CN108066901A - Radiation shield device and method based on medical image - Google Patents
Radiation shield device and method based on medical image Download PDFInfo
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- CN108066901A CN108066901A CN201611029477.8A CN201611029477A CN108066901A CN 108066901 A CN108066901 A CN 108066901A CN 201611029477 A CN201611029477 A CN 201611029477A CN 108066901 A CN108066901 A CN 108066901A
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- 238000012545 processing Methods 0.000 claims abstract description 16
- 230000002285 radioactive effect Effects 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 21
- 238000001959 radiotherapy Methods 0.000 claims description 20
- 238000007493 shaping process Methods 0.000 claims description 17
- 239000002245 particle Substances 0.000 claims description 14
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 13
- 229910052796 boron Inorganic materials 0.000 claims description 13
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 238000009434 installation Methods 0.000 claims description 8
- 230000001225 therapeutic effect Effects 0.000 claims description 8
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- 239000003814 drug Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 claims description 5
- 238000001727 in vivo Methods 0.000 claims description 4
- 230000002238 attenuated effect Effects 0.000 claims description 3
- 238000007639 printing Methods 0.000 claims description 3
- 238000012876 topography Methods 0.000 claims description 2
- 230000001133 acceleration Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 abstract description 3
- 238000002591 computed tomography Methods 0.000 description 15
- 210000004881 tumor cell Anatomy 0.000 description 15
- 238000006243 chemical reaction Methods 0.000 description 8
- 238000002595 magnetic resonance imaging Methods 0.000 description 6
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- 201000010915 Glioblastoma multiforme Diseases 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
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- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 description 1
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- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
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- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Radiation-Therapy Devices (AREA)
Abstract
The present invention provides a kind of radiation shield device and method based on medical image, it can be according to the individual difference of patient, such as knub position, size form radiation shield targeted, that accuracy is high, so as to which radiation of the radiation device to patient's normal structure be reduced or avoided.The screening arrangement of the present invention includes the irradiated site of scanning irradiated body and exports the medical image scanning means of medical image voxel data, three-dimensional prosthetic tissue model is established according to medical image voxel data and data processing and the three-dimensional modeling apparatus of body three-dimensional models are shielded according to three-dimensional prosthetic tissue model foundation, the shield formed is printed by shield three-dimensional modeling data input 3D printer, shield is between radiation device and irradiated site.
Description
Technical field
One aspect of the present invention is related to the radiation shield device of radiation cure, especially a kind of radiation based on medical image
Screening arrangement；Another aspect of the present invention is related to the radiation shielding methods of radiation cure, especially a kind of based on medical image
Radiation shielding methods.
Background technology
As the development of atomics, such as the radiation cures such as cobalt 60, linear accelerator, electron beam have become cancer
One of main means of disease treatment.However conventional photonic or electronic therapy are limited be subject to radioactive ray physical condition itself, are being killed
While dead tumour cell, substantial amounts of normal structure in beam approach can also be damaged；Additionally, due to tumour cell to putting
The difference of radiation-sensitive degree, traditional radiation therapy is for relatively having the malignant tumour of radiation resistance (such as：Multirow glioblast
Knurl (glioblastoma multiforme), melanocytoma (melanoma)) treatment effect it is often bad.
In order to reduce the radiation injury of tumour surrounding normal tissue, the target therapy in chemotherapy (chemotherapy)
Concept is just applied in radiation cure；And for the tumour cell of radiation resistance, also actively development has high phase at present
To the radiation source of biological effect (relative biological effectiveness, RBE), as proton therapeutic, heavy particle are controlled
Treatment, neutron capture treatment etc..Wherein, neutron capture treatment is to combine above two concept, if boron neutron capture is treated, by
Boracic drug gathers in the specificity of tumour cell, and accurately neutron beam regulates and controls for cooperation, provides more better than conventional radiation
Treatment of cancer selects.
Various radioactive ray can be generated during radiation cure, as boron neutron capture therapeutic process generates low energy to high energy
Neutron, photon, these radioactive ray may cause human normal tissue different degrees of damage.Therefore led in radiation cure
Domain, how to be reduced while effective treatment is reached is to the radiation pollution of external environment, medical worker or patient's normal structure
One particularly important problem.And existing radiation cure equipment, place apparatus is also focused primarily upon to the shielding of radiation
Room, equipment in itself, can not bases without being directed to the radiation of radioactive ray that slave device exports out to patient's normal structure
The individual difference of patient, such as knub position, size, shape form radiation shield targeted, that accuracy is high.
Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) or CT scan
Medical image datas such as (Computed Tomography, CT) can be directed to feature in body and provide more detailed tissue
Geometry information provides data basis for the solid modelling of body structures.Therefore, it is necessary to it proposes a kind of based on doctor
The radiation shielding methods and device of image are learned, radiation shield targeted, that accuracy is high can be formed, be reduced or avoided to suffering from
The radiation of person's normal structure.
The content of the invention
In order to shield radiation of the radiation device to the normal structure of irradiated body, one aspect of the present invention provides one
Kind of the radiation shield device based on medical image including medical image scanning means, scans the irradiated site of irradiated body, and
Export medical image voxel data；Data processing and three-dimensional modeling apparatus establish three-dimensional prosthetic according to medical image voxel data
Model is organized, and body three-dimensional models are shielded according to three-dimensional prosthetic tissue model foundation；Shield, by shield three-dimensional modeling data
Input 3D printer prints to be formed, between radiation device and irradiated site.
As one kind preferably, shielding body three-dimensional models are according to three-dimensional prosthetic tissue model, irradiate and fill with reference to radioactive ray
What the data message and radiation device and the position relationship of irradiated site put were established.
As one kind preferably, the material of shield is included in the material of shielding neutron or the material for shielding photon at least
One kind, shield are fixed on irradiated body surface, are mutually matched with irradiated body surface topography.Shield has central through hole,
The diameter of central through hole is in the maximum sized ratio section perpendicular to beam direction with the in vivo pathological tissues of irradiated body
1-2, the numberical range of shield maximum gauge is 3-20mm, and the areal extent for shielding external surface is 10-200cm2。
As it is a kind of preferably, the ratio that the radioactive ray that radiation device generates are attenuated after shield for >=
50%, the radiation depth of radioactive ray normal tissue after shield is the same as without ratio≤50% compared with shield.
Another aspect of the present invention provides a kind of radiotherapy apparatus, and radiotherapy apparatus includes radioactive ray irradiation dress
It puts and shield, radiation device irradiation irradiated body forms irradiated site；Shield be located at radiation device and
Between irradiated site, and printed and formed by 3D printer.
As one kind preferably, radiotherapy apparatus further includes 3-dimensional image scanning means and data processing and three-dimensional is built
Mold device, 3-dimensional image scanning means scanning irradiated site simultaneously export three-dimensional data；Data processing and three-dimensional modeling apparatus according to
Three-dimensional data establishes irradiated site threedimensional model, and shields body three-dimensional models according to irradiated site three-dimension modeling；Shield
It is printed and is formed by shield three-dimensional modeling data input 3D printer.
As one kind preferably, radiotherapy apparatus further includes medical image scanning means and data processing and three-dimensional is built
Mold device, medical image scanning means scanning irradiated site simultaneously export medical image voxel data；Data processing and three-dimensional modeling
Device establishes three-dimensional prosthetic tissue model according to medical image voxel data, and according to three-dimensional prosthetic tissue model foundation shield
Threedimensional model；Shield is printed by shield three-dimensional modeling data input 3D printer and formed.
As one kind preferably, radiation device includes radiation beam generating apparatus, beam-shaping body, collimator, puts
Ray generating devices can generate radioactive ray, and beam-shaping body can adjust the beam quality of radioactive ray, and collimator can converge
By the radioactive ray of the beam-shaping body, shield is between collimator and irradiated site.
Further, radiotherapy apparatus is boron neutron capture therapeutic device, and irradiated body is cancer patient, radioactive ray
Generation device is neutron generation device, and neutron generation device includes accelerator and target, and accelerator accelerates charged particle,
Neutron is generated by the charged particle accelerated with target effect.
Further, the dose of radiation that patient's normal structure receives in boron neutron capture therapeutic process is less than 18Gy.
As one kind preferably, radiotherapy apparatus further includes instrument table, and radioactive ray are applied to after shield and control
The pathological tissues of the patient on platform are treated, shield is fixed in irradiated body surface or instrument table or collimator.
Third aspect present invention provides a kind of radiation shielding methods based on medical image, includes the following steps：Pass through
Medical image scanning means scans the irradiated site of irradiated body, and exports the medical image voxel data of the irradiated site；
Three-dimensional prosthetic tissue model is established according to medical image voxel data；Shield three is established according to three-dimensional prosthetic tissue model data
Dimension module；By shield three-dimensional modeling data input 3D printer printing shield；Shielding is subjected to installation positioning.
As one kind preferably, also wrapped in the step of establishing shielding body three-dimensional models according to three-dimensional prosthetic tissue model data
Acquisition or the input data message of radiation device and the position relationship of radiation device and irradiated site are included, with reference to
Three-dimensional prosthetic tissue model data establishes shielding body three-dimensional models, and determines the installation site of shield.
Radiation shielding methods and device of the present invention based on medical image, shield are formed through 3D printing, can
Individual difference according to different irradiated bodies is separately formed, and can be to complicated shape rapid shaping, and specific aim is stronger, accuracy
Higher can obtain better radiation screening effect.
Description of the drawings
Fig. 1 is the boron neutron capture therapeutic device schematic diagram in the embodiment of the present invention；
Fig. 2 is the logic diagram of the radiation shielding methods based on medical image in the embodiment of the present invention；
Fig. 3 is the position relationship schematic diagram of the shield and irradiated body in the embodiment of the present invention.
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, to make those skilled in the art with reference to specification text
Word can be implemented according to this.
Such as Fig. 1, the radiotherapy apparatus in the present embodiment is preferably boron neutron capture therapeutic device 100, including neutron
Generation device 10, beam-shaping body 20, collimator 30 and instrument table 40.Neutron generation device 10 includes accelerator 11 and target T,
Accelerator 11 accelerates charged particle (such as proton, deuteron), generates the charged particle line P such as proton line, charged particle
Sub-line (neutron beam) N, target T is preferably metal targets during line P is irradiated to target T and is generated with target T effects.According to required
The characteristics such as neutron yield rate and energy, the available materialization for accelerating charged particle energy and size of current, metal targets are chosen
Suitable nuclear reaction is selected, the nuclear reaction being often discussed has7Li(p,n)7Be and9Be(p,n)9B, both reactions are all that heat absorption is anti-
It should.The energy threshold of two kinds of nuclear reactions is respectively 1.881MeV and 2.055MeV, due to the preferable neutron of boron neutron capture treatment
Source is the epithermal neutron of keV energy grades, can if being theoretically only slightly taller than the proton bombardment lithium metal target of threshold values using energy
The neutron of opposite low energy is generated, clinic can be used for by being not necessary to too many slow handle, however lithium metal (Li) and beryllium metal (Be)
The proton-effect section of two kinds of targets and threshold values energy is not high, to generate sufficiently large neutron flux, usually selects higher-energy
Proton trigger nuclear reaction.Preferable target should possess high neutron yield rate, the neutron energy generated is distributed close to epithermal neutron
The characteristics such as radiation generation, safe cheap easily operated and high temperature resistant are worn by force without too many by energy area (will be described in more detail below), but in fact
On border and it can not find and meet required nuclear reaction, target made of lithium metal is used in the embodiment of the present invention.But
Well known to those skilled in the art, the material of target T can also be made of the metal material outside lithium, beryllium, such as by tantalum (Ta)
Or the formation such as tungsten (W)；Target T can be disk-shaped, or other solid shapes can also use liquid material (liquid gold
Belong to).Accelerator 11 can be linear accelerator, cyclotron, synchrotron, synchrocyclotron, and neutron generates dress
It can also be nuclear reactor without using accelerator and target to put 10.No matter the neutron source of boron neutron capture treatment comes from nuclear reaction
The nuclear reaction of heap or accelerator charged particle and target, generation is actually all mixed radiation field, i.e. beam contains low energy
Neutron, photon to high energy.It is treated for the boron neutron capture of deep tumor, in addition to epithermal neutron, remaining radiation contains
Amount is more, and the ratio for causing the non-selective dosage deposition of normal structure is bigger, therefore these can cause the radiation of unnecessary dosage
Should try one's best reduction.In addition, for the normal structure of irradiated body, various radiation should avoid excessively, and equally causing need not
The dosage deposition wanted.
The neutron beam N that neutron generation device 10 generates passes sequentially through beam-shaping body 20 and collimator 30 is irradiated to instrument table
Patient 200 on 40.Beam-shaping body 20 can adjust the beam quality of the neutron beam N of the generation of neutron generation device 10, collimation
Device 30 makes neutron beam N have higher targeting during being treated, by adjusting collimation to converge neutron beam N
Device 30 can adjust the direction of beam and the position relationship of the patient 200 on beam and instrument table 40, instrument table 40 and patient 200
Position can also be adjusted, make 200 in vivo tumour cell M of beacon alignment patient.These adjustment can be grasped manually
It is making or realized automatically by a series of control mechanisms.It is appreciated that the present invention can not also have collimator,
Beam comes out rear direct irradiation to the patient 200 on instrument table 40 from beam-shaping body 20.
Beam-shaping body 20 further comprises reflector 21, slow body 22, thermal neutron absorber 23,24 and of radiation shield
Beam outlet 25, the neutron that neutron generation device 10 generates is since power spectrum is very wide, in addition to epithermal neutron meets treatment needs,
It needs to reduce other kinds of neutron as far as possible and photon content damages to avoid to operating personnel or patient, therefore from
The neutron that neutron generation device 10 comes out is needed fast neutron energy adjusting therein to epithermal neutron energy area by slow body 22,
Slow body 22 with fast neutron action section is big, epithermal neutron action section is small material by being made, as a kind of preferred embodiment,
Slow body 13 is by D2O、AlF3、Fluental、CaF2、Li2CO3、MgF2And Al2O3At least one of be made；Reflector 21 surrounds
Slow body 22, and the neutron reflection spread around through slow body 22 is returned into neutron beam N to improve the utilization rate of neutron, by
It is made with the strong material of neutron reflection ability, as a kind of preferred embodiment, reflector 21 is by least one of Pb or Ni
It is made；Slow 22 rear portion of body is made, as one kind there are one thermal neutron absorber 23 of the material big with thermal neutron action section
Preferred embodiment, thermal neutron absorber 23 are made of Li-6, and thermal neutron absorber 23 is hankered for absorbing through slow body 22
Son avoids causing multiple dose with shallow-layer normal structure during treatment to reduce the content of thermal neutron in neutron beam N；Radiation shield
24 are arranged on reflector rear portion around beam outlet 25, for shielding the neutron and light that are leaked from beam outlet 25 with outer portion
Son, the material of radiation shield 24 include at least one of photon shielding material and neutron shielding material, as a kind of preferred
Embodiment, the material of radiation shield 24 include photon shielding material lead (Pb) and neutron shielding material polyethylene (PE).Collimation
Device 30 is arranged on beam and exports 25 rear portions, and the epithermal neutron beam come out from collimator 30 is irradiated to patient 200, through normal group of shallow-layer
It is slowly that thermal neutron reaches tumour cell M after knitting.It is appreciated that beam-shaping body 20 can also have other constructions, as long as
Epithermal neutron beam needed for being treated.
After patient 200 takes or inject boracic (B-10) drug, it is gathered in tumour cell M boracic drug selectivity,
Then there is the characteristic of high capture cross section using boracic (B-10) drug to thermal neutron, by10B(n,α)7Li neutron captures and core
Dissociative reaction generates4He and7Two heavy burden charged particle of Li.The average energy of two charged particles is about 2.33MeV, has High Linear
(Linear Energy Transfer, LET), short range feature are shifted, the linear energy transfer of the short particles of α is respectively with range
150keV/ and penetrate, 815, and7Li heavy burdens particle is then 175keV/ μm, 5 μm, and the integrated range of two particle is approximately equivalent to a cell
Size, therefore radiation injury can be confined to cell level for caused by organism, just can be caused in not normal tissue too big
On the premise of injury, achieve the purpose that local kill tumour cell.
Boron neutron capture therapeutic device 100 further includes radiation shield device 50, although during neutron generation device 10 generates
Beamlet N is irradiated to the predominantly treatment epithermal neutron beam of patient 200 after beam-shaping body 20 and collimator 30, but actual
On be still difficult to that other neutrons and photon is avoided to mix wherein completely, when these radioactive ray are irradiated to 200 normal structure of patient still
Damage is likely to cause, although in addition, influence of the treatment epithermal neutron beam to human normal tissue is minimum, is still to further drop
The low possibility for causing dose accumulation, it is therefore desirable to set radiation shield device 50 by patient without by the position of beam exposure
It blocks and is protected by.
Radiation shield device 50 further includes medical image scanning means 51, data processing and three-dimensional modeling apparatus
52nd, shield 53.Medical image scanning means 51 scans 200 irradiated site of patient, and exports medical image voxel data, irradiates
Position is defined as controlling from radiation device (being made of neutron generation device 10, beam-shaping body 20, collimator 30) is close
The end face for treating platform 40 takes certain depth of shine along direction of illumination, and certain irradiated plane is taken perpendicular to direction of illumination, is formed
Solid space and patient body intersection.Medical image data can be Magnetic resonance imaging (Magnetic
Resonance Imaging, MRI), CT scan (Computed Tomography, CT), positron emission
Type computed tomography (Positron Emission Tomography, PET), PET-CT or x-ray imaging (X-Ray
Imaging), will be illustrated in Examples below based on the data of CT scan (CT), the file format of CT is led to
It is often DICOM.But the known ground of those skilled in the art, can also use other medical image datas, as long as the medical image
Data can be converted into three-dimensional prosthetic tissue model, it becomes possible to the radiation shield based on medical image disclosed applied to the present invention
It covers in device and method.
Patient 200, by 200 irradiated site of CT scan patient, forms CT data files after instrument table 40 is positioned,
That is medical image voxel data；Data processing and three-dimensional modeling apparatus 52 establish three-dimensional prosthetic group according to medical image voxel data
Organization model, such as carry out three-dimensional visualization, three-dimensional prosthetic tissue mould using MI-3DVS softwares or CAD software 3 d modeling software
Type includes pathological tissues and normal structure, according to three-dimensional prosthetic tissue model, resettles the threedimensional model of normal structure shield,
And determine the installation site of shield.Shield body three-dimensional models establishes the data message that can combine radiation device,
Such as position relationship of intensity of beam, beam flux, beam diameter, exposure pathways and radiation device and irradiated site,
Artificial amendment can also be carried out according to actual conditions in the process.It is appreciated that therapeutic room can also be entered in patient 200
Before with regard to carrying out CT scan, just medical image scanning means 51 need not be so integrated in therapeutic room, hospital can be utilized
Existing CT Scanner determines irradiated site by scanning, forms the CT data files of irradiated site.At this point, radioactive ray irradiate
The data message of device, such as intensity of beam, beam flux, beam diameter, exposure pathways and radiation device and irradiation
The position relationship at position will be also determined according to definite irradiated site is scanned, and then established and shielded according to above-mentioned data message
Cover body three-dimensional models.
Shield 53 is printed by shield three-dimensional modeling data input 3D printer and formed, and will record three-dimensional modeling data
STL formatted files are input in computer system, and separate into two dimensional slice data, the 3D printing system controlled by computer
It is successively printed, three-dimensional objects is finally obtained after superposition.Shield 53 can shield the beam of radiation device generation
Irradiation to 200 normal structure of patient, beam are applied to the tumour cell of the patient 200 on instrument table 40 after shield 53
M, shield 53 between radiation device and irradiated site, preferred shield be located at collimator or beam outlet and
Between irradiated site.The material of shield 53 includes at least one of the material of shielding neutron or the material of shielding photon.It is excellent
Shield 53 is selected to be directly anchored to the body surface of patient's irradiated site for plate, it is mutual with the body surface shape of patient position to be installed
Matching, is easy to correctly install, fixed form can be adherency, belt or buckle etc..Shield 53 has central through hole 531, in
The diameter of heart through hole 531 is in the maximum sized ratio section perpendicular to beam direction with 200 in vivo tumour cell M of patient
1-2 while tumour cell is killed, avoids the damage of normal structure to greatest extent, and central through hole 531 is preferably shaped to
For tumour cell M parallel to the outer contour shape of the projection of beam direction, it is outer that the diameter that central through hole limits can be interpreted as this
The diameter of contour shape.It is appreciated that shield 53 can not also have central through hole, but central part have and other
The different thickness in part or entire shield can have different thickness in different positions.53 maximum gauge of shield
Numberical range for 3-20mm, the areal extent of outer surface is 10-200cm2.Due to using 3D printing, shield 53 can be according to
It is separately formed according to the individual difference of different irradiated bodies, and can obtain better radiation to complicated shape rapid shaping
Shield effectiveness.At the special position of some shapes, shield 53 can also be multiple, facilitate installation.Shield 53 can also be consolidated
It is scheduled in instrument table or collimator or beam outlet, 3D printer and instrument table or collimator or beam outlet can also mutually be tied
It closes, directly shield is printed in correspondence position after determining mutual alignment relation.Patient tumors position is scanned by medical image,
>=50% can be reached by obtaining targetedly 3D printing shield, the ratio that radioactive ray are attenuated after shield, preferably
For >=80%, the dose of radiation that patient's normal structure receives in boron neutron capture therapeutic process is less than 18Gy.Radioactive ray pass through
The radiation depth of normal tissue is the same as without ratio≤50% compared with shield after shield.The material of shield 53, shape
Shape, structure can design increasingly complex, can change the path for the neutron beam for exporting out from collimator or beam, make its with
The three-dimensional shape of tumour cell matches, as central through hole 531 be made of along beam direction different line segments, shield 53 not
It is made of with part different materials.
The radiation shielding methods based on medical image of the present embodiment, include the following steps：
S1：200 irradiated site of patient is scanned by medical image scanning means 51, and exports the medicine of the irradiated site
Image voxel data；
S2：The medical image voxel that data processing and three-dimensional modeling apparatus 52 are obtained according to S1 establishes three-dimensional prosthetic tissue mould
Type；
S3：The three-dimensional prosthetic tissue model data that data processing and three-dimensional modeling apparatus 52 are obtained according to S2 establishes shield
Threedimensional model；
S4：By shield three-dimensional modeling data input 3D printer printing shield 53；
S5：Shield 53 is subjected to installation positioning.
Step S3 further includes acquisition or inputs the data message of radiation device, such as intensity of beam, beam flux, penetrates
The position relationship of beam diameter, exposure pathways etc. and radiation device and irradiated site, then in conjunction with three-dimensional prosthetic tissue mould
Type data establish shielding body three-dimensional models, and determine shield installation site, in the process can also according to actual conditions into
The amendment that pedestrian is.
The organizational composition of patient's irradiated site can be obtained in the embodiment of the present invention using medical image scanning means, from
And shield is targetedly obtained according to the shape of tumour cell, position, size etc..It is appreciated that the present invention can also adopt
With non-medical device of image scanning, the 3-dimensional image scanning means being such as only scanned to patient body-surface shape, so as to be suffered from
The three-dimensional data of person's irradiated site shape carries out three-dimensional modeling, and then the 3D printing obtained with irradiated site form fit shields
Body.
It is appreciated that it needs to carry out pathological tissues present invention can also apply to well known to those skilled in the art other
Radioactive ray irradiate, and protect again normal structure from or few radiation cure field by radiation/irradiation, then neutron
Generation device correspondingly replaces with other radiation beam generating apparatus, such as proton generation device, heavy ion generation device, X-ray production
Generating apparatus or gamma ray generation device etc.；Can also be applied to other can irradiate the disease treated with radioactive ray, such as
Alzheimer's disease, rheumatoid arthritis, then tumour cell is other pathological tissues.Irradiated body in the present embodiment is cancer
Patient, it will be understood that irradiated body or other biological body, such as mammal.
Position relationship in the embodiment of the present invention refers to the position relationship in the direction along beam transmission path, " rear portion "
Refer to along the downstream of beam direction.
Although the illustrative specific embodiment of the present invention is described above, in order to the technology of the art
Personnel understand the present invention, it should be apparent that the invention is not restricted to the scope of specific embodiment, to the common skill of the art
For art personnel, if various change appended claim limit and definite the spirit and scope of the present invention in, these
Variation is it will be apparent that all within the scope of protection of present invention.
Claims (14)
1. a kind of radiation shield device based on medical image, for shielding radiation device to normal group of irradiated body
The radiation knitted, which is characterized in that including：
Medical image scanning means, the medical image scanning means scan the irradiated site of the irradiated body, and export doctor
Learn image voxel data；
Data processing and three-dimensional modeling apparatus, the data processing and three-dimensional modeling apparatus are according to the medical image voxel data
Three-dimensional prosthetic tissue model is established, and body three-dimensional models are shielded according to the three-dimensional prosthetic tissue model foundation；
Shield, the shield are printed by shield three-dimensional modeling data input 3D printer and formed, the shield
Between radiation device and irradiated site.
2. the radiation shield device based on medical image as described in claim 1, which is characterized in that the shield three-dimensional mould
Type is according to the three-dimensional prosthetic tissue model, with reference to the data message and radiation device of the radiation device
It is established with the position relationship of irradiated site.
3. the radiation shield device based on medical image as described in claim 1, which is characterized in that the material of the shield
Including shielding at least one of the material of neutron or the material of shielding photon, the shield is fixed on the illuminated body surface
Face is mutually matched with the irradiated body surface topography.
4. the radiation shield device based on medical image as claimed in claim 3, which is characterized in that during the shield has
Heart through hole, the diameter of the central through hole is with the in vivo pathological tissues of the irradiated body in the maximum ruler perpendicular to beam direction
Very little ratio section is 1-2, and the numberical range of the shield maximum gauge is 3-20mm, the area of the shielding external surface
Scope is 10-200cm2。
5. the radiation shield device based on medical image as described in claim 1, which is characterized in that the radioactive ray irradiation dress
It is >=50% to put the ratio that the radioactive ray of generation are attenuated after shield, radioactive ray normal tissue after shield
Depth is radiated with without ratio≤50% compared with shield.
6. a kind of radiotherapy apparatus, which is characterized in that the radiotherapy apparatus includes radiation device and screen
Body is covered, the radiation device irradiates irradiated body, forms irradiated site；The shield is located at radioactive ray irradiation
Between device and irradiated site, and printed and formed by 3D printer.
7. radiotherapy apparatus as claimed in claim 6, which is characterized in that the radiotherapy apparatus further includes three-dimensional
Device of image scanning and data processing and three-dimensional modeling apparatus, the 3-dimensional image scanning means scan the irradiated site and defeated
Go out three-dimensional data；The data processing and three-dimensional modeling apparatus establish irradiated site threedimensional model according to the three-dimensional data, and
Body three-dimensional models are shielded according to the irradiated site three-dimension modeling；The shield is by the shield three-dimensional modeling data
Input 3D printer prints to be formed.
8. radiotherapy apparatus as claimed in claim 6, which is characterized in that the radiotherapy apparatus further includes medicine
Device of image scanning and data processing and three-dimensional modeling apparatus, the medical image scanning means scan the irradiated site and defeated
Go out medical image voxel data；The data processing and three-dimensional modeling apparatus are established three-dimensional according to the medical image voxel data
Prosthetic devices model, and body three-dimensional models are shielded according to the three-dimensional prosthetic tissue model foundation；The shield is by the screen
Body three-dimensional models data input 3D printer is covered to print to be formed.
9. the radiotherapy apparatus as described in claim 6 or 8, which is characterized in that the radiation device includes putting
Ray generating devices, beam-shaping body, collimator, the radiation beam generating apparatus can generate radioactive ray, the beam-shaping
Body can adjust the beam quality for the radioactive ray that the radiation beam generating apparatus generates, and the beam-shaping body goes out including beam
Mouthful, the collimator can converge the radioactive ray by the beam-shaping body, and the shield is located at the collimator or penetrates
Beam is exported between irradiated site.
10. radiotherapy apparatus as claimed in claim 9, which is characterized in that the radiotherapy apparatus is boron neutron
Therapeutic device is captured, the irradiated body is cancer patient, and the beam generating apparatus that radiates is neutron generation device, the neutron
Generation device includes accelerator and target, and the accelerator accelerates charged particle, neutron by the acceleration band electrochondria
Son is generated with target effect.
11. radiotherapy apparatus as claimed in claim 10, which is characterized in that patient's normal structure is caught in boron neutron
It obtains the dose of radiation received in therapeutic process and is less than 18Gy.
12. the radiotherapy apparatus as described in claim 9 or 10, which is characterized in that the radiotherapy apparatus also wraps
Instrument table is included, the radioactive ray are applied to the pathological tissues of the patient on the instrument table, the screen after the shield
Body is covered to be fixed in irradiated body surface or the instrument table or the collimator or beam outlet.
13. a kind of radiation shielding methods based on medical image, which is characterized in that include the following steps：
The irradiated site of irradiated body is scanned by medical image scanning means, and exports the medical image body of the irradiated site
Prime number evidence；
Three-dimensional prosthetic tissue model is established according to the medical image voxel data；
Shielding body three-dimensional models are established according to the three-dimensional prosthetic tissue model data；
By shield three-dimensional modeling data input 3D printer printing shield；
Shielding is subjected to installation positioning.
14. the radiation shielding methods based on medical image as claimed in claim 13, which is characterized in that according to described three-dimensional false
Body tissue model data, which was established in the step of shielding body three-dimensional models, to be further included acquisition or inputs the data of radiation device
The position relationship of information and radiation device and irradiated site establishes shield three with reference to three-dimensional prosthetic tissue model data
Dimension module, and determine the installation site of shield.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611029477.8A CN108066901B (en) | 2016-11-14 | 2016-11-14 | Radiation shielding device and method based on medical image |
| RU2019103225A RU2721658C1 (en) | 2016-11-14 | 2017-07-11 | Radiation based on medical images radiation shielding device and method |
| EP17870064.7A EP3473298B1 (en) | 2016-11-14 | 2017-07-11 | Medical image-based radiation shielding device and method |
| JP2019510411A JP7409869B2 (en) | 2016-11-14 | 2017-07-11 | Radiation shielding device and method based on medical images |
| PCT/CN2017/092499 WO2018086367A1 (en) | 2016-11-14 | 2017-07-11 | Medical image-based radiation shielding device and method |
| TW106128751A TWI646946B (en) | 2016-11-14 | 2017-08-24 | Radiation shielding device based on medical image |
| US16/246,645 US10994154B2 (en) | 2016-11-14 | 2019-01-14 | Medical image-based radiation shielding device and method thereof |
| JP2023081695A JP2023101009A (en) | 2016-11-14 | 2023-05-17 | Radiotherapy apparatus |
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| CN201611029477.8A CN108066901B (en) | 2016-11-14 | 2016-11-14 | Radiation shielding device and method based on medical image |
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| CN108066901A true CN108066901A (en) | 2018-05-25 |
| CN108066901B CN108066901B (en) | 2024-04-12 |
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