CN108118444A - 一种纳米银抗菌纤维膜的制备方法 - Google Patents

一种纳米银抗菌纤维膜的制备方法 Download PDF

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CN108118444A
CN108118444A CN201711329051.9A CN201711329051A CN108118444A CN 108118444 A CN108118444 A CN 108118444A CN 201711329051 A CN201711329051 A CN 201711329051A CN 108118444 A CN108118444 A CN 108118444A
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司荣美
潘中海
刘彩风
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Tianjin Baoxingwei Technology Co Ltd
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Abstract

本发明是一种纳米银抗菌纤维膜的制备方法，具体步骤如下：将聚乙烯醇吡咯烷酮溶解在还原剂中制成还原溶液；将硝酸银添加进配好的还原溶液中，震荡至完全溶解得到反应液；将反应液置于微波炉上加热反应获得灰褐色溶胶，将溶胶进行离心分离，固体用去离子水和乙醇洗涤5‑10次，烘干，获得灰褐色的银纳米颗粒分散液；配制质量分数分别为40％的明胶水溶液和12％的聚乙烯醇/二甲基亚砜/水溶液，将两种溶液混合，搅拌均匀后加入银纳米颗粒分散液，得到静电纺丝液；静电纺丝液采用静电纺丝技术得到载纳米银的抗菌纤维膜。本发明制备的载纳米银的抗菌纤维膜不但具有良好的物理性能、生物活性和抗菌性能，而且合成工艺简单。

Description

一种纳米银抗菌纤维膜的制备方法
技术领域
本发明涉及纳米银抗菌研究领域，尤其涉及一种纳米银抗菌纤维膜的制备方 法。
背景技术
健康是每个人都关心的问题，人人都关心自己和家人的健康。
然而，自然界的细菌与病毒无处不在，人体37摄氏度左右的温度和湿润的 体内黏膜，更是细菌安营扎寨的理想场所。皮肤、口腔、呼吸道、食管、胃，尤 其是肠道，都有数以百万亿计的细菌。细菌有好有坏，好的叫有益菌，坏的叫致 病菌。多数病菌对人体也不直接产生危害，而是病菌在生长繁殖过程中的代谢物 (医学上称为细菌外毒素)威胁人体健康。因此在高科学、高技术不断发展的今 天，消灭有害细菌、控制细菌的生长和繁殖，这一项与人类健康息息相关的重要 课题，正受到越来越多的关注。
纳米银抗菌材料结合了无机抗菌材料与纳米抗菌材料的双重优势。银系列抗 菌材料是一类纳米抗菌材料，具有比表面积大，表面反应活性高、表面活性中心 多、催化效率高、吸附能力强等性能。作为无机的载银抗菌材料在功能性方面具 有持续性、持久性和广谱性等特征，并同时具有耐热性好、安全性高、不易产生 耐药性等优势。
发明内容
本发明旨在开发一种纳米银抗菌材料，而提供一种纳米银抗菌纤维膜的制备 方法。
本发明为实现上述目的，采用以下技术方案：
一种纳米银抗菌纤维膜的制备方法，具体步骤如下：
(1)银纳米颗粒分散液的制备
准备工作：称取聚乙烯醇吡咯烷酮、硝酸银，其中聚乙烯醇吡咯烷酮、硝酸 银的质量比为1：1；
配制还原溶液：将聚乙烯醇吡咯烷酮溶解在还原剂中；
配制反应液：将硝酸银添加进配好的还原溶液中，震荡至完全溶解；
制备分散液：将反应液置于微波炉上加热反应获得灰褐色溶胶，将溶胶进行 离心分离，固体用去离子水和乙醇洗涤5-10次，烘干，获得灰褐色的银纳米颗 粒分散液；
(2)载纳米银的抗菌纤维膜的制备
将明胶、聚乙烯醇分别溶于蒸馏水和66％的二甲基亚砜/水溶液中，配制成 质量分数分别为40％的明胶水溶液和12％的聚乙烯醇/二甲基亚砜/水溶液，将两 种溶液混合，搅拌均匀后加入银纳米颗粒分散液，得到静电纺丝液；
静电纺丝液采用静电纺丝技术得到载纳米银的抗菌纤维膜。
银纳米颗粒分散液的制备过程中，所述还原剂为乙二醇或聚乙二醇。
载纳米银的抗菌纤维膜的制备过程中，静电纺丝时的控制参数为：接收距离14cm，纺丝电压25-28kV，流量为0.5ml/h。
本发明的有益效果是：本发明制备的载纳米银的抗菌纤维膜不但具有良好的 物理性能、生物活性和抗菌性能，而且合成工艺简单。
具体实施方式
下面结合具体实施例对本发明作进一步说明：
具体实施例1：
一种纳米银抗菌纤维膜的制备方法，具体步骤如下：
(1)银纳米颗粒分散液的制备
准备工作：称取聚乙烯醇吡咯烷酮、硝酸银，其中聚乙烯醇吡咯烷酮、硝酸 银的质量比为1：1；
配制还原溶液：将聚乙烯醇吡咯烷酮溶解在还原剂中；
配制反应液：将硝酸银添加进配好的还原溶液中，震荡至完全溶解；
制备分散液：将反应液置于微波炉上加热反应获得灰褐色溶胶，将溶胶进行 离心分离，固体用去离子水和乙醇洗涤5次，烘干，获得灰褐色的银纳米颗粒分 散液；
(2)载纳米银的抗菌纤维膜的制备
将明胶、聚乙烯醇分别溶于蒸馏水和66％的二甲基亚砜/水溶液中，配制成 质量分数分别为40％的明胶水溶液和12％的聚乙烯醇/二甲基亚砜/水溶液，将两 种溶液混合，搅拌均匀后加入银纳米颗粒分散液，得到静电纺丝液；
静电纺丝液采用静电纺丝技术得到载纳米银的抗菌纤维膜。
银纳米颗粒分散液的制备过程中，所述还原剂为乙二醇。
载纳米银的抗菌纤维膜的制备过程中，静电纺丝时的控制参数为：接收距离14cm，纺丝电压25kV，流量为0.5ml/h。
具体实施例2：
一种纳米银抗菌纤维膜的制备方法，具体步骤如下：
(1)银纳米颗粒分散液的制备
准备工作：称取聚乙烯醇吡咯烷酮、硝酸银，其中聚乙烯醇吡咯烷酮、硝酸 银的质量比为1：1；
配制还原溶液：将聚乙烯醇吡咯烷酮溶解在还原剂中；
配制反应液：将硝酸银添加进配好的还原溶液中，震荡至完全溶解；
制备分散液：将反应液置于微波炉上加热反应获得灰褐色溶胶，将溶胶进行 离心分离，固体用去离子水和乙醇洗涤10次，烘干，获得灰褐色的银纳米颗粒 分散液；
(2)载纳米银的抗菌纤维膜的制备
将明胶、聚乙烯醇分别溶于蒸馏水和66％的二甲基亚砜/水溶液中，配制成 质量分数分别为40％的明胶水溶液和12％的聚乙烯醇/二甲基亚砜/水溶液，将两 种溶液混合，搅拌均匀后加入银纳米颗粒分散液，得到静电纺丝液；
静电纺丝液采用静电纺丝技术得到载纳米银的抗菌纤维膜。
银纳米颗粒分散液的制备过程中，所述还原剂为聚乙二醇。
载纳米银的抗菌纤维膜的制备过程中，静电纺丝时的控制参数为：接收距离14cm，纺丝电压28kV，流量为0.5ml/h。
本发明制备的载纳米银的抗菌纤维膜不但具有良好的物理性能、生物活性和 抗菌性能，对大肠杆菌、金黄色葡萄球菌、链球菌、伤寒沙门菌均有良好的杀菌 效果，而且合成工艺简单，呈网状复合结构，透气性和保湿性良好，具有较高的 拉伸强，材料孔隙率高、空隙致密均匀。
上面结合具体实施例对本发明进行了示例性描述，显然本发明具体实现并不 受上述方式的限制，只要采用了本发明的方法构思和技术方案进行的各种改进， 或未经改进直接应用于其它场合的，均在本发明的保护范围之内。

Claims (3)

1.一种纳米银抗菌纤维膜的制备方法，其特征在于，具体步骤如下：
(1)银纳米颗粒分散液的制备
准备工作：称取聚乙烯醇吡咯烷酮、硝酸银，其中聚乙烯醇吡咯烷酮、硝酸银的质量比为1：1；
配制还原溶液：将聚乙烯醇吡咯烷酮溶解在还原剂中；
配制反应液：将硝酸银添加进配好的还原溶液中，震荡至完全溶解；
制备分散液：将反应液置于微波炉上加热反应获得灰褐色溶胶，将溶胶进行离心分离，固体用去离子水和乙醇洗涤5-10次，烘干，获得灰褐色的银纳米颗粒分散液；
(2)载纳米银的抗菌纤维膜的制备
将明胶、聚乙烯醇分别溶于蒸馏水和66％的二甲基亚砜/水溶液中，配制成质量分数分别为40％的明胶水溶液和12％的聚乙烯醇/二甲基亚砜/水溶液，将两种溶液混合，搅拌均匀后加入银纳米颗粒分散液，得到静电纺丝液；
静电纺丝液采用静电纺丝技术得到载纳米银的抗菌纤维膜。
2.根据权利要求1所述的一种纳米银抗菌纤维膜的制备方法，其特征在于，银纳米颗粒分散液的制备过程中，所述还原剂为乙二醇或聚乙二醇。
3.根据权利要求2所述的一种纳米银抗菌纤维膜的制备方法，其特征在于，载纳米银的抗菌纤维膜的制备过程中，静电纺丝时的控制参数为：接收距离14cm，纺丝电压25-28kV，流量为0.5ml/h。
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Cited By (4)

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Publication number Priority date Publication date Assignee Title
CN109338484A (zh) * 2018-10-15 2019-02-15 闽江学院 一种含纳米银粒子的静电纺织物及其生产方法和用途
CN110181071A (zh) * 2019-05-14 2019-08-30 深圳先进技术研究院 纳米银颗粒及其制备方法和应用
CN112481711A (zh) * 2020-11-20 2021-03-12 齐鲁工业大学 一种静电纺丝制备抗菌明胶膜的方法
CN114130188A (zh) * 2021-10-26 2022-03-04 甘肃旭康材料科技有限公司 空气净化复合材料的制备方法及空气净化复合材料

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