CN108096533A - 一种缓慢治愈偏头痛的中药制剂及其制造方法 - Google Patents
一种缓慢治愈偏头痛的中药制剂及其制造方法 Download PDFInfo
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Abstract
本发明公开了一种缓慢治愈偏头痛的中药制剂及其制造方法,该中药制剂分为内服组份和外用组份两部分,其中内服组份制取原料按重量份计包括皂甙白头翁素8份‑10份、红花甙2份‑3份、全蝎粉0.5份‑0.8份、桔梗2份‑3份、姜黄0.5份‑0.8份、菌群浓度1×108cfu/ml‑1×109cfu/ml的副干酪乳杆菌菌剂0.2份‑0.3份;外用组份制取原料按重量份计包括牡荆子黄酮3份‑5份、制川乌5份‑8份、石菖蒲挥发油3份‑5份、酶质量分数5%的辅酶A水剂0.2份‑0.3份。本发明的缓慢治愈偏头痛的中药制剂吸收性好、里外相佐、治疗深度高、无耐药性、不反弹。
Description
技术领域
本发明属于中药领域,特别涉及一种缓慢治愈偏头痛的中药制剂及其制造方法。
背景技术
偏头痛是一种反复发作的搏动性头痛,属众多头痛类型中的一种,它发作前常有闪光、视物模糊、肢体麻木等先兆,约数分钟至1小时左右出现一侧头部一跳一挑的疼痛,并逐渐加剧,知道出现恶心、呕吐后,感觉才会有所好转,在安静、黑暗环境中或睡眠后头痛缓解,使患者痛苦不堪。在偏头痛的治疗上,西医常用苯噻啶、阿米替林等药物来治疗,基本上均有一些疗效,但是只能治标不能治本,而且这些药的副作用很多,尤其是对肝肾损伤很大,吸收性差、治疗不彻底、长期使用会产生耐药性、甚至导致病情更加恶化反弹。
因此,市面上急需一种吸收性好、里外相佐、治疗深度高、无耐药性、不反弹的缓慢治愈偏头痛的中药制剂及其制造方法。
发明内容
针对现有技术中存在的上述缺陷,本发明旨在提供一种吸收性好、里外相佐、治疗深度高、无耐药性、不反弹的缓慢治愈偏头痛的中药制剂及其制造方法。
为了实现上述目的,本发明采用以下技术方案:一种缓慢治愈偏头痛的中药制剂,该中药制剂分为内服组份和外用组份两部分,其中内服组份制取原料按重量份计包括皂甙白头翁素8份-10份、红花甙2份-3份、全蝎粉0.5份-0.8份、桔梗2份-3份、姜黄0.5份-0.8份、菌群浓度1×108cfu/ml-1×109cfu/ml的副干酪乳杆菌菌剂0.2份-0.3份;外用组份制取原料按重量份计包括牡荆子黄酮3份-5份、制川乌5份-8份、石菖蒲挥发油3份-5份、酶质量分数5%的辅酶A水剂0.2份-0.3份。
上述缓慢治愈偏头痛的中药制剂的方法,包括以下步骤:
1)生产前准备
①原料准备:按重量份准备皂甙白头翁素8份-10份、红花甙2份-3份、全蝎粉0.5份-0.8份、桔梗2份-3份、姜黄0.5份-0.8份、菌群浓度1×108cfu/ml-1×109cfu/ml的副干酪乳杆菌菌剂0.2份-0.3份、牡荆子黄酮3份-5份、制川乌5份-8份、石菖蒲挥发油3份-5份、酶质量分数5%的辅酶A水剂0.2份-0.3份;
②设备及工装准备:磁场发生装置、药臼;
2)内服组份制取
①将阶段1)步骤①准备的皂甙白头翁素、红花甙、全蝎粉、桔梗、姜黄、副干酪乳杆菌菌剂混合并搅拌均匀,放入阶段1)步骤②准备的药臼中,捣碎成内服组份药浆;
②将步骤①获得的药浆密封在25℃-28℃环境内,发酵4天-6天,获得升华药浆;
③将步骤②获得的升华药浆放入阶段1)步骤②准备的药臼中,静置至药浆干燥成渣,敲碎后研成细粉,该细粉即为所需内服组份;
3)外用组份制取
①将阶段1)步骤①准备的牡荆子黄酮、制川乌、石菖蒲挥发油混合并搅拌均匀,放入阶段1)步骤②准备的药臼中,捣碎成外用组份药浆;
②将步骤①获得的外用组份药浆采用文火熬制1h,滤除固含药渣后将药液煎至重量份15份,然后自然冷却后添加阶段1)步骤①准备的辅酶A水剂,形成外用待处理药膏;
③将步骤②获得的待处理药膏置于磁场发生装置中,施加1T-3T磁场,待续5h-6h,获得加磁外用药膏,该加磁外用药膏即为所需外用组份。
本发明的使用方法为,将内服组份采用开水冲服,一天三服,均于空腹时服用,早中晚各一服;外用药膏使用时间为睡前10分钟-15分钟,具体使用方式为采用不高于40℃的与药膏等质量的温水调和后喷洒在易发偏头痛的病源头皮上,然后带药入睡。
与现技术比较,本发明由于采用了上述方案,具有以下优点:(1)使用的不是常规的中药制剂,而是部分中药中的有效成份(皂甙白头翁素、红花甙、牡荆子黄酮、石菖蒲挥发油等作为快速吸收和根本治疗的主药)、辅助成份(全蝎粉、桔梗、姜黄、制川乌用于作为药引和臣药)及对应辅助菌剂(副干酪乳杆菌菌剂,主要作用于促进药性吸收、减少药剂刺激性、同时可以减少对黏膜的刺激),吸收性好、里外相佐、治疗深度高、无耐药性、不反弹。(2)所有有效成分各司其职,配合巧妙:皂甙白头翁素祛风除湿,通络止痛,利于调节人体,恢复正常内分泌(偏头痛的诱因一般是异常刺激导致的内分泌紊乱);红花甙对血小板聚集反应有抑制作用;因此对血栓形成有明显抑制效果,可以彻底清除由于末端血淤导致的阵发性、顽固性偏头痛;牡荆子黄酮对动脉环具有舒张作用,活血化瘀,理气通脉,可以调肠胃、顺五脏,固本培元,当用于外用时可以消除头部末端神经受损鞘部的阻淤,散除毒灶,睡前用于头皮上可以在睡梦中直达患处,长治久安;石菖蒲挥发油化湿通络,开窍豁痰,醒神益智,当用于外用时可以消除头部末端神经外端的压迫源,消除炎症、降低继发可能性,并提升睡眠质量,改善人体平衡;本发明中全蝎粉、姜黄共同作为内服药之药引,前者引导药效、后者疏通经络,便于本药更好地直达患处发挥作用;桔梗、制川乌则共同作为臣药,前者能宣肺,利咽,祛痰,排脓,后者能麻醉止痛,缓解药理作用带来的伤痛。(3)特别选用副干酪乳杆菌进行发酵处理,主要作用是利用副干酪乳杆菌生命活动分泌的产物促进药性吸收,次要作用是通过发酵作用消除药的火气,降低药伤同时可以减少对经络的刺激。(4)采用γ射线辐照能进一步消除药的火性,同时将有效成份的长链有机物打断为相对短的有机分子,使本发明获得药理药性相当的、更具活性的小分子组合体,便于更深入地吸收作用,从根上缓解病痛,另一方面小分子化后人体更易吸收,药效作用更快。最后还可以达到灭毒杀菌的作用。(5)外用药添加辅酶A是为促进头皮直接吸收及提升药理活性,帮助药性直达头皮根部偏头疼常发患处,结合偏头痛发生原理一般为末梢神经鞘部受损变敏感后,人体在受到外界刺激的情况下内分泌紊乱或神经紧张就易导致敏感末端痉挛性疼痛的原理,从根本上减少患处受到刺激的可能性和降低发作时的痛感。(6)施加磁场可以使药膏具备微弱有序的电磁场,在施加在头皮上后获得一定磁疗的效果,本质上是通过磁场相谐使药理作用经络舒缓,便于药效发挥和经络的保护。
具体实施方式
实施例1:
一种缓慢治愈偏头痛的中药制剂,该中药制剂分为内服组份和外用组份两部分,其中内服组份制取原料按重量计包括皂甙白头翁素0.8g、红花甙0.2g、全蝎粉0.05g、桔梗0.2g、姜黄0.05g、菌群浓度1×108cfu/ml-1×109cfu/ml的副干酪乳杆菌菌剂0.02g;外用组份制取原料按重量计包括牡荆子黄酮0.3g、制川乌0.5g、石菖蒲挥发油0.3g、酶质量分数5%的辅酶A水剂0.2g。
上述缓慢治愈偏头痛的中药制剂的方法,包括以下步骤:
1)生产前准备
①原料准备:按重量准备包括皂甙白头翁素0.8g、红花甙0.2g、全蝎粉0.05g、桔梗0.2g、姜黄0.05g、菌群浓度1×108cfu/ml-1×109cfu/ml的副干酪乳杆菌菌剂0.02g、牡荆子黄酮0.3g、制川乌0.5g、石菖蒲挥发油0.3g、酶质量分数5%的辅酶A水剂0.02g;
②设备及工装准备:磁场发生装置、药臼;
2)内服组份制取
①将阶段1)步骤①准备的皂甙白头翁素、红花甙、全蝎粉、桔梗、姜黄、副干酪乳杆菌菌剂混合并搅拌均匀,放入阶段1)步骤②准备的药臼中,捣碎成内服组份药浆;
②将步骤①获得的药浆密封在25℃环境内,发酵4天,获得升华药浆;
③将步骤②获得的升华药浆放入阶段1)步骤②准备的药臼中,静置至药浆干燥成渣,敲碎后研成细粉,该细粉即为所需内服组份;
3)外用组份制取
①将阶段1)步骤①准备的牡荆子黄酮、制川乌、石菖蒲挥发油混合并搅拌均匀,放入阶段1)步骤②准备的药臼中,捣碎成外用组份药浆;
②将步骤①获得的外用组份药浆采用文火熬制1h,滤除固含药渣后将药液煎至重量份15份,然后自然冷却后添加阶段1)步骤①准备的辅酶A水剂,形成外用待处理药膏;
③将步骤②获得的待处理药膏置于磁场发生装置中,施加1T磁场,待续5h,获得加磁外用药膏,该加磁外用药膏即为所需外用组份。
本发明的使用方法为,将内服组份采用开水冲服,一天三服,均于空腹时服用,早中晚各一服;外用药膏使用时间为睡前10分钟-15分钟,具体使用方式为采用不高于40℃的与药膏等质量的温水调和后喷洒在易发偏头痛的病源头皮上,然后带药入睡。以10天为一疗程,三个疗程为一个完全治疗阶段,30天后,80%左右的患者可以从根本上减少偏头痛发病频率2/3(即发病平均间隔为原先的三倍),即使发作时痛感也由重度降为中度。
实施例2:
一种缓慢治愈偏头痛的中药制剂,该中药制剂分为内服组份和外用组份两部分,其中内服组份制取原料按重量计包括皂甙白头翁素1g、红花甙0.3g、全蝎粉0.08g、桔梗0.3g、姜黄0.08g、菌群浓度1×108cfu/ml-1×109cfu/ml的副干酪乳杆菌菌剂0.03g;外用组份制取原料按重量计包括牡荆子黄酮0.5g、制川乌0.8g、石菖蒲挥发油0.5g、酶质量分数5%的辅酶A水剂0.03g。
上述缓慢治愈偏头痛的中药制剂的方法,包括以下步骤:
1)生产前准备
①原料准备:按重量份准备皂甙白头翁素1g、红花甙0.3g、全蝎粉0.08g、桔梗0.3g、姜黄0.08g、菌群浓度1×108cfu/ml-1×109cfu/ml的副干酪乳杆菌菌剂0.03g、牡荆子黄酮0.5g、制川乌0.8g、石菖蒲挥发油0.5g、酶质量分数5%的辅酶A水剂0.03g;
②设备及工装准备:磁场发生装置、药臼;
2)内服组份制取
①将阶段1)步骤①准备的皂甙白头翁素、红花甙、全蝎粉、桔梗、姜黄、副干酪乳杆菌菌剂混合并搅拌均匀,放入阶段1)步骤②准备的药臼中,捣碎成内服组份药浆;
②将步骤①获得的药浆密封在28℃环境内,发酵6天,获得升华药浆;
③将步骤②获得的升华药浆放入阶段1)步骤②准备的药臼中,静置至药浆干燥成渣,敲碎后研成细粉,该细粉即为所需内服组份;
3)外用组份制取
①将阶段1)步骤①准备的牡荆子黄酮、制川乌、石菖蒲挥发油混合并搅拌均匀,放入阶段1)步骤②准备的药臼中,捣碎成外用组份药浆;
②将步骤①获得的外用组份药浆采用文火熬制1h,滤除固含药渣后将药液煎至重量份15份,然后自然冷却后添加阶段1)步骤①准备的辅酶A水剂,形成外用待处理药膏;
③将步骤②获得的待处理药膏置于磁场发生装置中,施加3T磁场,待续6h,获得加磁外用药膏,该加磁外用药膏即为所需外用组份。
本发明的使用方法为,将内服组份采用开水冲服,一天三服,均于空腹时服用,早中晚各一服;外用药膏使用时间为睡前10分钟-15分钟,具体使用方式为采用不高于40℃的与药膏等质量的温水调和后喷洒在易发偏头痛的病源头皮上,然后带药入睡。以10天为一疗程,三个疗程为一个完全治疗阶段,30天后,75%左右的患者可以基本根治偏头痛,剩的还有占总测试数20%的患者可以减少偏头痛发病频率2/3(即发病平均间隔为原先的三倍),即使发作时痛感也由重度降为轻度。
对所公开的实施例的上述说明,仅为了使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的,本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下,在其它实施例中实现。因此,本发明将不会被限制于本文所示的这些实施例,而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (2)
1.一种缓慢治愈偏头痛的中药制剂的制造方法,其特征在于包括以下步骤:
1)生产前准备
①原料准备:按重量份准备皂甙白头翁素8份-10份、红花甙2份-3份、全蝎粉0.5份-0.8份、桔梗2份-3份、姜黄0.5份-0.8份、菌群浓度1×108cfu/ml-1×109cfu/ml的副干酪乳杆菌菌剂0.2份-0.3份、牡荆子黄酮3份-5份、制川乌5份-8份、石菖蒲挥发油3份-5份、酶质量分数5%的辅酶A水剂0.2份-0.3份;
②设备及工装准备:磁场发生装置、药臼;
2)内服组份制取
①将阶段1)步骤①准备的皂甙白头翁素、红花甙、全蝎粉、桔梗、姜黄、副干酪乳杆菌菌剂混合并搅拌均匀,放入阶段1)步骤②准备的药臼中,捣碎成内服组份药浆;
②将步骤①获得的药浆密封在25℃-28℃环境内,发酵4天-6天,获得升华药浆;
③将步骤②获得的升华药浆放入阶段1)步骤②准备的药臼中,静置至药浆干燥成渣,敲碎后研成细粉,该细粉即为所需内服组份;
3)外用组份制取
①将阶段1)步骤①准备的牡荆子黄酮、制川乌、石菖蒲挥发油混合并搅拌均匀,放入阶段1)步骤②准备的药臼中,捣碎成外用组份药浆;
②将步骤①获得的外用组份药浆采用文火熬制1h,滤除固含药渣后将药液煎至重量份15份,然后自然冷却后添加阶段1)步骤①准备的辅酶A水剂,形成外用待处理药膏;
③将步骤②获得的待处理药膏置于磁场发生装置中,施加1T-3T磁场,待续5h-6h,获得加磁外用药膏,该加磁外用药膏即为所需外用组份。
2.一种采用权利要求1所述方法制造的缓慢治愈偏头痛的中药制剂,其特征在于:该中药制剂分为内服组份和外用组份两部分,其中内服组份制取原料按重量份计包括皂甙白头翁素8份-10份、红花甙2份-3份、全蝎粉0.5份-0.8份、桔梗2份-3份、姜黄0.5份-0.8份、菌群浓度1×108cfu/ml-1×109cfu/ml的副干酪乳杆菌菌剂0.2份-0.3份;外用组份制取原料按重量份计包括牡荆子黄酮3份-5份、制川乌5份-8份、石菖蒲挥发油3份-5份、酶质量分数5%的辅酶A水剂0.2份-0.3份。
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