CN108072757A - A kind of multi-joint detection card of the immunochromatography of time-saving and efficiency - Google Patents
A kind of multi-joint detection card of the immunochromatography of time-saving and efficiency Download PDFInfo
- Publication number
- CN108072757A CN108072757A CN201611012497.4A CN201611012497A CN108072757A CN 108072757 A CN108072757 A CN 108072757A CN 201611012497 A CN201611012497 A CN 201611012497A CN 108072757 A CN108072757 A CN 108072757A
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- test paper
- panel
- immunochromatography
- saving
- bottom plate
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
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- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention discloses a kind of multi-joint detection cards of immunochromatography of time-saving and efficiency, including bottom plate and panel, the panel is closely fixed on backplate surface, bottom plate is made with panel of acrylonitrile butadient styrene resin material, the insulating layer of heat-preservation cotton composition is provided between bottom plate and panel, panel surface is disposed with test paper, nitrocellulose filter is covered on test paper, test paper is provided with four and is arranged in parallel within panel surface, test paper one end is communicated by capillary with sample storage slot, well and pressing piece are provided in sample storage slot, test paper upper end is provided with label window, the control board of different size is disposed in label window.The present invention is once loaded detectable many indexes, and detection efficiency is high, colour developing is apparent, result is accurate, does not generate magnetic and fluorescent effect.
Description
Technical field
The present invention relates to detection card technique fields, are specially a kind of multi-joint detection card of immunochromatography of time-saving and efficiency.
Background technology
A kind of rapid clinical detection technique that immunochromatography technique is held in both hands recently for domestic and international medical field heat, its feature are single
Person-portion measures, easy to be quick, both can be used for represent qualitative detection also may be used with colloidal gold, electroselenium, coloured latex particle etc.
It is detected for Superparamagnetic particulates, fluorescent nano particles etc. for the qualitative and quantitative of representative, it can be achieved that accurate quantification.The skill at present
Art flourishes, and related reagent kind becomes increasingly abundant, and covers heart disease, infectious disease, lesion detection, prenatal and postnatal care, food prison
The various aspects such as survey, illicit drugs inspection and environmental monitoring.
Detection card detection project common at present is more single, can not meet some special detection diagnosis requirements, especially
It is in the diagnosis detection of heart disease relevant item, existing detection card detection speed is slow, and testing result is non-bulging, data analysis
Difficulty detects and takes inconvenience.
The content of the invention
It is an object of the invention to provide a kind of multi-joint detection cards of immunochromatography of time-saving and efficiency, and possessing once sample-adding can examine
The advantages of surveying many indexes, and detection efficiency is high, colour developing is apparent, result is accurate, does not generate magnetic and fluorescent effect.
To achieve the above object, the present invention provides following technical solution：A kind of multi-joint detection of the immunochromatography of time-saving and efficiency
Card, including bottom plate and panel, the panel is closely fixed on backplate surface, bottom plate and panel using acrylonitrile-butadiene-
Styrene copolymer resin material is made, and the insulating layer of heat-preservation cotton composition is provided between bottom plate and panel, and panel surface is disposed with
Test paper is covered with nitrocellulose filter on test paper, and test paper is provided with four and is arranged in parallel within panel surface, and test paper one end passes through hair
Tubule is communicated with sample storage slot, is provided with well and pressing piece in sample storage slot, and test paper upper end is provided with label window, cloth in label window
It is equipped with the control board of different size
Preferably, the test paper surface offers air hole, and air hole is opposite with capillary tube connection ports and is separately positioned on test paper
Two endpoints on.
Preferably, the air hole lower end is provided with observation window, and demarcation strip, observation window institute are arranged between observation window and air hole
Added with immune enzyme material on the test paper of end.
Preferably, the test paper center is filled with different types of specific antibody and forms cTnI, hs-CRP, NT- successively
ProBNP, Myo test paper, specific antibody one end are connected with absorbing membrane, and absorbing membrane is associated with air hole.
Preferably, the sample storage slot is provided with barrier test paper with capillary connecting pin, and barrier test paper surface is covered with waterproof
Film is simultaneously bonded on capillary port.
Compared with prior art, beneficial effects of the present invention are as follows：
1st, the present invention realizes that once sample-adding meets multinomial finger by setting four test paper arranged in parallel by multi-joint chromatography design
Target detects, while when individually being detected for a certain index, detaches the barrier test paper that surveyed object corresponds to test paper front end, subtract
The taken amount of few sample and useless measurement, practical convenient.
2nd, for the present invention by setting air hole, accelerate the climbing speed of sample prevents sample spluttering simultaneously, adds on test paper
Added with immune enzyme material so that the colour developing of sample is more obvious, saves the time of data analysis, improves detection speed, time saving height
Effect.
3rd, the present invention is avoided by counter plate, bottom plate using acrylonitrile-butadiene-styrene copolymer resin material
Magnetic and fluorescent effect generation improves the sensitivity and accuracy of testing result.
Description of the drawings
Fig. 1 is schematic structural view of the invention；
Fig. 2 is structure test paper schematic diagram of the present invention.
In figure：1- bottom plates, 2- panels, 3- test paper, 31- air holes, 32- demarcation strips, 33- observation windows, 34- absorbing membranes, 35-
Specific antibody, 4- label windows, 5- wells, 6- capillaries, 7- barrier test paper, 8- sample storage slots, 9- pressing pieces.
Specific embodiment
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other without making creative work
Embodiment belongs to the scope of protection of the invention.
- 2 are please referred to Fig.1, the present invention provides a kind of technical solution：A kind of multi-joint detection card of the immunochromatography of time-saving and efficiency,
Including bottom plate 1 and panel 2, the panel 2 is closely fixed on 1 surface of bottom plate, and bottom plate 1 uses acrylic nitrile-butadiene two with panel 2
Alkene-styrene copolymer resin material is made, and the insulating layer of heat-preservation cotton composition, 2 surface of panel are provided between bottom plate 1 and panel 2
Test paper 3 is disposed with, nitrocellulose filter is covered on test paper 3, test paper 3 is provided with four and is arranged in parallel within 2 surface of panel, test paper
3 one end are communicated by capillary 6 with sample storage slot 8, and well 5 and pressing piece 9 are provided in sample storage slot 8, and 3 upper end of test paper is provided with
Label window 4 is disposed with the control board of different size in label window 4.
3 surface of test paper offers air hole 31, and air hole 31 is opposite with 6 connector of capillary and is separately positioned on examination
On two endpoints of paper 3, air hole 31 is set on the one hand to accelerate the climbing speed of sample, is on the other hand arranged on capillary 6
Away from end to prevent sample spluttering, 31 lower end of air hole is provided with observation window 33, is arranged between observation window 33 and air hole 31
Demarcation strip 32, added with immune enzyme material on 33 place end test paper of observation window so that the colour developing of sample is more obvious, convenient for reading
Data save detection time, and 3 center of test paper is filled with different types of specific antibody 35 and forms cTnI, hs- successively
CRP, NT-proBNP, Myo test paper 3,35 one end of specific antibody are connected with absorbing membrane 34, and absorbing membrane 34 is associated with air hole 31,
Realize that once sample-adding meets the detection of many index, practical convenient, time-saving and efficiency, the sample storage slot 8 by multi-joint chromatography design
6 connecting pin of capillary is provided with barrier test paper 7,7 surface of barrier test paper is covered with impermeable layer and is bonded in 6 port of capillary
On, when individually being detected for a certain index, the barrier test paper 7 that surveyed object corresponds to 3 front end of test paper is detached, reduces sample
Taken amount and useless measurement.
Operation principle：The multi-joint detection card of immunochromatography of this kind of time-saving and efficiency is being used, by sample to be detected by being loaded
Hole 5 is added in sample storage slot 8, detach needed for measurement end barrier test paper 7, since capillary 6 acts on, sample is along cellulose nitrate
Plain film is moved and contact with specific antibody 35 and specifically bound, under the guiding function of air hole 31, accelerate to climb and with
Immuno-enzymatic contact colour developing expands, and is compared by observation window 33 by results acquisition and with model in label window 4, draws testing result.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (5)
1. a kind of multi-joint detection card of the immunochromatography of time-saving and efficiency, including bottom plate（1）And panel（2）, it is characterised in that：The face
Plate（2）Closely it is fixed on bottom plate（1）Surface, bottom plate（1）With panel（2）Use acrylonitrile-butadiene-styrene copolymer
Resin material is made, bottom plate（1）With panel（2）Between be provided with heat-preservation cotton composition insulating layer, panel（2）Surface layout has test paper
（3）, test paper（3）On be covered with nitrocellulose filter, test paper（3）It is provided with four and is arranged in parallel within panel（2）Surface, test paper
（3）One end passes through capillary（6）With sample storage slot（8）It communicates, sample storage slot（8）Inside it is provided with well（5）With pressing piece（9）, examination
Paper（3）Upper end is provided with label window（4）, label window（4）Inside it is disposed with the control board of different size.
2. a kind of multi-joint detection card of the immunochromatography of time-saving and efficiency according to claim 1, it is characterised in that：The test paper
（3）Surface offers air hole（31）, air hole（31）With capillary（6）Connector is opposite and is separately positioned on test paper（3）'s
On two endpoints.
3. a kind of multi-joint detection card of the immunochromatography of time-saving and efficiency according to claim 2, it is characterised in that：It is described ventilative
Hole（31）Lower end is provided with observation window（33）, observation window（33）With air hole（31）Between arrange demarcation strip（32）, observation window（33）
Added with immune enzyme material on the test paper of place end.
4. a kind of multi-joint detection card of the immunochromatography of time-saving and efficiency according to claim 1, it is characterised in that：The test paper
（3）Center is filled with different types of specific antibody（35）And cTnI, hs-CRP, NT-proBNP, Myo test paper are formed successively
（3）, specific antibody（35）One end is connected with absorbing membrane（34）, absorbing membrane（34）With air hole（31）It is associated.
5. a kind of multi-joint detection card of the immunochromatography of time-saving and efficiency according to claim 1, it is characterised in that：The sample storage
Slot（8）With capillary（6）Connecting pin is provided with barrier test paper（7）, barrier test paper（7）Surface is covered with impermeable layer and is bonded in hair
Tubule（6）On port.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611012497.4A CN108072757A (en) | 2016-11-17 | 2016-11-17 | A kind of multi-joint detection card of the immunochromatography of time-saving and efficiency |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611012497.4A CN108072757A (en) | 2016-11-17 | 2016-11-17 | A kind of multi-joint detection card of the immunochromatography of time-saving and efficiency |
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| Publication Number | Publication Date |
|---|---|
| CN108072757A true CN108072757A (en) | 2018-05-25 |
Family
ID=62163555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611012497.4A Pending CN108072757A (en) | 2016-11-17 | 2016-11-17 | A kind of multi-joint detection card of the immunochromatography of time-saving and efficiency |
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|---|---|
| CN (1) | CN108072757A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108802402A (en) * | 2018-06-15 | 2018-11-13 | 重庆大学 | A kind of kit of quick discriminating respiratory tract infection type and its application |
| CN110146495A (en) * | 2019-05-13 | 2019-08-20 | 青海大学 | A kind of micro explosive and drugs device for fast detecting |
| WO2020143220A1 (en) * | 2019-01-11 | 2020-07-16 | 广州万孚生物技术股份有限公司 | Immunochromatographic assay device |
| CN111624331A (en) * | 2020-05-22 | 2020-09-04 | 军事科学院系统工程研究院卫勤保障技术研究所 | Multichannel synchronous fluorescence immunochromatography detection system |
| CN112945869A (en) * | 2021-02-01 | 2021-06-11 | 深圳市普兴医疗设备有限公司 | Film carrier for intelligent hospital liquid sample detection kit, preparation method of film carrier and liquid sample detection method |
| CN113189328A (en) * | 2021-05-10 | 2021-07-30 | 齐鲁工业大学 | Multi-channel detection test paper box and application thereof |
| EP3910333A4 (en) * | 2019-01-11 | 2022-04-13 | Guangzhou Wondfo Biotech. Co., Ltd. | Sample loading bottom plate and immunochromatography detection apparatus containing sample loading bottom plate |
| CN117825697A (en) * | 2024-03-01 | 2024-04-05 | 中国科学院过程工程研究所 | Hazard factor detection reagent card and detection method |
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| CN204008659U (en) * | 2014-03-20 | 2014-12-10 | 普迈德（北京）科技有限公司 | A kind of Novel immune chromatographic apparatus |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108802402A (en) * | 2018-06-15 | 2018-11-13 | 重庆大学 | A kind of kit of quick discriminating respiratory tract infection type and its application |
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| EP3910333A4 (en) * | 2019-01-11 | 2022-04-13 | Guangzhou Wondfo Biotech. Co., Ltd. | Sample loading bottom plate and immunochromatography detection apparatus containing sample loading bottom plate |
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| CN110146495A (en) * | 2019-05-13 | 2019-08-20 | 青海大学 | A kind of micro explosive and drugs device for fast detecting |
| CN111624331A (en) * | 2020-05-22 | 2020-09-04 | 军事科学院系统工程研究院卫勤保障技术研究所 | Multichannel synchronous fluorescence immunochromatography detection system |
| CN112945869A (en) * | 2021-02-01 | 2021-06-11 | 深圳市普兴医疗设备有限公司 | Film carrier for intelligent hospital liquid sample detection kit, preparation method of film carrier and liquid sample detection method |
| CN113189328A (en) * | 2021-05-10 | 2021-07-30 | 齐鲁工业大学 | Multi-channel detection test paper box and application thereof |
| CN113189328B (en) * | 2021-05-10 | 2023-10-13 | 齐鲁工业大学 | Multi-channel test paper box and application thereof |
| CN117825697A (en) * | 2024-03-01 | 2024-04-05 | 中国科学院过程工程研究所 | Hazard factor detection reagent card and detection method |
| CN117825697B (en) * | 2024-03-01 | 2024-05-07 | 中国科学院过程工程研究所 | Hazard factor detection reagent card and detection method |
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Application publication date: 20180525 |
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