CN108042739A - It is a kind of to be used to prevent composition of diabetes and its preparation method and application - Google Patents
It is a kind of to be used to prevent composition of diabetes and its preparation method and application Download PDFInfo
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The present invention provides a kind of for preventing the food, health products or pharmaceutical composition of diabetes, it is that the raw material containing following weight proportioning is prepared：5~20 parts of Chinese yam, 3~10 parts of sealwort, 5~15 parts of coix seed, 2~13 parts of mulberries, 3~15 parts of radix polygonati officinalis, 5~20 parts of hawthorn.The present invention also provides the preparation methods of above-mentioned composition.The results show, composition of the invention can effectively reduce blood glucose, prevent diabetes, and the raw material of the present invention is medicine-food two-purpose, can be long-term use of, and long-term use of better.
Description
Technical field
The present invention relates to a kind of for preventing composition of diabetes and its preparation method and application.
Background technology
Diabetes (Diabetes Mellitus, DM) are a kind of metabolic diseases of common, chronic, multifactor induction.
Diabetes are often clinically divided into insulin-dependent diabetes mellitus (IDDM, type-1 diabetes mellitus) and Non-Insulin Dependent Diabetes Mellitus
(NIDDM, type II diabetes) two classes, wherein type II diabetes number of patients account for more than 90%.At present, the incidence of diabetes exists
In ascendant trend is continued in global range, the death rate is only second to cardiovascular and cerebrovascular disease and cancer, is referred to as human health the 3rd
Big killer, is one of important health problem that current mankind is faced, and active prevention and treatment diabetes are imperative.
Prediabetes belongs to the sick scope such as the traditional Chinese medical science " the spleen-warm syndrome ", " quenching one's thirst ".Its sick position is related to the five internal organs, more based on spleen kidney
Based on simulataneous insufficiency and excessive, be deficiency of both qi and yin.The key that this disease is fallen ill using the deficiency of Yin as it, patient's natural endowment is abnormal or bad life
The factors such as mode cause yin jin consumption wound, and initially then common Yin Xu Nei Re Zheng, the deficiency of Yin run through this disease in lung kidney, excess heat in lung stomach, the deficiency of Yin
The overall process of disease.And long-term overfeeding delicious food savoury pure wine, impairing the spleen and stomach cause transporting and transforming function of the spleen and stomach mistake department, it is important pathogenic for what is quenched one's thirst
Factor.The spleen being the foundation of acquired constitution, source of generating QI and blood, temper virtual loss, spleen do not dissipate essence, and spleen does not rise clearly, then the defeated cloth of body fluid, blood loses
Often, cereal nutrient not reforming, poly- and be turbid pathogenic factor, turbid pathogenic factor is polymerized to poison long, and consumption hinders body.And yin asthenia generating intrinsic heat, bright body fluid the moon blood is decocted,
Blood is viscous, and blood vessels stasis of blood plug or body fluid deficiency are not enough to carry blood operation and be blood stasis, that is, cause " deficiency of Yin stasis ".Therefore hemostasis is diabetes hair
The reason of hair tonic exhibition.The multiple pathological factors of this disease can cause hemostasis, and hemostasis runs through this disease always.
TCM Treatment of Diabetes is with a long history, and abundant Couple herbs are had accumulated in long-term clinical practice, obtains
Good therapeutic effect.The characteristics of Chinese medicine treatment has its own, existing reliable hypoglycemic effect, and various complication can be reduced
Generation, therefore TCM Treatment of Diabetes has vast potential for future development.
At present, have no and the relevant report of the present composition.
The content of the invention
It is an object of the invention to provide a kind of for preventing the food, health products or pharmaceutical composition of diabetes, it is
Raw material containing following weight proportioning is prepared：
5~20 parts of Chinese yam, 3~10 parts of sealwort, 5~15 parts of coix seed, 2~13 parts of mulberries, 3~15 parts of radix polygonati officinalis, hawthorn 5~
20 parts.
Further, it is the preparation being prepared by the raw material of following weight proportioning：
5~20 parts of Chinese yam, 3~10 parts of sealwort, 5~15 parts of coix seed, 2~13 parts of mulberries, 3~15 parts of radix polygonati officinalis, hawthorn 5~
20 parts.
Further, it is the preparation being prepared by the raw material of following weight proportioning：
10 parts of Chinese yam, 5 parts of sealwort, 10 parts of coix seed, 5 parts of mulberries, 5 parts of radix polygonati officinalis, 5 parts of hawthorn.
Further, it be by the medicinal powder of bulk pharmaceutical chemicals, the water of bulk pharmaceutical chemicals or extractive with organic solvent be active ingredient, in addition
The preparation that acceptable auxiliary material or complementary ingredient are prepared in pharmacy.
Further, the preparation is oral formulations；Preferably, the oral formulations are decoction, powder, capsule, piece
Agent, granule.
Further, the preparation is decoction, powder, capsule, tablet, granule.
Above-mentioned food, health products or pharmaceutical composition are prepared the present invention provides a kind of, it includes the following steps：
1) each raw material is weighed by weight ratio；
2) medicinal powder, water or extractive with organic solvent of bulk pharmaceutical chemicals are taken, and in pharmacy acceptable auxiliary material or it is complementary into
Divide and be prepared into preparation.
The present invention provides above-mentioned food, health products or pharmaceutical compositions to prepare prevention and/or treat diabetes
Purposes in drug or health products.
The present invention provides above-mentioned food, health products or pharmaceutical compositions to prepare the drug or health products of supplementing qi and nourishing yin
In purposes.
The present invention provides above-mentioned food, health products or pharmaceutical composition in the drug or health products for preparing promoting blood circulation
Purposes.
The experimental results showed that composition of the invention can effectively reduce blood glucose, diabetes, and the raw material of the present invention are prevented
It is medicine-food two-purpose, can be long-term use of, and it is long-term use of better.
Obviously, the above according to the present invention according to the ordinary technical knowledge and customary means of this field, is not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically the above of the present invention
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized all belongs to the scope of the present invention.
Specific embodiment
The preparation of embodiment 1, food of the present invention
1. it is formulated (amount of 10 steamed buns)：Chinese yam 100g, sealwort 50g, coix seed 100g, mulberries 50g, radix polygonati officinalis 50g, hawthorn
50g, mixed flour 300g.
2. preparation method：
A takes sealwort, mulberries, radix polygonati officinalis, the hawthorn four traditional Chinese medicine material of formula ratio, adds in the water of medicinal material doubling dose, impregnates 15 minutes,
It decocts 30 minutes, filtering；Filter residue is taken to add in the water of one times of amount, is decocted 15 minutes, filtering；It is spare to merge filtrate twice.Take formula
The Chinese yam of amount and coix seed are crushed as 100~120 targeted fine powders.
Get it filled powder, 150~200g flour and the old faces of 100~150g of b is uniformly mixed, with concoction knead dough, normal temperature fermentation 6~8
Hour, it kneads dough by hand 5~6 times in fermentation process, excludes the gas in dough, kneading dough should reach that dough is fine and closely woven, and surface is smooth,
Until color and luster is consistent.
Dough is averagely divided into 10 pieces of square steamed bun bases by c.
For d by steamed bun base provocation, proofing temperature is 25~35 DEG C, do not touched with one's hand with base soft surface preferably.
Steamed bun is placed in food steamer by e to be steamed 20~25 minutes.
Application method：According to Gender, height calculate standard weight, then by age, standard weight, job specification,
Labor intensity calculates daily total amount of heat, is calculated further according to " nutrient allowance in the daily meals that Chinese Soclety of Nutrition is recommended "
Breakfast herbal cuisine steamed bun intake.Breakfast eats diabetes breakfast herbal cuisine steamed bun.
Illustrate beneficial effects of the present invention below by way of the mode of test example.
Test example 1
(1) experiment material
Steamed bun prepared by the embodiment of the present invention 1, control group are no more than according to diabetes less salt low fat diet, i.e., daily salt
6g, oil quantity are no more than the 30% of meals total amount.
(2) experimental subjects
79 people of diabetic, 46 people of male, 33 people of women, 28~67 years old age, the course of disease 1 month~3 years.
Diabetic is randomly divided into two groups：(1) treatment group, 24 people of male, 16 people of women, average age (49.37 ±
8.16) year, the course of disease 2 months~2 years；(2) control group, 22 people of male, 17 people of women, average age (50.32 ± 7.26) year, disease
Journey 1 month~3 years.Two groups of patient's general information comparing differences are not statistically significant (P ＞ 0.05), are comparable.
The diagnostic criteria of diabetes：
1. doctor trained in Western medicine diagnoses and parting standard is with reference to the mark suggested in the World Health Organization (WHO) expert consulting report in 1999
Standard is formulated.All one for meeting following condition, diagnosable is diabetes：Diabetic symptom+random time plasma glucose levels
≥11.1mmol/L(200mg/dl)；Fasting plasma glucose (FPG) level >=7.0mmol/L (126mg/dl)；Glucose is resistance to
In amount experiment, 2h plasma glucoses (2hPG) level >=11.1mmol/L (200mg/dl).Diabetes B：With insulin resistance
Based on based on hypoinsulinism and hypoinsulinism with insulin resistance.
2. Standards of Chinese Medical Syndrome Differentiation reference《New Chinese medicine guideline of clinical investigations (2002)》And Chinese traditional Chinese medicine and pharmacy can disappear
The phase CM syndrome differentiation criterion [diabete (diabetes)] of thirsty disease (diabetes) Professional Committee, formulates deficiency of both qi and yin stasis syndrome CM syndrome differentiation criterion
Primary symptom：(1) dry throat, (2) lassitude hypodynamia, (3) extremity numbness or pain
Minor symptom：(1) the lazy speech of shortness of breath, (2) feverishness in palms and soles, (3) constipation are urinated Huang
Tongue picture：Red tongue with a little fluid, tongue nature is dim ecchymosis, and sublingual train of thought is livid purple tortuous.
Pulse condition：Thready and rapid pulse without strength and puckery or string is thin or string is puckery.
Possesses in primary symptom 1, minor symptom 2, with reference to corresponding tongue picture, pulse condition, you can it is simultaneous to be diagnosed as diabetes B deficiency of both qi and yin
Syndrome of blood stasis.
It participates in the diabetic that the present invention tests and meets doctor trained in Western medicine T2DM diagnosis, glycosylated hemoglobin≤7.0%, and meet
Syndrome in TCM marquis's diagnosis person.
Exclusion criteria：
Merge the primary diseases persons such as the heart, renal insufficiency, hemopoietic system illness, mental illness trouble.Had before 6 months pernicious
Hypertension or acute coronary artery syndrome, cerebrovas-cularaccident history person.There is the disease that thyroid disease, adrenal gland diseases etc. influence glycometabolism
Patient.Transaminase is higher than 1.5 times of persons of normal upper limit value.Glucocorticoid, beta-blocker, thiazide are previously used in 3 months
Diuretics, oral contraceptive, niacin class drug person.Just taking biguanides, thiazolidine diketone derivative and alpha-glucosaccharase
Enzyme inhibitor etc. influences the drug of blood glucose level.The gestational period, women breast-feeding their children prepare pregnant woman.Allergic constitution or to this
Drug constituent allergy sufferers in medicine.Introduction period loner.
(3) experimental method and result
1. experimental method
All patients are according to diabetes less salt, low fat diet scheme.Treatment group calculates standard according to Gender, height
Weight, then by age, standard weight, job specification, labor intensity calculate daily total amount of heat, further according to " Chinese nutrition
Nutrient allowance in the daily meals that can recommend " calculates breakfast herbal cuisine steamed bun intake.Experimental period 24 weeks by a definite date.
Breakfast herbal cuisine steamed bun intake calculating method：
A. BMI values are calculated, determine patient's weight index, BMI=weight (kg)/2 (m of height2)；
B. ideal body weight, ideal body weight=[height (cm) -100] × 0.9 are calculated；
C. daily thermal energy quantity delivered E, E=ideal body weight × activity is determined according to patient activity's intensity, body mass index, age
Situation heat consumption (being shown in Table 1) × age coefficient.
The daily thermal energy quantity delivered of 1 maturity-onset diabetes patient of table (kcal/kg standard weights)
Note：From 50 years old, the age often increased by 10 years old, and heat reduces 10%.
D. breakfast heat is calculated by account for total amount of heat 30%.
E. according to composition table of foods, breakfast staple food life weight is calculated, you can obtain steamed bun intake.
Background information carries out once when observing the variation every four weeks follow-up with main clinic symptoms and sign, totally 6 times.On an empty stomach
It is carried out once during blood glucose (2hPG) every four weeks follow-up when blood glucose (FPG), morning postprandial 2 are small, totally 3 times.Glycosylated hemoglobin (HbA1c)
It tests every 12 weeks and detects 1 time, totally 2 times.
Clinical symptoms, sign are examined using Chinese medicine syndrome integral is apparent.Quality of life is commented using SF-36 quality of life scale
Valency, including Body health (PF), body role function (RP), body pain (BP), general health (GH), energy (VT), society
8 function (SF), mood role function (RE), mental health (MH) dimensions.FPG, 2hPG are detected using glucose oxidase method,
HbA1c is detected using chromatography.Experimental result is shown in Table 2- tables 6.
The standard of curative effect evaluation：
Tcm syndrome curative effect judges according to tcm syndrome point-score.Reference《New Chinese medicine treats the clinical research of diabetes
Guideline》It formulates.Therapeutic index (n)=(prior treatment integral-post treatment integral)/prior treatment integral * 100%.
Clinic control：N >=90%；It is effective：70%≤n<90%；Effectively：30%≤n<70%；It is invalid：n<30%.
Statistical method
All data application SPSS17.0 statistical softwares processing, measurement data meet the use " mean ± mark of normal distribution
It is accurate poor " (± s) expression, use " the median, interquartile range " expression of Non-Gaussian Distribution.Comparison among groups first carries out normality
With homogeneity test of variance, meet normality and homogeneity of variance person, using one-way analysis of variance and independent samples t-test, be unsatisfactory for just
State property and homogeneity of variance person, the Mann-Whitney U of 2 independent samples are examined in two comparison among groups non-parametric tests, in group
Compare the matched-pair design data rank sum test with 2 correlated sampleses in non-parametric test.It is to have statistics meaning with P ＜ 0.05
Justice.
2. experimental result
The pretherapy and post-treatment FPG of 2 two groups of patients of table is horizontal relatively
Note：Compared with before control group treatment, * P ＞ 0.05；Compared with after control group treatment, △ P ＜ 0.05.
From table 2 it can be seen that the equal no significant difference of fasting blood glucose level (* P ＞ 0.05) before two groups of patient's treatments, having can
Compare property.After treating 24 weeks, treatment group's fasting blood-glucose is significantly lower than control group, and △ P ＜ 0.05 have statistical significance.
The pretherapy and post-treatment 2hPG of 3 two groups of patients of table is horizontal relatively
Note：Compared with before control group treatment, * P ＞ 0.05；Compared with after control group treatment, △ P ＜ 0.05.
From table 3 it can be seen that before two groups of patients treatment it is postprandial 2 it is small when the equal no significant difference of blood glucose level (* P ＞ 0.05),
It is comparable.After treating 24 weeks, blood glucose is significantly lower than control group when treatment group postprandial 2 is small, and △ P ＜ 0.05 have statistics
Meaning.
The pretherapy and post-treatment HbA1c of 4 two groups of patients of table is horizontal relatively
Note：Compared with before control group treatment, * P ＞ 0.05；After treatment group's treatment compared with before treatment, * * P ＜ 0.05；With
Compare after control group treatment, △ P ＜ 0.05.
From table 4, it can be seen that it is examined through non-parametric test independent sample, glycated hemoglobin levels before two groups of patient's treatments
No significant difference (* P ＞ 0.05), is comparable.Treatment group reduces before glycosylated hemoglobin is relatively treated after 24 weeks, * * P ＜
0.05, there is statistical significance.Glycosylated hemoglobin has statistics less than control group, △ P ＜ 0.05 after treatment group treats 24 weeks
Learn meaning.
5 two groups of patient's therapeutic effect of syndrome of table compare
As can be seen from Table 5, treatment group's total effective rate has notable difference (P ＜ 0.05) with control group.
Each dimension integration of 6 two groups of pretherapy and post-treatment qualities of life of patient of table and overall score compare
Each dimension integral contrast of 6 (Continued) of table, two groups of pretherapy and post-treatment qualities of life of patient and overall score compare
Note：With this group before treatment, * P ＜ 0.05；Compared with after control group treatment, △ P ＜ 0.05.
As can be seen from Table 6, before GH, PF, RP, VT scoring are relatively treated after two groups of patient's treatments significantly raised (P ＜ 0.05),
Treatment group treatment after MH relatively treat before also apparent increase (P ＜ 0.05), after treatment treatment group GH, MH, PF, RE and RP apparently higher than
Control group (P ＜ 0.05).
To sum up, composition of the invention can effectively reduce blood glucose, prevent diabetes, and the raw material of the present invention is medicine food
Dual-purpose, it can be long-term use of, and it is long-term use of better.
Claims (10)
1. a kind of food, health products or pharmaceutical composition for being used to prevent diabetes, it is characterised in that：It is containing following weight
The raw material of proportioning is prepared：
5~20 parts of Chinese yam, 3~10 parts of sealwort, 5~15 parts of coix seed, 2~13 parts of mulberries, 3~15 parts of radix polygonati officinalis, hawthorn 5~20
Part.
2. food according to claim 1, health products or pharmaceutical composition, it is characterised in that：It is matched somebody with somebody by following weight
The preparation that the raw material of ratio is prepared：
5~20 parts of Chinese yam, 3~10 parts of sealwort, 5~15 parts of coix seed, 2~13 parts of mulberries, 3~15 parts of radix polygonati officinalis, hawthorn 5~20
Part.
3. food according to claim 1, health products or pharmaceutical composition, it is characterised in that：It is matched somebody with somebody by following weight
The preparation that the raw material of ratio is prepared：
10 parts of Chinese yam, 5 parts of sealwort, 10 parts of coix seed, 5 parts of mulberries, 5 parts of radix polygonati officinalis, 5 parts of hawthorn.
4. according to claims 1 to 3 any one of them food, health products or pharmaceutical composition, it is characterised in that：It is by original
Expect that the medicinal powder of medicine, the water of bulk pharmaceutical chemicals or extractive with organic solvent are active ingredient, in addition acceptable auxiliary material or auxiliary in pharmacy
The preparation that helping property ingredient is prepared.
5. according to claim 2~4 any one of them food, health products or pharmaceutical composition, it is characterised in that：The preparation
For oral formulations；Preferably, the oral formulations are decoction, powder, capsule, tablet, granule.
6. food according to claim 5, health products or pharmaceutical composition, it is characterised in that：The preparation is decoction, dissipates
Agent, capsule, tablet, granule.
7. a kind of prepare claim 1~6 any one of them food, health products or pharmaceutical composition, it is characterised in that：It is wrapped
Include following steps：
1) each raw material is weighed by weight ratio；
2) medicinal powder, water or extractive with organic solvent of bulk pharmaceutical chemicals are taken, in addition acceptable auxiliary material or complementary ingredient system in pharmacy
It is standby into preparation.
8. claim 1~6 any one of them food, health products or pharmaceutical composition are preparing prevention and/or treatment glycosuria
Purposes in the drug or health products of disease.
9. claim 1~6 any one of them food, health products or pharmaceutical composition are preparing the drug of supplementing qi and nourishing yin or guarantor
Purposes in strong product.
10. claim 1~6 any one of them food, health products or pharmaceutical composition are preparing the drug of promoting blood circulation or health care
Purposes in product.
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| CN114832063A (en) * | 2022-06-07 | 2022-08-02 | 廖志航 | Composition with function of regulating blood sugar, blood fat and/or uric acid |
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| CN106389757A (en) * | 2015-07-29 | 2017-02-15 | 陈明 | Diabetic nephropathy treating pharmaceutical composition, preparation method and uses thereof |
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| CN114832063A (en) * | 2022-06-07 | 2022-08-02 | 廖志航 | Composition with function of regulating blood sugar, blood fat and/or uric acid |
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Application publication date: 20180518 |