CN203929711U - The ion mobility spectrometry apparatus in a kind of surface desorption atmospheric chemical ionization source - Google Patents
The ion mobility spectrometry apparatus in a kind of surface desorption atmospheric chemical ionization source Download PDFInfo
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- CN203929711U CN203929711U CN201420130981.7U CN201420130981U CN203929711U CN 203929711 U CN203929711 U CN 203929711U CN 201420130981 U CN201420130981 U CN 201420130981U CN 203929711 U CN203929711 U CN 203929711U
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- 238000003795 desorption Methods 0.000 title claims abstract description 31
- 238000000451 chemical ionisation Methods 0.000 title claims abstract description 29
- 238000001871 ion mobility spectroscopy Methods 0.000 title claims abstract description 25
- 238000000926 separation method Methods 0.000 claims abstract description 33
- 238000002347 injection Methods 0.000 claims abstract description 6
- 239000007924 injection Substances 0.000 claims abstract description 6
- 230000005012 migration Effects 0.000 claims description 18
- 238000013508 migration Methods 0.000 claims description 18
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Abstract
The utility model discloses the ion mobility spectrometry apparatus in a kind of surface desorption atmospheric chemical ionization source, belong to trace materials detection field, comprise sample introduction device, ionization source and the separation detecting device for the treatment of measured ion, sample introduction device is positioned under the ionization district of separation detecting device, and be connected by rubber tube, described ionization source is surface desorption atmospheric chemical ionization device, the ionization district end face of this ionization device and separation detecting device closely cooperates, and the ionization needle discharge end of ionization device is arranged in directly over the injection port of ionization district sample introduction device of this separation detecting device.The utility model is on the basis of conventional ion mobility spectrometer, by provide a kind of highly sensitive, selectivity good, the scope of application is wide, simple to operate, harmless free of contamination surface desorption atmospheric chemical ionization source proposes a kind of novel ion mobility spectrometry apparatus, realizes the fast detecting to Trace Organic Compounds.
Description
Technical field
The utility model relates to a kind of ion mobility spectrometry apparatus of novel ionization source, specifically be applied in a kind of surface desorption atmospheric chemical ionization source on ionic migration spectrometer, and with the separation detecting device of ionic migration spectrometer can fine coupling trace compound device for fast detecting.
Background technology
In recent years, attack of terrorism activity occurred repeatedly, and drug trade smuggling activity is becoming increasingly rampant, and ecological deterioration is on the rise, many countries and department all at a kind of quick, portable, sensitive, safe detecting instrument of Study on Acceleration to these processes are controlled.In general, this detection can be divided into two kinds of fundamental types: a class is the detection to large explosive or drugs etc., and this can realize by X ray, gamma-ray detection technology or neutron imaging technology, in many occasions, has obtained application; Another kind of is that the gaseous molecular of measured object object or particle are made to trace detection, is the high-sensitivity detection based on molecular level.For a rear class detection technique, at present also in continuous exploration and improvement stage, can adopt chemoluminescence method, mass spectrometry and electrochemical process etc. technically, yet these detection techniques or need the sample pretreatment process of long period, or because instrument volume is large, expensive etc. former thereby cannot meet in real time, on-the-spot, fast detecting.
Ion mobility spectrometry (Ion Mobility Spectrometry, IMS) be a kind of trace chemistry material Detection Techniques that grow up in early 1970s, it is mainly to characterize various chemical substance by gaseous ion mobility, to realize the object to the analyzing and testing of various chemical substances.The many merits such as IMS is highly sensitive with it, detection speed is fast, volume is little, low in energy consumption, are widely used in the fast detecting of explosive, drugs, chemical warfare agent and environmental contaminants.The ionic migration spectrometer detecting for ion mobility spectrometry is generally comprised of six major parts such as sample drawing-in system, ionization source, ion gate, ion migration area, detecting device, Data Acquisition and Conversion System (DACS).The developing history of ion mobility spectrometry shows, the development of new ionization source and exploitation have the meaning of particular importance.The widely used ionization source of traditional ionic migration spectrometer is radioactive
63ni source, it has the advantages such as good stability, energy consumption is low, noiselessness disturbs, be simple and easy to use.But this ionization source ionic strength is low, the range of linearity is narrow, especially has radioactive contamination, thereby limited it, applies.
Utility model content
In order to overcome the deficiency that in existing ionic migration spectrometer, ionization source exists, the utility model provides a kind of ion mobility spectrometry apparatus that uses surface desorption atmospheric chemical ionization source.Its concrete scheme is as follows:
The ion mobility spectrometry apparatus in a kind of surface desorption atmospheric chemical ionization source, comprise sample introduction device, ionization source and treat the separation detecting device of measured ion, sample introduction device is positioned under the ionization district of separation detecting device, and be connected by rubber tube, described ionization source is surface desorption atmospheric chemical ionization device, the ionization district end face of this ionization device and separation detecting device closely cooperates to guarantee sealing, and the ionization needle discharge end of ionization device is arranged in directly over the injection port of ionization district sample introduction device of this separation detecting device.
Described surface desorption atmospheric chemical ionization device is provided with fixed mount, ionization tube and the ionization needle of coaxial placement, and ionization needle is placed in ionization tube inside, and ionization tube is fixed on vertical with it fixed mount, and coordinates with separation detecting device by fixed mount.
Ionization tube is an elongated hollow tube, and its front end stretches into the ionization district of separation detecting device, back-end sealing, and middle part is provided with gas interface.
Described ionization needle is the spray point of NI-G metal, is coaxially placed in the hollow tube chamber of ionization tube, and ionization needle front end discharge end stretches out ionization tube and stretches into the ionization district of the separation detecting device for the treatment of measured ion, and ionization needle rear end connects high-voltage power supply.
Fixed mount sealing is arranged on the ionization district end face of the separation detecting device for the treatment of measured ion.
Describedly treating that the separation detecting device of measured ion is the part except sample drawing-in system and radioactive ionization gauge source in conventional ion mobility spectrometer, is the general designation of conventional ion mobility spectrometer intermediate ion door, ion migration area, detecting device, data acquisition and control system.
The cavity migration tube that described ion migration area is comprised of several stainless steel metal rings and dead ring alternative arrangement, internal diameter 1cm, length 7-8cm; In migration tube, be equipped with the uniform electric field of 200-210V/cm, zone of heating is established in migration tube outside, and heating-up temperature is 140 ℃.
The utility model has the advantage of: 1, the utility model has substituted radioactive ionization gauge source with novel surface desorption atmospheric chemical ionization device in traditional ionic migration spectrometer, improved the performance of ionic migration spectrometer, eliminated and used the potential threat of radioactive ionization gauge source to operator.2, the utility model ionization device adopts surface desorption atmospheric chemical ionization mode, simple in structure, is easy to realize, and can dismantles easily and re-assembly.What 3, in surface desorption atmospheric chemical ionization device, use is all conventional laboratory equipment, and cost is low.
Accompanying drawing explanation
Fig. 1 is the utility model structural representation.
In figure, 1-sample introduction device, 2-surface desorption atmospheric chemical ionization device, 3-treats the separation detecting device of measured ion.
Embodiment
Below in conjunction with accompanying drawing, embodiment of the present utility model is described, in figure, the device of identical 26S Proteasome Structure and Function marks with identical Reference numeral, accompanying drawing is just for helping to explain the utility model, do not represent the restriction of the utility model scope, accompanying drawing is signal simultaneously, and draws not in scale.
The utility model proposes the ion mobility spectrometry apparatus in a kind of surface desorption atmospheric chemical ionization source, the sample introduction device 1 and the separation detecting device 3 for the treatment of measured ion that comprise equally conventional ion mobility spectrometer, on this basis, the utility model has increased novel surface desorption atmospheric chemical ionization device 2 as ionization source (replacing primary emission ionization source), shown in Figure 1;
In the utility model, sample introduction device 1 is identical with the sample drawing-in system of conventional ion mobility spectrometer, adopt the air-breathing sample introduction of circulation, and heating, the temperature of controlling sampling device of the control system by ionic migration spectrometer controls and assist gas flow is controlled, and on sample introduction device 1, puts permoselective membrane.
Ionization device 2 comprises ionization needle 22, ionization tube 23 and fixed mount 24, and ionization device 2 is by fixed mount 24 and treat that the separation detecting device 3 of measured ion closely cooperates, and ionization needle 22 is directly over sample introduction device 1; Ionization tube 23 is an elongated hollow tube, and its front end stretches into the ionization district of separation detecting device 3, back-end sealing, and middle part is provided with gas interface 25 for introducing auxiliary desorption gas; Ionization needle 22 is the spray point of material NI-G metal, coaxially be placed in the hollow tube chamber of ionization tube 23, the ionization district that ionization needle front end discharge end stretches out ionization tube 23 and stretches into the separation detecting device 3 for the treatment of measured ion is positioned at directly over the injection port of sampling device 1, and ionization needle 22 rear ends connect high-voltage power supplies; Fixed mount 24 sealings are arranged on the ionization district end face of the separation detecting device 3 for the treatment of measured ion.
The separation detecting device 3 for the treatment of measured ion comprises the part except sample drawing-in system and radioactive ionization gauge source in conventional ionic migration spectrometer, and soon conventional ion mobility spectrometer intermediate ion door (the ion fence gate shown in Fig. 1), ion migration area (drift region shown in Fig. 1), detecting device, Data Acquisition and Conversion System (DACS) general designation are treated the separation detecting device of measured ion.In the utility model, the cavity migration tube that ion migration area (drift region) is comprised of several stainless steel metal rings (focusing ring shown in Fig. 1) and dead ring alternative arrangement, internal diameter 1cm, length 7-8cm; In migration tube, be equipped with the uniform electric field of 200-210V/cm, zone of heating is established in migration tube outside, and heating-up temperature is 140 ℃.
In the utility model, the separation detecting device 3 for the treatment of measured ion is connected with sample introduction device 1 by rubber tube, the injection port installing permoselective membrane of sample introduction device 1 is for removing most of moisture and the amino molecule that sucks gas, and inhibition forms ion cluster and then improves the resolution of instrument; The ionization needle 22 of surface desorption atmospheric chemical ionization device 2 is placed in ionization tube 23 inside, and ionization tube 23 is fixed on vertical with it fixed mount 24, and closely cooperates by fixed mount 24 and separation detecting device 3.By above assembling, obtain surface desorption atmospheric chemical ionization ion mobility spectrometry apparatus.
While utilizing this device to test, the operation steps of taking is:
1, assembling surface desorption atmospheric chemical ionization ion mobility spectrometry apparatus;
2, open ion mobility spectrometry apparatus, wait for that ionization tube temperature, injector temperature, desorption temperature, migration gas etc. arrive setting value;
3, ionization needle is imposed to the high pressure of 3KV-5KV, make the aerosol ionization in ionization district;
4, sample is put into sample introduction device, by injection port to sample introduction in ion mobility spectrometry apparatus;
5, from ion mobility spectrometry apparatus, obtain and preserve testing result.
Utilize the utility model first the test substance ionization collecting to be made it to produce product ion, product ion is separated under the effect of electric field, thereby finally owing to reaching the asynchronism(-nization) of detecting device, realizes the fast detecting to Trace Organic Compounds.For example, utilize the utility model device to show the testing result of trace explosive TNT, compare with traditional radioactive ionization gauge source ion migration spectral apparatus, detection limit improves an order of magnitude, has reached pg magnitude.
The surface desorption atmospheric chemical ionization ion mobility spectrometry apparatus that the utility model provides, for ionic migration spectrometer provides a kind of novel ionization device, this ionization technique is by adopting spray point to flow at surface collision Ion reagent (air, water vapor etc.) corona discharge generation ion a fluid stream and sample, thereby thereby being extracted to ionization, the determinand in sample makes determinand generation ionization, produce the ion of determinand, owing to adopting spray point corona discharge to there is very high ionizing power, can be by even biomacromolecule ionization of non-polar molecule; Meanwhile, the utility model ionization device compact conformation, simple to operate, easy to use, can ionize analysis to various sample for references.
What deserves to be explained is; above-described embodiment is only for the utility model; wherein each modular construction, connected mode all can change to some extent, and every equivalents of carrying out on the basis of technical solutions of the utility model and improvement, all should not get rid of outside protection domain of the present utility model.
Claims (7)
1. the ion mobility spectrometry apparatus in a surface desorption atmospheric chemical ionization source, comprise sample introduction device, ionization source and treat the separation detecting device of measured ion, sample introduction device is positioned under the ionization district of separation detecting device, and be connected by rubber tube, it is characterized in that: described ionization source is surface desorption atmospheric chemical ionization device, the ionization district end face of this ionization device and separation detecting device closely cooperates, and the ionization needle discharge end of ionization device is arranged in directly over the injection port of ionization district sample introduction device of this separation detecting device.
2. the ion mobility spectrometry apparatus in surface desorption atmospheric chemical ionization according to claim 1 source, it is characterized in that: described surface desorption atmospheric chemical ionization device is provided with fixed mount, ionization tube and the ionization needle of coaxial placement, ionization needle is placed in ionization tube inside, ionization tube is fixed on vertical with it fixed mount, and coordinates with separation detecting device by fixed mount.
3. the ion mobility spectrometry apparatus in surface desorption atmospheric chemical ionization source according to claim 2, is characterized in that: ionization tube is an elongated hollow tube, and its front end stretches into the ionization district of separation detecting device, back-end sealing, and middle part is provided with gas interface.
4. the ion mobility spectrometry apparatus in surface desorption atmospheric chemical ionization according to claim 3 source, it is characterized in that: described ionization needle is the spray point of NI-G metal, coaxially be placed in the hollow tube chamber of ionization tube, ionization needle front end discharge end stretches out ionization tube and stretches into the ionization district of the separation detecting device for the treatment of measured ion, and ionization needle rear end connects high-voltage power supply.
5. the ion mobility spectrometry apparatus in surface desorption atmospheric chemical ionization according to claim 4 source, is characterized in that: fixed mount sealing is arranged on the ionization district end face of the separation detecting device for the treatment of measured ion.
6. the ion mobility spectrometry apparatus in surface desorption atmospheric chemical ionization according to claim 4 source, it is characterized in that: described in treat that the separation detecting device of measured ion is the part except sample drawing-in system and radioactive ionization gauge source in conventional ion mobility spectrometer, be the general designation of conventional ion mobility spectrometer intermediate ion door, ion migration area, detecting device, data acquisition and control system.
7. the ion mobility spectrometry apparatus in surface desorption atmospheric chemical ionization according to claim 6 source, it is characterized in that: the cavity migration tube that described ion migration area is comprised of several stainless steel metal rings and dead ring alternative arrangement, internal diameter 1cm, length 7-8cm; In migration tube, be equipped with the uniform electric field of 200-210V/cm, zone of heating is established in migration tube outside, and heating-up temperature is 140 ℃.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420130981.7U CN203929711U (en) | 2014-03-21 | 2014-03-21 | The ion mobility spectrometry apparatus in a kind of surface desorption atmospheric chemical ionization source |
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| CN201420130981.7U CN203929711U (en) | 2014-03-21 | 2014-03-21 | The ion mobility spectrometry apparatus in a kind of surface desorption atmospheric chemical ionization source |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105403614A (en) * | 2015-12-15 | 2016-03-16 | 清华大学深圳研究生院 | Tracing method of distribution of mobile ions in ionic migration spectrometer |
| CN108039312A (en) * | 2018-01-31 | 2018-05-15 | 谱瑞科技（大连）有限公司 | Transference tube |
| CN111220678A (en) * | 2018-11-23 | 2020-06-02 | 中国科学院大连化学物理研究所 | Ion mobility spectrometer |
-
2014
- 2014-03-21 CN CN201420130981.7U patent/CN203929711U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105403614A (en) * | 2015-12-15 | 2016-03-16 | 清华大学深圳研究生院 | Tracing method of distribution of mobile ions in ionic migration spectrometer |
| CN105403614B (en) * | 2015-12-15 | 2018-01-16 | 清华大学深圳研究生院 | The tracer method that mobile ion is distributed in ionic migration spectrometer |
| US10161904B2 (en) | 2015-12-15 | 2018-12-25 | Graduate School At Shenzhen, Tsinghua University | Method for tracing distribution of moving ions in ion mobility spectrometer |
| CN108039312A (en) * | 2018-01-31 | 2018-05-15 | 谱瑞科技（大连）有限公司 | Transference tube |
| CN111220678A (en) * | 2018-11-23 | 2020-06-02 | 中国科学院大连化学物理研究所 | Ion mobility spectrometer |
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