CN108091541A - A kind of array High-Field asymmetric waveform transference tube - Google Patents
A kind of array High-Field asymmetric waveform transference tube Download PDFInfo
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- CN108091541A CN108091541A CN201611040345.5A CN201611040345A CN108091541A CN 108091541 A CN108091541 A CN 108091541A CN 201611040345 A CN201611040345 A CN 201611040345A CN 108091541 A CN108091541 A CN 108091541A
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
Abstract
The invention discloses a kind of new array High-Field asymmetric waveform transference tubes, including ionized region, Disengagement zone, detection zone etc., are in axial direction arranged in order.Separation electrode pair in cylindrical shape external electrode and cylinder of the Disengagement zone by two or more and positioned at coaxial arrangement on electrode is formed；Detecting electrode in cylindrical shape external electrode and cylinder of the detection zone by two or more and positioned at coaxial arrangement on electrode is to forming.At least one per a pair of separated electrode pair is ground electrode, at least one electrode is high pressure asymmetric field electrode.Apply positive bias voltage to an electrode per a pair of detecting electrode, an electrode applies negative bias voltage.The present invention can provide two or more sense channels simultaneously, be measured while realizing multiple compounds, shorten detection cycle；It is simple in structure, small, easy to process and industrialization promotion.
Description
Technical field
The present invention relates to atmospheric pressure separate analytical technique, specifically a kind of novel combination type High-Field asymmetric waveform from
Sub- migration tube designs and produces technology, and the sense channel of the array High-Field asymmetric waveform transference tube is using one in structure
Bodyization designs, have integrated gas access, ion source, two and more than two separation electrode pairs, two and two with
On detecting electrode to, gas vent etc., realize opposed polarity ion and detect simultaneously, improve instrument detection applies model
It encloses；It is detected while realizing polyion using multiple separation electrodes and detecting electrode, so as to shorten detection time.
Background technology
High-Field asymmetric waveform ion mobility spectrometry is to continue to develop the object of getting up based on conventional ion migration spectral technology
Matter analysis and detection technology, first public report is in 1993, by propositions such as former Soviet Union Buryakov.It is in height based on ion
Field (E/N>40Td, 1Td=10- 17Vcm2), low field (E/N<2Td) intermediate ion mobility change realizes the detection of different material.
The principle of asymmetric field ion mobility spectrometry is as follows：The mobility of ion can be expressed as：
K=K0(1+α)
Wherein, K be High-Field under ion mobility, K0It is ionic mobility under High-Field for the mobility of ion under low field
Compared with the change rate under low field, value can just be born, different due to substance.α=0 under low field.
Make substance ion perpendicular to direction of an electric field by drift region with carrier gas, drift region applies with the non-of the positive and negative switching of radio frequency
SYMMETRICAL FIELD, in entire rf period, the time average of voltage is zero.In this way, in the section of height place, ion is with mobility K
There is a vertical displacement along electric field, still, if High-Field is different from the mobility under low field, ion generally will in one cycle
Perpendicular to the upward out original position in side, a net displacement is generated.By the accumulation of certain time, this displacement of ion
It will be made to get on pole plate and be neutralized.In order to which this ion is made to pass through detection zone, can be superimposed on original electric field
One DC electric field when added DC electric field where appropriate, the net displacement of ion in vertical direction is zero, and then can pass through
Sense channel is detected.By scanning above-mentioned DC electric field, it is possible to detect different ions.
High-Field asymmetric waveform Ion mobility spectrometry has detection sensitivity high, and equipment is simple, small, convenient for taking
Band, the advantages such as testing cost is low, is increasingly valued by people.At present, it can be employed the monitoring of explosive, and drugs are checked
It looks into, many fields such as detection of biochemical war agent.At present, the High-Field asymmetric waveform ion mobility spectrometry of document and patent report includes
Slab construction (200910086487.9,201310191739.0), cylindrical structural (200810229883.8).Tablet before this
Constructional device only realizes the detection of single polarity (electrophilicity or protophilia) ion.In order to improve detection speed, subtract
Small analysis time, patent 200810229883.8 propose a kind of parallel, combination in series formula High-Field asymmetric waveform ion
Migration tube, by the ground electrode sleeve for setting two or two or more；But due to be shunted to sample, target can be reduced
Compound concentration causes detection sensitivity to decline.
The present invention provides a kind of array High-Field asymmetric waveform transference tubes, are processed by integrated design, real
Now more compounds measure simultaneously, reduce analysis time, realize high throughput analysis.
The content of the invention
It is an object of the present invention to provide a kind of multi-channel assembled High-Field asymmetric waveform transference tube, migration tubes of the present invention
Ion transfer separation and detection sense channel using the integrated design in structure, realize binary channels or multichannel examined simultaneously
It surveys, reduces rate of false alarm, improve the accuracy and application range of instrument detection.
To achieve the above object, the technical solution adopted by the present invention is：
A kind of array High-Field asymmetric waveform transference tube, including the ionized region of order setting, Disengagement zone, inspection successively
Survey area, it is characterised in that：
Disengagement zone includes electrode in the cylindrical shape external electrode and cylinder of coaxial arrangement, and electrode is set in cylinder in cylinder
In shape external electrode, Disengagement zone is in cylindrical shape external electrode inner surface and cylinder between electrode outer surface；
Electrode, the first separation electrode are separated in being equipped with N number of bar shaped sheet first in cylinder on electrode outer surface vertically
Radial section to be arc-shaped, one side surface is fitted in cylinder completely on electrode outer surface；In in cylindrical shape external electrode
N number of bar shaped sheet second is equipped on surface vertically and separates electrode, the radial section of the second separation electrode is arc-shaped, one side
Surface is fitted in completely on cylindrical shape external electrode inner surface；First separation electrode separates electrode with second and is oppositely arranged one by one, structure
Into separation electrode pair, and the arc of the first separation electrode circular section for separating electrode with second in same separation electrode pair
It spends equal；
Detection zone includes electrode in the cylindrical shape external electrode and cylinder of coaxial arrangement, and electrode is set in cylinder in cylinder
In shape external electrode, detection zone is in cylindrical shape external electrode inner surface and cylinder between electrode outer surface；
In in cylinder on electrode outer surface vertically be equipped with N number of the first detecting electrode of bar shaped sheet, the first detecting electrode
Radial section to be arc-shaped, one side surface is fitted in cylinder completely on electrode outer surface；In in cylindrical shape external electrode
N number of the second detecting electrode of bar shaped sheet is equipped on surface vertically, the radial section of the second detecting electrode is arc-shaped, one side
Surface is fitted in completely on cylindrical shape external electrode inner surface；First detecting electrode is oppositely arranged one by one with the second detecting electrode, structure
Into detecting electrode pair, and the arc of the circular section of internal the first detecting electrode of same detecting electrode and the second detecting electrode
It spends equal；
N is the integer more than or equal to 2；
N number of separation electrode pair and N number of detecting electrode are set to corresponding along transference tube axial order, and opposite
Radian phase of the radian of the circular section for the detecting electrode centering electrode answered with separating the circular section of electrode in electrode pair
Deng.
Bucking electrode is equipped between separation electrode pair and detecting electrode pair；It is non-right for high pressure to separate an electrode in electrode pair
Claim field radio-frequency electrode, another electrode is ground electrode；It is each separation electrode pair it is mutual indepedent, in electrode pair ground electrode by conducting wire with
The earth is connected, and high-field electrode is connected by conducting wire with High-Field asymmetrical power supplies and DC compensation power supply；Between separation electrode pair
Spacing is 0.001 to 5mm.
The one end of ion source away from detection zone is provided with gas access, detection zone is provided with gas away from ion source one end
Outlet；Gas vent and gas access are located at two side of left and right of High-Field asymmetric waveform transference tube respectively.
Each detecting electrode applies positive bias voltage to mutual indepedent on an electrode in electrode pair, another electrode applies negative
Bias voltage；Spacing between detecting electrode pair is 0.001-5mm.
The positive bias voltage amplitude is 0 to 50V；Negative bias voltage is -50 between 0V.
Double sense channels that combined type high-field asymmetric waveform migration tube of the present invention is formed use integrated design in structure,
Gas access, ion source, migration area, high pressure asymmetric field electrode, Faraday plate, gas vent with combined integral etc.
Component detects while realizing double sense channels.Identical ion may be employed in combined type high-field asymmetric waveform migration tube
Injection mode, the separation of opposed polarity ion and ioncollection mode.In some of the invention or several electrode sleeves
One or more of dopants can simultaneously or separately be added or use different carrier gas, detectability can be greatly improved.
It is an advantage of the invention that：
1. design realizes the array High-Field asymmetric waveform transference tube of integrated design；
2. realizing the ion of the positive and negative polarity of multi-channel detection, electrophilicity and protophilia substance can be detected simultaneously,
Detection range is not only expanded, but also improves the efficiency of detection, shortens analysis time；
3. realize analysis multiple compounds in the same time, it is suitable for the same of multiple target compounds in mixed system
When detect；
4. it is the configuration of the present invention is simple, easy to process, it is easy to mass production；
The present invention can two and more than two sense channels, realize multiple compounds while measure, shorten analysis
Cycle improves analysis efficiency, realizes the quick analysis of batch samples；In addition, the present invention can also be directed to same compound,
Apply different High-Field asymmetrical wave radio frequency high tensions to upper in Different electrodes, the two of offset voltage and radio-frequency voltage is obtained in the short time
Position spectrogram improves identification accuracy.The new High-Field asymmetric waveform ion mobility spectrometry can reduce temperature, environment, drift gas
Etc. parameters influence, be particularly suitable for the environment of high humidity of air, so as to fulfill the high sensitivity to determinand and high identify
Accuracy.
Description of the drawings
Fig. 1 is the schematic diagram of array High-Field asymmetric waveform transference tube；
Specific embodiment
The schematic diagram of the array High-Field asymmetric waveform transference tube of the present invention is as shown in Figure 1.
A kind of array High-Field asymmetric waveform transference tube, including the ionized region 10 of order setting, Disengagement zone successively
11st, detection zone 12, Disengagement zone 11 include electrode in the cylindrical shape external electrode and cylinder of coaxial arrangement, and electrode is worn in cylinder
In in cylindrical shape external electrode, Disengagement zone 11 is in cylindrical shape external electrode inner surface and cylinder between electrode outer surface；
Electrode 6 ', the first separation electricity are separated in being equipped with N number of bar shaped sheet first in cylinder on electrode outer surface vertically
The radial section of pole 6 ' is arc-shaped, and one side surface is fitted in cylinder completely on electrode outer surface；In cylindrical shape dispatch from foreign news agency
N number of bar shaped sheet second is equipped on the inner surface of pole vertically and separates electrode 6, second separates the radial section of electrode 6 to be arc-shaped,
One side surface is fitted in completely on cylindrical shape external electrode inner surface；First separation electrode 6 ' separates the phase one by one of electrode 6 with second
To setting, the separation electrode pair of composition, and the circle that the first separation electrode 6 ' in same separation electrode pair separates electrode 6 with second
The radian of arc section is equal；
Detection zone 12 includes electrode in the cylindrical shape external electrode and cylinder of coaxial arrangement, and electrode is set in circle in cylinder
In tubular external electrode, detection zone 12 is in cylindrical shape external electrode inner surface and cylinder between electrode outer surface；
In being equipped with N number of the first detecting electrode 8 ' of bar shaped sheet in cylinder on electrode outer surface vertically, the first detection is electric
The radial section of pole 8 ' is arc-shaped, and one side surface is fitted in cylinder completely on electrode outer surface；In cylindrical shape dispatch from foreign news agency
Be equipped with N number of the second detecting electrode of bar shaped sheet 8 on the inner surface of pole vertically, the radial section of the second detecting electrode 8 be it is arc-shaped,
One side surface is fitted in completely on cylindrical shape external electrode inner surface；First detecting electrode 8 ' and the second detecting electrode 8 phase one by one
To setting, the circle of the first internal detecting electrode 8 ' of the detecting electrode pair of composition, and same detecting electrode and the second detecting electrode 8
The radian of arc section is equal；
N is the integer more than or equal to 2；
N number of separation electrode pair and N number of detecting electrode are set to corresponding along transference tube axial order, and opposite
Radian phase of the radian of the circular section for the detecting electrode centering electrode answered with separating the circular section of electrode in electrode pair
Deng.
Bucking electrode 9 is equipped between separation electrode pair and detecting electrode pair；It is non-for high pressure to separate an electrode in electrode pair
SYMMETRICAL FIELD radio-frequency electrode, another electrode are ground electrode；Each separation electrode pair is mutual indepedent, and ground electrode passes through conducting wire in electrode pair
It is connected with the earth, high-field electrode is connected by conducting wire with High-Field asymmetrical power supplies and DC compensation power supply；Between separation electrode pair
Spacing for 0.001 to 5mm.
The one end of ion source 2 away from detection zone is provided with gas access 1, detection zone is provided with gas away from ion source one end
Body outlet 7；Gas vent 7 and gas access 1 are located at two side of left and right of High-Field asymmetric waveform transference tube respectively.
Each detecting electrode applies positive bias voltage to mutual indepedent on an electrode in electrode pair, another electrode applies negative
Bias voltage；Spacing between detecting electrode pair is 0.001-5mm.
The positive bias voltage amplitude is 0 to 50V；Negative bias voltage is -50 to 0V.
During measurement, sample is ionized in ionized region 10, and Disengagement zone 11 is then entered under carrier gas rolling action；Migration
Different High-Field asymmetric waveforms is applied on an electrode in area 11 in two or more separation electrode pairs above to penetrate
Frequency voltage and a compensating direct current voltage, another electrode ground connection；So separated in N number of bar shaped sheet second separation electrode 6 and first
Electric field in N number of different Disengagement zone between electrode 6 ' is different, and the ion for allowing mobility change different is by realizing different
It is separated while compound；Detection zone 12 is entered by the ion of Disengagement zone 11, negative ions are distinguished under bias voltage effect
Detecting electrode 8 and 8 ' is reached to detect.Tail gas is discharged by gas vent 7.
Claims (5)
1. a kind of array High-Field asymmetric waveform transference tube, including the ionized region (10) of order setting, Disengagement zone successively
(11), detection zone (12), it is characterised in that：
Disengagement zone (11) includes electrode in the cylindrical shape external electrode and cylinder of coaxial arrangement, and electrode is set in cylinder in cylinder
In shape external electrode, Disengagement zone (11) are in cylindrical shape external electrode inner surface and cylinder between electrode outer surface；
In being equipped with N number of bar shaped sheet first separation electrode (6 ') in cylinder on electrode outer surface vertically, first separates electrode
The radial section of (6 ') is arc-shaped, and one side surface is fitted in cylinder completely on electrode outer surface；In cylindrical shape dispatch from foreign news agency
N number of bar shaped sheet second separation electrode (6) is equipped on the inner surface of pole vertically, the radial section of the second separation electrode (6) is circle
Arc, one side surface are fitted in completely on cylindrical shape external electrode inner surface；First separation electrode (6 ') separates electrode with second
(6) it is oppositely arranged one by one, the separation electrode pair of composition, and the first separation electrode (6 ') in same separation electrode pair and second point
The radian of circular section from electrode (6) is equal；
Detection zone (12) includes electrode in the cylindrical shape external electrode and cylinder of coaxial arrangement, and electrode is set in cylinder in cylinder
In shape external electrode, detection zone (12) is in cylindrical shape external electrode inner surface and cylinder between electrode outer surface；
In in cylinder on electrode outer surface vertically be equipped with N number of the first detecting electrode of bar shaped sheet (8 '), the first detecting electrode
The radial section of (8 ') is arc-shaped, and one side surface is fitted in cylinder completely on electrode outer surface；In cylindrical shape dispatch from foreign news agency
N number of the second detecting electrode of bar shaped sheet (8) is equipped on the inner surface of pole vertically, the radial section of the second detecting electrode (8) is circle
Arc, one side surface are fitted in completely on cylindrical shape external electrode inner surface；First detecting electrode (8 ') and the second detecting electrode
(8) it is oppositely arranged one by one, the detecting electrode pair of composition, and the first detecting electrode (8 ') of same detecting electrode internally and the second inspection
The radian for surveying the circular section of electrode (8) is equal；
N is the integer more than or equal to 2；
N number of separation electrode pair and N number of detecting electrode are set to corresponding along transference tube axial order, and corresponding
The radian of the circular section of detecting electrode centering electrode is equal with the radian for separating the circular section of electrode in electrode pair.
2. transference tube as described in claim 1, it is characterised in that：
Bucking electrode (9) is equipped between separation electrode pair and detecting electrode pair；It is non-right for high pressure to separate an electrode in electrode pair
Claim field radio-frequency electrode, another electrode is ground electrode；It is each separation electrode pair it is mutual indepedent, in electrode pair ground electrode by conducting wire with
The earth is connected, and high-field electrode is connected by conducting wire with High-Field asymmetrical power supplies and DC compensation power supply；Between separation electrode pair
Spacing is 0.001 to 5mm.
3. transference tube as described in claim 1, it is characterised in that：
The one end of ion source (2) away from detection zone is provided with gas access (1), detection zone is provided with gas away from ion source one end
Body exports (7)；Gas vent (7) and gas access (1) are located at two side of left and right of High-Field asymmetric waveform transference tube respectively.
4. transference tube as described in claim 1, it is characterised in that：Each detecting electrode is to mutual indepedent, one in electrode pair
Apply positive bias voltage on electrode, another electrode applies negative bias voltage；Spacing between detecting electrode pair is 0.001-5mm.
5. bias voltage as claimed in claim 4, it is characterised in that：The positive bias voltage amplitude is 0 to 50V；Negative bias
Voltage is put -50 between 0V.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420424A (en) * | 1994-04-29 | 1995-05-30 | Mine Safety Appliances Company | Ion mobility spectrometer |
| US20070252082A1 (en) * | 2003-11-25 | 2007-11-01 | Sionex Corporation | Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample |
| US20090108195A1 (en) * | 2005-02-17 | 2009-04-30 | Roger Guevremont | Apparatus and method for forming a gas composition gradient between faims electrodes |
| US20100264306A1 (en) * | 2009-03-13 | 2010-10-21 | University Of Florida Research Foundation, Inc. | Pneumatic ion beam focusing in high-field asymmetric waveform ion mobility spectrometry (faims) |
| WO2013176580A1 (en) * | 2012-05-22 | 2013-11-28 | Закрытое Акционерное Общество "Инновационный Центр "Бирюч" (Зао "Инновационный Центр "Бирюч") | Differential ion mobility spectrometer |
| CN104538274A (en) * | 2014-12-31 | 2015-04-22 | 清华大学 | Separation voltage applying method for high-field asymmetric waveform ion mobility spectrometer |
-
2016
- 2016-11-21 CN CN201611040345.5A patent/CN108091541B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420424A (en) * | 1994-04-29 | 1995-05-30 | Mine Safety Appliances Company | Ion mobility spectrometer |
| US20070252082A1 (en) * | 2003-11-25 | 2007-11-01 | Sionex Corporation | Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample |
| US20090108195A1 (en) * | 2005-02-17 | 2009-04-30 | Roger Guevremont | Apparatus and method for forming a gas composition gradient between faims electrodes |
| US20100264306A1 (en) * | 2009-03-13 | 2010-10-21 | University Of Florida Research Foundation, Inc. | Pneumatic ion beam focusing in high-field asymmetric waveform ion mobility spectrometry (faims) |
| WO2013176580A1 (en) * | 2012-05-22 | 2013-11-28 | Закрытое Акционерное Общество "Инновационный Центр "Бирюч" (Зао "Инновационный Центр "Бирюч") | Differential ion mobility spectrometer |
| CN104538274A (en) * | 2014-12-31 | 2015-04-22 | 清华大学 | Separation voltage applying method for high-field asymmetric waveform ion mobility spectrometer |
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