CN108042613A - A kind of pharmaceutical composition containing Glipizide and preparation method thereof - Google Patents
A kind of pharmaceutical composition containing Glipizide and preparation method thereof Download PDFInfo
- Publication number
- CN108042613A CN108042613A CN201711478616.XA CN201711478616A CN108042613A CN 108042613 A CN108042613 A CN 108042613A CN 201711478616 A CN201711478616 A CN 201711478616A CN 108042613 A CN108042613 A CN 108042613A
- Authority
- CN
- China
- Prior art keywords
- parts
- glipizide
- pharmaceutical composition
- mixture
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of pharmaceutical composition containing Glipizide, including below according to the raw material of parts by weight：8 12 parts of Glipizide, 15 19 parts of mulberry bark extract, 59 parts of polysorbate, 90 100 parts of pregelatinized starch, 45 50 parts of microcrystalline cellulose, 13 17 parts of hydroxypropyl cellulose, 12 parts of stearyl alcohol fumaric acid sodium.The invention also discloses the preparation methods of the pharmaceutical composition containing Glipizide.The present invention is based on the pharmaceutical compositions prepared by Glipizide, and hypoglycemic effect is excellent, disclosure satisfy that the market demand, have a vast market prospect.
Description
Technical field
It is specifically a kind of to contain the pharmaceutical composition of Glipizide and its preparation side the present invention relates to pharmaceutical technology field
Method.
Background technology
Diabetes are one group of metabolic diseases characterized by hyperglycaemia.Hyperglycaemia be then due to defect of insulin secretion or
Its biological effect is damaged, or both have concurrently and cause.Diabetes are long-standing hyperglycaemia, cause various tissues, particularly eye,
Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.
The drug of current treatment diabetes has very much, can be divided into sulfonylureas, biguanides, other antidiabetic drugs and auxiliary and use
Medicine.Wherein.Fiest-tire medication of the sulfonylureas drugs for diabetes as diabetes B, since the beginning of the 1950s, by answering for nearly half a century
With having obtained the accreditation of numerous doctors, be at present using the most abundant oral hypoglycemic agents of experience.
Glipizide is a kind of lipophilicity weak acid, is second generation sulfonylureas oral hypoglycemic agents.Oral Gastrointestinal Tract absorb completely,
Rapidly, and without first pass effect.Both visible blood glucose is decreased obviously after 30 minutes.Glipizide is mainly disappeared by liver bioconversion
It removes, the dosage less than 10% is drained with original shape through urine and excrement, and about 90% dosage is with bioconversion product through urinating (80%)
It is drained with excrement (10%).The main metabolites of Glipizide be aromatic hydroxy group reaction product, no hypoglycemic activity.Secondary generation
It thanks to the 2% of product deficiency dosage, is a kind of acetamide ethylbenzene derivative, its hypoglycemic activity with parent 1/10-1/3, therefore nothing
Or the side effect of " hypoglycemia " is seldom generated due to accumulation.But with the development of the times, the drug effect of Glipizide by
The market demand can not gradually be met, if more excellent performance of hypoglycemic medicine can be worked out based on Glipizide, will be had wide
Market prospects.
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition containing Glipizide and preparation method thereof, in solution
State the problem of being proposed in background technology.
To achieve the above object, the present invention provides following technical solution：
A kind of pharmaceutical composition containing Glipizide, including below according to the raw material of parts by weight：8-12 parts of Glipizide,
15-19 parts of mulberry bark extract, 5-9 parts of polysorbate, 90-100 parts of pregelatinized starch, 45-50 parts of microcrystalline cellulose, hydroxypropyl
13-17 parts of cellulose, 1-2 parts of stearyl alcohol fumaric acid sodium.
As further embodiment of the present invention：Including below according to the raw material of parts by weight：9-11 parts of Glipizide, the root bark of white mulberry
16-18 parts of extract, 6-8 parts of polysorbate, 93-97 parts of pregelatinized starch, 47-48 parts of microcrystalline cellulose, hydroxypropyl cellulose
14-16 parts, 1.2-1.8 parts of stearyl alcohol fumaric acid sodium.
As further scheme of the invention：Including below according to the raw material of parts by weight：10 parts of Glipizide, the root bark of white mulberry
17 parts of extract, 7 parts of polysorbate, 95 parts of pregelatinized starch, 47 parts of microcrystalline cellulose, 15 parts of hydroxypropyl cellulose, stearyl alcohol
1.5 parts of fumaric acid sodium.
As further scheme of the invention：The preparation method of the mulberry bark extract is as follows：The root bark of white mulberry is weighed, clearly
It washes, dries, grind, put into percolator, diacolation processing is carried out with the ethanol water of 12-15 times of weight, obtain diacolation and carry
Liquid and seepage pressure effects residue are taken, then seepage pressure effects residue is added in the water of 6-8 times of weight, put into together into autoclave,
140-150 DEG C, handle 30-40min under 0.7-1.0Mpa, filter, obtain high pressure extraction liquid and high pressure extraction residue, high pressure is carried
Residue is taken to add in the ethanol water of 5-6 times of weight, impregnates 3-5h, ultrasonic wave extraction 50-60min, filtering obtains ultrasonic wave and carries
Liquid and ultrasonic extraction residue are taken, percolate, high pressure extraction liquid and ultrasonic extract are merged, concentration is evaporated under reduced pressure as original
The 15-18% of volume, then be spray-dried, the desciccate obtained is mulberry bark extract.
As further scheme of the invention：The volumetric concentration of ethyl alcohol is 50% in the ethanol water.
As further scheme of the invention：The ultrasonic wave extraction temperature is 50-55 DEG C.
As further scheme of the invention：The ultrasonic wave extraction power is 40-50kHz.
The preparation method of the pharmaceutical composition containing Glipizide, step are as follows：
1) Glipizide, pregelatinized starch and microcrystalline cellulose are weighed, after merging, is uniformly mixed, it is mixed to obtain first
Close object；
2) deionized water of 8-10 times of weight of its total weight is added in into the first mixture, after being uniformly mixed, is obtained
Second mixture；
3) mulberry bark extract, polysorbate and stearyl alcohol fumaric acid sodium are weighed, is added in into the second mixture, stirring is mixed
After closing uniformly, 35-40min is ultrasonically treated, obtains the 3rd mixture；
4) the 3rd mixture is spray-dried, obtains the 4th mixture；
5) hydroxypropyl cellulose is weighed, adds in into the 4th mixture, is uniformly mixed, carries out compressing tablet process, you can.
As further scheme of the invention：The sonification power is 30-40kHz.
Aforementioned pharmaceutical compositions are preparing the purposes in treating diabetes medicament.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention is based on the pharmaceutical compositions prepared by Glipizide, and hypoglycemic effect is excellent, disclosure satisfy that the market demand,
Have a vast market prospect.
Specific embodiment
Technical scheme is described in more detail With reference to embodiment.
Embodiment 1
A kind of pharmaceutical composition containing Glipizide, including below according to the raw material of parts by weight：8 parts of Glipizide, mulberry
It is white 15 parts of bark extract, 5 parts of polysorbate, 90 parts of pregelatinized starch, 45 parts of microcrystalline cellulose, 13 parts of hydroxypropyl cellulose, hard
1 part of lipidol fumaric acid sodium.
The preparation method of the mulberry bark extract is as follows：The root bark of white mulberry is weighed, is cleaned, drying is ground, put into percolator
In, diacolation processing is carried out with the ethanol water of 12 times of weight, percolate and seepage pressure effects residue are obtained, then by diacolation
The water that residue adds in 6 times of weight is extracted, puts into together into autoclave, 30min is handled under 140 DEG C, 0.7Mpa, filters, obtains
High pressure extraction liquid and high pressure extraction residue are obtained, high pressure extraction residue is added in the ethanol water of 5 times of weight, impregnates 3h, ultrasound
Ripple extracts 50min, and filtering obtains ultrasonic extract and ultrasonic extraction residue, by percolate, high pressure extraction liquid and ultrasound
Ripple extracting solution merges, and reduction vaporization concentration is the 15% of original volume, then is spray-dried, and the desciccate obtained is mulberry
White bark extract.Wherein, the volumetric concentration of ethyl alcohol is 50% in the ethanol water；The ultrasonic wave extraction temperature is 50
DEG C, the ultrasonic wave extraction power is 40kHz.
In the present embodiment, the preparation method of the pharmaceutical composition containing Glipizide, step is as follows：
1) Glipizide, pregelatinized starch and microcrystalline cellulose are weighed, after merging, is uniformly mixed, it is mixed to obtain first
Close object；
2) deionized water of its 8 times of weight of total weight is added in into the first mixture, after being uniformly mixed, obtains second
Mixture；
3) mulberry bark extract, polysorbate and stearyl alcohol fumaric acid sodium are weighed, is added in into the second mixture, stirring is mixed
After closing uniformly, 35min is ultrasonically treated, obtains the 3rd mixture, wherein, the sonification power is 30kHz；
4) the 3rd mixture is spray-dried, obtains the 4th mixture；
5) hydroxypropyl cellulose is weighed, adds in into the 4th mixture, is uniformly mixed, carries out compressing tablet process, you can.
Embodiment 2
A kind of pharmaceutical composition containing Glipizide, including below according to the raw material of parts by weight：9 parts of Glipizide, mulberry
It is white 16 parts of bark extract, 6 parts of polysorbate, 97 parts of pregelatinized starch, 48 parts of microcrystalline cellulose, 16 parts of hydroxypropyl cellulose, hard
1.2 parts of lipidol fumaric acid sodium.
The preparation method of the mulberry bark extract is as follows：The root bark of white mulberry is weighed, is cleaned, drying is ground, put into percolator
In, diacolation processing is carried out with the ethanol water of 13 times of weight, percolate and seepage pressure effects residue are obtained, then by diacolation
The water that residue adds in 6 times of weight is extracted, puts into together into autoclave, 33min is handled under 145 DEG C, 0.8Mpa, filters, obtains
High pressure extraction liquid and high pressure extraction residue are obtained, high pressure extraction residue is added in the ethanol water of 5 times of weight, impregnates 3.5h, is surpassed
Sound wave extracts 52min, and filtering obtains ultrasonic extract and ultrasonic extraction residue, by percolate, high pressure extraction liquid and surpasses
Sound wave extracting solution merges, and reduction vaporization concentration is the 16% of original volume, then is spray-dried, and the desciccate obtained is
Mulberry bark extract.Wherein, the volumetric concentration of ethyl alcohol is 50% in the ethanol water；The ultrasonic wave extraction temperature is 52
DEG C, the ultrasonic wave extraction power is 40kHz.
In the present embodiment, the preparation method of the pharmaceutical composition containing Glipizide, step is as follows：
1) Glipizide, pregelatinized starch and microcrystalline cellulose are weighed, after merging, is uniformly mixed, it is mixed to obtain first
Close object；
2) deionized water of its 8.5 times of weight of total weight is added in into the first mixture, after being uniformly mixed, obtains the
Two mixtures；
3) mulberry bark extract, polysorbate and stearyl alcohol fumaric acid sodium are weighed, is added in into the second mixture, stirring is mixed
After closing uniformly, 36min is ultrasonically treated, obtains the 3rd mixture, wherein, the sonification power is 30kHz；
4) the 3rd mixture is spray-dried, obtains the 4th mixture；
5) hydroxypropyl cellulose is weighed, adds in into the 4th mixture, is uniformly mixed, carries out compressing tablet process, you can.
Embodiment 3
A kind of pharmaceutical composition containing Glipizide, including below according to the raw material of parts by weight：10 parts of Glipizide, mulberry
It is white 17 parts of bark extract, 7 parts of polysorbate, 95 parts of pregelatinized starch, 47 parts of microcrystalline cellulose, 15 parts of hydroxypropyl cellulose, hard
1.5 parts of lipidol fumaric acid sodium.
The preparation method of the mulberry bark extract is as follows：The root bark of white mulberry is weighed, is cleaned, drying is ground, put into percolator
In, diacolation processing is carried out with the ethanol water of 14 times of weight, percolate and seepage pressure effects residue are obtained, then by diacolation
The water that residue adds in 7 times of weight is extracted, puts into together into autoclave, 35min is handled under 145 DEG C, 0.9Mpa, filters, obtains
High pressure extraction liquid and high pressure extraction residue are obtained, high pressure extraction residue is added in the ethanol water of 6 times of weight, impregnates 4h, ultrasound
Ripple extracts 55min, and filtering obtains ultrasonic extract and ultrasonic extraction residue, by percolate, high pressure extraction liquid and ultrasound
Ripple extracting solution merges, and reduction vaporization concentration is the 16% of original volume, then is spray-dried, and the desciccate obtained is mulberry
White bark extract.Wherein, the volumetric concentration of ethyl alcohol is 50% in the ethanol water；The ultrasonic wave extraction temperature is 52
DEG C, the ultrasonic wave extraction power is 45kHz.
In the present embodiment, the preparation method of the pharmaceutical composition containing Glipizide, step is as follows：
1) Glipizide, pregelatinized starch and microcrystalline cellulose are weighed, after merging, is uniformly mixed, it is mixed to obtain first
Close object；
2) deionized water of its 9 times of weight of total weight is added in into the first mixture, after being uniformly mixed, obtains second
Mixture；
3) mulberry bark extract, polysorbate and stearyl alcohol fumaric acid sodium are weighed, is added in into the second mixture, stirring is mixed
After closing uniformly, 38min is ultrasonically treated, obtains the 3rd mixture, wherein, the sonification power is 35kHz；
4) the 3rd mixture is spray-dried, obtains the 4th mixture；
5) hydroxypropyl cellulose is weighed, adds in into the 4th mixture, is uniformly mixed, carries out compressing tablet process, you can.
Embodiment 4
A kind of pharmaceutical composition containing Glipizide, including below according to the raw material of parts by weight：11 parts of Glipizide, mulberry
It is white 18 parts of bark extract, 8 parts of polysorbate, 93 parts of pregelatinized starch, 47 parts of microcrystalline cellulose, 14 parts of hydroxypropyl cellulose, hard
1.8 parts of lipidol fumaric acid sodium.
The preparation method of the mulberry bark extract is as follows：The root bark of white mulberry is weighed, is cleaned, drying is ground, put into percolator
In, diacolation processing is carried out with the ethanol water of 14 times of weight, percolate and seepage pressure effects residue are obtained, then by diacolation
The water that residue adds in 8 times of weight is extracted, puts into together into autoclave, 40min is handled under 145 DEG C, 0.9Mpa, filters, obtains
High pressure extraction liquid and high pressure extraction residue are obtained, high pressure extraction residue is added in the ethanol water of 5 times of weight, impregnates 4.5h, is surpassed
Sound wave extracts 57min, and filtering obtains ultrasonic extract and ultrasonic extraction residue, by percolate, high pressure extraction liquid and surpasses
Sound wave extracting solution merges, and reduction vaporization concentration is the 17% of original volume, then is spray-dried, and the desciccate obtained is
Mulberry bark extract.Wherein, the volumetric concentration of ethyl alcohol is 50% in the ethanol water；The ultrasonic wave extraction temperature is 52
DEG C, the ultrasonic wave extraction power is 50kHz.
In the present embodiment, the preparation method of the pharmaceutical composition containing Glipizide, step is as follows：
1) Glipizide, pregelatinized starch and microcrystalline cellulose are weighed, after merging, is uniformly mixed, it is mixed to obtain first
Close object；
2) deionized water of its 10 times of weight of total weight is added in into the first mixture, after being uniformly mixed, obtains the
Two mixtures；
3) mulberry bark extract, polysorbate and stearyl alcohol fumaric acid sodium are weighed, is added in into the second mixture, stirring is mixed
After closing uniformly, 36min is ultrasonically treated, obtains the 3rd mixture, wherein, the sonification power is 30kHz；
4) the 3rd mixture is spray-dried, obtains the 4th mixture；
5) hydroxypropyl cellulose is weighed, adds in into the 4th mixture, is uniformly mixed, carries out compressing tablet process, you can.
Embodiment 5
A kind of pharmaceutical composition containing Glipizide, including below according to the raw material of parts by weight：12 parts of Glipizide, mulberry
It is white 19 parts of bark extract, 9 parts of polysorbate, 100 parts of pregelatinized starch, 50 parts of microcrystalline cellulose, 17 parts of hydroxypropyl cellulose, hard
2 parts of lipidol fumaric acid sodium.
The preparation method of the mulberry bark extract is as follows：The root bark of white mulberry is weighed, is cleaned, drying is ground, put into percolator
In, diacolation processing is carried out with the ethanol water of 15 times of weight, percolate and seepage pressure effects residue are obtained, then by diacolation
The water that residue adds in 8 times of weight is extracted, puts into together into autoclave, 40min is handled under 150 DEG C, 1.0Mpa, filters, obtains
High pressure extraction liquid and high pressure extraction residue are obtained, high pressure extraction residue is added in the ethanol water of 6 times of weight, impregnates 5h, ultrasound
Ripple extracts 60min, and filtering obtains ultrasonic extract and ultrasonic extraction residue, by percolate, high pressure extraction liquid and ultrasound
Ripple extracting solution merges, and reduction vaporization concentration is the 18% of original volume, then is spray-dried, and the desciccate obtained is mulberry
White bark extract.Wherein, the volumetric concentration of ethyl alcohol is 50% in the ethanol water；The ultrasonic wave extraction temperature is 55
DEG C, the ultrasonic wave extraction power is 50kHz.
In the present embodiment, the preparation method of the pharmaceutical composition containing Glipizide, step is as follows：
1) Glipizide, pregelatinized starch and microcrystalline cellulose are weighed, after merging, is uniformly mixed, it is mixed to obtain first
Close object；
2) deionized water of its 10 times of weight of total weight is added in into the first mixture, after being uniformly mixed, obtains the
Two mixtures；
3) mulberry bark extract, polysorbate and stearyl alcohol fumaric acid sodium are weighed, is added in into the second mixture, stirring is mixed
After closing uniformly, 40min is ultrasonically treated, obtains the 3rd mixture, wherein, the sonification power is 40kHz；
4) the 3rd mixture is spray-dried, obtains the 4th mixture；
5) hydroxypropyl cellulose is weighed, adds in into the 4th mixture, is uniformly mixed, carries out compressing tablet process, you can.
Comparative example 1
Compared with Example 3, without mulberry bark extract, other are same as Example 3.
Comparative example 2
Compared with Example 3, mulberry bark extract is contained only, and the preparation method of mulberry bark extract is same as Example 3.
Curative effect
Kunming mouse, weight 25-30g are taken, for 24 hours, Alloxan 200mg/kg, once a day, 72h is injected intraperitoneally in fasting
Fasting 10h afterwards, venous sinus take blood to centrifuge, and serum is taken to measure blood glucose value, choose blood glucose value and are carried out in fact in more than 11.1mol/L persons
It tests, chooses 80 altogether, be randomly divided into four groups, every group 20.The physiology salt of drug wherein prepared by first group of gavage embodiment 3
Aqueous dispersions, and the dosage of drug is 200mg/kg, the physiological saline of the drug prepared by second group of gavage comparative example 1 disperses
Liquid, and the dosage of drug is 180mg/kg, the normal saline dispersion of the drug prepared by the 3rd group of gavage comparative example 2, and medicine
The dosage of object be 20mg/kg, the physiological saline of the 4th group of gavage equal volume.Successive administration l5 days, after the last administration fasting
10h, orbital sinus take blood, and centrifuging and taking serum by determination of glucose oxidase blood glucose level, the results are shown in Table shown in one.
One result of the test table of table
| Group | Quantity | Blood glucose value (mol/L) |
| First group | 20 | 15.47±2.69 |
| Second group | 20 | 19.96±2.32 |
| 3rd group | 20 | 23.38±3.05 |
| 4th group | 20 | 25.62±2.17 |
As can be seen from the above table, the pharmaceutical composition that prepared by the present invention can effectively inhibit the rise of mouse blood sugar.
In addition, as can be seen that the present invention is carried by adding in the root bark of white mulberry from data comparison of the embodiment 3 with comparative example 1-2
Object is taken, mulberry bark extract mutually acts synergistically with Glipizide, is conducive to improve the inhibition to mouse blood sugar level.
The present invention is based on the pharmaceutical compositions prepared by Glipizide, and hypoglycemic effect is excellent, disclosure satisfy that the market demand,
Have a vast market prospect.
The better embodiment of the present invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party
Formula, can also be on the premise of present inventive concept not be departed from the knowledge that one skilled in the relevant art possesses
Various changes can be made.
Claims (10)
1. a kind of pharmaceutical composition containing Glipizide, which is characterized in that including below according to the raw material of parts by weight：Lattice row pyrrole
8-12 parts of piperazine, 15-19 parts of mulberry bark extract, 5-9 parts of polysorbate, 90-100 parts of pregelatinized starch, microcrystalline cellulose 45-50
Part, 13-17 parts of hydroxypropyl cellulose, 1-2 parts of stearyl alcohol fumaric acid sodium.
2. the pharmaceutical composition according to claim 1 containing Glipizide, which is characterized in that including below according to weight
The raw material of part：9-11 parts of Glipizide, 16-18 parts of mulberry bark extract, 6-8 parts of polysorbate, 93-97 parts of pregelatinized starch,
47-48 parts of microcrystalline cellulose, 14-16 parts of hydroxypropyl cellulose, 1.2-1.8 parts of stearyl alcohol fumaric acid sodium.
3. the pharmaceutical composition according to claim 2 containing Glipizide, which is characterized in that including below according to weight
The raw material of part：10 parts of Glipizide, 17 parts of mulberry bark extract, 7 parts of polysorbate, 95 parts of pregelatinized starch, microcrystalline cellulose
47 parts, 15 parts of hydroxypropyl cellulose, 1.5 parts of stearyl alcohol fumaric acid sodium.
4. the pharmaceutical composition according to claim 1 containing Glipizide, which is characterized in that the mulberry bark extract
Preparation method it is as follows：The root bark of white mulberry is weighed, is cleaned, drying is ground, put into percolator, with the ethanol water of 12-15 times of weight
Solution carries out diacolation processing, obtains percolate and seepage pressure effects residue, and seepage pressure effects residue then is added in 6-8 times of weight
Water, put into together into autoclave, 30-40min handled under 140-150 DEG C, 0.7-1.0Mpa, filter, obtain high pressure carry
Liquid and high pressure extraction residue are taken, high pressure extraction residue is added in the ethanol water of 5-6 times of weight, impregnates 3-5h, ultrasonic wave carries
50-60min is taken, is filtered, ultrasonic extract and ultrasonic extraction residue are obtained, by percolate, high pressure extraction liquid and ultrasound
Ripple extracting solution merges, and 15-18% of the concentration for original volume is evaporated under reduced pressure, then is spray-dried, and the desciccate obtained is i.e.
For mulberry bark extract.
5. the pharmaceutical composition according to claim 4 containing Glipizide, which is characterized in that in the ethanol water
The volumetric concentration of ethyl alcohol is 50%.
6. the pharmaceutical composition according to claim 4 containing Glipizide, which is characterized in that the ultrasonic wave extraction temperature
It spends for 50-55 DEG C.
7. the pharmaceutical composition according to claim 4 containing Glipizide, which is characterized in that the ultrasonic wave extraction work(
Rate is 40-50kHz.
8. a kind of preparation method of pharmaceutical composition containing Glipizide as described in claim 1-7 is any, feature exist
In step is as follows：
1) Glipizide, pregelatinized starch and microcrystalline cellulose are weighed, after merging, is uniformly mixed, obtains the first mixture；
2) deionized water of 8-10 times of weight of its total weight is added in into the first mixture, after being uniformly mixed, obtains second
Mixture；
3) mulberry bark extract, polysorbate and stearyl alcohol fumaric acid sodium are weighed, is added in into the second mixture, is stirred
After even, 35-40min is ultrasonically treated, obtains the 3rd mixture；
4) the 3rd mixture is spray-dried, obtains the 4th mixture；
5) hydroxypropyl cellulose is weighed, adds in into the 4th mixture, is uniformly mixed, carries out compressing tablet process, you can.
9. the preparation method of the pharmaceutical composition according to claim 8 containing Glipizide, which is characterized in that described super
Sonication power is 30-40kHz.
10. the pharmaceutical composition as described in claim 1-7 is any is preparing the purposes in treating diabetes medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711478616.XA CN108042613A (en) | 2017-12-29 | 2017-12-29 | A kind of pharmaceutical composition containing Glipizide and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711478616.XA CN108042613A (en) | 2017-12-29 | 2017-12-29 | A kind of pharmaceutical composition containing Glipizide and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108042613A true CN108042613A (en) | 2018-05-18 |
Family
ID=62129027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711478616.XA Pending CN108042613A (en) | 2017-12-29 | 2017-12-29 | A kind of pharmaceutical composition containing Glipizide and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108042613A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114642721A (en) * | 2022-04-24 | 2022-06-21 | 华裕(无锡)制药有限公司 | Glipizide tablet preparation for treating diabetes and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213335A (en) * | 2015-09-28 | 2016-01-06 | 宁夏康亚药业有限公司 | Glipizide tablet and preparation method thereof and application |
| CN105616581A (en) * | 2016-03-27 | 2016-06-01 | 济南邦文医药科技有限公司 | Glipizide-containing pharmaceutical composition for treating diabetes and preparation method thereof |
-
2017
- 2017-12-29 CN CN201711478616.XA patent/CN108042613A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213335A (en) * | 2015-09-28 | 2016-01-06 | 宁夏康亚药业有限公司 | Glipizide tablet and preparation method thereof and application |
| CN105616581A (en) * | 2016-03-27 | 2016-06-01 | 济南邦文医药科技有限公司 | Glipizide-containing pharmaceutical composition for treating diabetes and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 周锋等: "桑白皮总黄酮抗糖尿病作用的初步研究", 《激光杂志》 * |
| 赵文杰等: "桑白皮提取物对胰岛素抵抗2型糖尿病小鼠的降糖作用", 《中国医药指南》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114642721A (en) * | 2022-04-24 | 2022-06-21 | 华裕(无锡)制药有限公司 | Glipizide tablet preparation for treating diabetes and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103750107B (en) | Health-care product with blood glucose reducing function | |
| CN110538189A (en) | Eucommia ulmoides extract composition for treating renal fibrosis and application thereof | |
| CN109734761A (en) | A kind of preparation method and applications of Enteromorpha fucose complex compound | |
| CN1382478A (en) | Extract of mulberry twig and its extracting process and novel usage | |
| CN108042613A (en) | A kind of pharmaceutical composition containing Glipizide and preparation method thereof | |
| CN107854656B (en) | Lipid-lowering traditional Chinese medicine composition and preparation method and application thereof | |
| CN1206236C (en) | Manyprickle acanthopanax general saponin extractive and its medicinal composition | |
| CN102018903B (en) | Pure traditional Chinese medicine preparation for treating glomerular diseases and preparation method thereof | |
| CN113476561A (en) | Traditional Chinese medicine formula for treating diabetes | |
| CN107137490A (en) | One kind treats diabetes B and complication compound Chinese medicinal preparation and preparation method | |
| CN111869877A (en) | Camellia oil health-care capsule and preparation method thereof | |
| CN106334180A (en) | Chinese and Western medicine oral preparation for treating type II diabetes | |
| CN101152223A (en) | Use of poplar leaf phenols extract in treating cardiovascular disease and extracting method thereof | |
| CN111821325A (en) | Application of photorhaponticum flower extract | |
| CN1247232C (en) | Radix zanthoxyli powder injection and preparing method thereof | |
| CN107811907A (en) | A kind of body lotion for promoting subcutaneous fat to decompose | |
| CN107029124A (en) | It is a kind of to be used to treat Chinese medicine composition of essential hypertension and preparation method thereof | |
| CN105920288B (en) | Improve Chinese medicine preparation of insulin resistance syndrome and preparation method and application | |
| CN1689593A (en) | Method for preparing ginseng and aconite powdered injection | |
| CN105709010A (en) | Pharmaceutical composition having blood-sugar reducing assisting function | |
| CN116920026A (en) | Traditional Chinese medicine for treating hypertension and diabetes | |
| CN105596429B (en) | Preparation and application of lotus plumule total flavonoids for preventing and treating type II diabetes | |
| CN106262818A (en) | A kind of blood sugar lowering oral liquid and preparation method thereof | |
| CN115957249A (en) | Application of tripterygium wilfordii bidirectional solid fermentation product in preparation of medicine for treating kidney disease | |
| CN110151942A (en) | A kind of drug and preparation method for improving sugar tolerance and treating diabetes and obesity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180518 |