CN108066901B - Radiation shielding device and method based on medical image - Google Patents
Radiation shielding device and method based on medical image Download PDFInfo
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- A—HUMAN NECESSITIES
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Abstract
The invention provides a radiation shielding device and a radiation shielding method based on medical images, which can form a radiation shielding with high pertinence and high accuracy according to individual differences of patients, such as tumor positions, sizes and the like, so that radiation of a radiation irradiation device to normal tissues of the patients is reduced or avoided. The shielding device comprises a medical image scanning device for scanning an irradiation part of an irradiated object and outputting medical image voxel data, a data processing and three-dimensional modeling device for establishing a three-dimensional prosthesis tissue model according to the medical image voxel data and establishing a shielding body three-dimensional model according to the three-dimensional prosthesis tissue model, a shielding body formed by inputting the shielding body three-dimensional model data into a 3D printer for printing, and the shielding body is positioned between the radioactive ray irradiation device and the irradiation part.
Description
Technical Field
The present invention relates in one aspect to radiation shielding devices for radiotherapy, in particular to a medical image-based radiation shielding device; another aspect of the invention relates to a radiation shielding method for radiotherapy, in particular a radiation shielding method based on medical images.
Background
With the development of atomic science, radiation therapy such as cobalt sixty, linac, electron beam, etc. has become one of the main means for cancer therapy. However, the traditional photon or electron treatment is limited by the physical condition of the radioactive rays, and a large amount of normal tissues on the beam path can be damaged while killing tumor cells; in addition, due to the different sensitivity of tumor cells to radiation, traditional radiotherapy often has poor therapeutic effects on malignant tumors with relatively high radiation resistance (such as glioblastoma multiforme (glioblastoma multiforme) and melanoma (melanoma)).
In order to reduce radiation damage to normal tissue surrounding a tumor, the concept of target treatment in chemotherapy (chemotherapy) has been applied to radiotherapy; for tumor cells with high radiation resistance, radiation sources with high relative biological effects (relative biological effectiveness, RBE) such as proton therapy, heavy particle therapy, neutron capture therapy, etc. are also actively developed. The neutron capture treatment combines the two concepts, such as boron neutron capture treatment, and provides better cancer treatment selection than the traditional radioactive rays by means of the specific aggregation of boron-containing medicaments in tumor cells and the accurate neutron beam regulation.
Various radioactive rays, such as neutrons and photons with low to high energy, are generated in the radiotherapy process, and may cause different degrees of damage to normal tissues of a human body. Therefore, in the field of radiotherapy, it is an extremely important task to reduce radiation pollution to the external environment, medical staff or normal tissues of a patient while achieving effective treatment. The existing radiation therapy equipment mainly focuses on a room where the equipment is placed and the equipment, but does not radiate normal tissues of a patient aiming at the radiation coming out of the outlet of the equipment, and can not form a radiation shield with pertinence and high accuracy according to individual differences of the patient, such as tumor positions, sizes, shapes and the like.
Medical image data such as magnetic resonance imaging (Magnetic Resonance Imaging, MRI) or computerized tomography (Computed Tomography, CT) can provide detailed tissue geometry information for internal features of the human body, providing a data base for solid modeling of internal structures of the human body. Therefore, there is a need for a method and apparatus for radiation shielding based on medical images that can form a targeted, highly accurate radiation shield that reduces or avoids radiation to normal tissue of a patient.
Disclosure of Invention
In order to shield the radiation of the radiation irradiating device to the normal tissue of the irradiated body, one aspect of the invention provides a medical image-based radiation shielding device, which comprises a medical image scanning device for scanning the irradiated part of the irradiated body and outputting medical image voxel data; the data processing and three-dimensional modeling device establishes a three-dimensional prosthesis tissue model according to the medical image voxel data and establishes a shielding three-dimensional model according to the three-dimensional prosthesis tissue model; and a shield formed by inputting shield three-dimensional model data into a 3D printer for printing, and positioned between the radioactive ray irradiation device and the irradiation part.
Preferably, the three-dimensional model of the shield is established based on the three-dimensional prosthetic tissue model by combining data information of the radiation irradiating device and a positional relationship between the radiation irradiating device and the irradiation site.
Preferably, the material of the shielding includes at least one of a neutron shielding material and a photon shielding material, the shielding is fixed on the surface of the irradiated body,matching with the surface shape of the irradiated body. The shielding body has a central through hole, the ratio of the diameter of the central through hole to the maximum size of the pathological tissue in the irradiated body in the direction perpendicular to the beam direction is 1-2, the maximum thickness of the shielding body is 3-20mm, and the area of the outer surface of the shielding body is 10-200cm 2 。
Preferably, the proportion of the radiation generated by the radiation irradiating device that passes through the shield is not less than 50%, and the proportion of the depth of radiation that passes through the shield to the normal tissue is not more than 50% compared with the depth of radiation that does not pass through the shield.
Another aspect of the present invention provides a radiation therapy apparatus including a radiation irradiating apparatus that irradiates an irradiated object to form an irradiated portion, and a shielding body; the shield is located between the radiation irradiating device and the irradiated portion, and is formed by printing by a 3D printer.
Preferably, the radiotherapy apparatus further comprises a three-dimensional image scanning device and a data processing and three-dimensional modeling device, the three-dimensional image scanning device scans the irradiation part and outputs three-dimensional data; the data processing and three-dimensional modeling device establishes a three-dimensional model of the irradiation part according to the three-dimensional data, and establishes a three-dimensional model of the shielding body according to the three-dimensional model of the irradiation part; the shield is formed by inputting three-dimensional model data of the shield into a 3D printer for printing.
Preferably, the radiotherapy apparatus further comprises a medical image scanning apparatus which scans the irradiation region and outputs medical image voxel data, and a data processing and three-dimensional modeling apparatus; the data processing and three-dimensional modeling device establishes a three-dimensional prosthesis tissue model according to the medical image voxel data, and establishes a shielding three-dimensional model according to the three-dimensional prosthesis tissue model; the shield is formed by inputting three-dimensional model data of the shield into a 3D printer for printing.
Preferably, the radiation irradiating device includes a radiation generating device capable of generating radiation, a beam shaping body capable of adjusting beam quality of the radiation, and a collimator capable of converging the radiation passing through the beam shaping body, the shielding body being located between the collimator and the irradiation site.
Further, the radiotherapy device is a boron neutron capture therapy device, the irradiated body is a cancer patient, the radiation generating device is a neutron generating device, the neutron generating device comprises an accelerator and a target, the accelerator accelerates charged particles, and neutrons are generated by the action of the accelerated charged particles and the target.
Further, the patient normal tissue receives a radiation dose of less than 18Gy during the boron neutron capture treatment.
Preferably, the radiotherapy apparatus further comprises a treatment table, and the radiation is applied to a lesion tissue of a patient on the treatment table through a shield fixed to the surface of the irradiated body or the treatment table or the collimator.
A third aspect of the present invention provides a radiation shielding method based on medical imaging, comprising the steps of: scanning an irradiation part of an irradiated object by a medical image scanning device, and outputting medical image voxel data of the irradiation part; establishing a three-dimensional prosthesis tissue model according to the medical image voxel data; establishing a three-dimensional model of the shielding body according to the three-dimensional prosthesis tissue model data; inputting the three-dimensional model data of the shielding body into a 3D printer to print the shielding body; and (5) installing and positioning the shielding.
Preferably, the step of establishing the three-dimensional model of the shielding body based on the three-dimensional prosthetic tissue model data further includes collecting or inputting data information of the radiation irradiating device and a positional relationship between the radiation irradiating device and the irradiation site, establishing the three-dimensional model of the shielding body based on the three-dimensional prosthetic tissue model data, and determining an installation position of the shielding body.
According to the medical image-based radiation shielding method and device, the shielding body is formed through 3D printing, can be formed according to individual differences of different irradiated bodies, can be used for quickly forming complex shapes, and is stronger in pertinence, higher in accuracy and capable of obtaining a better radiation shielding effect.
Drawings
FIG. 1 is a schematic diagram of a boron neutron capture therapy device in an embodiment of the invention;
FIG. 2 is a logic diagram of a medical image-based radiation shielding method in an embodiment of the present invention;
fig. 3 is a schematic diagram of a positional relationship between a shielding body and an irradiated body in an embodiment of the present invention.
Detailed Description
The present invention is described in further detail below with reference to the drawings to enable those skilled in the art to practice the invention by referring to the description.
As shown in fig. 1, the radiotherapy apparatus in the present embodiment is preferably a boron neutron capture therapy apparatus 100 including a neutron production apparatus 10, a beam shaper 20, a collimator 30, and a therapy table 40. The neutron generating device 10 includes an accelerator 11 and a target T, and the accelerator 11 accelerates charged particles (such as protons, deuterons, etc.) to generate charged particle rays P such as proton lines, and the charged particle rays P irradiate the target T and interact with the target T to generate neutron rays (neutron beams) N, and the target T is preferably a metal target. Suitable nuclear reactions are selected according to the required neutron yield and energy, the available energy and current of the accelerated charged particles, the physicochemical properties of the metal target, etc., and are usually discussed as 7 Li(p,n) 7 Be and Be 9 Be(p,n) 9 And B, performing an endothermic reaction. The energy threshold values of the two nuclear reactions are respectively 1.881MeV and 2.055MeV, because the ideal neutron source for boron neutron capture treatment is epithermal neutrons with the energy level of keV, in theory, if protons with the energy only slightly higher than the threshold value are used for bombarding a metal lithium target material, relatively low-energy neutrons can Be generated, the nuclear reactions can Be clinically used without too much slowing treatment, however, the proton action cross sections of the two targets of lithium metal (Li) and beryllium metal (Be) and the threshold energy are not high, and in order to generate enough neutron flux, protons with higher energy are generally selected for initiating the nuclear reactions. The ideal target should have the characteristics of high neutron yield, close neutron energy distribution generated to the epithermal neutron energy region (which will be described in detail later), no too much strong penetrating radiation generation, safety, low cost, easy operation, high temperature resistance, etc., but practically no nuclear reaction meeting all the requirements can be found, and the target is made of lithium metal in the embodiment of the invention. But one skilled in the artAs is well known, the material of the target T may also be made of a metal material other than lithium, beryllium, for example, tantalum (Ta) or tungsten (W), etc.; the target T may be disk-shaped, may be another solid shape, or may be a liquid (liquid metal). The accelerator 11 may be a linear accelerator, a cyclotron, a synchrotron, a synchrocyclotron, or the neutron production device 10 may be a nuclear reactor without using an accelerator or a target. Regardless of whether the neutron source of the boron neutron capture treatment is derived from nuclear reaction of charged particles of a nuclear reactor or accelerator with a target, the generated radiation field is actually a mixed radiation field, i.e. the beam contains neutrons and photons with low energy to high energy. For boron neutron capture treatment of deep tumors, the more radiation content, except for epithermal neutrons, the greater the proportion of non-selective dose deposition of normal tissue, and therefore the less radiation that will cause unnecessary doses. In addition, the various radiation rays should be avoided from being excessive for normal tissues of the irradiated body, as well as causing unnecessary dose deposition.
The neutron beam N generated by the neutron generator 10 is irradiated to the patient 200 on the treatment table 40 through the beam shaping body 20 and the collimator 30 in this order. The beam shaping body 20 can adjust the beam quality of the neutron beam N generated by the neutron generating device 10, the collimator 30 is used for converging the neutron beam N, so that the neutron beam N has higher targeting property in the treatment process, the direction of the beam and the positional relationship between the beam and the patient 200 on the treatment table 40 can be adjusted by adjusting the collimator 30, and the positions of the treatment table 40 and the patient 200 can be adjusted, so that the beam is aligned to the tumor cells M in the patient 200. These adjustments may be manually operated or may be automatically accomplished by a series of control mechanisms. It will be appreciated that the present invention may also be practiced without a collimator and that the beam is directed to the patient 200 on the treatment table 40 after exiting the beam shaper 20.
The beam shaping body 20 further comprises a reflector 21, a retarder 22, a thermal neutron absorber 23, a radiation shielding 24 and a beam outlet 25, and neutrons generated by the neutron generating device 10 are required to reduce the neutron and photon content of other types as far as possible except epithermal neutrons meet treatment requirements due to wide energy spectrumTo avoid injury to operators or patients, neutrons from the neutron generator 10 are required to adjust the fast neutron energy thereof to the epithermal neutron energy region by passing through a retarder 22, the retarder 22 is made of a material with a large fast neutron action section and a small epithermal neutron action section, and as a preferred embodiment, the retarder 13 is made of D 2 O、AlF 3 、Fluental、CaF 2 、Li 2 CO 3 、MgF 2 And Al 2 O 3 At least one of them; the reflector 21 surrounds the retarder 22 and reflects neutrons diffused around through the retarder 22 back to the neutron beam N to improve neutron utilization, and is made of a material having strong neutron reflection capability, and as a preferred embodiment, the reflector 21 is made of at least one of Pb or Ni; the rear part of the retarder 22 is provided with a thermal neutron absorber 23 which is made of a material with a large cross section for reacting with thermal neutrons, and as a preferred embodiment, the thermal neutron absorber 23 is made of Li-6, and the thermal neutron absorber 23 is used for absorbing the thermal neutrons passing through the retarder 22 so as to reduce the content of thermal neutrons in a neutron beam N and avoid excessive dosage caused by shallow normal tissues during treatment; a radiation shield 24 is arranged at the rear of the reflector around the beam outlet 25 for shielding neutrons and photons leaking from parts outside the beam outlet 25, the material of the radiation shield 24 comprising at least one of photon shielding material and neutron shielding material, as a preferred embodiment the material of the radiation shield 24 comprises photon shielding material lead (Pb) and neutron shielding material Polyethylene (PE). The collimator 30 is disposed at the rear of the beam outlet 25, and the epithermal neutron beam coming out of the collimator 30 irradiates the patient 200, and is retarded to thermal neutrons after passing through the shallow normal tissue, to reach the tumor cells M. It will be appreciated that other configurations of the beam shaping body 20 are possible, as long as the epithermal neutron beam required for treatment is obtained.
After the patient 200 takes or injects the boron-containing (B-10) drug, the boron-containing drug is selectively accumulated in the tumor cells M, and then the boron-containing (B-10) drug is utilized to have the characteristic of high capture section for thermal neutrons, by 10 B(n,α) 7 Li neutron capture and nuclear fission reaction generation 4 He (He) 7 Li two heavy charged particles. Flat of two charged particlesWith an average energy of about 2.33MeV, with high linear transfer (Linear Energy Transfer, LET), short range characteristics, linear energy transfer and range of the alpha short particles are 150 keV/and injection, 815, respectively 7 The Li heavy-load particles are 175 keV/mum and 5 μm, and the total range of the two particles is approximately equal to one cell size, so that the radiation injury to organisms can be limited at the cell level, and the aim of killing tumor cells locally can be fulfilled on the premise of not causing too great injury to normal tissues.
The boron neutron capture treatment device 100 further includes a radiation shielding device 50, and although the neutron beam N generated by the neutron generating device 10 passes through the beam shaping body 20 and the collimator 30 and irradiates the patient 200 with the main therapeutic epithermal neutron beam, it is still difficult to completely avoid mixing other neutrons and photons, and the radiation may damage the normal tissue of the patient 200, and the therapeutic epithermal neutron beam has little influence on the normal tissue of the human body, so that the possibility of causing dose accumulation is still further reduced, and therefore, the patient needs to be protected by shielding the portion where the radiation shielding device 50 does not need to irradiate the beam.
The radiation shielding device 50 further comprises a medical image scanning device 51, a data processing and three-dimensional modeling device 52, a shielding 53. The medical image scanning apparatus 51 scans an irradiation site of the patient 200, which is defined as a portion where a three-dimensional space formed by overlapping the patient body and the patient body is formed, and outputs medical image voxel data, by taking a certain irradiation depth in the irradiation direction from an end surface of the radiation irradiation apparatus (composed of the neutron generator 10, the beam shaper 20, and the collimator 30) close to the treatment table 40, and taking a certain irradiation plane perpendicular to the irradiation direction. The medical image data may be magnetic resonance imaging (Magnetic Resonance Imaging, MRI), electronic computed tomography (Computed Tomography, CT), positron emission computed tomography (Positron Emission Tomography, PET), PET-CT or X-Ray imaging (X-Ray imaging), as will be explained based on electronic Computed Tomography (CT) data, the file format of CT typically being DICOM. It is well known to those skilled in the art that other medical image data may be used, and that the medical image data may be converted into a three-dimensional prosthetic tissue model for use in the medical image-based radiation shielding apparatus and method of the present disclosure.
After the patient 200 is positioned on the treatment table 40, the irradiation part of the patient 200 is scanned by CT to form a CT data file, that is, medical image voxel data; the data processing and three-dimensional modeling apparatus 52 establishes a three-dimensional prosthetic tissue model based on the medical image voxel data, such as three-dimensional visualization using three-dimensional modeling software such as MI-3DVS software or CAD software, the three-dimensional prosthetic tissue model including lesion tissue and normal tissue, re-establishes a three-dimensional model of the normal tissue shield based on the three-dimensional prosthetic tissue model, and determines the installation position of the shield. The three-dimensional model of the shielding body can be established by combining data information of the radiation irradiation device, such as beam intensity, beam flux, beam diameter, irradiation path and the like, and the positional relationship between the radiation irradiation device and the irradiation part, and can be manually corrected according to actual conditions in the process. It will be appreciated that a CT scan may also be performed prior to the patient 200 entering the treatment room, such that the medical image scanning apparatus 51 need not be integrated within the treatment room, and the irradiation site may be determined by scanning using a CT scanner currently available in hospitals to form CT data files for the irradiation site. At this time, data information of the radiation irradiating apparatus, such as beam intensity, beam flux, beam diameter, irradiation path, and the like, and positional relationship of the radiation irradiating apparatus and the irradiation site are also determined in accordance with the irradiation site determined by scanning, and then a three-dimensional model of the shield is built based on the data information.
The shielding body 53 is formed by inputting three-dimensional model data of the shielding body into a 3D printer for printing, inputting an STL format file for recording the three-dimensional model data into a computer system, layering the STL format file into two-dimensional slice data, printing layer by layer through a 3D printing system controlled by the computer, and finally obtaining a three-dimensional product after superposition. The shield 53 is capable of shielding the normal tissue of the patient 200 from the radiation beam generated by the radiation irradiating device, and the radiation beam passes through the shield 53 and then acts on the tumor cells M of the patient 200 on the treatment table 40, and the shield 53 is preferably located between the radiation irradiating device and the irradiation siteThe shield is located between the collimator or beam outlet and the irradiation site. The material of the shielding 53 includes at least one of a neutron shielding material or a photon shielding material. The shield 53 is preferably plate-shaped and is directly fixed to the body surface of the patient's irradiation site, and is adapted to the shape of the body surface of the patient's site to be mounted, so that the shield can be easily and correctly mounted, and the fixing means may be an adhesive, a tape, a buckle, or the like. The shielding body 53 has a central through hole 531, the ratio of the diameter of the central through hole 531 to the maximum size of the tumor cells M in the patient 200 perpendicular to the beam direction is 1-2, damage to normal tissues is avoided to the greatest extent while killing the tumor cells, the shape of the central through hole 531 is preferably the outer contour shape of the projection of the tumor cells M parallel to the beam direction, and the diameter defined by the central through hole can be understood as the diameter of the outer contour shape. It will be appreciated that the shield 53 may not have a central through hole, but may have a different thickness in the central portion than in the other portions or the entire shield may have a different thickness in different locations. The maximum thickness of the shield 53 has a value ranging from 3 to 20mm and the area of the outer surface has a value ranging from 10 to 200cm 2 . Since 3D printing is adopted, the shielding bodies 53 can be molded respectively according to individual differences of different irradiated bodies, and can be molded rapidly in complex shapes, and a better radiation shielding effect can be obtained. In some special-shaped parts, a plurality of shielding bodies 53 can be arranged, so that the installation is convenient. The shielding body 53 may be fixed to the treatment table, the collimator, or the beam outlet, or the 3D printer may be combined with the treatment table, the collimator, or the beam outlet to determine the positional relationship, and then print the shielding body directly at the corresponding position. The tumor part of the patient is scanned by the medical image, a targeted 3D printing shielding body is obtained, the attenuation ratio of the radioactive rays after passing through the shielding body can be more than or equal to 50 percent, preferably more than or equal to 80 percent, and the radiation dose received by normal tissues of the patient in the boron neutron capture treatment process is less than 18Gy. The proportion of the radiation depth of the radiation passing through the shielding body to the normal tissue is less than or equal to 50 percent compared with the radiation depth of the radiation not passing through the shielding body. The shielding 53 can be designed with more complex materials, shapes and structures, and can change the path of the neutron beam coming out of the collimator or beam outlet to make it stereoscopic with the tumor cellsThe shapes are matched, for example, the central through hole 531 is composed of different line segments along the beam direction, and different parts of the shielding body 53 are composed of different materials.
The radiation shielding method based on the medical image of the embodiment comprises the following steps:
s1: scanning an irradiated portion of the patient 200 by the medical image scanning apparatus 51 and outputting medical image voxel data of the irradiated portion;
s2: the data processing and three-dimensional modeling device 52 establishes a three-dimensional prosthesis tissue model according to the medical image voxels obtained in the step S1;
s3: the data processing and three-dimensional modeling device 52 establishes a three-dimensional model of the shielding body according to the three-dimensional prosthesis tissue model data obtained in the step S2;
s4: inputting the shield three-dimensional model data into a 3D printer to print the shield 53;
s5: the shield 53 is mounted and positioned.
Step S3 also includes collecting or inputting data information of the radiation irradiation device, such as beam intensity, beam flux, beam diameter, irradiation path, etc., and positional relationship between the radiation irradiation device and the irradiation part, then combining three-dimensional prosthetic tissue model data to build a three-dimensional model of the shielding body, and determining the mounting position of the shielding body, wherein in the process, artificial correction can be performed according to actual conditions.
In the embodiment of the invention, the medical image scanning device is adopted to obtain the tissue composition of the irradiation part of the patient, so that the shielding body is obtained according to the shape, the position, the size and the like of tumor cells in a targeted manner. It can be understood that the invention can also be used with non-medical image scanning devices, such as three-dimensional image scanning devices that scan only the shape of the patient's body surface, so as to obtain three-dimensional data of the shape of the illuminated portion of the patient for three-dimensional modeling, and further obtain a 3D printed shield that matches the shape of the illuminated portion.
It will be appreciated that the present invention may also be applied to other fields of radiotherapy known to those skilled in the art where irradiation of diseased tissue is required, while normal tissue is to be protected from or less irradiated/irradiated radiation, and the neutron production device is accordingly replaced by other radiation production devices, such as proton production devices, heavy ion production devices, X-ray production devices or gamma ray production devices, etc.; it can also be used for treating other diseases by irradiation, such as Alzheimer disease and rheumatoid arthritis, and tumor cells are other pathological tissues. The irradiated body in this embodiment is a cancer patient, and it is understood that the irradiated body may be another organism, such as a mammal.
The positional relationship in the embodiment of the present invention refers to a positional relationship in the direction of the beam transmission path, and the "rear" refers to downstream in the beam direction.
While the foregoing describes illustrative embodiments of the present invention to facilitate an understanding of the present invention by those skilled in the art, it should be understood that the present invention is not limited to the scope of the embodiments, but rather that various changes can be made within the spirit and scope of the present invention as defined and defined by the appended claims as would be apparent to those skilled in the art.
Claims (14)
1. A radiation shielding apparatus based on medical imaging for shielding radiation of a radiation irradiating apparatus to normal tissue of an irradiated body, comprising:
a medical image scanning device that scans an irradiation portion of the irradiated object and outputs medical image voxel data;
the data processing and three-dimensional modeling device establishes a three-dimensional prosthesis tissue model according to the medical image voxel data and establishes a shielding body three-dimensional model according to the three-dimensional prosthesis tissue model;
a shield formed by inputting three-dimensional model data of the shield into a 3D printer for printing, the shield being positioned between the radiation irradiation device and the irradiation part;
the shield body is provided with a central through hole, the shape of the central through hole is the outer contour shape of the projection of the tumor cells parallel to the beam direction, and the diameter of the central through hole is the diameter of the outer contour shape.
2. The medical image-based radiation shielding apparatus according to claim 1, wherein the three-dimensional model of the shielding body is established based on the three-dimensional prosthetic tissue model in combination with data information of the radiation irradiating apparatus and a positional relationship of the radiation irradiating apparatus and an irradiated portion.
3. The medical image based radiation shielding apparatus of claim 1, wherein the material of the shielding comprises at least one of neutron shielding material or photon shielding material, the shielding being affixed to the surface of the irradiated body and matching the surface profile of the irradiated body.
4. A medical image based radiation shielding apparatus according to claim 3, wherein a ratio of a diameter of said central through hole to a maximum dimension of a lesion tissue in said irradiated body in a direction perpendicular to a beam direction is in a range of 1 to 2, a maximum thickness of said shielding body is in a range of 3 to 20mm, and an area of an outer surface of said shielding body is in a range of 10 to 200cm 2 。
5. The medical image-based radiation shielding apparatus according to claim 1, wherein the proportion of radiation generated by the radiation irradiating apparatus that is attenuated after passing through the shielding body is not less than 50%, and the proportion of the depth of radiation that is irradiated to normal tissue after passing through the shielding body is not more than 50% compared with that without passing through the shielding body.
6. A radiation therapy apparatus including a radiation irradiation device that irradiates an irradiation target to form an irradiation site, and a shielding body; the shielding body is positioned between the radioactive ray irradiation device and the irradiation part and is formed by printing of a 3D printer; the shield body is provided with a central through hole, the shape of the central through hole is the outer contour shape of the projection of the tumor cells parallel to the beam direction, and the diameter of the central through hole is the diameter of the outer contour shape.
7. The radiation therapy device as claimed in claim 6, wherein said radiation therapy device further comprises a three-dimensional image scanning device which scans said irradiation site and outputs three-dimensional data, and a data processing and three-dimensional modeling device; the data processing and three-dimensional modeling device establishes a three-dimensional model of an irradiation part according to the three-dimensional data, and establishes a three-dimensional model of a shielding body according to the three-dimensional model of the irradiation part; the shielding body is formed by inputting three-dimensional model data of the shielding body into a 3D printer for printing.
8. The radiation therapy device as claimed in claim 6, further comprising a medical image scanning device that scans said irradiation site and outputs medical image voxel data, and a data processing and three-dimensional modeling device; the data processing and three-dimensional modeling device establishes a three-dimensional prosthesis tissue model according to the medical image voxel data, and establishes a shielding body three-dimensional model according to the three-dimensional prosthesis tissue model; the shielding body is formed by inputting three-dimensional model data of the shielding body into a 3D printer for printing.
9. The radiation therapy device according to claim 6 or 8, wherein the radiation irradiating device comprises a radiation generating device capable of generating radiation, a beam shaping body capable of adjusting a beam quality of the radiation generated by the radiation generating device, and a collimator capable of converging the radiation passing through the beam shaping body, the shielding body being located between the collimator or beam outlet and an irradiation site.
10. The radiation therapy device according to claim 9, wherein the radiation therapy device is a boron neutron capture therapy device, the irradiated body is a cancer patient, the radiation generation device is a neutron generation device, the neutron generation device includes an accelerator that accelerates charged particles, and a target, and neutrons are generated by the accelerated charged particles acting on the target.
11. The radiation therapy device defined in claim 10, wherein said patient normal tissue receives a radiation dose of less than 18Gy during boron neutron capture therapy.
12. The radiation therapy device according to claim 10, further comprising a treatment table, wherein the radiation passes through the shield and then is applied to a lesion of a patient on the treatment table, and wherein the shield is fixed to a surface of the irradiated body or the treatment table or the collimator or the beam outlet.
13. A radiation shielding method based on medical imaging, comprising the steps of:
scanning an irradiation part of an irradiated object by a medical image scanning device, and outputting medical image voxel data of the irradiation part;
establishing a three-dimensional prosthesis tissue model according to the medical image voxel data;
establishing a shielding body three-dimensional model according to the three-dimensional prosthesis tissue model data;
inputting the shield three-dimensional model data into a 3D printer for printing a shield;
installing and positioning the shielding body;
the shield body is provided with a central through hole, the shape of the central through hole is the outer contour shape of the projection of the tumor cells parallel to the beam direction, and the diameter of the central through hole is the diameter of the outer contour shape.
14. The medical image-based radiation shielding method according to claim 13, wherein the step of creating a three-dimensional model of the shielding body from the three-dimensional prosthetic tissue model data further comprises collecting or inputting data information of the radiation irradiating device and a positional relationship between the radiation irradiating device and the irradiation site, creating the three-dimensional model of the shielding body in combination with the three-dimensional prosthetic tissue model data, and determining an installation position of the shielding body.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611029477.8A CN108066901B (en) | 2016-11-14 | 2016-11-14 | Radiation shielding device and method based on medical image |
| JP2019510411A JP7409869B2 (en) | 2016-11-14 | 2017-07-11 | Radiation shielding device and method based on medical images |
| PCT/CN2017/092499 WO2018086367A1 (en) | 2016-11-14 | 2017-07-11 | Medical image-based radiation shielding device and method |
| EP17870064.7A EP3473298B1 (en) | 2016-11-14 | 2017-07-11 | Medical image-based radiation shielding device and method |
| RU2019103225A RU2721658C1 (en) | 2016-11-14 | 2017-07-11 | Radiation based on medical images radiation shielding device and method |
| TW106128751A TWI646946B (en) | 2016-11-14 | 2017-08-24 | Radiation shielding device based on medical image |
| US16/246,645 US10994154B2 (en) | 2016-11-14 | 2019-01-14 | Medical image-based radiation shielding device and method thereof |
| JP2023081695A JP2023101009A (en) | 2016-11-14 | 2023-05-17 | Radiotherapy apparatus |
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| CN201611029477.8A CN108066901B (en) | 2016-11-14 | 2016-11-14 | Radiation shielding device and method based on medical image |
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| CN108888876B (en) * | 2018-06-28 | 2021-06-29 | 广州医科大学附属肿瘤医院 | Radiotherapy radiation field stray radiation protection device based on 3D printing and manufacturing method |
| EP4371609A4 (en) * | 2021-07-16 | 2024-10-16 | Neuboron Therapy System Ltd | Neutron capture therapy system |
| CN118001622B (en) * | 2024-04-08 | 2024-06-25 | 华硼中子科技(杭州)有限公司 | Normal tissue protection device for BNCT (brain-based cancer therapy) treatment of lung cancer |
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