CN108079034A - Preparation method of lyophilized superfine notoginseng powder and products thereof - Google Patents
Preparation method of lyophilized superfine notoginseng powder and products thereof Download PDFInfo
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Abstract
The present invention relates to a kind of preparation method of lyophilized superfine notoginseng powder and products thereof, Ultramicro-powder grinding method includes step：By lyophilized Radix Notoginseng under cryogenic, crushed using micronizer, obtain lyophilized superfine notoginseng powder；Wherein, cryogenic conditions are less than 0 DEG C for temperature, freeze in superfine notoginseng powder, and quality accounting is that the grain size of more than 95% particle is less than 1000 mesh；Lyophilized Radix Notoginseng is less than 5% containing water quality, and the time of crushing is 2~10min.The preparation method of lyophilized superfine notoginseng powder provided by the invention, by crushing under cryogenic, it can be to avoid destruction of the long-time heating to pseudo-ginseng activity ingredient and mouthfeel, Radix Notoginseng naturally original freshness, color and luster, taste and nutritional ingredient are maintained to greatest extent, notoginsenoside is retained to greatest extent, organized enzyme, volatile oil retention ratio are high, and trace element exists with free state state.
Description
Technical field
The present invention relates to Chinese medicine processing technique fields, and in particular to a kind of preparation method of lyophilized superfine notoginseng powder and its
Product.
Background technology
Radix Notoginseng also known as invaluable, is the Chinese medicine of China's preciousness, Radix Notoginseng category Araliaceae herbaceos perennial, because of its sowing
Digging in 3 to seven years is adopted afterwards and every plant long three petioles, each petiole give birth to seven blades, therefore named Radix Notoginseng.Its stem, leaf and Hua Junke
It is used as medicine.The Radix Notoginseng place of production is Yunnan mountain of papers, is had containing saponin(e, polysaccharide, flavones, carbene alcohol, amino acid, aliphatic acid and cyclic peptide etc.
Ingredient is imitated, it is sweet in flavor, slight bitter, warm-natured, return liver and kidney channel, there is dissipate stasis of blood hemostasis, swelling and pain relieving.Research shows Radix Notoginseng also
With antitumor, antiatherosclerosis and enhance the pharmacological activity effect such as immune.
A kind of " Radix Notoginseng superfine powder and preparation method thereof " is disclosed in the prior art, is that standard is dried by the conventional field of Chinese medicines
Radix Notoginseng after being dried is ground into Radix Notoginseng material coarse crushing, then sterilizes, is dry, then during coarse crushing processing is ground into it is broken,
Finally Radix Notoginseng superfine powder is ground into airslide disintegrating mill.The processing method that traditional solarization or baking are used in the patent application,
The unstable active ingredient of some in Radix Notoginseng is highly vulnerable to breakage, so as to influence the medical value of Radix Notoginseng.Therefore, it is also desirable to it develops new
Radix Notoginseng processing method, preferably to retain the medical value of Radix Notoginseng.
The content of the invention
For in the prior art the defects of, present invention aims at providing a kind of preparation method of lyophilized superfine notoginseng powder,
It, can be to avoid destruction of the long-time heating to pseudo-ginseng activity ingredient and mouthfeel, to greatest extent by crushing under cryogenic
Maintaining Radix Notoginseng, naturally original freshness, color and luster, taste and nutritional ingredient, notoginsenoside are retained to greatest extent,
Organized enzyme, volatile oil retention ratio are high, and trace element exists with free state state.
To achieve the above object, technical solution provided by the invention is：
The present invention provides a kind of preparation method of lyophilized superfine notoginseng powder, including step：By lyophilized Radix Notoginseng in low temperature item
It under part, is crushed using micronizer, obtains lyophilized superfine notoginseng powder；Wherein, cryogenic conditions are less than 0 DEG C for temperature, freeze
In dry superfine notoginseng powder, quality accounting is that the grain size of more than 95% particle is less than 1000 mesh.It should be noted that the present invention adopts
Radix Notoginseng refers to mountain of papers Radix Notoginseng, originates in Yunnan Wenshan Prefecture, is panax araliaceae plant.
Preferably, freeze Radix Notoginseng is less than 5% containing water quality, and the time of crushing is 2~10min.
The preparation method of lyophilized Radix Notoginseng includes step：Fresh Roots of Panax Notoginseng is cleaned and removes surface attachments, is then dripped
Solid carbon dioxide point；Roots of Panax Notoginseng after draining away the water is freezed；Roots of Panax Notoginseng after freezing is subjected to vacuum freeze drying, is freezed
Radix Notoginseng.
Preferably, cleaning is cleaned using cleaning solution, the raw material components of cleaning solution by weight, including：Ethyl alcohol
30~50 parts by weight, 400~500 parts by weight of water, 6~8 parts by weight of sodium benzoate, 5~10 parts by weight of Tea Saponin, sodium acid carbonate 7
~9 parts by weight, 10~15 parts by weight of 15~20 parts by weight of alkyl glycosides, 5~10 parts by weight of sodium chloride and sorbierite.
Preferably, the temperature of freezing is -40~-10 DEG C, time of freezing for 12~for 24 hours.
Preferably, the vacuum degree of vacuum freeze drying is 0.05~0.07mBar, and condenser temperature is -50~-48 DEG C, vacuum
The time of freeze-drying is 28~48h.
Preferably, before being freezed, the step of being pre-processed the Roots of Panax Notoginseng after draining away the water is further included：It will drain
Roots of Panax Notoginseng after moisture is stood in first environment and in second environment successively；Wherein, the gas in first environment include oxygen,
Carbon dioxide, nitrogen and 1- methyl cyclopropenes；Gas in second environment includes oxygen, carbon dioxide and ozone.
Preferably, in first environment：Temperature is 5~15 DEG C, and relative humidity is 5%~10%, and the concentration of gas is 0.35
~0.4 μ L/L；The time stood in first environment is 70~80h；Wherein, oxygen, carbon dioxide, nitrogen and 1- methyl ring third
The molar ratio of alkene is 1:(0.3~0.6):(2.5~3):(0.3~0.4)；In second environment：Temperature is 2~4 DEG C, relative humidity
For 3%~6%, the concentration of gas is 0.1~0.2 μ L/L；The time stood in second environment is 30~40h；Wherein, oxygen
The molar ratio of gas, carbon dioxide and ozone is 1:(0.3~0.5):(0.1~0.2).
Preferably, further include and carry out lyophilized superfine notoginseng powder closed the step of sealing up for safekeeping, it is closed to seal up for safekeeping using vacuum packaging
Machine carries out；Closed seal up for safekeeping is to carry out closed seal up for safekeeping using vacuum tight PVC compound membrane bags.
The present invention also protects the lyophilized superfine notoginseng powder being prepared according to the above method.
Technical solution provided by the invention has following advantageous effect：
(1) present invention is dried fresh Radix Notoginseng using the method for freeze-drying, avoids heat drying, crushes for a long time
Temperature raises destruction of the process to pseudo-ginseng activity ingredient and mouthfeel, can more fully play the drug effect of Radix Notoginseng；
(2) present invention carries out low-temperature grinding after Radix Notoginseng is freezed, and obtained Ultramicro-powder is more prone to be dissolved in water, favorably
In the dissolution of active ingredient；
(3) present invention is packed using vacuum tightness method according to different specification grams, can meet lyophilized Radix Notoginseng
The storage demand of Ultramicro-powder；Processing method provided by the invention is simple, and production cost is low, has good commercial promise.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
It obtains substantially or is recognized by the practice of the present invention.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme is clearly and completely described.Implement below
Example is only used for clearly illustrating technical scheme, therefore be intended only as example, and cannot limit this hair with this
Bright protection domain.
Experimental method in following embodiments is conventional method unless otherwise specified.Examination used in following embodiments
Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following embodiment, is respectively provided with three
Secondary to repeat to test, data are the average value or mean+SD of three repeated experiments.
The present invention provides a kind of preparation method of lyophilized superfine notoginseng powder, includes the following steps：
S1：By autumn before the flowers are in blossom the fresh Roots of Panax Notoginseng of excavation select, reject the fibrous root of fresh Roots of Panax Notoginseng and suede root, obtain
To Radix Notoginseng main root, clean Radix Notoginseng main root and remove surface attachments, then drain away the water；Wherein, cleaning be using cleaning solution into
Row cleaning, the raw material components of cleaning solution by weight, including：30~50 parts by weight of ethyl alcohol, 400~500 parts by weight of water, benzene first
Sour 6~8 parts by weight of sodium, 5~10 parts by weight of Tea Saponin, 7~9 parts by weight of sodium acid carbonate, 15~20 parts by weight of alkyl glycosides, chlorination
10~15 parts by weight of 5~10 parts by weight of sodium and sorbierite；
S2：Radix Notoginseng main root after draining away the water is placed in household freezer, and -40~-10 DEG C of freezings 12~for 24 hours, make Radix Notoginseng main root
Freeze；
Preferably, before being freezed, the step of Radix Notoginseng main root after draining away the water is pre-processed is further included：It will drip
Radix Notoginseng main root after solid carbon dioxide point is stood in first environment successively stands 30~40h in 70~80h and second environment；Wherein,
In one environment：Temperature is 5~15 DEG C, and relative humidity is 5%~10%, and the concentration of gas is 0.35~0.4 μ L/L；Oxygen, two
The molar ratio of carbonoxide, nitrogen and 1- methyl cyclopropenes is 1:(0.3~0.6):(2.5~3):(0.3~0.4)；Second environment
In：Temperature is 2~4 DEG C, and relative humidity is 3%~6%, and the concentration of gas is 0.1~0.2 μ L/L；Oxygen, carbon dioxide and smelly
The molar ratio of oxygen is 1:(0.3~0.5):(0.1~0.2)；
S3：Radix Notoginseng main root after freezing is put into vacuum freeze drier, is vacuumized, make vacuum degree for 0.05~
0.07mBar, condenser temperature are -50~-48 DEG C, freeze 28~48h, then take out, obtain aqueous from vacuum freeze drier
Quality is less than 5% lyophilized Radix Notoginseng；
S4：Under conditions of temperature is less than 0 DEG C, lyophilized Radix Notoginseng micronizer is crushed into 2~10min, obtains quality
Accounting is that the grain size of more than 95% particle freezes superfine notoginseng powder less than 1000 purposes；
S5：Using vacuum tight PVC compound membrane bags, lyophilized superfine notoginseng powder is carried out by weight with vacuum packaging machine
It is closed to seal up for safekeeping.
The preparation method of lyophilized superfine notoginseng powder provided by the invention is described further with reference to specific embodiment.
Embodiment one
The present embodiment provides a kind of preparation methods of lyophilized superfine notoginseng powder, include the following steps：
S1：By autumn before the flowers are in blossom the fresh Roots of Panax Notoginseng of excavation select, reject the fibrous root of fresh Roots of Panax Notoginseng and suede root, obtain
To Radix Notoginseng main root, clean Radix Notoginseng main root and remove surface attachments, then drain away the water；Wherein, cleaning be using cleaning solution into
Row cleaning, the raw material components of cleaning solution by weight, including：40 parts by weight of ethyl alcohol, 450 parts by weight of water, 7 weight of sodium benzoate
Part, 8 parts by weight of Tea Saponin, 8 parts by weight of sodium acid carbonate, 12 weight of 17 parts by weight of alkyl glycosides, 6 parts by weight of sodium chloride and sorbierite
Part；
S2：Radix Notoginseng main root after draining away the water is stood in first environment in 75h and second environment successively stands 35h；
Wherein, in first environment：Temperature is 10 DEG C, relative humidity 8%, and the concentration of gas is 0.38 μ L/L；Oxygen, carbon dioxide,
The molar ratio of nitrogen and 1- methyl cyclopropenes is 1:0.4:2.8:0.36；In second environment：Temperature is 3 DEG C, and relative humidity is
4%, the concentration of gas is 0.15 μ L/L；The molar ratio of oxygen, carbon dioxide and ozone is 1:0.4:0.15；
Radix Notoginseng main root after standing is placed in household freezer, -30 DEG C of freezing 18h freeze Radix Notoginseng main root；
S3：Radix Notoginseng main root after freezing is put into vacuum freeze drier, is vacuumized, and makes vacuum degree for 0.06mBar,
Condenser temperature is -49 DEG C, freezes 38h, is then taken out from vacuum freeze drier, is obtained lyophilized less than 5% containing water quality
Radix Notoginseng；
S4：Under conditions of temperature is less than 0 DEG C, lyophilized Radix Notoginseng micronizer is crushed into 6min, obtains quality accounting
Grain size for more than 95% particle freezes superfine notoginseng powder less than 1000 purposes；
S5：Using vacuum tight PVC compound membrane bags, lyophilized superfine notoginseng powder is carried out by weight with vacuum packaging machine
It is closed to seal up for safekeeping.
Embodiment two
The present embodiment provides a kind of preparation methods of lyophilized superfine notoginseng powder, include the following steps：
S1：By autumn before the flowers are in blossom the fresh Roots of Panax Notoginseng of excavation select, reject the fibrous root of fresh Roots of Panax Notoginseng and suede root, obtain
To Radix Notoginseng main root, clean Radix Notoginseng main root and remove surface attachments, then drain away the water；Wherein, cleaning be using cleaning solution into
Row cleaning, the raw material components of cleaning solution by weight, including：30 parts by weight of ethyl alcohol, 500 parts by weight of water, 6 weight of sodium benzoate
Part, 10 parts by weight of Tea Saponin, 7 parts by weight of sodium acid carbonate, 15 weight of 20 parts by weight of alkyl glycosides, 5 parts by weight of sodium chloride and sorbierite
Measure part；
S2：Radix Notoginseng main root after draining away the water is stood in first environment in 70h and second environment successively stands 30h；
Wherein, in first environment：Temperature is 5 DEG C, relative humidity 5%, and the concentration of gas is 0.35 μ L/L；Oxygen, carbon dioxide, nitrogen
The molar ratio of gas and 1- methyl cyclopropenes is 1:0.3:2.5:0.3；In second environment：Temperature is 2 DEG C, relative humidity 3%, gas
The concentration of body is 0.1 μ L/L；The molar ratio of oxygen, carbon dioxide and ozone is 1:0.3:0.1；
Radix Notoginseng main root after standing is placed in household freezer, -40 DEG C of freezing 12h freeze Radix Notoginseng main root；
S3：Radix Notoginseng main root after freezing is put into vacuum freeze drier, is vacuumized, and makes vacuum degree for 0.05mBar,
Condenser temperature is -48 DEG C, freezes 28h, is then taken out from vacuum freeze drier, is obtained lyophilized less than 5% containing water quality
Radix Notoginseng；
S4：Under conditions of temperature is less than 0 DEG C, lyophilized Radix Notoginseng micronizer is crushed into 2min, obtains quality accounting
Grain size for more than 95% particle freezes superfine notoginseng powder less than 1000 purposes；
S5：Using vacuum tight PVC compound membrane bags, lyophilized superfine notoginseng powder is carried out by weight with vacuum packaging machine
It is closed to seal up for safekeeping.
Embodiment three
The present embodiment provides a kind of preparation methods of lyophilized superfine notoginseng powder, include the following steps：
S1：By autumn before the flowers are in blossom the fresh Roots of Panax Notoginseng of excavation select, reject the fibrous root of fresh Roots of Panax Notoginseng and suede root, obtain
To Radix Notoginseng main root, clean Radix Notoginseng main root and remove surface attachments, then drain away the water；Wherein, cleaning be using cleaning solution into
Row cleaning, the raw material components of cleaning solution by weight, including：50 parts by weight of ethyl alcohol, 400 parts by weight of water, 8 weight of sodium benzoate
Part, 5 parts by weight of Tea Saponin, 9 parts by weight of sodium acid carbonate, 10 weight of 15 parts by weight of alkyl glycosides, 10 parts by weight of sodium chloride and sorbierite
Measure part；
S2：Radix Notoginseng main root after draining away the water is stood in first environment in 80h and second environment successively stands 40h；
Wherein, in first environment：Temperature is 15 DEG C, relative humidity 10%, and the concentration of gas is 0.4 μ L/L；Oxygen, carbon dioxide,
The molar ratio of nitrogen and 1- methyl cyclopropenes is 1:0.6:3:0.4；In second environment：Temperature is 4 DEG C, relative humidity 6%, gas
The concentration of body is 0.2 μ L/L；The molar ratio of oxygen, carbon dioxide and ozone is 1:0.5):0.2；
Radix Notoginseng main root after standing is placed in household freezer, -10 DEG C of freezings for 24 hours, freeze Radix Notoginseng main root；
S3：Radix Notoginseng main root after freezing is put into vacuum freeze drier, is vacuumized, and makes vacuum degree for 0.07mBar,
Condenser temperature is -50 DEG C, freezes 48h, is then taken out from vacuum freeze drier, is obtained lyophilized less than 5% containing water quality
Radix Notoginseng；
S4：Under conditions of temperature is less than 0 DEG C, lyophilized Radix Notoginseng micronizer is crushed into 10min, obtains quality accounting
Grain size for more than 95% particle freezes superfine notoginseng powder less than 1000 purposes；
S5：Using vacuum tight PVC compound membrane bags, lyophilized superfine notoginseng powder is carried out by weight with vacuum packaging machine
It is closed to seal up for safekeeping.
Comparative example one
This comparative example provides a kind of preparation method of lyophilized superfine notoginseng powder, includes the following steps：
S1：By autumn before the flowers are in blossom the fresh Roots of Panax Notoginseng of excavation select, reject the fibrous root of fresh Roots of Panax Notoginseng and suede root, obtain
To Radix Notoginseng main root, clean Radix Notoginseng main root and remove surface attachments, then drain away the water；Wherein, cleaning be using cleaning solution into
Row cleaning, the raw material components of cleaning solution by weight, including：40 parts by weight of ethyl alcohol, 450 parts by weight of water, 7 weight of sodium benzoate
Part, 8 parts by weight of Tea Saponin, 8 parts by weight of sodium acid carbonate, 12 weight of 17 parts by weight of alkyl glycosides, 6 parts by weight of sodium chloride and sorbierite
Part；
S2：Radix Notoginseng main root after standing is placed in household freezer, -30 DEG C of freezing 18h freeze Radix Notoginseng main root；
S3：Radix Notoginseng main root after freezing is put into vacuum freeze drier, is vacuumized, and makes vacuum degree for 0.06mBar,
Condenser temperature is -49 DEG C, freezes 38h, is then taken out from vacuum freeze drier, is obtained lyophilized less than 5% containing water quality
Radix Notoginseng；
S4：Under conditions of temperature is less than 0 DEG C, lyophilized Radix Notoginseng micronizer is crushed into 6min, obtains quality accounting
Grain size for more than 95% particle freezes superfine notoginseng powder less than 1000 purposes；
S5：Using vacuum tight PVC compound membrane bags, lyophilized superfine notoginseng powder is carried out by weight with vacuum packaging machine
It is closed to seal up for safekeeping.
Comparative example two
This comparative example provides a kind of preparation method of lyophilized superfine notoginseng powder, includes the following steps：
S1：By autumn before the flowers are in blossom the fresh Roots of Panax Notoginseng of excavation select, reject the fibrous root of fresh Roots of Panax Notoginseng and suede root, obtain
To Radix Notoginseng main root, clean Radix Notoginseng main root and remove surface attachments, then drain away the water；Wherein, cleaning be using cleaning solution into
Row cleaning, the raw material components of cleaning solution by weight, including：40 parts by weight of ethyl alcohol, 450 parts by weight of water, 7 weight of sodium benzoate
Part, 8 parts by weight of Tea Saponin, 8 parts by weight of sodium acid carbonate, 12 weight of 17 parts by weight of alkyl glycosides, 6 parts by weight of sodium chloride and sorbierite
Part；
S2：Radix Notoginseng main root after draining away the water stands 75h in first environment successively；Wherein, in first environment：Temperature
For 10 DEG C, relative humidity 8%, the concentration of gas is 0.38 μ L/L；Oxygen, carbon dioxide, nitrogen and 1- methyl cyclopropenes
Molar ratio is 1:0.4:2.8:0.36；
Radix Notoginseng main root after standing is placed in household freezer, -30 DEG C of freezing 18h freeze Radix Notoginseng main root；
S3：Radix Notoginseng main root after freezing is put into vacuum freeze drier, is vacuumized, and makes vacuum degree for 0.06mBar,
Condenser temperature is -49 DEG C, freezes 38h, is then taken out from vacuum freeze drier, is obtained lyophilized less than 5% containing water quality
Radix Notoginseng；
S4：Under conditions of temperature is less than 0 DEG C, lyophilized Radix Notoginseng micronizer is crushed into 6min, obtains quality accounting
Grain size for more than 95% particle freezes superfine notoginseng powder less than 1000 purposes；
S5：Using vacuum tight PVC compound membrane bags, lyophilized superfine notoginseng powder is carried out by weight with vacuum packaging machine
It is closed to seal up for safekeeping.
Comparative example three
This comparative example provides a kind of preparation method of lyophilized superfine notoginseng powder, includes the following steps：
S1：By autumn before the flowers are in blossom the fresh Roots of Panax Notoginseng of excavation select, reject the fibrous root of fresh Roots of Panax Notoginseng and suede root, obtain
To Radix Notoginseng main root, clean Radix Notoginseng main root and remove surface attachments, then drain away the water；Wherein, cleaning be using cleaning solution into
Row cleaning, the raw material components of cleaning solution by weight, including：80 parts of ethyl alcohol, 200 parts of water, 10 parts of hydroxyethyl cellulose, lemon
20 parts of 5 parts of acid, 16 parts of sodium acid carbonate, 5 parts of sodium chloride and sorbierite；
S2：Radix Notoginseng main root after draining away the water is stood in first environment in 75h and second environment successively stands 35h；
Wherein, in first environment：Temperature is 10 DEG C, relative humidity 8%, and the concentration of gas is 0.38 μ L/L；Oxygen, carbon dioxide,
The molar ratio of nitrogen and 1- methyl cyclopropenes is 1:0.4:2.8:0.36；In second environment：Temperature is 3 DEG C, and relative humidity is
4%, the concentration of gas is 0.15 μ L/L；The molar ratio of oxygen, carbon dioxide and ozone is 1:0.4:0.15；
Radix Notoginseng main root after standing is placed in household freezer, -30 DEG C of freezing 18h freeze Radix Notoginseng main root；
S3：Radix Notoginseng main root after freezing is put into vacuum freeze drier, is vacuumized, and makes vacuum degree for 0.06mBar,
Condenser temperature is -49 DEG C, freezes 38h, is then taken out from vacuum freeze drier, is obtained lyophilized less than 5% containing water quality
Radix Notoginseng；
S4：Under conditions of temperature is less than 0 DEG C, lyophilized Radix Notoginseng micronizer is crushed into 6min, obtains quality accounting
Grain size for more than 95% particle freezes superfine notoginseng powder less than 1000 purposes；
S5：Using vacuum tight PVC compound membrane bags, lyophilized superfine notoginseng powder is carried out by weight with vacuum packaging machine
It is closed to seal up for safekeeping.
The lyophilized superfine notoginseng powder that the present invention is prepared, by function assessment experiment come its performance of system evaluation, and
The lyophilized superfine notoginseng powder being prepared with comparative example one to comparative example three.
1st, storage effect
It is prepared by the lyophilized superfine notoginseng powder and comparative example one to comparative example three that embodiment one to embodiment three is prepared
Obtained lyophilized superfine notoginseng powder carries out the measure of total number of bacteria respectively, time point of measure for it is closed seal up for safekeeping 1 month, 3 months,
6 months and 12 months, the concrete outcome of measure was as shown in table 1 below.
1 storage effect of table
2nd, the effect of superfine notoginseng powder reducing blood lipid is freezed
The small white mouse 80 (each 40 of male and female) that weight is selected to be 18~22g, is divided into 8 groups, is denoted as A-H groups respectively, every group female
Male each 5.A groups are set to control group, normal pill feed is provided；B groups are set to high blood lipid model group, provide the high lipid of autogamy and raise
Material；C-H groups are when providing hyperlipidemia diet, while gavage gives the 2g/kg embodiment of the present invention one to embodiment three, comparison respectively
The lyophilized superfine notoginseng powder that example one to comparative example three is prepared；It is grouped cage, drinking-water of freely ingesting.Once a day, continuous 30
My god, it in next day after the last administration, takes a blood sample on an empty stomach, measures serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein
(HDL) and low-density lipoprotein (LDL) is horizontal, and concrete outcome is as shown in table 2.
Table 2 freezes influence of the superfine notoginseng powder to hyperlipemia small white mouse blood lipid level
| Group | TC(mg/dL) | TG(mg/dL) | HDL(mg/dL) | LDL(mg/dL) |
| Control group | 73.68 | 56.38 | 222.3 | 45.4 |
| High blood lipid model group | 217.05 | 205.26 | 479.4 | 53.9 |
| Embodiment one | 95.28 | 72.84 | 287.4 | 47.2 |
| Embodiment two | 98.62 | 73.21 | 291.3 | 47.0 |
| Embodiment three | 101.27 | 74.05 | 289.6 | 47.3 |
| Comparative example one | 123.34 | 120.03 | 357.9 | 48.3 |
| Comparative example two | 119.17 | 117.67 | 346.0 | 48.9 |
| Comparative example three | 88.65 | 76.35 | 308.4 | 47.4 |
The present invention is dried fresh Radix Notoginseng using the method for freeze-drying, avoids heat drying, crushes temperature for a long time
Destruction of the degree rise process to pseudo-ginseng activity ingredient and mouthfeel can more fully play the drug effect of Radix Notoginseng；The present invention is by three
Seven it is lyophilized after carry out low-temperature grinding, obtained Ultramicro-powder is more prone to be dissolved in water, and is conducive to the dissolution of active ingredient, for
The effect for reducing hyperlipidemia becomes apparent；The present invention is packed using vacuum tightness method according to different specification grams, can
To meet the storage demand of lyophilized superfine notoginseng powder；Processing method provided by the invention is simple, and production cost is low, has good
Commercial promise.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, otherwise illustrate in these embodiments
Component and opposite step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely illustrative, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the present invention, it is to be understood that term " first ", " second " are only used for description purpose, and cannot
It is interpreted as indicating or implies relative importance or imply the quantity of the technical characteristic indicated by indicating.Define as a result, " the
One ", one or more this feature can be expressed or be implicitly included to the feature of " second ".In the description of the present invention,
" multiple " are meant that two or more, unless otherwise specifically defined.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe is described in detail the present invention with reference to foregoing embodiments, it will be understood by those of ordinary skill in the art that：Its according to
Can so modify to the technical solution recorded in foregoing embodiments either to which part or all technical characteristic into
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is not made to depart from various embodiments of the present invention technology
The scope of scheme should all cover among protection scope of the present invention.
Claims (10)
1. a kind of preparation method of lyophilized superfine notoginseng powder, which is characterized in that including step：
By lyophilized Radix Notoginseng under cryogenic, crushed using micronizer, obtain lyophilized superfine notoginseng powder；
Wherein, the cryogenic conditions are temperature less than 0 DEG C, and in the lyophilized superfine notoginseng powder, quality accounting is more than 95%
The grain size of particle is less than 1000 mesh.
2. the preparation method of lyophilized superfine notoginseng powder according to claim 1, it is characterised in that：
The lyophilized Radix Notoginseng is less than 5% containing water quality, and the time of the crushing is 2~10min.
3. the preparation method of lyophilized superfine notoginseng powder according to claim 1, it is characterised in that：
The preparation method of the lyophilized Radix Notoginseng includes step：Fresh Roots of Panax Notoginseng is cleaned and removes surface attachments, is then dripped
Solid carbon dioxide point；Roots of Panax Notoginseng after draining away the water is freezed；Roots of Panax Notoginseng after freezing is subjected to vacuum freeze drying, is obtained described
Lyophilized Radix Notoginseng.
4. the preparation method of lyophilized superfine notoginseng powder according to claim 3, it is characterised in that：
The cleaning is cleaned using cleaning solution, the raw material components of the cleaning solution by weight, including：Ethyl alcohol 30~
50 parts by weight, 400~500 parts by weight of water, 6~8 parts by weight of sodium benzoate, 5~10 parts by weight of Tea Saponin, 7~9 weight of sodium acid carbonate
Measure part, 10~15 parts by weight of 15~20 parts by weight of alkyl glycosides, 5~10 parts by weight of sodium chloride and sorbierite.
5. the preparation method of lyophilized superfine notoginseng powder according to claim 3, it is characterised in that：
The temperature of the freezing is -40~-10 DEG C, time of the freezing for 12~for 24 hours.
6. the preparation method of lyophilized superfine notoginseng powder according to claim 3, it is characterised in that：
The vacuum degree of the vacuum freeze drying is 0.05~0.07mBar, and condenser temperature is -50~-48 DEG C, and the vacuum is cold
The lyophilized dry time is 28~48h.
7. the preparation method of lyophilized superfine notoginseng powder according to claim 3, it is characterised in that：
Before carrying out the freezing, the step of being pre-processed the Roots of Panax Notoginseng after draining away the water is further included：After draining away the water
Roots of Panax Notoginseng stand successively in first environment and in second environment；Wherein, the gas in the first environment includes oxygen, two
Carbonoxide, nitrogen and 1- methyl cyclopropenes；Gas in the second environment includes oxygen, carbon dioxide and ozone.
8. the preparation method of lyophilized superfine notoginseng powder according to claim 7, it is characterised in that：
In the first environment：Temperature is 5~15 DEG C, and relative humidity is 5%~10%, and the concentration of gas is 0.35~0.4 μ L/
L；The time stood in the first environment is 70~80h；Wherein, the oxygen, the carbon dioxide, the nitrogen and institute
The molar ratio for stating 1- methyl cyclopropenes is 1:(0.3~0.6):(2.5~3):(0.3~0.4)；
In the second environment：Temperature is 2~4 DEG C, and relative humidity is 3%~6%, and the concentration of gas is 0.1~0.2 μ L/L；
The time stood in the second environment is 30~40h；Wherein, the oxygen, the carbon dioxide and the ozone rub
You are than being 1:(0.3~0.5):(0.1~0.2).
9. the preparation method of lyophilized superfine notoginseng powder according to claim 1, it is characterised in that：
Further include and carry out the lyophilized superfine notoginseng powder closed the step of sealing up for safekeeping, it is described it is closed seal up for safekeeping using vacuum packing machine into
Row；Closed seal up for safekeeping is to carry out closed seal up for safekeeping using vacuum tight PVC compound membrane bags.
10. the lyophilized superfine notoginseng powder that claim 1-9 any one of them methods are prepared.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109174407A (en) * | 2018-08-30 | 2019-01-11 | 云南金不换生物科技有限责任公司 | Ultramicro-powder cryogrinding technology |
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|---|---|---|---|---|
| WO2012122678A1 (en) * | 2011-03-16 | 2012-09-20 | Dong Ling | Uniform freeze-dried preparation containning all components of pilose antler and production method thereof |
| CN106963786A (en) * | 2017-05-02 | 2017-07-21 | 杭州华东医药集团贵州中药发展有限公司 | The drying and processing method of Chinese medicine |
| CN107455531A (en) * | 2017-09-12 | 2017-12-12 | 昆明电掣广告有限公司 | A kind of lyophilized Baggeed pseudo-ginseng powder tea and preparation method thereof |
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2018
- 2018-02-07 CN CN201810123038.6A patent/CN108079034A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012122678A1 (en) * | 2011-03-16 | 2012-09-20 | Dong Ling | Uniform freeze-dried preparation containning all components of pilose antler and production method thereof |
| CN106963786A (en) * | 2017-05-02 | 2017-07-21 | 杭州华东医药集团贵州中药发展有限公司 | The drying and processing method of Chinese medicine |
| CN107455531A (en) * | 2017-09-12 | 2017-12-12 | 昆明电掣广告有限公司 | A kind of lyophilized Baggeed pseudo-ginseng powder tea and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109174407A (en) * | 2018-08-30 | 2019-01-11 | 云南金不换生物科技有限责任公司 | Ultramicro-powder cryogrinding technology |
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