CN108114171A - A kind of capsule medicine and preparation method for being used to treat hypertension - Google Patents

Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to a kind of capsule medicine for being used to treat hypertension be provided according to the understanding mechanism of Chinese traditional treatment hypertension, each component and its mass parts ratio of the drug are as follows：50~120g of mulberry leaf, 150~350g of raw Radix Astragali, 150~300g of Cortex Eucommiae, 60~250g of rhizoma alismatis, 100~260g of the fruit of Chinese wolfberry, 30~100g of rhizoma atractylodis, 30~120g of Rhizoma Gastrodiae, 50~120g of Rhizoma Chuanxiong, 50~120g of sophora flower, 100~160g of Radix Ophiopogonis, 60~180g of selfheal, 100~160g of Ramulus Taxilli, 90~150g of raspberry 60~150g, Common St.Paulswort Herbs, 50~180g of the root of bidentate achyranthes, 150~350g of willow leaf, Changchun 50~120g of grass, 20~80g of Schisandra chinensis；Drug provided by the invention is a good Chinese prescription.

Description

A kind of capsule medicine and preparation method for being used to treat hypertension

Technical field

The invention belongs to field of traditional Chinese, and in particular to and it is a kind of for treating the capsule medicine of hypertension, particularly The capsule medicine used for hyperpietic and the field of preparation method.

Background technology

Motherland's medicine thinks：Hypertension（hypertension）Refer to systemic arterial blood pressure（Systolic pressure and/or diastole Pressure）Increase as main feature（The millimetres of mercury of systolic pressure >=140, the millimetres of mercury of diastolic pressure >=90）, can be with devices such as the heart, brain, kidneys The function of official or the clinical syndrome of organic lesion.Hypertension is that most common chronic disease and cardiovascular and cerebrovascular diseases are main Risk factor.The blood pressure of normal person fluctuates within the specific limits with internal and external environment variation.In whole crowd, blood pressure level is with year Age gradually rises, and is become apparent with systolic pressure, but downward trend is presented in diastolic pressure after 50 years old, and pulse pressure also increases therewith.

Since in recent years, effect of the people to cardiovascular disease multiple risk factors, Yi Jixin, brain, kidney target-organ protection Understanding deepens continuously, and the diagnostic criteria of hypertension is also constantly adjusting, it is now recognized that painstaking effort occur for the patient of same blood pressure level The danger of pipe disease is different, therefore the concept for having blood pressure to be layered, that is, the different patient of cardiovascular disease danger level occurs, suitable for blood pressure Level should be different.Pressure value and hazard factor assessment are diagnosis and the Main Basiss for formulating hypertension therapeutic scheme, and difference is suffered from The target of person's hypertension management is different, and when doctor faces patient, on the basis of normative reference, being judged according to its concrete condition should The most suitable blood pressure range of patient, using targetedly remedy measures.On the basis of the mode of making the life better, it is recommended to use 24 is small Shi Changxiao antihypertensive drugs controls blood pressure.In addition to Clinical blood pressure is assessed, patient should also be noted that the monitoring and management of family's Morning Blood Pressure, To control blood pressure, the incidence of cardiocerebrovasculaevents events is reduced.

So, just how to find a kind of Chinese medicine composition that can effectively treat hypertension, be those skilled in the art urgently It solves the problems, such as.

The content of the invention

With the continuous development of China's traditional Chinese medicine, in treatment hypertension, people gradually appreciate Chinese traditional treatment It is the advantages of hypertension, and good effect, the advantages such as quick, toxic side effect is small over the course for the treatment of, high for existing western medical treatment The present situation of blood pressure, the purpose of the invention is to provide a kind of for treating the capsule medicine of hypertension, to solve hypertension The problem of patient gets well early.The drug is using common Chinese medicine as raw material, by selecting rational drug and mass parts Than can effectively treat above-mentioned hypertension.

To achieve the purpose that foregoing invention, the technical solution adopted in the present invention is：One kind is provided for treating hypertension Capsule medicine and preparation method, which is characterized in that each component and mass parts of the drug are than as follows：

50~120g of mulberry leaf, raw 150~350g of Radix Astragali, 150~300g of Cortex Eucommiae, 60~250g of rhizoma alismatis, 100~260g of the fruit of Chinese wolfberry, 30~100g of rhizoma atractylodis, 30~120g of Rhizoma Gastrodiae, 50~120g of Rhizoma Chuanxiong, 50~120g of sophora flower, 100~160g of Radix Ophiopogonis, selfheal 60~ 180g, 100~160g of Ramulus Taxilli, 90~150g of raspberry 60~150g, Common St.Paulswort Herbs, 50~180g of the root of bidentate achyranthes, willow leaf 150~ 350g, Changchun 50~120g of grass, 20~80g of Schisandra chinensis, auxiliary material：Talcum powder and appropriate starch.

A kind of capsule medicine and preparation method for being used to treat hypertension, which is characterized in that each group of the drug Divide and mass parts are than as follows：

58~105g of mulberry leaf, raw 180~310g of Radix Astragali, 180~260g of Cortex Eucommiae, 70~220g of rhizoma alismatis, 115~230g of the fruit of Chinese wolfberry, 36~90g of rhizoma atractylodis, 36~105g of Rhizoma Gastrodiae, 58~105g of Rhizoma Chuanxiong, 58~105g of sophora flower, 115~140g of Radix Ophiopogonis, selfheal 70~ 150g, 115~140g of Ramulus Taxilli, 100~130g of raspberry 70~130g, Common St.Paulswort Herbs, 58~150g of the root of bidentate achyranthes, willow leaf 180~ 310g, Changchun 58~105g of grass, 26~70g of Schisandra chinensis, auxiliary material：Talcum powder and appropriate starch.

A kind of capsule medicine and preparation method for being used to treat hypertension, which is characterized in that each group of the drug Divide and mass parts are than as follows：

Mulberry leaf 95g, raw Radix Astragali 260g, 210~230g of Cortex Eucommiae, 80~200g of rhizoma alismatis, fruit of Chinese wolfberry 200g, rhizoma atractylodis 80g, Rhizoma Gastrodiae 95g, Rhizoma Chuanxiong 95g, sophora flower 95g, Radix Ophiopogonis 120g, selfheal 130g, Ramulus Taxilli 120g, raspberry 115g, Common St.Paulswort Herbs 118g, the root of bidentate achyranthes 130g, willow leaf 280g, Changchun grass 95g, Schisandra chinensis 60g, auxiliary material：Talcum powder and appropriate starch.

A kind of capsule medicine and preparation method for being used to treat hypertension, which is characterized in that the described method includes as follows Step is prepared：

A, after above-mentioned raw materials Chinese medicine being picked impurity and dust, decoct a drug wrapped according to mass parts than being ground into coarse altogether；

B, the raw material Chinese medicine wrapped is put into after impregnating 60min in cold boiling water, then soaked drug is put into marmite and is decocted Three times：1. amount of water is 9~10 times of medicinal material total amount, high heat decoction is first carried out, when decocting to 15min, turns slow boiling tanning 115 Min, leaching liquid；2. amount of water is 8~9 times of dry dregs of a decoction total amount, high heat decoction is first carried out, when decocting to 10min, is turned Slow boiling boils 105 min, leaching liquid；3. amount of water is 7~8 times of dry dregs of a decoction total amount, high heat decoction is first carried out, waits to decoct During to 8min, turn slow boiling and boil 90 min, leaching liquid；4. merging liquid three times, and it is concentrated under reduced pressure into every milliliter contained 3g Standard after to get to drug extract.

C, by the extract dry prepared in above-mentioned B, disinfection, and it is spare according to mass parts ratio to be ground into superfine end；

D, the method for preparing Chinese medicine capsules according to traditional common process and auxiliary material, by superfine myrrh object mistake ground in C After sieve, then starch and talcum powder are put into together in medicine device and are uniformly mixed, be then prepared into capsule（It is total after its capsule is sealed Length is 23.3mm, medicinal powder capacity 0.4~0.5g/）, then polish, sterilize, sealed packaging to obtain the final product.

It is a kind of for treating the capsule medicine and preparation method of hypertension, which is characterized in that the instructions of taking is：It will The capsule medicine prepared is twice a day to take, and once a dose sooner or later, dosage 2g（5）/ time, warm water delivery service（Meal It is preceding 1 it is small when take）.45 days as a treatment course, after treating 1~2 course for the treatment of, hypertension symptom disappears, and blood pressure recovers normal, advises its blood After positive pressure is normal, it is changed to 1 time by taking 2 times daily.

Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine It carries.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component：

Mulberry leaf, nature and flavor：It is bitter, sweet, cold in nature, there is the effect of dispelling wind and heat from the body, clearing away the lungheat and moisturizing, flat liver improving eyesight, cooling blood and hemostasis, be used for Treat anemopyretic cold, warm disease from the beginning of, cough with lung heat, the diseases such as liver-yang hyperactivity dizziness, hot eyes be dim-sighted, hemoptysis of blood-heat bleeding, haematemesis；

Raw Radix Astragali, nature and flavor：Sweet, tepor has the effect of invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation, for treating gas Empty weak, anorexia and loose stool, the sinking of qi of middle-jiao, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, are burst not at rush down prolapse of the anus for a long time long It holds back, the diseases such as flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes, chronic rephrilis protinuria, diabetes；

Cortex Eucommiae, nature and flavor：Sweet micro-pungent, temperature have the effect of filling liver kidney, strengthening the bones and muscles, tocolysis, for treating spinal column ache, sufficient knee impotence The diseases such as weak, dribbling urination, uncontrolled urination, threatened abortion are intended to fall, fetal irritability, hypertension；

Rhizoma alismatis, nature and flavor：It is sweet in flavor, light, cold in nature, there is clearing damp and promoting diuresis, expel the heat-evil the effect for the treatment of stranguria, for treating difficult urination, heat gonorrhea The diseases such as puckery pain, oedema turgor, diarrhea, phlegmatic vertigo, seminal emission；

The fruit of Chinese wolfberry, nature and flavor：It is sweet in flavor, mild-natured, have nourishing the liver, nourshing kidney, moistening lung the effect of, for treat caused by liver and kidney deficiency, have a dizzy spell, Visual one is clear, soreness and weakness of waist and knees, the expensive essence of impotence, cough due to consumptive disease, quenches one's thirst and draws drink；

Rhizoma atractylodis, nature and flavor：Acrid, bitter, warm has the effect of drying damp and strengthening spleen, curing rheumatism, and transporting caused by for treating the spleen being blocked by dampness is lost Tune, loss of appetite, evil of vomitting unhappiness, abdominal distention diarrhea, joint limbs pain；

Rhizoma Gastrodiae, nature and flavor：It is sweet, pungent, flat, it is nontoxic, there is the effect of Inflammation Zhijing, Pinggan Yang, dispelling wind and removing obstruction in the meridians, it is anxious slow frightened for treating The diseases such as wind, twitch contraction, dizziness, headache, hemiplegia, limb fiber crops, arthralgia pain due to rheumatism；

Rhizoma Chuanxiong, nature and flavor：It is pungent, warm, there is the effect of wet promote breath and open depression, method wind-dryness, promoting blood circulation and stopping pain, for treating air-cooled headache rotation Dizzy, hypochondriac pain abdomen pain, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block pain, ulcer sores, irregular menstruation, lump in the abdomen abdominal pain, chest side of body thorn Bitterly, tumbling and swelling, arthralgia pain due to rheumatism；

Sophora flower, nature and flavor：It is bitter, be slightly cold, there is the effect of cooling blood and hemostasis, clearing liver-fire, have blood in stool, hemorrhoid blood, bloody flux, collapse for treating The diseases such as leakage, haematemesis, bleeding from five sense organs or subcutaneous tissue, the hot hot eyes of liver, dizziness of having a headache；

Radix Ophiopogonis, nature and flavor：Property sweet, slight bitter, be slightly cold, have nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire the effect of, for treating dryness of the lung dry cough, void The diseases such as consumptive disease cough, injury thirst, vexed insomnia, Heat Diabetes, dry constipation of intestines, pharyngeal diphtheria；

Selfheal, nature and flavor：It is bitter, pungent, cold in nature, there is the effect of clearing liver and improving vision, powder detoxifcation, for treating mesh also photophobia, mesh Pearl pain, dizziness of having a headache, tinnitus, scrofula, goiter and tumor, acute mastitis, mumps, carbuncle furuncle poison, acute hepatitis, chronic hepatitis, high blood pressure；

Ramulus Taxilli, nature and flavor：It is bitter, sweet, flat, there is the effect of filling liver kidney, strengthening the bones and muscles, wind-damp dispelling, tocolysis member, for treating rheumatism numbness Bitterly, the illnesss such as soreness and weakness of waist and knees, muscles and bones is powerless, uterine bleeding warp is more, blood leaking in gestation, fetal irritability, hypertension；

Raspberry, nature and flavor：It is sweet in flavor, sour, warm-natured, there is the effect of supplementing the kidney to control the nocturnal contracting urine, nourish the liver to improve visual acuity, slided for treating seminal emission Essence, enuresis frequent micturition, impotence and premature ejaculation, mesh are secretly dim-sighted；

Common St.Paulswort Herb, nature and flavor：It is bitter, pungent, cold in nature, there is the effect of wind-damp dispelling, sharp joint, removing toxic substances, for treating arthralgia pain due to rheumatism, muscle Bone is powerless, soreness and weakness of waist and knees, quadriplegia, hemiplegia, rubella wet sore；

The root of bidentate achyranthes, nature and flavor：It is bitter, acid, mild-natured, have filling liver kidney, strengthening the bones and muscles, invigorate blood circulation, draw enemy state (fire) downlink, inducing diuresis for treating strangurtia it Effect, for treat soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhoea, postpartum abdominal pain due to blood stasis, note of the ancient Chinese lump in the abdomen, placenta retension, heat gonorrhea, Blood strangury, traumatic injury, Carbuncle swells dislikes sore, abscess of throat are additionally operable to powerless soreness of waist and knee joint, muscles and bones, Jing Bi Disorder lumps in the abdomen, dizziness due to hyperactivity of liver-YANG；

Willow leaf, nature and flavor：It is bitter, cold in nature, there is the effect of heat-clearing, removing toxic substances, diuresis, soothing the liver, analgesic, promoting eruption, it is chronic for treating Tracheitis, urethritis, cystitis, vesical calculus, gonorrhoea, hypertension, swollen ulcer drug, burn and scald, painful swelling of joints, toothache, acute diseases such as cholera and sunstroke rash, The diseases such as pruitus；

Changchun grass, nature and flavor：It is bitter, cold in nature, there is the effect of detoxicating and fighting cancer, The flat liver of heat-clearing, for treating a variety of cancerous swellings, high blood The diseases such as pressure, carbuncle sore tumefacting virus, scald；

Schisandra chinensis, nature and flavor：It is sour, sweet, warm-natured, there is the effect of convergence astringent method, nourishing generate fluid, kidney calming, for treating long The diseases such as void of coughing asthma, emission, enuresis frequent micturition, endless diarrhea, spontaneous sweating, injury thirst, Heat Diabetes, palpitation and insomnia.

Drug of the present invention is the principle based on Chinese traditional treatment hypertension, from the pathomechanism according to hypertension and pharmacological action Think：With regard to hypertension, each raw material herbal medicine efficacy in drug provided by the present invention is played altogether, has good treatment to above-mentioned disease Effect.

Specific embodiment

A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned hypertension, the medicine prepared using the formula Object good drug efficacy, it is quick, it is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific reality of the present invention The mode of applying is described in further detail：

Embodiment 1：

A kind of capsule medicine for being used to treat hypertension, which is characterized in that each component and mass parts of the drug are such as Shown in lower：

Mulberry leaf 95g, raw Radix Astragali 260g, 210~230g of Cortex Eucommiae, 80~200g of rhizoma alismatis, fruit of Chinese wolfberry 200g, rhizoma atractylodis 80g, Rhizoma Gastrodiae 95g, Rhizoma Chuanxiong 95g, sophora flower 95g, Radix Ophiopogonis 120g, selfheal 130g, Ramulus Taxilli 120g, raspberry 115g, Common St.Paulswort Herbs 118g, the root of bidentate achyranthes 130g, willow leaf 280g, Changchun grass 95g, Schisandra chinensis 60g, auxiliary material：Talcum powder and appropriate starch.

Embodiment 2：

A kind of capsule medicine for being used to treat hypertension, which is characterized in that each component and mass parts of the drug are such as Shown in lower：

Mulberry leaf 105g, raw Radix Astragali 310g, Cortex Eucommiae 260g, rhizoma alismatis 220g, fruit of Chinese wolfberry 230g, rhizoma atractylodis 90g, Rhizoma Gastrodiae 105g, Rhizoma Chuanxiong 105g, sophora flower 105g, Radix Ophiopogonis 140g, selfheal 150g, Ramulus Taxilli 140g, raspberry 130g, Common St.Paulswort Herbs 130g, root of bidentate achyranthes 150g, Willow leaf 310g, Changchun grass 105g, Schisandra chinensis 70g, auxiliary material：Talcum powder and appropriate starch.

Embodiment 3：

A kind of capsule medicine for being used to treat hypertension, which is characterized in that each component and mass parts of the drug are such as Shown in lower：

Mulberry leaf 120g, raw Radix Astragali 350g, Cortex Eucommiae 300g, rhizoma alismatis 50g, fruit of Chinese wolfberry 260g, rhizoma atractylodis 100g, Rhizoma Gastrodiae 120g, Rhizoma Chuanxiong 120g, sophora flower 120g, Radix Ophiopogonis 160g, selfheal 180g, Ramulus Taxilli 160g, raspberry 150g, Common St.Paulswort Herbs 150g, root of bidentate achyranthes 180g, Willow leaf 350g, Changchun grass 120g, Schisandra chinensis 80g, auxiliary material：Talcum powder and appropriate starch.

Model case：

Through clinical conditions hyperpietic totally 1350, the age is 705 of 62 years old or more, only 645 for 62 years old with Under.That fully recovers in 1350 patients has 914, effective 368, invalid 68.Total effective rate is up to 95%.

Claims (3)

1. a kind of capsule medicine for being used to treat hypertension, which is characterized in that each component and its mass parts of the drug Than as follows：

50~120g of mulberry leaf, raw 150~350g of Radix Astragali, 150~300g of Cortex Eucommiae, 60~250g of rhizoma alismatis, 100~260g of the fruit of Chinese wolfberry, 30~100g of rhizoma atractylodis, 30~120g of Rhizoma Gastrodiae, 50~120g of Rhizoma Chuanxiong, 50~120g of sophora flower, 100~160g of Radix Ophiopogonis, selfheal 60~ 180g, 100~160g of Ramulus Taxilli, 90~150g of raspberry 60~150g, Common St.Paulswort Herbs, 50~180g of the root of bidentate achyranthes, willow leaf 150~ 350g, Changchun 50~120g of grass, 20~80g of Schisandra chinensis, auxiliary material：Talcum powder and appropriate starch.

It is 2. according to claim 1 for treating the capsule medicine of hypertension, which is characterized in that the drug it is each Component and its mass parts are than as follows：

58~105g of mulberry leaf, raw 180~310g of Radix Astragali, 180~260g of Cortex Eucommiae, 70~220g of rhizoma alismatis, 115~230g of the fruit of Chinese wolfberry, 36~90g of rhizoma atractylodis, 36~105g of Rhizoma Gastrodiae, 58~105g of Rhizoma Chuanxiong, 58~105g of sophora flower, 115~140g of Radix Ophiopogonis, selfheal 70~ 150g, 115~140g of Ramulus Taxilli, 100~130g of raspberry 70~130g, Common St.Paulswort Herbs, 58~150g of the root of bidentate achyranthes, willow leaf 180~ 310g, Changchun 58~105g of grass, 26~70g of Schisandra chinensis, auxiliary material：Talcum powder and appropriate starch.

3. the capsule medicine for being used to treat hypertension according to claim 1 to 2, which is characterized in that the drug Each component and its mass parts are than as follows：

Mulberry leaf 95g, raw Radix Astragali 260g, 210~230g of Cortex Eucommiae, 80~200g of rhizoma alismatis, fruit of Chinese wolfberry 200g, rhizoma atractylodis 80g, Rhizoma Gastrodiae 95g, Rhizoma Chuanxiong 95g, sophora flower 95g, Radix Ophiopogonis 120g, selfheal 130g, Ramulus Taxilli 120g, raspberry 115g, Common St.Paulswort Herbs 118g, the root of bidentate achyranthes 130g, willow leaf 280g, Changchun grass 95g, Schisandra chinensis 60g, auxiliary material：Talcum powder and appropriate starch.