CN108077591A - A kind of livestock and poultry disease-resistant growth-promoting feed addictive and preparation method - Google Patents
A kind of livestock and poultry disease-resistant growth-promoting feed addictive and preparation method Download PDFInfo
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- CN108077591A CN108077591A CN201810041266.9A CN201810041266A CN108077591A CN 108077591 A CN108077591 A CN 108077591A CN 201810041266 A CN201810041266 A CN 201810041266A CN 108077591 A CN108077591 A CN 108077591A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention discloses a kind of livestock and poultry disease-resistant growth-promoting feed addictive preparation method, using the montmorillonite-loaded carvacrol of cetylpyridinium chloride modification, cinnamic acid.Montmorillonite has high-specific surface area and the characteristics such as strong suction/desorption power, stability height, protection gastrointestinal mucosal, cheap as controlled release carrier.Montmorillonite through cetylpyridinium chloride modification adds montmorillonite layer spacing/specific surface area and hydrophobicity, greatly enhances the adsorption rate to carvacrol, cinnamic acid.Montmorillonite-loaded carvacrol, cinnamic acid are conducive to its full enteron aisle control release, more effectively play its antibacterial, anti-inflammatory, antioxidation, there is combination synergy and synergistic effect on antibacterial activity, reduce carvacrol, cinnamic acid toxicity.Carvacrol, cinnamic acid induced by endotoxin adsorbance are 0, and livestock and poultry disease-resistant growth-promoting feed addictive of the invention is 91EU/mg to bacterial endotoxin adsorbance.
Description
Technical field
The present invention relates to livestock and poultry disease-resistant growth-promoting feed addictive and preparation methods.
Background technology
Feeding antibiotic is widely used in animal and fowl fodder, can effectively be prevented livestock and poultry, be improved production performance, drop
Low aquaculture cost.But antibiotic adds for a long time has triggered pathogenic bacteria resistance to drugs generation, the decline of animal immune function, internal flora to lose
It adjusts, a series of Tough questions such as residual and environmental pollution in meat, eggs and milk.There is a growing awareness that long-time service antibiotic causes
Adverse consequences.In terms of development, disabling limits the use of antibiotic feed additive and has become world's common recognition, is trend of the times.European Union
It was first begin to completely forbid application of the antibiotic growth accelerator in feed from 2006, but European Union's disabling antibiotic is instant
The result is that many bacteriosises frequently occur, the incidence of Denmark live pig, the death rate increase by 600%, are mostly intestines problem institute
It causes.Forbidding the Sweden using antibiotic first, be also noted after 10 years and simply change antibiotic usage mode, total amount does not have
How much there is change, and cause the use (being used as anti diar rhea) of heavy dose of zinc oxide after disabling, hundred times of growth is presented in dosage.Limit
With disabling antibiotic feed additive, it is necessary to which selection can be with the substitute of substitute antibiotics feed addictive, to ensure herding
The benefit of industry production is unaffected.The decrement and replacement of Antibiotic Additive in livestock and poultry cultivation, it should consider growth of animals or poultry
Intestinal health and reparation, the enhancing of itself nonspecific immunity, new type of safe antiseptic application, it is multi-pronged, could realize
On the premise of not reducing breeding performonce fo animals and increasing considerably production cost, being effectively reduced or replace for feeding antibiotic is realized
Generation.
Cinnamic acid, triphenyl methacrylaldehyde, yellow liquid have strong oil of bay special odor and burn fragranced, meet light
It is oxidizable in air with air mutability into burgundy thick liquid.Cinnamic acid, which has, to be promoted growth, improves feed efficiency work(
Can, and have attractant effect to animal, moreover it is possible to prevent feed mold.Carvacrol, Carvacrol are colourless to yellowish
Color slightly has the fluid of sticky property, empties in gas and light, and color and luster deepens, in pungent perfume, cool incense, herbal.Due to cinnamic acid and Sheep's-parsley
Phenol is liquid in normal temperature state, generally requires and makes solid state by certain processing technology, is suitable in feed
Addition, the current cinnamic acid and the method for carvacrol preparation of producing is produced with simple premixing process, that is, is adsorbed in
On silica or rice chaff powder carrier.There are clearly disadvantageous for this processing technology：Since cinnamic acid and carvacrol do not dissolve in
Water, make an addition in feed by after feed intake cannot in enteron aisle it is perfectly homogenous miscible with chyme, be not easy to absorb.Although
Cinnamic acid and carvacrol have intestinal health many effects, but since it in alimentary canal leading portion is easily rapidly absorbed entrance
The circulatory system, it is difficult to reach enteron aisle and play a role, greatly limit the performance of its effect.In addition, their high volatilities, easily by oxygen
Change, if using cinnamic acid and carvacrol without protection processing, the stability of active ingredient cannot be guaranteed.This explanation
Cinnamic acid and carvacrol must be handled by preparation protection is sent to enteron aisle, is possible to play the works such as antibacterial, anti-inflammatory, anti-oxidant
With.In order to allow cinnamic acid and carvacrol can reach back segment enteron aisle and pinpoint release, reach suitable in certain time and space
Concentration, while avoid feed ingredient to destruction of essential oil etc., it is necessary to cinnamic acid and carvacrol are carried out preparation processing or
Person's chemical modification.
Controlled release system to the release position of drug, speed and mode has selectivity and controllability, it can be achieved that object
Targeting delivery and control are sustained, and improve its utilization rate and effect.The key of controlled-release technology is the selection of controlled release carrier.Montmorillonite
The layer mineral being made of the superfine aqueous alumino-silicate of particle, in its lamellar structure, intermediate alumina octahedral sub-layer
Two oxygen-octahedron sub-layers are connected to by covalent bond by oxygen atom, form sandwich structure, thickness about 1nm, length and width are about
100nm.Isomorphous replacement can occur for alumina octahedral sub-layer and oxygen-octahedron sub-layer, make smectite structure layer negatively charged
Lotus forms tradable cation and hydrone in crystal structure interlayer.Montmorillonite high-specific surface area and strong suction/desorption force characteristic
Make it that intercalation, physical and chemical adsorption and ion-exchange reactions can occur with drug, controlled release drug carrier can be used as, there is adsorbance
Characteristics, the potentialities to be exploited such as greatly, stability is high, cheap, nontoxic are huge.In recent years, montmorillonite is as pharmaceutical carrier, especially
Montmorillonite by modification is increasingly paid close attention to as the research of medicine controlled release carrier be subject to scholar and industrial circle.
The content of the invention
The object of the present invention is to provide a kind of livestock and poultry disease-resistant growth-promoting feed addictive and preparation methods.
The preparation method of livestock and poultry disease-resistant growth-promoting feed addictive comprises the following steps：
1) by montmorillonite, together with sodium chloride, water is added to stir evenly, the suspension ore pulp that concentration is 10%~20% is made
(pulp density refers both to the weight percent of solid ore particle in slurries in the present invention, similarly hereinafter), room temperature sodium is made dense again with water
Spend the ore pulp for 20%~45%；
2) by cetylpyridinium chloride, it is slowly added into stirring in the ore pulp of step 1), room temperature continuously stirs instead
Answer certain time；
3) by carvacrol, it is slowly added into stirring in the ore pulp of step 2), room temperature continuously stirs reaction certain time,
Cinnamic acid is added, is stirred；
4) the reaction fluid dewatering of step 3), the filter cake drying of gained crush, and obtain the addition of livestock and poultry disease-resistant growth-promoting feed
Agent.
In said program, following preferred parameter can be used in the parameter in each step.
Preferably, in step 1), the additive amount of the sodium chloride is the 5%~15% of montmorillonite weight.
Preferably, in step 1), when the room temperature sodium time is 10~15 small, washing times are 3~5 times.
Preferably, in step 2), the additive amount of the hexadecyl pyrrole is the 10%~15% of montmorillonite weight.
Preferably, in step 2), room temperature continuously stir the reaction time for 4~8 it is small when.
Preferably, in step 3), the additive amount of the carvacrol is the 2%~10% of montmorillonite weight.
Preferably, in step 3), room temperature continuously stir the reaction time for 3~5 it is small when.
Preferably, in step 3), the additive amount of the cinnamic acid is the 2%~10% of montmorillonite weight, adds in Chinese cassia tree
When mixing time is 1.5~3 small after aldehyde.
Preferably, in step 3), the dehydration is using filtering or centrifugation.
Another object of the present invention is to provide a kind of livestock and poultry disease-resistant growth-promoting feed prepared by any of the above-described method to add
Add agent.
Montmorillonite, cetylpyridinium chloride, carvacrol, the cinnamic acid used in the present invention is commercial goods.It prepares
The dewatering slurries technique of method, can adaptation to local conditions, select centrifugation or filtering the methods of be dehydrated.The filter cake of gained is adopted after dehydration
Use vacuum dehydrating at lower temperature.Normal pulverizing equipment can be selected to crush.
It is an advantage of the invention that：
(1) montmorillonite is low with high-specific surface area and strong suction/desorption force characteristic, stability height, price as controlled release carrier
The characteristics such as honest and clean, nontoxic.Cetylpyridinium chloride is cationic quaternary ammonium salt compound, is non-antibiotic series bactericidal agent.Through chlorine
Change the montmorillonite of cetyl pyridinium modification, add the interlamellar spacing and specific surface area of montmorillonite, and make montmorillonite surface
Organic phase is formed, montmorillonite surface hydrophobic is improved, greatly enhances the adsorption rate to carvacrol, cinnamic acid.
(2) montmorillonite has good gastrointestinal tract mucous compatibility and controlled release properties, and it is complete can be conducive to carvacrol, cinnamic acid
Enteron aisle control release, so as to more effectively play the works such as carvacrol, the antibacterial of cinnamic acid, anti-inflammatory, anti-oxidant, protection intestinal mucosa
With, and the toxicity of carvacrol, cinnamic acid can be significantly reduced.The livestock and poultry disease-resistant growth-promoting feed addictive feeding effect of the present invention
Fruit is significantly better than the carvacrol of identical additive amount, cinnamic acid.
(3) additive of the present invention is loaded cetylpyridinium chloride, carvacrol, cinnamic acid have group on antibacterial activity
Close synergy and antibacterial synergistic effect.
(4) carvacrol, cinnamic acid, the livestock and poultry disease-resistant growth-promoting feed addictive of the present invention are had studied to bacterial endotoxin
Suction-operated obtains the maximal absorptive capacity of each material induced by endotoxin through being fitted Langmiur equation calculations.Carvacrol, cinnamic acid pair
Endotoxin adsorption amount is 0, and livestock and poultry disease-resistant growth-promoting feed addictive of the invention is 91EU/mg to bacterial endotoxin adsorbance.
(5) montmorillonite is due to the special physicochemical properties in its surface, to various viruses, pathogen and generated poison
Element etc. has excellent adsorption capacity；Montmorillonite can form colloid protective film in alimentary canal, and can accelerate impaired mucomembranous epithelial cell
Reparation and regeneration, play the role of reinforcement, reparation, protection gastrointestinal mucosal barrier.
(6) implementation of the present invention is easy, and suitable for industrialized production, cost is relatively low.Livestock and poultry obtained by the present invention are disease-resistant
Feed additive for promoting growth is easy to mix with feed, forms homodisperse system, easy to use；
Specific embodiment
Present invention combination following instance is further described.
Embodiment l：
1) by montmorillonite, together with the sodium chloride for being equivalent to montmorillonite weight 15%, water is added to stir evenly, concentration, which is made, is
10% suspension ore pulp when room temperature sodium 15 is small, is washed 5 times, and the ore pulp that concentration is 20% is made again with water；
2) cetylpyridinium chloride of montmorillonite weight 15% is will be equivalent to, is slowly added into step 1) with stirring
In ore pulp, room temperature continuously stir reaction 8 it is small when；
3) carvacrol of montmorillonite weight 10% is will be equivalent to, is slowly added into stirring in the ore pulp of step 2), room
Temperature continuously stir reaction 5 it is small when, the cinnamic acid for being equivalent to montmorillonite weight 10% is added, when stirring 3 is small；
4) the reacting liquid filtering dehydration of step 3), the filter cake dries pulverizing of gained obtain livestock and poultry disease-resistant growth-promoting feed and add
Add agent.
Minimal inhibitory concentration measurement result shows that carvacrol is antibacterial dense to the minimum of Escherichia coli and salmonella typhimurium
Degree is respectively 300,400 μ g/mL；Cinnamic acid is respectively 450 to the minimal inhibitory concentration of Escherichia coli and salmonella typhimurium,
300μg/mL；The livestock and poultry disease-resistant growth-promoting feed addictive of the present invention is antibacterial to the minimum of Escherichia coli and salmonella typhimurium
Concentration is respectively 150 and 100 μ g/mL (in terms of carvacrol).
Have studied the suction of carvacrol, cinnamic acid, the livestock and poultry disease-resistant growth-promoting feed addictive of the present invention to bacterial endotoxin
Attached effect obtains the maximal absorptive capacity of each material induced by endotoxin through being fitted Langmiur equation calculations.Carvacrol, cinnamic acid are internal
Toxin adsorbance is 0；The livestock and poultry disease-resistant growth-promoting feed addictive of the present invention is 91EU/mg to bacterial endotoxin adsorbance.
21 ± 1 ages in days " Ternary Pig " weanling pig is selected, is divided into 4 groups, (1) control group：Basal diet group；(2) I is tested
Group：Basal diet+80mg/kg carvacrol+80mg/kg cinnamic acids；(3) II group is tested：The intestinal mucosa screen of basal diet+present invention
Hinder protective agent (+40mg/kg the cinnamic acids of carvacrol containing 40mg/kg, additive amount are the 50% of I group of experiment)；(4) III group is tested：Base
The gut barrier protective agent of plinth daily ration+present invention (carvacrol, cinnamic aldehyde content are identical with I group of experiment).2 weeks experimental periods.Knot
Fruit is as follows：
Compared with the control group, test group diarrhea rate is remarkably decreased；It tests II groups and experiment I group differences is not notable, test III
Group and experiment I group significant differences；Experiment I group jejunal content Escherichia coli are remarkably decreased, and test II groups and III group jejunum contents
Object and colonic contents Escherichia coli are remarkably decreased；Test II groups jejunal content and colonic contents Escherichia coli and experiment I
Group difference is not notable；It tests III group colonic contentses Escherichia coli and is substantially less than experiment I groups (P<0.05)；I groups 12 are tested to refer to
Villi height/Crypt depth ratio dramatically increases, and tests II groups and III groups jejunum and ileum height of naps/Crypt depth ratio
Rate dramatically increases；Experiment II groups duodenum, jejunum and ileum height of naps/Crypt depth ratio are not shown with experiment I groups difference
It writes；Experiment III groups height of naps/Crypt depth ratio is significantly higher than experiment I groups；Test II groups endotoxin content and experiment I groups
Difference is not notable, tests III groups D-lactate and endotoxin content and experiment I, II group significant difference.
The above results show the livestock and poultry disease-resistant growth-promoting feed addictive (40mg/kg carvacrols+40mg/ using the present invention
Kg cinnamic acids) effects of 80mg/kg carvacrol+80mg/kg cinnamic acids can be reached.Use the disease-resistant rush of livestock and poultry of the present invention
Growth feed addictive feeding effect is significantly better than carvacrol+cinnamic acid of identical additive amount.The disease-resistant growth-promoting of livestock and poultry of the present invention
Long feed addictive is conducive to carvacrol and the full enteron aisle control release of cinnamic acid, can promote enteron aisle holistic health, more effective to play
The effect of carvacrol and cinnamic acid.
Embodiment 2：
1) by montmorillonite, together with the sodium chloride for being equivalent to montmorillonite weight 5%, water is added to stir evenly, concentration, which is made, is
20% suspension ore pulp when room temperature sodium 10 is small, is washed 3 times, and the ore pulp that concentration is 45% is made again with water；
2) cetylpyridinium chloride of montmorillonite weight 10% is will be equivalent to, is slowly added into step 1) with stirring
In ore pulp, room temperature continuously stir reaction 4 it is small when；
3) carvacrol of montmorillonite weight 2% is will be equivalent to, is slowly added into stirring in the ore pulp of step 2), room temperature
Continuously stir reaction 3 it is small when, the cinnamic acid for being equivalent to montmorillonite weight 2% is added, when stirring 1.5 is small；
4) the reaction solution centrifugal dehydration of step 3), the filter cake dries pulverizing of gained obtain livestock and poultry disease-resistant growth-promoting feed and add
Add agent.
1 daily ration Ross 308 Broiler is selected, is divided into 3 groups, (1) control group：Basal diet group；(2) I group is tested：Basal diet
+ 35mg/kg carvacrol+35mg/kg cinnamic acids；(3) II group is tested：The gut barrier protective agent of basal diet+present invention is (fragrant
Celery phenol, cinnamic aldehyde content are identical with I group of experiment), it feeds 21 days.It turns out that compared with the control group, I group of experiment is to broiler chicken day
Weightening has no significant effect, to Intestine of Broiler Tiny ecosystem, endo enteritis factor expression, broiler chick, serum oxidation resistance
It is significantly not notable.Compared with the control group, test II group and significantly improve Intestine of Broiler Tiny ecosystem, broiler chick, oxidation resistance,
Endo enteritis factor expression is reduced, and I group of group of These parameters and experiment compares significant difference.The above results show this
The livestock and poultry disease-resistant growth-promoting feed addictive of invention is conducive to the full enteron aisle control release of carvacrol, cinnamic acid, more effective to play perfume
Celery phenol, the antibacterial of cinnamic acid, anti-inflammatory, antioxidation, so as to play disease-resistant growth-promoting effect.
Embodiment 3：
1) by montmorillonite, together with the sodium chloride for being equivalent to montmorillonite weight 10%, water is added to stir evenly, concentration, which is made, is
12% suspension ore pulp when room temperature sodium 12 is small, is washed 3 times, and the ore pulp that concentration is 30% is made again with water；
2) cetylpyridinium chloride of montmorillonite weight 11% is will be equivalent to, is slowly added into step 1) with stirring
In ore pulp, room temperature continuously stir reaction 6 it is small when；
3) carvacrol of montmorillonite weight 7% is will be equivalent to, is slowly added into stirring in the ore pulp of step 2), room temperature
Continuously stir reaction 4 it is small when, the cinnamic acid for being equivalent to montmorillonite weight 7% is added, when stirring 2 is small；
4) the reacting liquid filtering dehydration of step 3), the filter cake dries pulverizing of gained obtain livestock and poultry disease-resistant growth-promoting feed and add
Add agent.
1 age in days commercial generation chick is taken to be divided into 3 groups, i.e. basal diet；The livestock and poultry of the basal diet+500mg/kg present invention are disease-resistant
Feed additive for promoting growth；Basal diet+50mg/kg aureomycin.As a result it is as follows：
Compared with blank control group, livestock and poultry disease-resistant growth-promoting feed addictive of the invention significantly improves increasing day by day for broiler chicken
Weight and feed efficiency；Significantly reduce small intestine and cecal content Escherichia coli and C.perfringens quantity；Significantly carry
High duodenum, jejunum and ileal mucosa height of naps:The ratio of Crypt depth.
Compared with aureomycin group, livestock and poultry disease-resistant growth-promoting feed addictive group broiler fodder transformation efficiency of the invention is notable
It improves, it is not notable in other indicator differences.Illustrating the livestock and poultry disease-resistant growth-promoting feed addictive of the present invention can substitute in feed
Antibiotic.
Claims (10)
1. a kind of preparation method of livestock and poultry disease-resistant growth-promoting feed addictive, which is characterized in that the step of method is as follows：
1) by montmorillonite, together with sodium chloride, water is added to stir evenly, the suspension ore pulp that concentration is 10%~20%, room temperature is made
The ore pulp that concentration is 20%~45% is made with water again for sodium；
2) by cetylpyridinium chloride, it is slowly added into stirring in the ore pulp of step 1), room temperature continuously stirs reaction one
It fixes time；
3) by carvacrol, it is slowly added into stirring in the ore pulp of step 2), room temperature continuously stirs reaction certain time, then adds
Enter cinnamic acid, stir；
4) the reaction fluid dewatering of step 3), the filter cake drying of gained crush, and obtain livestock and poultry disease-resistant growth-promoting feed addictive.
2. the preparation method of livestock and poultry disease-resistant growth-promoting feed addictive as described in claim 1, which is characterized in that step 1)
In, the additive amount of the sodium chloride is the 5%~15% of montmorillonite weight.
3. the preparation method of livestock and poultry disease-resistant growth-promoting feed addictive as described in claim 1, which is characterized in that step 1)
In, when the room temperature sodium time is 10~15 small, washing times are 3~5 times.
4. the preparation method of livestock and poultry disease-resistant growth-promoting feed addictive as described in claim 1, which is characterized in that step 2)
In, the additive amount of the hexadecyl pyrrole is the 10%~15% of montmorillonite weight.
5. the preparation method of livestock and poultry disease-resistant growth-promoting feed addictive as described in claim 1, which is characterized in that step 2)
In, room temperature continuously stir the reaction time for 4~8 it is small when.
6. the preparation method of livestock and poultry disease-resistant growth-promoting feed addictive as described in claim 1, which is characterized in that step 3)
In, the additive amount of the carvacrol is the 2%~10% of montmorillonite weight.
7. the preparation method of livestock and poultry disease-resistant growth-promoting feed addictive as described in claim 1, which is characterized in that step 3)
In, room temperature continuously stir the reaction time for 3~5 it is small when.
8. the preparation method of livestock and poultry disease-resistant growth-promoting feed addictive as described in claim 1, which is characterized in that step 3)
In, the additive amount of the cinnamic acid is the 2%~10% of montmorillonite weight, and mixing time is small for 1.5~3 after adding in cinnamic acid
When.
9. the preparation method of livestock and poultry disease-resistant growth-promoting feed addictive as described in claim 1, which is characterized in that step 3)
In, the dehydration is using filtering or centrifugation.
10. a kind of livestock and poultry disease-resistant growth-promoting feed addictive prepared by any the method for claim 1~9.
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| CN110419630A (en) * | 2019-08-01 | 2019-11-08 | 山东晟奇生物科技有限公司 | A kind of somatotrophic functional additive of antibacterial |
| CN112931720A (en) * | 2021-03-04 | 2021-06-11 | 安佑生物科技集团股份有限公司 | Feed additive for improving salpingitis of laying fowls, preparation method and application thereof |
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Application publication date: 20180529 |