KR101676963B1 - The real-time monitoring method using boron fusion reaction during antiproton device - Google Patents
The real-time monitoring method using boron fusion reaction during antiproton device Download PDFInfo
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- KR101676963B1 KR101676963B1 KR1020150103828A KR20150103828A KR101676963B1 KR 101676963 B1 KR101676963 B1 KR 101676963B1 KR 1020150103828 A KR1020150103828 A KR 1020150103828A KR 20150103828 A KR20150103828 A KR 20150103828A KR 101676963 B1 KR101676963 B1 KR 101676963B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
- A61N5/1065—Beam adjustment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
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Abstract
Description
The present invention relates to an imaging apparatus and a monitoring method for real time monitoring of a target during a radiation treatment using a boron nuclear reaction. More particularly, the present invention relates to an apparatus and a method for real-time monitoring of information generated in a target by generating three alpha particles and an immediate gamma ray by irradiating an antiproton on boron particles accumulated in a tumor tissue .
At present, the latest radiation therapy for cancer treatment uses proton therapy as well as conventional photon and heavy ion therapy.
In recent radiotherapy, the amount of radiation delivered to the target corresponding to the tumor tissue of the patient is increasing.
Therefore, each treatment requires a treatment plan to correct / compensate for the target position according to the target and the patient's movements.
Proton therapy, which is applied to recent radiotherapy, has a characteristic (Bragg peak) that releases most of the radiation dose at the target site just before losing energy in the material, unlike general photon beam therapy.
Therefore, proton therapy is widely recognized worldwide, and reports of treatment prognosis are increasing.
However, there is a risk of inconsistency between prescription dose and target in all radiotherapy including actual proton.
Nowadays, we are predicting and considering the intensity, angle, and extent of the radiation beam by measuring with an aid device such as a phantom, not the patient before or after the treatment.
However, this method has disadvantages in that real-time target monitoring is impossible and information accuracy is degraded.
On the other hand, the antiproton, discovered in 1955, is the recipient of a proton, which has the same mass and spin as a proton but has a charge and a magnetic moment.
Therefore, it is possible to apply Bragg Peak, which is a characteristic of proton, to the treatment by using the properties of the proton, and to apply antiproton to the boron particle accumulated in the tumor tissue to prepare three alpha particles and a gamma ray There is a need for an apparatus and method for monitoring information generated in a target in real time.
It is an object of the present invention to provide an imaging apparatus and a monitoring method for monitoring a target in real time during a radiation treatment using a nuclear boron nuclear reaction while solving the above-described problems.
More particularly, the present invention relates to an apparatus and a method for real-time monitoring of information generated in a target by generating three alpha particles and an instant gamma ray by irradiating an antiproton on boron particles accumulated in a tumor tissue, .
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are not restrictive of the invention, unless further departing from the spirit and scope of the invention as defined by the appended claims. It will be possible.
According to an aspect of the present invention, there is provided a method of monitoring a target of radiation therapy in real time, comprising: a first step of accumulating boron in a cancer tissue of a specimen; A second step of irradiating the integrated boron with an antioxidant; A third step in which a nuclear reaction occurs between the boron and the antiproton; A fourth step in which a gamma ray is generated through the nuclear reaction; A fifth step of detecting the generated gamma ray immediately; A sixth step of judging whether or not the cancerous tissue is irradiated to the cancerous tissue through the generation of the immediate gamma ray; And a seventh step of changing the irradiation position of the anti-cancer when it is determined that the anti-cancer is not irradiated to the cancer tissue.
Further, a third step between the third step and the fourth step, in which the nuclear particles are collapsed into three alpha particles, wherein the gamma rays are generated through the three alpha particle collisions have.
In addition, the effect of the radiation therapy using the anti-cancer can be maximized by using the Bragg peak characteristic that releases the radiation dose to the cancerous tissue immediately before the anti-cancer agent loses energy in the specimen.
In addition, in the fifth step, the generated gamma ray is detected through the photographing device, and between the fifth and sixth steps, the fifth- Stage 1; And displaying the generated image information through a display device.
According to another aspect of the present invention, there is provided an apparatus for monitoring a target of radiation therapy in real time, the apparatus comprising: a reaction unit for irradiating boron accumulated in a cancer tissue of a specimen with an antiproton; A gamma ray detector for detecting the gamma ray immediately when the nuclear reaction occurs between the boron and the non-reactant and the gamma ray is generated through the nuclear reaction; And a monitoring device for determining whether the anti-cancer is irradiated to the cancer tissue through the generation of the gamma ray.
The apparatus further includes a display device for generating image information using the information sensed by the gamma ray sensing device and displaying the generated image information, wherein the alpha particle is collapsed into three alpha particles through the nuclear reaction, Immediate gamma rays are generated through the collapse of the three alpha particles and are detected using the Bragg peak property that releases the dose of radiation to the cancerous tissue immediately before the anti- The effect of the radiation therapy can be maximized.
The present invention can provide a user with an imaging device and a monitoring method that monitors a target in real time during a radiation treatment using a boron nuclear reaction.
More particularly, the present invention relates to an apparatus and a method for real-time monitoring of information generated in a target by generating three alpha particles and an instant gamma ray by irradiating an antiproton on boron particles accumulated in a tumor tissue, .
In addition, the treatment method proposed in the present invention can enable real-time imaging of a treatment site through a non-real-time boron nuclear reaction.
Further, according to the present invention, the overall treatment efficiency and the improvement of the performance can be expected more than the boron neutron capture treatment and the proton boron fusion treatment.
The effects obtained by the present invention are not limited to the above-mentioned effects, and other effects not mentioned can be clearly understood by those skilled in the art from the following description will be.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagram for explaining a concept of detecting and imaging a gamma ray generated during a physical mechanism and a boron nuclear reaction of a boron nucleus according to the present invention. FIG.
FIG. 2 is a diagram for explaining the Bragg-peak curve, which is a characteristic of a proton and an antiproton according to the present invention.
FIG. 3 is a diagram for explaining an example of an energy spectrum generated in a radiation treatment using a nuclear reactor boron nuclear reactor in connection with the present invention. FIG.
FIG. 4 is a diagram for explaining an image using a human simulated phantom including boron-integrated regions and an immediate gamma ray generated in a nuclear reaction of a boronoidal boron in the context of the present invention.
FIG. 5 is a view for explaining an example of a method for monitoring a target in real time through boron fusion used in the treatment of a proto-poser proposed by the present invention.
FIG. 6 is a diagram for explaining another example of a method for monitoring a target in real time through boron fusion used for anti-repetitive treatment, in the context of the present invention. FIG.
The latest radiation therapy for cancer treatment is using proton therapy as well as conventional photon and heavy ion therapy.
In recent radiotherapy, the amount of radiation delivered to the target corresponding to the tumor tissue of the patient is increasing. Therefore, each treatment requires a treatment plan to correct / compensate for the target position according to the target and the patient's movements.
Particle radiation, such as a proton beam or a carbon ion beam, has a unique dose distribution characteristic called Bragg peak, which differs from X-ray. It transmits a large amount of radiation to the tumor during radiation therapy and protects the surrounding normal organs There is an advantage to be able to.
On the other hand, as described above, the proton therapy applied to the recent radiation therapy is different from the general photon beam therapy in that the most of the radiation dose is released from the target site immediately before the energy is lost in the material (Bragg Peak, Bragg peak. Therefore, proton therapy is widely recognized worldwide, and reports of treatment prognosis are increasing.
Proton boron fusion therapy is a technique to detect the degree of progress of treatment using tumor monitoring equipment to overcome the difficulty in monitoring the site being treated during proton therapy.
In the case of boron neutron capture therapy, boron is accumulated and treated in Japan and USA. However, it has physical characteristics that normal tissues can receive high exposure compared to proton.
However, there is a risk of inconsistency between prescription dose and target in all radiotherapy including actual proton. Nowadays, we are predicting and considering the intensity, angle, and extent of the radiation beam by measuring with an aid device such as a phantom, not the patient before or after the treatment.
However, this method has disadvantages in that real-time target monitoring is impossible and information accuracy is degraded.
Accordingly, the present invention aims at providing a user with an imaging apparatus and a monitoring method for monitoring a target in real time during a radiation treatment using a nuclear boron nuclear reaction while solving the existing problems.
More particularly, the present invention relates to an apparatus and a method for real-time monitoring of information generated in a target by generating three alpha particles and an instant gamma ray by irradiating an antiproton on boron particles accumulated in a tumor tissue, .
The antiproton, discovered in 1955, is the recipient of a proton, which has the same mass and spin as a proton but has a charge and a magnetic moment.
Therefore, it is possible to apply Bragg Peak, which is a characteristic of proton, to the treatment by using the properties of the proton, and to apply antiproton to the boron particle accumulated in the tumor tissue to prepare three alpha particles and a gamma ray It is possible to monitor information generated in the target in real time.
The present invention is characterized by: 1) the use of a nuclear reaction caused by a biochemical reactant and boron; 2) a minimization of dose absorption of a normal tissue using a Bragg-peak curve of the treatment of a reactant; and 3) And a diagnostic device.
With respect to boron neutron capture therapy (BNCT), scientific validation has already been completed in the nuclear reactions of boron and neutrons and has been applied to actual treatment.
Therefore, inducing the nuclear reaction of boron and antiproton at the target site can lead to an improvement in the overall treatment performance over boron neutron capture therapy and proton therapy used in the past.
The nuclear reactions of the protons and boron collapse to 3.76 MeV of alpha particles and beryllium to stabilize the primary excited carbon, as in the proton boron nuclear reaction.
In the second reaction, it collapses into two alpha particles of 2.46 MeV, and the alpha particles generated at this time increase the treatment efficiency in the radiation treatment.
In addition, during the above physical mechanism, an immediate gamma ray of 719 keV occurs, which is generated by reaction with the accumulated boron in the tumor area of the patient.
Therefore, it is possible to maximize the treatment efficiency by detecting the immediate gamma rays generated by the gamma camera or the single photon emission computed tomography apparatus, and realizing the imaging of the tumor tissue in real time through the image reconstruction.
The present invention is directed to boron capture therapy, which combines the advantages of proton boron fusion therapy and boron neutron capture therapy and is an advanced technique.
The present invention basically uses a Bragg-peak, which is a physical characteristic of a non-epithelial bones, as a treatment for a biopsy, and injects a boron compound into the body such as a boron neutron capture treatment, integrates the tumor into the tumor tissue, By matching the maximum of -peak to the tumor tissue in which boron is incorporated, the therapeutic effect can be increased.
Also, when compared to proton therapy, the treatment effect is four times higher.
In addition, in order to visualize the real-time treatment site during treatment, it is possible to detect and visualize the immediate gamma ray of 719 keV generated during the nuclear reaction of the anti-cancer and boron by using a single photon detector or a gamma camera.
This allows imaging of the area undergoing treatment during treatment and subsequent treatment planning and treatment verification.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagram for explaining a concept of detecting and imaging a gamma ray generated during a physical mechanism and a boron nuclear reaction of a boron nucleus according to the present invention. FIG.
Referring to FIG. 1, the three alpha particles generated through the nuclear reaction of the boron atoms enhance the effect of radiation therapy, and the immediate gamma rays of 719 keV can be used for imaging.
Meanwhile, FIG. 2 is a diagram for explaining the Bragg-peak curve, which is a characteristic of a proton and an antiproton according to the present invention.
Referring to FIG. 2, the low dose delivery is maintained until a certain range after entering the inside of the body, and the maximum dose of the delivery dose is transmitted at a specific point.
At this time, the maximum dose delivery rate is 3.52 times higher than the conventional proton therapy (black) in the case of boron capture treatment (blue).
Meanwhile, FIG. 3 is a diagram for explaining an example of an energy spectrum generated in a radiation treatment using a nuclear reactor boron nuclear reaction in connection with the present invention.
In Fig. 3, the red region represents an immediate gamma ray of 719 keV generated in the treatment of the reciprocal boron fusion.
The specific steps to which the present invention is applied will be described with reference to flowcharts using the technical features of the present invention.
FIG. 5 is a view for explaining an example of a method for monitoring a target in real time through boron fusion used in the treatment of a proto-poser proposed by the present invention.
Referring to FIG. 5, first, a step S100 of accumulating boron in cancer tissue located in at least a part of the body is performed.
Thereafter, step S200 of irradiating the accumulated boron with the antiproton is carried out.
Further, a step (S300) in which a nuclear reaction occurs between boron and a non-reactant is performed.
Here, the effect of the radiation therapy using the anti-cancer can be maximized by using the Bragg peak characteristic that releases the radiation dose to the cancerous tissue immediately before the energy of the anti-cancer is lost in the body.
Thereafter, a step S400 in which a gamma ray is generated through the nuclear reaction proceeds.
In addition, the step of detecting the immediately-occurring gamma ray (S500) is performed, and a step S600 of determining whether the anti-cancer is irradiated to the cancer tissue through the generation of the gamma ray immediately is performed.
In other words, when the anti-cancer is not irradiated to the cancer tissue, the gamma ray will not be generated immediately. Therefore, the existing problem can be solved by taking measures in real time so that the cancer tissue is irradiated with the anti-cancer.
Meanwhile, FIG. 6 is a diagram for explaining another example of a method of monitoring a target in real time through boron fusion used in the treatment of antiprotonies, in the context of the present invention.
Referring to FIG. 6, steps S100 to S600 are matched to the respective steps described in FIG.
However, between step S300 and step 400, a step (S350) in which three alpha particles are collapsed through the nuclear reaction proceeds.
In other words, the nuclear reactions of the protons and boron collapse to 3.76 MeV of alpha particles and beryllium to stabilize the primary excited carbon, as in the proton boron nuclear reaction.
In the second reaction, it collapses into two alpha particles of 2.46 MeV, and the alpha particles generated at this time increase the treatment efficiency in the radiation treatment.
In addition, during the above physical mechanism, an immediate gamma ray of 719 keV occurs, which is generated by reaction with the accumulated boron in the tumor area of the patient.
Further, between steps S500 and 600, a step S520 of generating image information using the information sensed by the image sensing device and a step S540 of displaying the generated image information through the display device are performed.
FIG. 4 is a diagram for explaining an image using a human simulated phantom including boron-integrated regions and an immediate gamma ray generated in a nuclear reaction of a boronoidal boron in the context of the present invention.
4 (a) shows a human simulated phantom including regions (A, B, and C) in which boron is integrated.
Fig. 4 (b) shows a reconstructed image using the gamma rays generated in the nuclear reactor boron nuclear reaction.
Referring to FIGS. 4A and 4B, it can be demonstrated that real-time treatment site imaging is possible using the immediate gamma ray.
Accordingly, the process of displaying the image information according to steps S520 and S540 through the display device will be described with reference to FIG.
When the above-described configuration of the present invention is applied, by irradiating an antiproton on boron particles accumulated in the tumor tissue to generate three alpha particles and a gamma ray, the information generated in the target is monitored in real time The apparatus and method can be provided to the user.
In addition, the treatment method proposed in the present invention can enable real-time imaging of a treatment site through a non-real-time boron nuclear reaction. Further, according to the present invention, it is possible to maximize the therapeutic effect as compared with boron neutron capture therapy and proton boron fusion therapy.
Meanwhile, the features of the present invention described above are described through the monitoring method, but it is obvious that the present invention can be implemented through the apparatus.
That is, an apparatus for monitoring the target of the radiation therapy in real time proposed by the present invention includes a boron accumulation apparatus for accumulating boron in cancer tissue located in at least a part of the body, an anti-cancer irradiator for irradiating the accumulated boron with the anti- A gamma ray detector for detecting the gamma ray generated immediately when the nuclear reaction occurs between the boron and the non-reactant and the gamma ray is generated through the nuclear reaction, and a gamma ray detector for detecting the gamma ray generated by the gamma ray, And a monitoring device for judging whether or not it is possible.
The apparatus may further include a display device for generating image information using the information sensed by the gamma ray sensing device and displaying the generated image information.
Also, the nuclear reaction breaks down into three alpha particles, which can be generated through the three alpha particle decay.
Further, the effect of the radiation therapy using the anti-cancer can be maximized by using the Bragg peak characteristic that the radiation dose is released to the cancer tissue immediately before the energy of the anti-cancer is lost in the body.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The foregoing description of the preferred embodiments of the invention disclosed herein has been presented to enable any person skilled in the art to make and use the present invention. While the present invention has been particularly shown and described with reference to preferred embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. For example, those skilled in the art can utilize each of the configurations described in the above-described embodiments in a manner of mutually combining them. Accordingly, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
The invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. Accordingly, the above description should not be construed in a limiting sense in all respects and should be considered illustrative. The scope of the present invention should be determined by rational interpretation of the appended claims, and all changes within the scope of equivalents of the present invention are included in the scope of the present invention. The present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein. In addition, claims that do not have an explicit citation in the claims may be combined to form an embodiment or be included in a new claim by amendment after the filing.
Claims (6)
A gamma ray detector for detecting the gamma ray immediately when the nuclear reaction occurs between the boron and the non-reactant and the gamma ray is generated through the nuclear reaction; And
And a monitoring device for determining whether the anti-cancer is being irradiated to the cancerous tissue through the detection of the immediate gamma ray generation.
And a display device for generating image information using the information sensed by the gamma ray sensing device and displaying the generated image information,
Wherein the three alpha particles collapse into three alpha particles through a nuclear reaction between the boron and the counteractant, the gamma rays are generated through the three alpha particles collapse,
Characterized in that the effect of the radiation therapy using the anti-cancer is maximized by using a Bragg peak characteristic that releases the radiation dose to the cancerous tissue immediately before the antiphyseal loses energy in the specimen. A device that monitors the target of radiation therapy in real time.
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Citations (4)
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| KR20080055688A (en) * | 2006-12-13 | 2008-06-19 | 한양대학교 산학협력단 | Prompt gamma scanning system and a discrimination level determination method for detecting prompt gammas using the same |
| JP2009175065A (en) * | 2008-01-28 | 2009-08-06 | Japan Atomic Energy Agency | Simultaneous three-dimensional distribution-visualization observation-measurement method of a plurality of elements by neutron prompt gamma-ray analysis, and device thereof |
| KR101500247B1 (en) | 2013-12-31 | 2015-03-06 | 가톨릭대학교 산학협력단 | Neutron therapy equipment with PET and SPECT collimator |
| KR101568938B1 (en) * | 2014-07-30 | 2015-11-12 | 가톨릭대학교 산학협력단 | The radiation therapy and diagnosis device using proton boron fusion reaction |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080055688A (en) * | 2006-12-13 | 2008-06-19 | 한양대학교 산학협력단 | Prompt gamma scanning system and a discrimination level determination method for detecting prompt gammas using the same |
| JP2009175065A (en) * | 2008-01-28 | 2009-08-06 | Japan Atomic Energy Agency | Simultaneous three-dimensional distribution-visualization observation-measurement method of a plurality of elements by neutron prompt gamma-ray analysis, and device thereof |
| KR101500247B1 (en) | 2013-12-31 | 2015-03-06 | 가톨릭대학교 산학협력단 | Neutron therapy equipment with PET and SPECT collimator |
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