CN108100481B - Intelligent cornea preservation device - Google Patents
Intelligent cornea preservation device Download PDFInfo
- Publication number
- CN108100481B CN108100481B CN201711419276.3A CN201711419276A CN108100481B CN 108100481 B CN108100481 B CN 108100481B CN 201711419276 A CN201711419276 A CN 201711419276A CN 108100481 B CN108100481 B CN 108100481B
- Authority
- CN
- China
- Prior art keywords
- cornea
- storage box
- preservation
- cornea storage
- intelligent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000004087 cornea Anatomy 0.000 title claims abstract description 208
- 238000004321 preservation Methods 0.000 title claims abstract description 39
- 239000007853 buffer solution Substances 0.000 claims abstract description 16
- 239000011229 interlayer Substances 0.000 claims abstract description 9
- 238000007789 sealing Methods 0.000 claims abstract description 8
- 239000000243 solution Substances 0.000 claims abstract description 8
- 239000002245 particle Substances 0.000 claims abstract description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 239000003761 preservation solution Substances 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 4
- 239000005457 ice water Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 4
- 230000004888 barrier function Effects 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 238000012544 monitoring process Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 3
- 238000005057 refrigeration Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 239000010410 layer Substances 0.000 description 6
- 238000002054 transplantation Methods 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000003511 endothelial effect Effects 0.000 description 3
- 210000000744 eyelid Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 239000004065 semiconductor Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 210000000399 corneal endothelial cell Anatomy 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 230000005679 Peltier effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010023365 keratopathy Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
- B65D81/05—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
- B65D81/09—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents using flowable discrete elements of shock-absorbing material, e.g. pellets or popcorn
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
- B65D81/22—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient in moist conditions or immersed in liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
- B65D85/30—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
- B65D85/50—Containers, packaging elements or packages, specially adapted for particular articles or materials for living organisms, articles or materials sensitive to changes of environment or atmospheric conditions, e.g. land animals, birds, fish, water plants, non-aquatic plants, flower bulbs, cut flowers or foliage
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Evolutionary Biology (AREA)
- General Health & Medical Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an intelligent cornea preservation device, which comprises: the anti-vibration device comprises an outer shell, an inner shell arranged in the outer shell, and an interlayer formed between the outer shell and the inner shell, wherein vibration-proof particles are filled in the interlayer to prevent damage to cornea caused by vibration in the transportation process. The cornea preserving room comprises a openable sealing cover arranged on the top wall, at least three fixing rods, a fixing tray, a cornea storage box and buffer solution, wherein one end of each fixing rod is connected to the side wall of the cornea preserving room, the other end of each fixing rod is connected to the other end of the corresponding fixing tray, the fixing tray is arranged in the center of the cornea preserving room, the cornea storage box is arranged on the fixing tray, the cornea preserving room is filled with the buffer solution, and the cornea storage box is filled with the preserving solution.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a cornea preservation device.
Background
Keratopathy is one of the leading blinding eye diseases in the world today. According to the statistics of the world health organization in 1991, about 2700 to 3500 ten thousand blind people are worldwide, wherein about 1000 ten thousand blind people are cornea due to cornea and eye trauma. With the current medical conditions, cornea transplantation is the most effective method for helping cornea blind patients recover vision, and effective cornea preservation is the basis of cornea transplantation success, and can fully utilize limited cornea resources to provide favorable conditions for cornea transplantation.
The preserved cornea endothelial survival rate reaches seventy percent to be used for transplantation. Therefore, the key to cornea preservation is to protect the corneal endothelial cell activity, and preservation time of the corneal endothelial cell activity is classified into short, medium, long and long preservation. At present, the cornea preservation technology is continuously improved, and the quality of cornea transplantation operation is ensured. However, the continuous development and perfection of cornea implantation procedures also place higher demands on the preservation technique of the cornea.
The remote cornea delivering, storing and fixing device for mid-term cornea preservation disclosed in Chinese patent application No. 200820187553.2 consists of a bottle body, a bottle cap, a fixing rod and a fixing cross. The bottle body is divided into an inner layer and an outer layer, the fixed cross is fixed on the bottle cover through two fixing rods, the bottle cover is anastomotic and fixed with two clamping grooves of the bottle mouth through two lug structures, the bottle body is tightly closed through a frosted hole, the cornea arch is upwards arranged on the fixed cross, the four lug structures of the fixed cross play a fixing role, the cornea is located in the inner space of the bottle body, the inner layer is filled with sterile vacuum preservation liquid, the outer layer is filled with ice-water mixture, and the outer layer opening is sealed by a rubber plug. However, the remote delivery and storage fixing device for the cornea in the middle-term preservation cannot monitor and further adjust and meet the change of the cornea preservation environment in time, and is difficult to ensure the activity of the corneal epithelial cells in the long-term remote delivery process, and the shape change of the preserved cornea is easy to cause.
Another example is a cornea preservation and rehydration apparatus as disclosed in chinese patent application No. 201510466857.7, comprising: the cornea box comprises a box body and a box cover, wherein the box body is detachably connected with the box cover, a cornea bracket used for bearing a cornea is arranged in the box body, the surface of the cornea bracket used for placing the cornea is a convex spherical surface, and a stop part used for preventing the cornea from falling out is arranged around the convex spherical surface. However, the cornea preservation and rehydration apparatus preserves the cornea by drying the cornea, which is vulnerable to damage in a dry environment, and the use of a desiccant is difficult to control and is vulnerable to damage to the cornea tissue.
As disclosed in chinese patent application 201620344123.1, a cornea storage device includes a main body casing and a cornea fixing support which is clearance-fitted with an inner wall of the main body casing, a spiral flow guide tube is provided on the inner wall of the main body casing, and an upper end of the cornea fixing support can extend out of the main body casing, and the cornea fixing support includes a handle, a cornea fixing support body and a cornea storage device. The cornea storage device can rotate around the main shaft, a cornea accommodating cavity which is separated by at least three grids is further arranged on the cornea storage device, a cornea access window is further arranged on the main body shell corresponding to the cornea accommodating cavity, and a cornea access door is arranged on the cornea access window. However, this cornea storage device cannot control the temperature of the storage solution, and it is difficult to ensure a constant temperature, and it is extremely easy to cause a change in the shape of the cornea to be stored, and it is impossible to lengthen the time that the cornea can be stored under the same circumstances.
Therefore, it is an urgent problem in the industry to provide a cornea preservation apparatus that can prolong the cornea preservation time, reduce the cornea damage, maintain the cornea intact to the maximum extent, and improve the cornea preservation success rate.
Disclosure of Invention
The invention aims to provide an intelligent cornea storage device which can remarkably prolong the storage time, maintain the cornea to the maximum extent and improve the cornea storage success rate.
According to one aspect of the present invention, there is provided an intelligent ocular cornea storage apparatus comprising: the device comprises an outer shell, an inner shell arranged in the outer shell, and an interlayer formed between the outer shell and the inner shell. Wherein, the interlayer is filled with vibration-proof particles to prevent damage to cornea caused by vibration during transportation. The cornea preserving room comprises a openable sealing cover arranged on the top wall, at least three fixing rods, a fixing tray, a cornea storage box and buffer solution, wherein one end of each fixing rod is connected to the side wall of the cornea preserving room, the other end of each fixing rod is connected to the other end of the corresponding fixing tray, the fixing tray is arranged in the center of the cornea preserving room, the cornea storage box is arranged on the fixing tray, the cornea preserving room is filled with the buffer solution, and the cornea storage box is filled with the preserving solution.
Optionally, the intelligent cornea storage device further comprises a control device arranged on the outer surface of the shell, and the control device is electrically connected with the uninterrupted power supply and comprises a parameter setting unit and an alarm unit, wherein the parameter setting unit is used for setting the temperature and the pressure in the cornea storage chamber.
Alternatively, the uninterruptible power supply may be a UPS power supply including a power input circuit, a rectifier, an inverter and bypass output switching circuit, and an energy storage battery. The rectifier completes the voltage stabilizing function of the uninterrupted power supply, and can control the output amplitude according to the change of the external power, and the output amplitude is basically unchanged when the external power is changed.
Optionally, when an external power supply connected with the uninterruptible power supply is interrupted, the uninterruptible power supply can continue to supply power to the load, so that the load can maintain normal operation and the intelligent cornea storage device can be protected from damage.
Alternatively, the uninterruptible power supply is a rechargeable battery, such as a power battery used on an electric vehicle.
Alternatively, the temperature parameter set by the parameter setting unit is-50-10 ℃, preferably-20-0 ℃, and the pressure parameter is 1.3 kilopascals-2.80 kilopascals, preferably 1.8-2.2 kilopascals.
Optionally, the control device further includes: the pressure sensor is used for monitoring the pressure in the cornea preservation chamber, the bubble detector is used for detecting bubbles of the buffer solution in the cornea preservation chamber, and the temperature sensing unit is used for detecting the temperature in the cornea preservation chamber, and the pressure sensing unit, the bubble detecting unit and the temperature sensing unit are respectively connected with the alarm unit. When the pressure parameter or the temperature parameter detected by the pressure sensing unit and the temperature sensing unit exceeds the parameter preset by the parameter setting unit, the alarm unit is started. When the bubble detection unit detects that bubbles exist in the buffer solution in the cornea preservation chamber, the alarm device is started.
Optionally, 2-4 ear structures are arranged on the fixed tray, 2-4 clamping grooves matched with the ear structures are arranged on the cornea storage box, and the ear structures of the fixed tray are clamped in the clamping grooves of the cornea storage box to fix the cornea storage box on the fixed tray, so that the cornea storage box is prevented from being separated from the fixed tray due to shaking.
Optionally, the fixed tray is arch downward, the bottom of cornea storage box is laminated in the fixed tray, cornea storage box bottom convex curvature is unanimous with cornea convex curvature.
Optionally, the inner wall of the cornea storage box is provided with a supporting separation net so as to avoid physical damage caused by direct contact between the cornea and the inner wall of the cornea storage box.
Preferably, the supporting spacer in the cornea storage box is made of a membrane material simulating the cornea of a human eye, such as a material simulating the elasticity and viscoelasticity of the cornea of the human eye by adopting materials such as silica gel or rubber.
Alternatively, the inner wall material of the cornea storage box is a membrane material simulating the eyelid of a human body, such as a material simulating the elasticity and viscoelasticity of the eyelid of the human body by adopting materials such as silica gel or rubber.
Optionally, the preservation solution in the cornea storage box is a glycerol solution added with 0.1% -1% sodium hyaluronate, and the buffer solution in the cornea storage chamber is an ice-water mixture.
Optionally, the preparation before the cornea is placed in the cornea storage box is further included: 0.1 to 0.3 milliliter of sodium hyaluronate solution with the concentration of 0.1 to 1 percent is uniformly adhered on the endothelial surface of the cornea.
Preferably, the cornea storage box is placed into the cornea storage chamber by opening the openable sealing cover under the full power state of the uninterrupted power supply.
Alternatively, the cornea storage chamber is cylindrical or spherical.
Optionally, the top wall of the housing is provided with an opening to place the cornea storage cassette into the cornea storage chamber.
Optionally, further comprising pressure regulating means provided in the intermediate layer for regulating the pressure in the cornea storage chamber by means of the control means.
Optionally, the cornea preserved in the cornea preservation chamber is taken out and then placed in electrolyte intraocular flushing liquid at 0-5 ℃, the cornea is rinsed once every 2-4 minutes to remove glycerol adhered to the endothelial surface of the cornea, the cornea is taken out from the intraocular flushing liquid after rinsing for 3-5 times and placed in water at 0-5 ℃, and the cornea can be used after rehydration for 5-10 minutes.
Optionally, the user can select the preservation mode according to the specific situation by himself, prepare preservation solution as required and adjust preservation temperature and preservation pressure.
Alternatively, the vibration-proof particles filled in the interlayer between the outer casing and the inner casing may be foam particles or plastic buffer balls.
Alternatively, the refrigeration device of the intelligent cornea storage apparatus can employ a refrigeration module such as a semiconductor refrigeration module or a compressor refrigeration module as used in a vehicle-mounted refrigerator.
The principle of the semiconductor refrigeration module is to refrigerate by an electronic chip, and the refrigeration temperature range is-5 to 65 degrees. Semiconductor electronic refrigeration is also called thermoelectric refrigeration or thermoelectric refrigeration, and is a refrigeration method utilizing the Peltier effect.
The refrigerating capacity of the refrigerating module of the compressor can reach-18 ℃, and the refrigerating module can stably and effectively refrigerate, and the vehicle-mounted refrigerator of the compressor consists of a compressor, a condenser, a dry filter, a capillary tube, an evaporator and the like.
The beneficial effects of the invention are as follows: (1) According to the intelligent cornea storage device, an uninterrupted power supply is arranged, so that the cornea storage environment can be flexibly regulated and controlled by charging at any time, and the storage time can be prolonged to 20 days; (2) The interlayer of the intelligent cornea storage device is filled with shockproof particles, and the cornea storage chamber is filled with buffer solution, so that unexpected situations such as unpredictable collision or vibration in the conveying process are avoided to damage the cornea; (3) The curvature of the convex surface at the bottom of the cornea storage box is consistent with the curvature of the convex surface of the cornea, and a supporting separation net for preventing the cornea from being in direct contact with the inner wall is arranged, so that the damage of the cornea is reduced, and the cornea is maintained to the greatest extent; (4) Precisely controlling cornea preservation environment, achieving equivalent preservation time, preserving cornea with higher endothelial cell activity, and improving cornea preservation success rate; (5) The intelligent cornea storage device can store the isolated cornea well for a long time, and can conveniently carry out remote transportation, so that the use value of the isolated cornea can be exerted to the greatest extent.
Drawings
Fig. 1 is a schematic diagram of the structure of the intelligent cornea storage apparatus of the present invention.
Fig. 2 is a schematic view of the cornea storage case of the intelligent eye cornea storage apparatus of the present invention.
Detailed Description
Referring to fig. 1 and 2, according to one non-limiting embodiment of the present invention, there is provided an intelligent cornea storage apparatus, comprising: an outer case 100, an inner case 200 provided in the outer case, and a sandwich 150 formed between the outer case 100 and the inner case 200.
The interlayer 150 is filled with vibration-proof particles to prevent damage to the cornea due to vibration during transportation. The inner case 200 is provided therein with a cornea storage chamber 300 for storing an isolated cornea, a refrigerating device 500 for maintaining the cornea storage chamber temperature constant, an uninterruptible power supply 600 for continuously supplying power to the refrigerating device 500, and a control device 700 provided at an outer surface of the outer case 100 in this order from top to bottom.
The cornea storage chamber 300 includes a openable and closable sealing cover 310 mounted to the top wall 301, three fixing bars 330 having one ends connected to the side walls of the cornea storage chamber 300, a fixing tray 335 connected to the other ends of the fixing bars 330 and placed in the center of the interior of the cornea storage chamber 300, and a cornea storage case 800 placed on the fixing tray 335. The cornea storage chamber 300 is filled with a buffer solution, and the cornea storage cassette 800 is filled with a preservation solution. The cornea storage box 800 is placed in the cornea storage chamber 300 by the openable and closable sealing cover 310, and the cornea storage box 800 is taken out by the openable and closable sealing cover 310 as needed.
The control device 700 is electrically connected to the uninterruptible power supply 600, and the control device 700 includes a parameter setting unit 710 for setting the temperature and pressure in the cornea storage compartment 300, and an alarm unit 750.
In this non-limiting embodiment, the control device 700 further includes: a pressure sensor 720 for monitoring the pressure in the cornea storage chamber 300, a bubble detector 730 for detecting bubbles of the buffer solution in the cornea storage chamber 300, and a temperature sensing unit 740 for detecting the temperature in the cornea storage chamber 300. The pressure sensing unit 720, the bubble detecting unit 730, and the temperature sensing unit 740 are respectively signal-connected to the alarm unit 750. When the pressure parameter or the temperature parameter detected by the pressure sensing unit 720 and the temperature sensing unit 730 exceeds the parameter preset by the parameter setting unit 710, the alarm unit 750 is activated. When the bubble detecting unit 740 detects the presence of bubbles in the buffer solution in the cornea storage chamber 300, the alarm unit 750 is activated.
As shown in fig. 2, the fixed tray 335 is provided with 4 ear-shaped structures (not numbered), the cornea storage box 800 is provided with 4 clamping grooves 850 matched with the ear-shaped structures, and the ear-shaped structures of the fixed tray 335 are clamped in the clamping grooves 850 of the cornea storage box 800 to fix the cornea storage box 800 on the fixed tray 335, so that the cornea storage box 800 is prevented from being separated from the fixed tray 335 due to shaking. The fixed tray 335 is arched downward, the bottom of the cornea storage box 800 is attached to the fixed tray 330, and the convex curvature of the bottom of the cornea storage box 800 is consistent with the convex curvature of the cornea. The inner wall of the cornea storage cassette 800 is provided with a supporting barrier 870 to prevent physical damage caused by direct contact of the cornea with the inner wall of the cornea storage cassette 800.
As an alternative embodiment, the temperature parameter set by the parameter setting unit 710 of the control device 700 is-15 degrees celsius, and the pressure parameter is 2.1 kilopascals.
As an alternative embodiment, the preservation solution in the cornea storage box is a glycerol solution added with 0.6% sodium hyaluronate, and the buffer solution in the cornea storage chamber is an ice-water mixture.
As an alternative embodiment, the cornea storage box is placed into the cornea storage chamber by opening the openable sealing cover under the full power state of the uninterrupted power supply.
As an alternative embodiment, the cornea storage chamber is cylindrical.
As an alternative embodiment five, the inner and outer shells of the intelligent cornea storage apparatus are made of shockproof and shatter-resistant materials.
As an alternative embodiment six, the support barrier 870 within the cornea storage case 800 is made of medical-specific silicone that mimics the elasticity and viscoelasticity of the cornea of a human eye.
As an alternative embodiment seven, the material of the cornea storage case 800 is prepared from medical-specific silicone that mimics the elasticity and viscoelasticity of the human eyelid.
Although preferred embodiments of the present invention have been described in detail herein, it is to be understood that the invention is not limited to the precise construction and steps set forth herein, and that other modifications and variations may be effected by one skilled in the art without departing from the spirit and scope of the invention. In addition, parameters such as temperature, pressure and the like in the present invention can be appropriately selected within the scope of the present disclosure according to specific use conditions.
Claims (5)
1. An intelligent ocular cornea preservation device, comprising: an outer shell, an inner shell disposed in the outer shell, and an interlayer formed between the outer shell and the inner shell;
wherein, the interlayer is filled with vibration-proof particles to prevent the damage of vibration to cornea during transportation;
the cornea preservation room comprises an openable sealing cover arranged on the top wall, at least three fixing rods, a fixing tray and a cornea storage box, wherein one end of each fixing rod is connected to the side wall of the cornea preservation room, the fixing tray is connected to the other end of each fixing rod and is arranged in the center of the inside of the cornea preservation room, the cornea storage box is arranged on the fixing tray, buffer solution is filled in the cornea preservation room, and preservation solution is filled in the cornea storage box;
the cornea preservation chamber comprises a shell, a cornea preservation chamber and a control device, wherein the shell is provided with a plurality of external surfaces, the external surfaces of the shell are provided with a plurality of external surfaces, the control device is electrically connected with the uninterrupted power supply and comprises a parameter setting unit and an alarm unit, and the parameter setting unit is used for setting the temperature and the pressure in the cornea preservation chamber;
the temperature parameter set by the parameter setting unit is-50-10 ℃, and the pressure parameter is 1.3 kilopascals-2.80 kilopascals;
the control device further includes: the pressure sensor is used for monitoring the pressure in the cornea storage chamber, the bubble detector is used for detecting bubbles of the buffer solution in the cornea storage chamber, and the temperature sensing unit is used for detecting the temperature in the cornea storage chamber, and the pressure sensing unit, the bubble detection unit and the temperature sensing unit are respectively connected with the alarm unit in a signal manner;
when the pressure parameter or the temperature parameter detected by the pressure sensing unit and the temperature sensing unit exceeds the parameter preset by the parameter setting unit, the alarm unit is started;
when the bubble detection unit detects that bubbles exist in the buffer solution in the cornea preservation chamber, the alarm device is started;
2-4 ear-shaped structures are arranged on the fixed tray, 2-4 clamping grooves matched with the ear-shaped structures are arranged on the cornea storage box, and the ear-shaped structures of the fixed tray are clamped in the clamping grooves of the cornea storage box so as to fix the cornea storage box on the fixed tray and prevent the cornea storage box from being separated from the fixed tray due to shaking;
the fixed tray is downward in an arch shape, the bottom of the cornea storage box is attached to the fixed tray, and the convex curvature of the bottom of the cornea storage box is consistent with the convex curvature of the cornea.
2. The intelligent ocular cornea storage apparatus of claim 1, wherein the cornea storage box inner wall is provided with a supporting barrier to avoid physical damage caused by direct contact of cornea with the cornea storage box inner wall.
3. The intelligent cornea storage apparatus according to claim 2, wherein the storage solution in the cornea storage box is a glycerol solution added with 0.1% -1% sodium hyaluronate, and the buffer solution in the cornea storage chamber is an ice-water mixture.
4. The intelligent ocular cornea storage apparatus of any one of claims 1 to 3, wherein the cornea storage chamber is cylindrical or spherical.
5. The intelligent ocular cornea storage apparatus of claim 4, wherein a top wall of said housing is provided with an opening to place said cornea storage cartridge into said cornea storage chamber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711419276.3A CN108100481B (en) | 2017-12-25 | 2017-12-25 | Intelligent cornea preservation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711419276.3A CN108100481B (en) | 2017-12-25 | 2017-12-25 | Intelligent cornea preservation device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108100481A CN108100481A (en) | 2018-06-01 |
| CN108100481B true CN108100481B (en) | 2023-10-31 |
Family
ID=62212973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711419276.3A Active CN108100481B (en) | 2017-12-25 | 2017-12-25 | Intelligent cornea preservation device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108100481B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114368536B (en) * | 2022-03-03 | 2023-11-21 | 蓝山中西医结合医院有限公司 | Intelligent cornea preservation device |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006089103A (en) * | 2004-09-27 | 2006-04-06 | Hitachi Transport Syst Ltd | Fixed temperature transport packing apparatus and heat retaining sheet |
| CN201243576Y (en) * | 2008-08-08 | 2009-05-27 | 吴志勇 | Fixing device for remote delivery and storage of cornea for mid-term preservation |
| CN102275086A (en) * | 2011-08-04 | 2011-12-14 | 中国科学院过程工程研究所 | Damping vibration absorbing cutter bar |
| CN202819431U (en) * | 2012-06-29 | 2013-03-27 | 厦门大学附属厦门眼科中心 | Container for cornea donor materials |
| CN202987862U (en) * | 2012-12-24 | 2013-06-12 | 佳木斯大学 | Shockproof medicament box |
| CN105076111A (en) * | 2015-07-31 | 2015-11-25 | 深圳艾尼尔角膜工程有限公司 | Cornea storage and rehydration device |
| CN105188361A (en) * | 2013-03-14 | 2015-12-23 | 让·莫奈大学 | Medical device intended for the long-term storage of a cornea, or for ex vivo experimentation on a human or animal cornea |
| CN205574530U (en) * | 2016-04-23 | 2016-09-14 | 程钧 | Cornea save set |
| CN107349801A (en) * | 2017-08-24 | 2017-11-17 | 萍乡市普天高科实业有限公司 | A kind of earthenware slab film |
| CN208264974U (en) * | 2017-12-25 | 2018-12-21 | 青岛大学附属医院 | Brilliant Eyes preservation of cornea equipment |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7662611B2 (en) * | 2004-10-26 | 2010-02-16 | Cleo Cosmetic And Pharmaceutical Company, Llc | Apparatus and method for in vitro storage of a cornea |
-
2017
- 2017-12-25 CN CN201711419276.3A patent/CN108100481B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006089103A (en) * | 2004-09-27 | 2006-04-06 | Hitachi Transport Syst Ltd | Fixed temperature transport packing apparatus and heat retaining sheet |
| CN201243576Y (en) * | 2008-08-08 | 2009-05-27 | 吴志勇 | Fixing device for remote delivery and storage of cornea for mid-term preservation |
| CN102275086A (en) * | 2011-08-04 | 2011-12-14 | 中国科学院过程工程研究所 | Damping vibration absorbing cutter bar |
| CN202819431U (en) * | 2012-06-29 | 2013-03-27 | 厦门大学附属厦门眼科中心 | Container for cornea donor materials |
| CN202987862U (en) * | 2012-12-24 | 2013-06-12 | 佳木斯大学 | Shockproof medicament box |
| CN105188361A (en) * | 2013-03-14 | 2015-12-23 | 让·莫奈大学 | Medical device intended for the long-term storage of a cornea, or for ex vivo experimentation on a human or animal cornea |
| CN105076111A (en) * | 2015-07-31 | 2015-11-25 | 深圳艾尼尔角膜工程有限公司 | Cornea storage and rehydration device |
| CN205574530U (en) * | 2016-04-23 | 2016-09-14 | 程钧 | Cornea save set |
| CN107349801A (en) * | 2017-08-24 | 2017-11-17 | 萍乡市普天高科实业有限公司 | A kind of earthenware slab film |
| CN208264974U (en) * | 2017-12-25 | 2018-12-21 | 青岛大学附属医院 | Brilliant Eyes preservation of cornea equipment |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108100481A (en) | 2018-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108100481B (en) | Intelligent cornea preservation device | |
| RU2079273C1 (en) | Transportable container of enclosed system for storing biological material | |
| EP3003025B1 (en) | Device for use in evaluation, transportation or storage of a donor heart | |
| EP2311935B1 (en) | Tissue-derived biomaterial carrier device | |
| US4470264A (en) | Life support apparatus for human blood and compositions thereof | |
| AU2012231821A1 (en) | Apparatus for maintaining a harvested organ viable and transportable | |
| HU211079B (en) | Method of freezing red blood cells using reduced quantity of he as a cryoprotectant | |
| CN201095484Y (en) | Vehicle-carrying platelet transporting box | |
| CN112806351B (en) | Organ perfusion device, organ transportation system and perfusate | |
| CN113424002B (en) | Method and apparatus for freezing biological products | |
| CN209270471U (en) | Multifunctional insulin box | |
| CN206950305U (en) | First aid trammer with temperature adjustment medicine-chest | |
| CN208264974U (en) | Brilliant Eyes preservation of cornea equipment | |
| EP3303943A1 (en) | Apparatus and methods for freezing, storing, and thawing biological materials | |
| US20220268507A1 (en) | Temperature controlled storage container | |
| CN106267344A (en) | A kind of cornea takes off cell system | |
| WO2023215611A1 (en) | System for hypothermic transport | |
| CN113686072B (en) | Constant temperature refrigerator is transplanted to liver convenient to transport | |
| CN104973336A (en) | Incubator used for disaster assistance | |
| CN217262017U (en) | Intelligent cigarette storage device | |
| CN212244394U (en) | Insulin drug storage box with automatic reminding function | |
| CN207911915U (en) | A kind of stem cell cryopreserving bag freezing storing box | |
| CN212075047U (en) | Portable thermostated container with shock-absorbing function | |
| CN214190911U (en) | Constant temperature blood transfusion case | |
| CN214113590U (en) | Medicine storage cabinet for storing diabetes medicine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |