/41—Beam current control
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
- H04N23/56—Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
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Abstract
The present invention relates to a kind of micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe and the method for shooting microflow hole chip, the camera arrangement includes box body and guiding device；The upper top surface of the box body is provided with camera shooting head bore and flash lamp aperture；The guiding device is in " people " font perforation tubular structure and is fixed on inside top surface on the box body, and one of opening is optical entrance；Other two opening is optical emission exit；The optical entrance is connected with the flash lamp aperture, the device can avoid influence of the external illumination condition to effect of taking pictures, prevent light source direct projection from causing the exposure effect of photo to micro-fluidic chip, ensure uniform illumination degree, and other circuit devices need not be added in, it can be used in micro-fluidic chip shooting and analysis.
Description
Technical field
The invention belongs to detection device field, it is related to the micro-fluidic chip based on smart mobile phone and simple light pipe and takes pictures dress
It puts, also relates to the method using filming apparatus shooting micro-fluidic chip.
Background technology
In recent years, the widely available and its function of smart mobile phone is gradually become strong so that people no longer meet to mobile phone
The use of basic communication function.Since smart mobile phone has light weight portable, popularization scope is wide, and sensor is more, data processing
Numerous advantages such as powerful, make it show great potential in context of detection.Wherein, smart mobile phone built-in camera is to obtain
The most intuitively one of sensor, the digital picture information obtained with it can provide more extensively information for the popularization detected in time
Prospect.With the fast development of mobile phone hardware, the ability of taking pictures of mobile phone also becomes the major criterion for weighing Mobile phone performance,
This promotes the growths of mobile phone camera pixel.It says to a certain extent, numerous mobile phone pixels and has surmounted card phase
The machine even list of low and middle-end are anti-.So the digital picture analysis based on smart mobile phone is as a kind of new, quickly quantitative detection
Method is paid attention to by researcher.
Colorimetric analysis is using detected solution color in itself or adds in the color presented after reagent, range estimation or is utilized
The method that relevant device calculates solution concentration.It is low that micro-fluidic chip possesses few sample consumption, easy of integrationization, testing cost
The advantages that make its in colorimetric analysis have wide application prospect.It will be in the picture collection function of smart mobile phone and micro-fluidic chip
Color reaction be combined, by digital picture color position carry out numerical analysis, can realize the quantitative detection of sample, from
And testing cost is effectively reduced, by Many researchers application.
However (example can be had a huge impact to image quality when gathering picture with mobile phone since the condition of illumination is different
Intensity of illumination, uniform illumination degree and the mirror-reflection effect of such as sample), finally directly affect the quantitative detection of object to be checked.
The interference effect of external environment is reduced from software algorithm in order to solve this Study on Problems person's some, some is by providing one
External light source provides a stable illumination condition to sample.But either set about from software algorithm or provide a special light sources all
Undoubtedly add the complexity of work.
Therefore, it is badly in need of a kind of simple, convenience and can solves to influence the device of image quality due to illumination condition, utilizes intelligence
Energy mobile phone built-in light source and camera carry out digital picture acquisition to micro-fluidic chip, without complicated external circuit device, and clap
Take the photograph effect ideal.
The content of the invention
In view of this, one of the objects of the present invention is to provide a kind of micro-fluidic based on smart mobile phone and simple light pipe
Chip camera arrangement；The second object of the present invention is to provide using described micro-fluidic based on smart mobile phone and simple light pipe
The method that chip camera arrangement shoots micro-fluidic chip；The third object of the present invention is to provide based on smart mobile phone and simply leads
Application of the micro-fluidic chip camera arrangement of light pipe in glucose detection chromogenic reaction；The fourth object of the present invention is to provide
Micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe is in the Visual retrieval of enzyme-linked immunosorbent assay
Application.
In order to achieve the above objectives, the present invention provides following technical solution：
1st, the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe, including box body and guiding device；
The upper top surface of the box body is provided with camera shooting head bore and flash lamp aperture；The box external surface is to be protected from light material
Material, inner wall is white material；
The guiding device is in " people " font perforation tubular structure and is fixed on inside top surface on the box body, wherein one
A opening is optical entrance；Other two opening is optical emission exit；The optical entrance is connected with the flash lamp aperture；It is and described
Guiding device inner wall is specular material, and outer surface is white material.
In the present invention, for the design of box external surface with material is protected from light, its purpose is to avoid external illumination condition to clapping
It is preferably black coating according to the influence of effect；Wall is in order to which uniform light is irradiated to core for the purpose of white material in box body
Piece surface, preferably posts blank sheet of paper.
In the present invention, in order to prevent light source direct projection to micro-fluidic chip and cause the exposure effect of photo, and ensure light
According to the uniformity, simple guiding device is added in box body, light is oriented to box two side.In order to reduce light loss, lead
Light sole duty inner wall is designed as minute surface material, and in order to provide diffusing reflection condition, outer surface is white material, preferably posts blank sheet of paper.
Currently preferred, the flash lamp aperture is located at the center of the upper top surface.
In order to ensure intensity of illumination, box body underrun sliding groove is connected with side and can be by sliding bottom surface tune
The width of box body is saved, to adapt to die size, preferred box body is designed as drawer structure, changes bottom width by pull
The width of damper box daughter.
2nd, micro-fluidic chip is shot based on the micro-fluidic chip camera arrangement of smart mobile phone and simple light pipe using described
Method, include the following steps：
(1) sample of required progress picture analyzing is positioned over box body bottom center position, adjusts the width of box
To the minimum widith that can accommodate chip；
(2) mobile phone camera and flash lamp are respectively aligned to the camera shooting head bore and flash lamp aperture of upper top surface, and ensure to glisten
Lamp hole is in the center of upper top surface；
(3) the upper top surface of box body is covered, opens mobile phone built-in camera software, and flash lamp is set on shape
State；
(5) sample shot to needs is focused, shoots.
3rd, the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe is anti-in glucose detection colour developing
Application in answering.
4th, the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe is in enzyme-linked immunosorbent assay
Visual retrieval in application.
In the present invention, in order to which the camera arrangement is made to be suitable for different types of mobile phone, top surface on box body is designed as not
Ellipse is arranged to the flash lamp aperture of size or by flash lamp aperture, and increase in flash lamp aperture lower part can bidirectional modulation
Slide plate adjusts flash lamp aperture and flash lamp aperture and the distance of cell-phone camera head bore, to adapt to different brands by adjusting slide plate
And different model mobile phone uses.
The beneficial effects of the present invention are：The invention discloses the micro-fluidic chips based on smart mobile phone and simple light pipe
Camera arrangement has the following advantages that：
1st, influence of the external light environment to effect of taking pictures is avoided.
2nd, constant illumination is provided to take pictures using mobile phone built-in light source, controls illumination variable, and other electricity need not be added in
Road device makes device more simplify.
3rd, each picture-taking position is fixed, can be to avoid the error because of caused by picture-taking position difference.
4th, can box width be regulated and controled by pull bottom surface, in the case where not influencing chip, width is transferred to minimum,
Reduce illumination loss.
5th, illumination is more uniform, it is possible to prevente effectively from the mirror because caused by directly returning to camera after light source incidence to chip
Face reflection effect (photo lithography).
Description of the drawings
In order to make the purpose of the present invention, technical solution and advantageous effect clearer, the present invention provides drawings described below and carries out
Explanation：
Fig. 1 is adjustable box body schematic diagram (a. box body component constitutional diagrams of taking pictures；B. box body reduced width mode
Figure；C. box body component scatter diagram).
Fig. 2 dissects concept map (a for guiding device：Guiding device stereogram；b：Guiding device internal cross section figure；1st, light enters
Loophole；2nd, optical emission exit；3rd, outer wall；4th, inner wall).
Fig. 3 is top surface-light pipe combine analog figure on box of taking pictures and box entirety simulation drawing (a：Top surface-light pipe group
Close simulation drawing；b：Box entirety simulation drawing, 5：Light pipe, 6, camera shooting head bore；7th, flash lamp aperture).
When Fig. 4 is is not added with light pipe and adds light pipe, compared with the mirror-reflection effect-size of Tracepro analog chips
Scheme (a：It is not added with the illumination figure of camera lens during guiding device；b：The illumination figure of camera lens when adding guiding device).
When Fig. 5 is is not added with light pipe and adds light pipe, take pictures effect contrast figure (a, c, e：It is not added with camera lens during guiding device
It takes pictures design sketch；b、d、f：The design sketch of taking pictures of camera lens when adding guiding device).
Fig. 6 is glucose visual test result (A：It takes pictures under the conditions of natural lighting；B：Box of taking pictures adds photoconductive tube to be used in conjunction
It takes pictures；C：Illumination box is taken pictures；D:Average gray and concentration of glucose standard curve).
Fig. 7 is the visual test result (A of enzyme-linked immunosorbent assay：It takes pictures under the conditions of natural lighting；C：Illumination box
It takes pictures；B：Box of taking pictures adds photoconductive tube to be used in conjunction to take pictures；D:Average gray and antigen concentration standard curve).
Specific embodiment
Below in conjunction with attached drawing, the preferred embodiment of the present invention is described in detail.
Embodiment 1, the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe
Micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe, including box body (Fig. 1) and guide-lighting dress
It puts (Fig. 2)；
Wherein box body is designed according to drawer principle, and underrun sliding groove is connected with side, can be by sliding bottom surface
Adjust the width of box；Cartridge outer surface be black layer material, inner surface blank sheet of paper material；The upper top surface of box body is in different positions
It installs and is equipped with camera shooting head bore and flash lamp aperture and can meet different money type of cell phone (Fig. 3), and flash lamp aperture is located in upper top surface
Entreat position.
Guiding device penetrates through tubular structure for " people " font, and one of opening is optical entrance；Other two opening is
Optical emission exit；It is arranged on box body below top surface flash lamp aperture, guiding device is fixed on inside top surface on the box body, institute
Optical entrance is stated to connect with the flash lamp aperture；And inside pipe wall be minute surface material to reduce light loss, outer wall is blank sheet of paper to carry
For diffusing reflection condition, the light that " people " font structure of guiding device can send flash lamp is divided into two parts, and shines
It is mapped to two side walls.In order to ensure that guiding device does not cover the coverage of camera, its height is turned down as far as possible, accounts for leaded light
The 1/5 of device.
The micro-fluidic chip camera arrangement that the present invention designs can guarantee that external light environment will not have an impact sample, and
And offer one can make the irreflexive surface of light, while the intensity of illumination that be irradiated to chip can be improved with adjustment width.
When taking pictures, chip to be detected is put in the bottom surface center of box body.Mobile phone is put in the (support of upper top surface
Face), the camera of mobile phone and flash lamp are respectively aligned to camera shooting head bore and flash lamp aperture, then complete shooting.
Application method：
(1) sample of required progress picture analyzing is positioned over box body bottom center position (sample test position),
The width of box is adjusted to the minimum widith that can accommodate chip, to reduce light loss；
(2) mobile phone camera and flash lamp are respectively aligned to the camera shooting head bore and flash lamp aperture of upper top surface, and ensure to glisten
Lamp hole is in the center of upper top surface；
(3) top surface on box is covered, opens mobile phone built-in camera software, and flash lamp is set on state；
(4) sample shot to needs is focused, shoots.
Then data analysis is carried out to the digital picture of acquisition, and obtained a result.
For the uniformity on proofing chip surface, simulation flowchart is carried out by optical simulation software Tracepro, it will
Light source transmitting form is arranged to luminous flux, and unit is amplitude, and rink corner is distributed as Lambertian and shines field pattern, luminous flux setting
For 1watts, light is arranged to 10,000,000.The results are shown in Figure 4, it is possible to prevente effectively from because direct after light source incidence to chip
Return to mirror-reflection effect (photo lithography) caused by camera.With under verification uniform illumination degree the same terms, utilizing
Tracepro verifies the size of mirror-reflection, and is compared with being not added with light pipe, it is found that adding in light pipe can effectively reduce
Mirror-reflection effect (Fig. 5).(can also find out apparent difference from following example of taking pictures).
Glucose Visual retrieval：It is taken pictures using mobile phone to glucose detection chromogenic reaction result, as a result such as Fig. 6 institutes
Show.It is respectively shown in figure：It takes pictures under the conditions of natural lighting, takes pictures box and photoconductive tube is used in conjunction (apparatus of the present invention) and takes pictures, it is single
It is pure to be taken pictures using illumination box.The photo obtained carries out gray analysis.The grey scale change value of detection zone (color change area) is such as
Shown in what.Average gray and concentration of glucose are made standard curve to show：It can using photoconductive tube+photo obtained by box of taking pictures
To improve the repeatability of Visual retrieval (reliability) and minimum detection limit.
The Visual retrieval of enzyme-linked immunosorbent assay：The antigen based on enzyme-linked immunosorbent assay is detected using mobile phone
Chromogenic reaction result is taken pictures, and the results are shown in Figure 7.It is respectively shown in figure：It takes pictures under the conditions of natural lighting, box of taking pictures
(apparatus of the present invention) are used in conjunction with photoconductive tube to take pictures, are taken pictures using illumination box merely.The photo obtained carries out gray analysis.Detection
How shown the grey scale change value in region (color change area) is.Average gray and antigen concentration are made standard curve to show：
The repeatability (reliability) and minimum detection limit of Visual retrieval can be improved using photoconductive tube+photo obtained by box of taking pictures.This
Outside, based on photoconductive tube+variation tendency taken pictures obtained by the gray analysis of photo obtained by box with using microplate reader detection number
It is consistent according to variation tendency.
Finally illustrate, preferred embodiment above is merely illustrative of the technical solution of the present invention and unrestricted, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (9)
1. the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe, it is characterised in that：Including box body and lead
Electro-optical device；
The upper top surface of the box body is provided with camera shooting head bore and flash lamp aperture；The box external surface is interior to be protected from light material
Wall is white material；
The guiding device is in " people " font perforation tubular structure and is fixed on inside top surface on the box body, one of them is opened
Mouth is optical entrance；Other two opening is optical emission exit；The optical entrance is connected with the flash lamp aperture；And the leaded light
Device inner wall is specular material, and outer surface is white material.
2. the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe, feature exist according to claim 1
In：The external surface of the box scribbles black coating, and inner wall posts blank sheet of paper.
3. the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe, feature exist according to claim 1
In：Post blank sheet of paper in the outer surface of the guiding device.
4. the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe, feature exist according to claim 1
In：Described, the flash lamp aperture is located at the center of the upper top surface.
5. the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe, feature exist according to claim 1
In：The underrun sliding groove of the box body is connected with side and can be by sliding the width of bottom surface damper box daughter.
6. the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe, feature exist according to claim 5
In：The box body is designed as drawer structure, changes the width of bottom width damper box daughter by pull.
7. utilize the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe described in any one of claim 1~6
The method for shooting micro-fluidic chip, which is characterized in that include the following steps：
(1) sample of required progress picture analyzing is positioned over box body bottom center position, adjusts the width of box to can
Accommodate the minimum widith of chip；
(2) mobile phone camera and flash lamp are respectively aligned to the camera shooting head bore and flash lamp aperture of upper top surface, and ensure flash lamp aperture
In the center of upper top surface；
(3) the upper top surface of box body is covered, opens mobile phone built-in camera software, and flash lamp is set on state；
(4) sample shot to needs is focused, shoots.
8. the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe described in any one of claim 1~6 is in Portugal
Application in grape sugar detection chromogenic reaction.
9. the micro-fluidic chip camera arrangement based on smart mobile phone and simple light pipe described in any one of claim 1~6 is in enzyme
Join the application in the Visual retrieval of immunoadsorption assay.
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Cited By (4)
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| CN108802992A (en) * | 2018-06-14 | 2018-11-13 | 西南大学 | Sample uniform transillumination based on smart mobile phone illuminates camera arrangement |
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| CN110530854A (en) * | 2019-09-26 | 2019-12-03 | 合肥工业大学 | A kind of chemiluminescence signal time and space two-dimensional resolution type detection device and detection method |
| CN113612909A (en) * | 2021-07-30 | 2021-11-05 | 上海建工四建集团有限公司 | Existing terrazzo information survey equipment and use method thereof |
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Application publication date: 20180605 |