CN108100481A - Brilliant Eyes preservation of cornea device - Google Patents
Brilliant Eyes preservation of cornea device Download PDFInfo
- Publication number
- CN108100481A CN108100481A CN201711419276.3A CN201711419276A CN108100481A CN 108100481 A CN108100481 A CN 108100481A CN 201711419276 A CN201711419276 A CN 201711419276A CN 108100481 A CN108100481 A CN 108100481A
- Authority
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- China
- Prior art keywords
- cornea
- preservation
- storage box
- holding room
- brilliant eyes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004087 cornea Anatomy 0.000 title claims abstract description 195
- 238000004321 preservation Methods 0.000 title claims abstract description 55
- 239000007853 buffer solution Substances 0.000 claims abstract description 13
- 239000011229 interlayer Substances 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 10
- 230000006378 damage Effects 0.000 claims abstract description 9
- 238000007789 sealing Methods 0.000 claims abstract description 8
- 238000000338 in vitro Methods 0.000 claims abstract description 6
- 239000002245 particle Substances 0.000 claims abstract description 6
- 230000008569 process Effects 0.000 claims abstract description 4
- 238000001514 detection method Methods 0.000 claims description 10
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 4
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 4
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Chinese gallotannin Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims description 3
- 208000027418 Wounds and injury Diseases 0.000 claims description 3
- 238000012544 monitoring process Methods 0.000 claims description 3
- 239000005457 ice water Substances 0.000 claims 1
- 239000000463 material Substances 0.000 description 7
- 238000004088 simulation Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 238000005057 refrigeration Methods 0.000 description 4
- 239000000741 silica gel Substances 0.000 description 4
- 229910002027 silica gel Inorganic materials 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 201000004569 Blindness Diseases 0.000 description 3
- 208000028006 Corneal injury Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000000871 endothelium corneal Anatomy 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000000744 eyelid Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000004065 semiconductor Substances 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000013013 elastic material Substances 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 239000003190 viscoelastic substance Substances 0.000 description 2
- 230000005679 Peltier effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
- B65D81/05—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
- B65D81/09—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents using flowable discrete elements of shock-absorbing material, e.g. pellets or popcorn
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
- B65D81/22—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient in moist conditions or immersed in liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
- B65D85/30—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
- B65D85/50—Containers, packaging elements or packages, specially adapted for particular articles or materials for living organisms, articles or materials sensitive to changes of environment or atmospheric conditions, e.g. land animals, birds, fish, water plants, non-aquatic plants, flower bulbs, cut flowers or foliage
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Evolutionary Biology (AREA)
- General Health & Medical Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention discloses a kind of Brilliant Eyes preservation of cornea device, including：Shell, the inner casing in shell, the interlayer being formed between shell and inner casing, filled with vibrationproof particle to prevent the damage of the vibration corneal in transportational process in interlayer.It is set gradually from top to bottom in inner casing and is useful for the cornea holding room for preserving in vitro cornea, for the refrigerating plant that maintains cornea holding room constant temperature and for the uninterruptible power supply of refrigerating plant continued power, cornea holding room includes the retractable sealing cover for being installed on roof, at least three one end are connected to the fixed link of the side wall of cornea holding room, the other end for being connected to fixed link is placed in the fixed tray of cornea holding room center of inside, and it is positioned over the cornea the storage box on fixed tray, buffer solution is filled in cornea holding room, filled with preservation liquid in cornea the storage box.
Description
Technical field
The present invention relates to the field of medical instrument technology more particularly to a kind of preservation of cornea devices.
Background technology
Keratonosus is one of main diseases causing blindness in the world today.According to World Health Organization's statistics of 1991, the whole world there are about
2700~35,000,000 blind persons, wherein, due to about 10,000,000 people of corneal blindness caused by cornea and eye traumas.With current medical item
Part, corneal transplantation are to aid in the most effective method that corneal blindness patient recovers eyesight, cornea it is effective preserve be corneal transplantation into
The basis of work(can make full use of limited cornea resource, advantage is provided for corneal transplantation.
The corneal endothelium survival rate of preservation, which reaches more than 70 percent, can be used to transplant.Therefore, preservation of cornea
Key be protection cornea endothelial cell activity, by the holding time of corneal endothelium activity be divided into it is short, in, middle length and for a long time
It preserves.At present, preservation of cornea technology is continuously improved, and guarantee is provided for corneal graft quality.However, corneal graft
The continuous Techniques of preserving carried out and improve also corneal propose higher requirement.
It is solid that a kind of Mid-term preservation cornea as disclosed in Chinese patent application the 200820187553.2nd remotely delivers storage
Determine device, be made of bottle, bottle cap, fixed link, fixed cross frame.Wherein, bottle is divided into two layers inside and outside, and fixed cross frame passes through
Two fixed links are fixed on bottle cap, and bottle cap is coincide fixation by two ear structures and two card slots of bottleneck, passes through frosted mouth
With bottle tight closure, cornea arch is placed in upwards on fixed cross frame, and four angled constructions of fixed cross frame play fixation
Effect, cornea are located at bottle inner space, and internal layer fills Sterile vacuum and preserves liquid, and outer layer fills mixture of ice and water, outer layer opening
It is sealed with rubber stopper.However, the Mid-term preservation cornea remotely delivers change nothing of the storage fixing device for preservation of cornea environment
Method monitors and then is adjusted satisfaction in time, and the work for the corneal epithelial cell being difficult to ensure that in long-term long-range distributing procedure
Property, the shape of cornea preservation is easily triggered to change.
For another example a kind of preservation of cornea and rehydration device of No. 201510466857.7 announcement of Chinese patent application, including：
Box body and box cover, the box body are detachably connected with the box cover, are equipped with to carry the cornea bracket of cornea in the box body,
The cornea bracket be used to place the surface of cornea is equipped with to prevent cornea from dropping out for convex spherical, around the convex spherical only
Stopper.However, the preservation of cornea and rehydration device use the method cornea preservation of dry cornea, cornea is easy in dry environments
It is damaged, and the use of drier is difficult to control easily damage cornea tissue.
For another example a kind of preservation of cornea device of the announcement of Chinese patent application the 201620344123.1st, including main body outside
Shell and with the matched cornea fixing bracket in main body cover inner wall gap, be provided with spiral stream guidance pipe, angle on main body cover inner wall
Film fixing bracket the upper end is extended outside main body cover, cornea fixing bracket include handle, cornea fixing bracket main body and
Cornea storing unit.Cornea storing unit can rotate around the spindle, be additionally provided on cornea storing unit by least three grids every
Disconnected cornea accommodating chamber, corresponding to being additionally provided with cornea slot, cornea slot on the main body cover of cornea accommodating chamber
It is equipped with cornea access door.However, the preservation of cornea device can not regulate and control to preserve the temperature of liquid, it is difficult to ensure the constant of temperature,
The shape of cornea preservation is easily triggered to change, the time that cornea can preserve can not be extended under square one.
Therefore it provides one kind can extend the preservation of cornea time, reduce corneal injury, maintain to greatest extent cornea it is complete,
Improving the preservation of cornea device of preservation of cornea success rate becomes urgent problem in the industry.
The content of the invention
The object of the present invention is to provide a kind of Brilliant Eyes preservation of cornea devices, which can be notable
Extend the holding time, maintenance cornea is complete to greatest extent, improves preservation of cornea success rate.
According to an aspect of the present invention, a kind of Brilliant Eyes preservation of cornea device is provided, including：Shell, in shell
Inner casing, the interlayer that is formed between shell and inner casing.Wherein, vibrationproof particle is filled in interlayer to prevent in transportational process
Vibrate the damage of corneal.It is set gradually from top to bottom in inner casing and is useful for the cornea holding room for preserving in vitro cornea, is used for
Maintain the refrigerating plant of cornea holding room constant temperature and for the uninterruptible power supply of refrigerating plant continued power, cornea to be protected
Hide room include be installed on the retractable sealing cover of roof, at least three one end be connected to cornea holding room side wall fixed link,
The other end for being connected to fixed link is placed in the fixed tray of cornea holding room center of inside and is positioned on fixed tray
Cornea the storage box, cornea holding room is interior to be filled with buffer solution, is filled in cornea the storage box and preserves liquid.
Selectively, which further comprises the control device for the outer surface for being arranged at shell,
Control device is electrically connected with uninterruptible power supply, including for setting the parameter setting list of temperature and pressure in cornea holding room
Member and alarm unit.
Selectively, uninterruptible power supply can be ups power, including power supply input circuit, rectifier, inverter, inversion
With bypass output switching circuit and energy storage battery.Rectifier completes the voltage stabilizing function of uninterruptible power supply, can be according to the change of dispatch from foreign news agency
Change control output amplitude, the rectified voltage that output amplitude is basically unchanged when dispatch from foreign news agency changes.
Selectively, when the external power supply being connected with uninterruptible power supply interrupts, uninterruptible power supply, which can continue to load, to be continued
Electric energy is supplied, load is made to maintain to work normally and protects the Brilliant Eyes preservation of cornea device without damage.
Selectively, uninterruptible power supply is rechargeable battery, such as the power battery used on electric car.
Selectively, the temperature parameter that parameter setting unit is set is -50~10 degree Celsius, preferably -20~0 degree Celsius,
Pressure parameter is 1.3 kPas~2.80 kPas, preferably 1.8~2.2 kPas.
Selectively, control device further comprises：For monitoring the pressure sensor of cornea preservation room pressure, being used for
It detects the gas bubble detection of the bubble of buffer solution in cornea holding room and is passed for detecting the temperature of cornea preservation indoor temperature
Feel unit, pressure sensitive unit, bubble detection unit and temperature sensing unit are connected respectively with alarm unit.Work as pressure sensing
When the pressure parameter or temperature parameter that unit and temperature sensing unit detect are beyond parameter setting unit default parameter, open
Dynamic alarm unit., there are during bubble, start warning device when bubble detection unit detects buffer solution in cornea holding room.
Selectively, fixed tray is equipped with 2~4 ear structures, and cornea the storage box is equipped with and ear structure phase
2~4 card slots matched somebody with somebody, the ear structure of fixed tray are sticked in the card slot of cornea the storage box cornea the storage box being fixed on
Fixed tray prevents cornea the storage box because rocking disengaging fixed tray.
Selectively, fixed tray is domed downwards, and the bottom of cornea the storage box is domed downwards, the bottom of cornea the storage box
Portion fits in fixed tray, and cornea the storage box bottom convex surface curvature is consistent with cornea convex curvature.
Selectively, cornea the storage box inner wall is equipped with support filter and is directly connect to avoid cornea and the inner wall of cornea the storage box
It touches and causes physical injury.
Preferably, the support filter in cornea the storage box is the membrane material of simulation human cornea, such as uses silica gel or rubber
The elastic and viscoelastic material preparation of the material simulations human cornea such as glue.
Selectively, cornea the storage box inner-wall material is the membrane material of simulation human body eyelid, such as using silica gel or rubber
The elastic and viscoelastic material of material simulation human body eyelid.
Selectively, liquid is preserved as the glycerite added with 0.1%~1% sodium hyaluronate in cornea the storage box, angle
The indoor buffer solution of film preservation is mixture of ice and water.
Selectively, the preparation that cornea is inserted before cornea the storage box is further comprised：It is uniform in the interior surface of cornea
Adhere to 0.1~0.3 milliliter of the sodium hyaluronate solution of concentration 0.1%~1%.
Preferably, under uninterruptible power supply full power state, cornea the storage box inserts cornea by opening retractable sealing cover
In holding room.
Selectively, cornea holding room is cylindrical shape or spherical shape.
Selectively, the roof of shell is provided with opening so that cornea the storage box is put into cornea holding room.
Selectively, further comprise the pressure-regulating device being arranged in interlayer, cornea is adjusted by control device
The indoor pressure of preservation.
Selectively, the cornea taking-up preserved in cornea holding room is placed on 0~5 degree Celsius of electrolyte intra-ocular flushing liquor
In, rinsing in every 2~4 minutes is once to remove the glycerine of contact with corneal endothelium adherency, by cornea from intraocular washing lotion after rinsing 3~5 times
Middle taking-up is inserted in 0~5 degree Celsius of water, and rehydration can be used for 5~10 minutes.
Selectively, user can voluntarily select preserving type as the case may be, prepare to preserve liquid as needed and adjust
Whole storage temperature and preservation pressure.
Selectively, the vibrationproof particle filled in the interlayer between shell and inner casing can be foam beads or plastic. buffer
Ball.
Selectively, the refrigeration mould as used in car refrigerator can be used in the refrigerating plant of the Brilliant Eyes preservation of cornea device
Group, such as semiconductor refrigerating module or compressor cooling module.
The principle of semiconductor refrigerating module is freezed by electronic chip, and refrigeration temperature levels are -5 to 65 degree.Semi-conductor electricity
Son refrigeration is also known as thermoelectric cooling or thermoelectric cooling, it is a kind of refrigerating method for utilizing " peltier effect ".
Compressor cooling module refrigerating capacity can reach -18 DEG C, can stablize and refrigeration is effectively performed, and compressor is vehicle-mounted
Refrigerator is made of components such as compressor, condenser, device for drying and filtering, capillary, evaporators.
The beneficial effects of the invention are as follows：(1), Brilliant Eyes preservation of cornea device according to the present invention, is provided with uninterrupted electricity
Source, the Conservation environment for the flexible modulation cornea that can charge at any time, holding time can extend to 20 days；(2), intelligence of the invention
Filled with shockproof particle in the interlayer of cornea save set, cornea holding room is interior filled with buffer solution, avoids in transmission process
The fortuitous events corneal damage such as uncertain collision or concussion；(3), cornea the storage box bottom convex surface curvature and cornea convex surface are bent
Rate is consistent and equipped with the support filter that cornea is avoided to be contacted directly with inner wall, reduces corneal injury, maintains cornea complete to greatest extent
It is whole；(4), precise control of angular film Conservation environment, reaches the equal holding time, and the cornea of preservation is lived with higher endothelial cell
Property, improve preservation of cornea success rate；(5), Brilliant Eyes preservation of cornea device of the invention can properly preserve in vitro for a long time
It while cornea, is advantageously remotely transported, can farthest play the use value of in vitro cornea.
Description of the drawings
Fig. 1 is the structure diagram of the Brilliant Eyes preservation of cornea device of the present invention.
Fig. 2 is the structure diagram of the cornea the storage box of the Brilliant Eyes preservation of cornea device of the present invention.
Specific embodiment
Fig. 1 and Fig. 2 is refer to, a kind of non-limiting embodiment according to the present invention provides a kind of intelligent cornea
Save set, including：Shell 100, the inner casing 200 in shell, the interlayer being formed between shell 100 and inner casing 200
150。
Vibrationproof particle is filled in interlayer 150 to prevent the damage of the vibration corneal in transportational process.In inner casing 200 certainly
It is upper and under set gradually and be useful for the cornea holding room 300 for preserving in vitro cornea, for maintaining cornea holding room constant temperature
Refrigerating plant 500, for the uninterruptible power supply 600 of 500 continued power of refrigerating plant and being arranged at the appearance of shell 100
The control device 700 in face.
310, three one end of retractable sealing cover that cornea holding room 300 includes being installed on roof 301 are connected to cornea guarantor
The fixed link 330 for hiding the side wall of room 300, the other end for being connected to fixed link 330 are placed in 300 center of inside of cornea holding room
Fixed tray 335 and the cornea the storage box 800 being positioned on fixed tray 335.Filled with buffering in cornea holding room 300
Liquid, filled with preserving liquid in cornea the storage box 800.Cornea the storage box 800 can be put into cornea by retractable sealing cover 310 to protect
Hide room 300 in, it is necessary to when cornea the storage box 800 is taken out by retractable sealing cover 310 again.
Control device 700 is electrically connected with uninterruptible power supply 600, and control device 700 includes setting cornea holding room 300
Interior temperature and the parameter setting unit 710 of pressure and alarm unit 750.
In the non-limiting embodiment, control device 700 further comprises：For monitoring in cornea holding room 300
The pressure sensor 720 of pressure, gas bubble detection 730, Yi Jiyong for detecting the bubble of buffer solution in cornea holding room 300
In the temperature sensing unit 740 of temperature in detection cornea holding room 300.Pressure sensitive unit 720, bubble detection unit 730 with
And temperature sensing unit 740 is connected respectively with 750 signal of alarm unit.When pressure sensitive unit 720 and temperature sensing unit
When 730 pressure parameters detected or temperature parameter exceed 710 default parameter of parameter setting unit, start alarm unit 750.
, there are during bubble, start alarm unit 750 when bubble detection unit 740 detects buffer solution in cornea holding room 300.
As shown in Fig. 2, fixed tray 335 be equipped with 4 ear structures (non-label), cornea the storage box 800 be equipped with
4 card slots 850 that ear structure matches, the ear structure of fixed tray 335 are sticked in the card slot 850 of cornea the storage box 800
In cornea the storage box 800 is fixed on fixed tray 335, prevent cornea the storage box 800 from departing from fixed tray 335 because rocking.
Fixed tray 335 is domed downwards, and the bottom of cornea the storage box 800 is domed downwards, and the bottom of cornea the storage box 800 fits in
Fixed tray 330,800 bottom convex surface curvature of cornea the storage box are consistent with cornea convex curvature.800 inner wall of cornea the storage box is equipped with
Support filter 870 contacts directly to avoid the inner wall of cornea and cornea the storage box 800 and causes physical injury.
As a kind of alternative embodiments one, the temperature parameter of the setting of parameter setting unit 710 of control device 700
For -15 degrees Celsius, pressure parameter is 2.1 kPas.
As a kind of alternative embodiments two, the liquid that preserves in cornea the storage box is added with 0.6% sodium hyaluronate
Glycerite, the indoor buffer solution of cornea preservation are mixture of ice and water.
As a kind of alternative embodiments three, under uninterruptible power supply full power state, cornea the storage box can by opening
Folding sealing cover is inserted in cornea holding room.
As a kind of alternative embodiments four, cornea holding room is cylindrical shape.
As a kind of alternative embodiments five, inner casing, the shell of Brilliant Eyes preservation of cornea device fall material by shockproof, resistance to
It is made.
As a kind of alternative embodiments six, the support filter 870 in cornea the storage box 800 is by simulation human cornea
Elasticity and viscoelastic medical silica gel special prepare.
As a kind of alternative embodiments seven, the material of cornea the storage box 800 is by the elastic and viscous of simulation human body eyelid
It is prepared by the medical silica gel special of elasticity.
Although detailed description of the present invention preferred embodiment herein, it is to be understood that the invention is not limited in this
In the concrete structure being described in detail and show and step, without departing from the spirit and scope of the present invention can be by this field
Technical staff realize other modifications and variant.In addition, the temperature, pressure and other parameters in the present invention can be according to specifically used
Condition is suitably chosen in scope disclosed in this invention.
Claims (10)
1. a kind of Brilliant Eyes preservation of cornea device, which is characterized in that including：Shell, the inner casing in the shell are formed at
Interlayer between the shell and the inner casing；
Wherein, vibrationproof particle is filled in the interlayer to prevent the damage of the vibration corneal in transportational process；
It is set gradually from top to bottom in the inner casing and is useful for the cornea holding room for preserving in vitro cornea, for maintaining the angle
The refrigerating plant of film holding room constant temperature and for the uninterruptible power supply of the refrigerating plant continued power, the cornea
Holding room includes being installed on the retractable sealing cover of roof, at least three one end are connected to the side wall of the cornea holding room and consolidate
Fixed pole, be connected to the fixed link the other end be placed in the cornea holding room center of inside fixed tray and place
In being filled with buffer solution in the cornea the storage box on the fixed tray, the cornea holding room, filled out in the cornea the storage box
Filled with preservation liquid.
2. Brilliant Eyes preservation of cornea device as described in claim 1, which is characterized in that further comprise being arranged at the shell
Outer surface control device, the control device is electrically connected with the uninterruptible power supply, including for setting the cornea
The parameter setting unit and alarm unit of the indoor temperature of preservation and pressure.
3. Brilliant Eyes preservation of cornea device as claimed in claim 2, which is characterized in that the temperature of the parameter setting unit setting
It is -50~10 degrees Celsius to spend parameter, and pressure parameter is 1.3 kPas~2.80 kPas.
4. Brilliant Eyes preservation of cornea device as claimed in claim 3, which is characterized in that the control device further comprises：
Pressure sensor for monitoring the cornea preservation room pressure, the bubble for detecting buffer solution in the cornea holding room
Gas bubble detection and temperature sensing unit for detecting the cornea preservation indoor temperature, the pressure sensitive unit,
The bubble detection unit and the temperature sensing unit are connected respectively with the alarm unit signal；
Described in exceeding when the pressure parameter or temperature parameter that the pressure sensitive unit and the temperature sensing unit detect
During the default parameter of the parameter setting unit, start the alarm unit；
When the bubble detection unit detects buffer solution in the cornea holding room, there are during bubble, start the alarm dress
It puts.
5. Brilliant Eyes preservation of cornea device as claimed in claim 4, which is characterized in that the fixed tray is equipped with 2~4
Ear structure, the cornea the storage box are equipped with 2~4 card slots to match with the ear structure, the fixed tray
The ear structure is sticked in the card slot of the cornea the storage box cornea the storage box being fixed on the fixation
Pallet prevents the cornea the storage box from departing from the fixed tray because rocking.
6. Brilliant Eyes preservation of cornea device as claimed in claim 5, which is characterized in that the fixed tray is domed downwards,
The bottom of the cornea the storage box is domed downwards, and the bottom of the cornea the storage box fits in the fixed tray, the angle
Film the storage box bottom convex surface curvature is consistent with cornea convex curvature.
7. Brilliant Eyes preservation of cornea device as claimed in claim 6, which is characterized in that the cornea the storage box inner wall is equipped with branch
Support filter contacts directly to avoid the inner wall of cornea and the cornea the storage box and causes physical injury.
8. Brilliant Eyes preservation of cornea device as claimed in claim 7, which is characterized in that the guarantor in the cornea the storage box
Liquid storage is the glycerite added with 0.1%~1% sodium hyaluronate, and the indoor buffer solution of cornea preservation mixes for ice water
Close object.
9. such as Brilliant Eyes preservation of cornea device according to any one of claims 1 to 8, which is characterized in that the cornea preservation
Room is cylindrical shape or spherical shape.
10. Brilliant Eyes preservation of cornea device as claimed in claim 9, which is characterized in that the roof of the shell is provided with out
Mouthful the cornea the storage box is put into the cornea holding room.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711419276.3A CN108100481B (en) | 2017-12-25 | 2017-12-25 | Intelligent cornea preservation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711419276.3A CN108100481B (en) | 2017-12-25 | 2017-12-25 | Intelligent cornea preservation device |
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| CN108100481A true CN108100481A (en) | 2018-06-01 |
| CN108100481B CN108100481B (en) | 2023-10-31 |
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| CN201711419276.3A Active CN108100481B (en) | 2017-12-25 | 2017-12-25 | Intelligent cornea preservation device |
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Cited By (1)
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| CN114368536A (en) * | 2022-03-03 | 2022-04-19 | 蓝山中西医结合医院有限公司 | Intelligent cornea storage device |
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| Publication number | Publication date |
|---|---|
| CN108100481B (en) | 2023-10-31 |
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