CN108042363A - One kind can on-line checking Chinese patent medicine tablet preparation system and method - Google Patents
One kind can on-line checking Chinese patent medicine tablet preparation system and method Download PDFInfo
- Publication number
- CN108042363A CN108042363A CN201810042180.8A CN201810042180A CN108042363A CN 108042363 A CN108042363 A CN 108042363A CN 201810042180 A CN201810042180 A CN 201810042180A CN 108042363 A CN108042363 A CN 108042363A
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- Prior art keywords
- tabletting
- raw material
- raman
- infrared
- chinese patent
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- 239000003814 drug Substances 0.000 title claims abstract description 98
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 18
- 239000002994 raw material Substances 0.000 claims abstract description 92
- 238000001069 Raman spectroscopy Methods 0.000 claims abstract description 80
- 238000001514 detection method Methods 0.000 claims abstract description 68
- 229940079593 drug Drugs 0.000 claims abstract description 67
- 238000002156 mixing Methods 0.000 claims abstract description 16
- 238000004806 packaging method and process Methods 0.000 claims abstract description 7
- 238000003825 pressing Methods 0.000 claims description 39
- 239000006071 cream Substances 0.000 claims description 33
- 239000000523 sample Substances 0.000 claims description 30
- 238000004566 IR spectroscopy Methods 0.000 claims description 16
- 239000011230 binding agent Substances 0.000 claims description 16
- 239000011248 coating agent Substances 0.000 claims description 12
- 238000000576 coating method Methods 0.000 claims description 12
- 239000013307 optical fiber Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000012856 packing Methods 0.000 claims description 10
- 238000012360 testing method Methods 0.000 claims description 10
- 230000003287 optical effect Effects 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 238000001237 Raman spectrum Methods 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 235000012343 cottonseed oil Nutrition 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000002329 infrared spectrum Methods 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- 238000004611 spectroscopical analysis Methods 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims 1
- 238000001228 spectrum Methods 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 41
- 239000004615 ingredient Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000008899 fufang danshen Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 2
- 235000003143 Panax notoginseng Nutrition 0.000 description 2
- 241000180649 Panax notoginseng Species 0.000 description 2
- 229940116229 borneol Drugs 0.000 description 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 238000001157 Fourier transform infrared spectrum Methods 0.000 description 1
- 238000001530 Raman microscopy Methods 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- -1 sublimed preparation Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
Abstract
It can on-line checking Chinese patent medicine tablet preparation system and method the invention belongs to drug preparation field more particularly to one kind.Including raw material mixing system, sheeting system, Raman detection system, Fourier's infrared detection system, overlapping system and packaging system.It first sufficiently mixed, ground before drug mixing, drug is made sufficiently to mix, the inhomogeneities when preparing tablet can be reduced；Tablet is first prepared into flakiness, carries out Raman detection and Fourier's infrared detection, and the spectrum of itself and known qualified thin slice is compared, substantially increases judgement accuracy and speed, can be whether to contain enough active ingredient in accurate judgement thin slice；It is combined using the infrared two kinds of detection methods of Raman and Fourier, substantially increases the accuracy of detection；Detection qualified drug such as is overlapped and is coated again at the operations, not only ensure that the accuracy of detection of drug, but also has not influenced the dosage of drug.
Description
Technical field
The invention belongs to drug preparation fields, and in particular to a kind of Chinese patent medicine tablet preparation system and method more particularly to
One kind can on-line checking Chinese patent medicine tablet preparation system and method.
Background technology
Chinese patent drug Traditional Chinese Medicine Patent Prescription be using Chinese medicine as raw material,
The Chinese herbal product of various different dosage forms is made through preparation processing, including ball, dissipates, cream, red various dosage forms.It is China's successive dynasties medicine and pharmacology
Family created by medical practice in 1,100, the elite of effective prescription of summary.
Tibetan medicine is to absorb extensively, merging traditional Chinese medicine and pharmacy, on the basis of Indian Medicinal and big dietitian's pharmacy scheduling theory,
The unique medicine systems formed by long-term practice have the history of more than one thousand years so far, are that China is more complete, relatively have shadow
One of loud ethnic drug.It is by the effective way of Tibetan medicine utilization that Tibetan medicine is prepared into Chinese patent drug.
Chinese patent drug includes pill, powder, soft extract, sublimed preparation, tablet, granule, pastille, jelly, hard capsule, soft capsule
Agent, syrup, mixture, vina, tincture, distillate medicinal water, injection, aerosol, plaster, film, suppository.
Since the ingredient that drug effect is played in Chinese patent drug is different from Western medicine, the ingredient that Western medicine plays therapeutic effect is known to chemistry
Ingredient, the detection in preparation process are relatively simple, it is only necessary to carry out content detection to the chemical composition to work.In and into
The ingredient that medicine generally works is complex, and drug effect is related with many factors, and current detection means is difficult to effectively be examined
It surveys.It is especially detected in preparation process, there is presently no particularly effective means.
The patent application of application number 2014204428220, devises a kind of micro-Raman spectroscopy sample stage, in sample stage
Between have the groove body of an opening, groove body top edge is equipped with rectangular horizontal flange, and bottom sets that there are one nuts in groove body
Fixed frame, for fixing nut, effect that sample stage can move up and down focuses on so as to reach.The sample stage is easy to use, behaviour
Make simply, suitable for the detection of tablet, but its detection is only limitted to the detection of fixed position, and uses reflective detection, it is impossible to
Perform the infrared detection of Fourier.
The patent application of application number 2015800007446 discloses a kind of tablet automatic checking device, according to the upside
It detects the inspection result of camera after detecting camera and the reversion and is characterized as the undesirable tablet and is arranged by compressed air in face
Go out to the first bad tablet delivery cassette, the normal tablet is expelled to normal tablets delivery cassette.Its detection is only limitted to appearance
Detection, it is impossible to realize the detection to ingredient, particularly effective ingredient, it is impossible to be detected.
The patent application of application number 201510678947.2 is prepared for a kind of Chinese medicine composition for treating dysmenorrhoea, and can make
Into decoction, pill, capsule or tablet, preparation method is simple, is easy to industrialize.It is tested, detected using thin-layered chromatography
Method is simple, and specificity is strong, and testing result is reliable.But its detection speed is slow, it is impossible to realize on-line checking.
Raman spectrum detection technique and FTIR spectrum detection technique are the high speed detection skills currently for organic matter
Art, can be by the spectrum after detection compared with effective drug spectrum, so as to judge whether drug to be measured is effective medicine
Object.
The content of the invention
The present invention overcomes disadvantages described above, devise one kind can on-line checking Chinese patent medicine tablet preparation system, mixed including raw material
Collaboration system, sheeting system, Raman detection system, Fourier's infrared detection system, overlapping system and packaging system；
The raw material mixing system includes Raw material pail, pulverizer and mixer, and the number of the Raw material pail is multiple, each is former
Raw material is prepared equipped with a kind of Chinese patent drug in charging basket, the Chinese patent drug prepares raw material and prepares auxiliary material for herb powder or tablet；It is described
Multiple Raw material pails are connected respectively with pulverizer entrance, and Chinese patent drug prepares raw material and enters pulverizer by pulverizer entrance, and in powder
It is sufficiently crushed in broken machine；The pulverizer includes mixing roll and oscillator, can be prepared by Chinese patent drug raw material and is fully ground
And vibrate mixing；The pulverizer connects mixer, and the mixer contains water inlet, the Chinese patent drug after grinding prepare raw material into
Enter after mixer plus water is mixed to form Chinese patent drug and prepares raw material cream；
The sheeting system is connected with the outlet of mixer, the sheeting system be provided with feeding port, squeeze pallet, scraper plate,
Precompressed pressing plate, Chinese patent drug prepare raw material cream and are reached by feeding port on extruding pallet, and the extruding pallet is provided with array-like
Pre- indent, the depth of the pre- indent is 0.7-1mm, and the scraper plate is arranged at the top for squeezing pallet, for that will exceed precompressed
The Chinese patent drug of slot prepares raw material cream and scrapes one side；The precompressed pressing plate is arranged on the top for squeezing pallet, on the precompressed pressing plate
It is provided with and squeezes the corresponding protrusion of pre- indent on pallet, raised height is 0.2-0.5mm on the precompressed pressing plate, described
Protrusion is pressed into pre- tabletting for be prepared by the Chinese patent drug in pre- indent raw material cream；
The bottom for squeezing tray slot is provided with inflatable mouth, and the inflatable mouth can be blown out pre- tabletting outside slot with blow out air；
Raman detection system includes first laser device, Raman the output optical fiber, Raman outgoing head, Raman collection probe, Raman collection
Optical fiber, raman spectroscopy instrument；
Fourier's infrared detection system includes second laser, infrared the output optical fiber, and infrared outgoing head, infrared collection pop one's head in, are red
Outer collection optical fiber, Infrared Spectroscopy；
Chinese patent medicine tablet preparation system further includes computer and hollow conveyer belt, and the hollow conveyer belt is two parallel biographies
Band is sent, the Raman outgoing head and infrared outgoing head may be contained within above hollow conveyer belt, Raman collection probe and infrared collection
Probe is arranged on the downside of hollow conveyer belt, and the position that the hollow conveyer belt is located at below Raman outgoing head and infrared outgoing head is set
Transversely movable first sliding block and the second sliding block are equipped with, first sliding block and the second sliding block are used for when the pre- tabletting detection
Transverse shifting makes precompressed piece fall on outside hollow conveyer belt when unqualified；
The first laser device, second laser, raman spectroscopy instrument, Infrared Spectroscopy, the first sliding block and the second sliding block with meter
Calculation machine connects；The calculator memory contains the Raman and infrared spectra model of qualified pre- tabletting, and computer is according to raman spectroscopy
The spectroscopy data of instrument and Infrared Spectroscopy judges whether detected pre- tabletting is qualified；To the first sliding block and second if unqualified
Sliding block sends instruction, slides unqualified pre- tabletting；
The overlapping system includes superposition conveyer belt, bonds nozzle, superposition slot and superposition pressing plate, and the cohesive nozzle is arranged on folded
Add above conveyer belt, for spraying binding agent to pre- tabletting, the binding agent is edible binding agent；The superposition conveyer belt end
End is provided with superposition slot, and superposition pressing plate is arranged at the top of superposition slot, is superimposed on pressing plate and is provided with protrusion corresponding with superposition slot；
Pre- tabletting forms the tablet of superposition by the extruding for being superimposed pressing plate after superposition conveyer belt enters superposition slot；
The packaging system is provided with seed-coating machine and packing machine, and seed-coating machine is coated tablet processing, and packing machine will be at coating
Tablet after reason is packaged, mounted box.
The first laser device is He-Ne laser or Nd：YAG laser, the launch wavelength of He-Ne laser are
632.8nm, Nd：The launch wavelength of YAG laser is 1064nm；Condenser lens is provided in the Raman emission head, it is described poly-
The focal length of focus lens is 150-250mm, and optical filter is provided with before the Raman collection probe；
The test position of the Raman detection system is provided with spuious light shielding mask, and the shielding case appearance is a cuboid, is drawn
Graceful outgoing head, Raman collection probe are arranged on inside shielding case；
The second laser is Nd：YAG laser, Nd：The launch wavelength of YAG laser is 1064nm；The infrared emission
Condenser lens is provided in head, the focal length of the condenser lens is 150-250mm, and optical filtering is provided with before the infrared collection probe
Piece；
The test position of the infrared detection system is provided with spuious light shielding mask, and the shielding case appearance is a cuboid, red
Outer outgoing head, infrared collection probe are arranged on inside shielding case；The depth of the superposition slot is 3-4mm, on the superposition pressing plate
The height of protrusion is 1-2mm.
The superposition trench bottom is additionally provided with heat drying apparatus, and the dry heat device is connected with computer, passes through
Computer can control the temperature of heat drying apparatus, and the heater is infrared ray heating tube, infrared ray heating tube transmitting
Infrared ray alignment superposition trench bottom, is evenly heated superposition slot.
The tablet prepare auxiliary material include starch, Icing Sugar, dextrin, lactose, microcrystalline cellulose or mannitol in one kind or
It is a variety of.
The present invention additionally provides a kind of methods that tablet preparation is carried out using foregoing system, it is characterised in that including following
Step：
1）Raw material mixes；The required raw material for preparing Chinese patent medicine tablet is separately added into different Raw material pails, raw material passes through raw material
Bucket is sufficiently crushed and vibrated in pulverizer into pulverizer；Enter mixing afterwards by the raw material for crushing and vibrating
Machine, raw material are sufficiently stirred to form Chinese patent drug and prepare raw material cream in mixer plus water；
2）It is prepared by pre- tabletting；The Chinese patent drug enters the pre- indent squeezed on pallet, scraper plate after preparing raw material cream outflow mixer
Mobile that the Chinese patent drug for being higher by pre- indent on extruding pallet is caused to prepare raw material cream and scraped to one side, precompressed pressing plate falls, and squeezes pre-
Chinese patent drug in indent prepares raw material cream, and Chinese patent drug is made to prepare raw material cream and is squeezed into laminar pre- tabletting；
3）Optical detection；Pre- tabletting is positioned on hollow conveyer belt, the both sides of pre- tabletting are carried on a shoulder pole respectively in hollow conveyer belt both sides
Conveyer belt on；Pre- tabletting is emitted the lower section of head by Raman, and Raman outgoing hair penetrates Raman detection laser, Raman detection laser
Through pre- tabletting by Raman collection probe collection, the light of collection enters raman spectroscopy instrument, and the data of raman spectroscopy instrument are transferred into
Computer, computer judge whether the pre- tabletting is qualified；Into next process if qualified, if unqualified to the first sliding block
Instruction is sent, slides unqualified pre- tabletting；
The lower section of infrared outgoing head is passed through in pre- tabletting, and infrared outgoing hair penetrates infrared detection laser, and infrared detection laser is through in advance
Tabletting enters Infrared Spectroscopy by infrared collection probe collection, the light of collection, and the data of Infrared Spectroscopy are transferred into computer,
Computer judges whether the pre- tabletting is qualified；Into next process if qualified, if unqualified refer to the transmission of the first sliding block
Order slides unqualified pre- tabletting；
4）Pre- tabletting superposition；Qualified pre- tabletting is transferred into superposition conveyer belt after testing, bonds nozzle and is sprayed to pre- tabletting and is glued
Agent is tied, the pre- tabletting through spraying binding agent enters superposition slot, and after multiple pre- tablettings enter superposition slot, superposition pressing plate falls, more
A pre- tabletting forms tablet under the extruding of superposition pressing plate；
5）Tablet is packed：Seed-coating machine is coated tablet processing, and the tablet after Cotton seeds is packaged by packing machine, dress
Box.
Beneficial effects of the present invention are：
1）Chinese medicine structure differs, and is first sufficiently mixed, ground before drug mixing, drug is made sufficiently to mix, can be with
Reduce the inhomogeneities when preparing tablet；
2）Tablet is first prepared into flakiness, carries out Raman detection and Fourier's infrared detection, and by itself and known qualified thin slice
Spectrum compared, substantially increase judgement accuracy and speed, can in accurate judgement thin slice whether containing it is enough effectively into
Point；
3）It is combined using the infrared two kinds of detection methods of Raman and Fourier, substantially increases the accuracy of detection；
4）Detection qualified drug such as is overlapped and is coated again at the operations, not only ensure that the accuracy of detection of drug, but also has not influenced medicine
The dosage of object.
Description of the drawings
The system structure diagram of Fig. 1 present invention；
Fig. 2 raw material mixing system structure diagrams of the present invention；
Fig. 3 sheeting system structure diagrams of the present invention；
Fig. 4 Raman detection systems of the present invention, Fourier's infrared detection system structure diagram；
Fig. 5 overlapping system structure diagrams of the present invention.
Specific embodiment
Embodiment 1
The present embodiment is specifically described for the device of the invention.
Such as Fig. 1-5, one kind can on-line checking Chinese patent medicine tablet preparation system, including raw material mixing system 1, sheeting system 2,
Raman detection system 3, Fourier's infrared detection system 4, overlapping system 5 and packaging system 6；
The raw material mixing system 1 includes Raw material pail 101, pulverizer 102 and mixer 103, and the number of the Raw material pail 101 is
It is multiple, raw material is prepared equipped with a kind of Chinese patent drug in each Raw material pail 101, the Chinese patent drug prepares raw material as herb powder or piece
Agent prepares auxiliary material；The multiple Raw material pail 101 is connected respectively with 102 entrance of pulverizer, and Chinese patent drug prepares raw material by pulverizer
102 entrances enter pulverizer 102, and are sufficiently crushed in pulverizer 102；The pulverizer 102 includes mixing roll and shakes
Device is swung, Chinese patent drug can be prepared to raw material and be fully ground and vibrate mixing；The pulverizer 102 connects mixer 103, described mixed
Conjunction machine 103 contains water inlet, and the Chinese patent drug after grinding, which is prepared after raw material enters mixer 103, adds water to be mixed to form Chinese patent drug preparation
Raw material cream；
The sheeting system 2 is connected with the outlet of mixer 103, and the sheeting system 2 is provided with feeding port, squeezes pallet
201st, scraper plate, precompressed pressing plate 202, Chinese patent drug prepare raw material cream and are reached by feeding port on extruding pallet 201, the extruding pallet
201 are provided with the pre- indent 203 of array-like, and the depth of the pre- indent 203 is 0.7-1mm, and the scraper plate is arranged at extruding support
The top of disk 201 scrapes one side for be prepared by the Chinese patent drug for exceeding pre- indent 203 raw material cream；The precompressed pressing plate 202 is set
The top of pallet 201 is being squeezed, is being provided on the precompressed pressing plate 202 corresponding convex with the pre- indent 203 on extruding pallet 201
It rises, raised height is 0.2-0.5mm on the precompressed pressing plate 202, and the protrusion is used for the Chinese patent drug system in pre- indent 203
Standby raw material cream is pressed into pre- tabletting 701；
The bottom for squeezing 201 slot of pallet is provided with inflatable mouth 204, and the inflatable mouth 204 can be with blow out air, by pre- tabletting
Outside 701 blowout slots；
Raman detection system 3 includes first laser device 301, Raman the output optical fiber 302, and Raman is emitted first 303, Raman collection probe
306th, Raman collection optical fiber 305, raman spectroscopy instrument 304；
Fourier's infrared detection system 4 includes second laser 401, infrared the output optical fiber 402, and infrared outgoing is first 403, infrared receipts
Collection probe 406, infrared collection optical fiber 405, Infrared Spectroscopy 404；
Chinese patent medicine tablet preparation system further includes computer 7 and hollow conveyer belt 702, and the hollow conveyer belt 702 is flat for two
Capable conveyer belt, the Raman outgoing first 303 and infrared outgoing first 403 may be contained within hollow 702 top of conveyer belt, Raman collection
Probe 306 is arranged on hollow 702 downside of conveyer belt with infrared collection probe 406, and the hollow conveyer belt 702 is located at Raman outgoing
First 303 and the position of first 403 lower section of infrared outgoing be provided with transversely movable first sliding block and the second sliding block, described first slides
Block and the second sliding block, which are used for the transverse shifting when the pre- tabletting 701 detects unqualified, makes pre- tabletting 701 fall on hollow conveyer belt
Outside 702；
The first laser device 301, second laser 401, raman spectroscopy instrument 304, Infrared Spectroscopy 404, the first sliding block and
Two sliding blocks are connected with computer 7；7 memory of computer contains the Raman and infrared spectra model of qualified pre- tabletting 701, meter
Calculation machine 7 judges whether detected pre- tabletting 701 is qualified according to the spectroscopy data of raman spectroscopy instrument 304 and Infrared Spectroscopy 404；
Instruction is sent to the first sliding block and the second sliding block if unqualified, slides unqualified pre- tabletting 701；
The overlapping system 5 includes superposition conveyer belt 501, bonds nozzle 502, superposition slot 503 and superposition pressing plate 504, described viscous
Knot nozzle 502 is arranged on 501 top of superposition conveyer belt, and for spraying binding agent to pre- tabletting 701, the binding agent is edible
Binding agent；501 end of the superposition conveyer belt is provided with superposition slot 503, and superposition pressing plate 504 is arranged at the top of superposition slot 503,
It is provided on superposition pressing plate 504 with being superimposed 503 corresponding protrusion of slot；Pre- tabletting 701 enters superposition slot by superposition conveyer belt 501
After 503, the tablet of superposition is formed by the extruding for being superimposed pressing plate 504；
The packaging system 6 is provided with seed-coating machine and packing machine, and seed-coating machine is coated tablet processing, and packing machine will be at coating
Tablet after reason is packaged, mounted box.
The first laser device is He-Ne laser or Nd：YAG laser, the launch wavelength of He-Ne laser are
632.8nm, Nd：The launch wavelength of YAG laser is 1064nm；Condenser lens is provided in the Raman emission head, it is described poly-
The focal length of focus lens is 150-250mm, and optical filter is provided with before the Raman collection probe；
The test position of the Raman detection system is provided with spuious light shielding mask, and the shielding case appearance is a cuboid, is drawn
Graceful outgoing head, Raman collection probe are arranged on inside shielding case；
The second laser is Nd：YAG laser, Nd：The launch wavelength of YAG laser is 1064nm；The infrared emission
Condenser lens is provided in head, the focal length of the condenser lens is 150-250mm, and optical filtering is provided with before the infrared collection probe
Piece；
The test position of the infrared detection system is provided with spuious light shielding mask, and the shielding case appearance is a cuboid, red
Outer outgoing head, infrared collection probe are arranged on inside shielding case；
The depth of the superposition slot is 3-4mm, and raised height is 1-2mm on the superposition pressing plate.
The superposition trench bottom is additionally provided with heat drying apparatus, and the dry heat device is connected with computer, passes through
Computer can control the temperature of heat drying apparatus, and the heater is infrared ray heating tube, infrared ray heating tube transmitting
Infrared ray alignment superposition trench bottom, is evenly heated superposition slot.
The tablet prepare auxiliary material include starch, Icing Sugar, dextrin, lactose, microcrystalline cellulose or mannitol in one kind or
It is a variety of.
Embodiment 2
The present embodiment performs the method prepared mainly for the device of embodiment 1 and is specifically described.
The method of the present invention comprises the following steps：
1）Raw material mixes；The required raw material for preparing Chinese patent medicine tablet is separately added into different Raw material pails 101, raw material is by former
Charging basket 101 enters pulverizer 102, is sufficiently crushed and vibrated in pulverizer 102；Through the raw material that crushing and vibrate it
Afterwards into mixer 103, raw material is sufficiently stirred to form Chinese patent drug and prepare raw material cream in mixer 103 plus water；
2）It is prepared by pre- tabletting 701；The Chinese patent drug prepare raw material cream outflow mixer 103 after into squeeze pallet 201 on it is pre-
Indent 203, scraper plate move and prepare raw material cream so that squeezing and the Chinese patent drug of pre- indent 203 being higher by pallet 201 and scraped to one side, in advance
Pressure pressing plate 202 fall, the Chinese patent drug squeezed in pre- indent 203 prepares raw material cream, make Chinese patent drug prepare raw material cream be squeezed into it is thin
The pre- tabletting 701 of sheet；
3）Optical detection；Pre- tabletting 701 is positioned on hollow conveyer belt 702, the both sides of pre- tabletting 701 are carried on a shoulder pole respectively in hollow biography
On the conveyer belt for sending 702 both sides of band；Pre- tabletting 701 is emitted first 303 lower section, the first 303 transmitting Raman of Raman outgoing by Raman
Laser is detected, Raman detection laser is collected through pre- tabletting 701 by Raman collection probe 306, and the light of collection enters raman spectroscopy
Instrument 304, the data of raman spectroscopy instrument 304 are transferred into computer 7, and computer 7 judges whether the pre- tabletting 701 is qualified；If it closes
Lattice then into next process, send to the first sliding block if unqualified and instruct, slide unqualified pre- tabletting 701；
Lower section of the pre- tabletting 701 Jing Guo infrared outgoing first 403, the infrared first 403 transmitting infrared detection laser of outgoing, infrared detection swash
Light is collected through pre- tabletting 701 by infrared collection probe 406, and the light of collection enters Infrared Spectroscopy 404, Infrared Spectroscopy 404
Data be transferred into computer 7, computer 7 judges whether the pre- tabletting 701 qualified；Enter next process if qualified,
It sends and instructs to the first sliding block if unqualified, slide unqualified pre- tabletting 701；
4）Pre- tabletting 701 is superimposed；Qualified pre- tabletting 701 is transferred into superposition conveyer belt 501 after testing, bond nozzle 502 to
Binding agent is sprayed in pre- tabletting 701, and the pre- tabletting 701 through spraying binding agent enters into slot 503, multiple pre- tablettings 701 are superimposed
After being superimposed slot 503, superposition pressing plate 504 falls, and multiple pre- tablettings 701 form tablet under the extruding of superposition pressing plate 504；
5）Tablet is packed：Seed-coating machine is coated tablet processing, and the tablet after Cotton seeds is packaged by packing machine, dress
Box.
Embodiment 3
It is illustrated below for the preparation of specific Chinese patent drug.
Fufang Danshen Pian is prepared, step is as follows：
Raw material is prepared as Radix Salviae Miltiorrhizae, Radix Notoginseng, borneol and supplementary product starch.
1）Raw material mixes；The Radix Salviae Miltiorrhizae of Chinese patent medicine tablet, Radix Notoginseng will be prepared, borneol and supplementary product starch are separately added into different originals
In charging basket 101, raw material enters pulverizer 102 by Raw material pail 101, is sufficiently crushed and vibrated in pulverizer 102；Through
It crosses after the raw material for crushing and vibrating into mixer 103, raw material adds water in mixer 103, is sufficiently stirred to form Chinese patent drug
Prepare raw material cream；
2）It is prepared by pre- tabletting 701；The Chinese patent drug prepare raw material cream outflow mixer 103 after into squeeze pallet 201 on it is pre-
Indent 203, scraper plate move and prepare raw material cream so that squeezing and the Chinese patent drug of pre- indent 203 being higher by pallet 201 and scraped to one side, in advance
Pressure pressing plate 202 fall, the Chinese patent drug squeezed in pre- indent 203 prepares raw material cream, make Chinese patent drug prepare raw material cream be squeezed into it is thin
The pre- tabletting 701 of sheet；
3）Optical detection；The Raman spectrum of the pre- tabletting of the Fufang Danshen Pian of pre-selection storage certified products and Fourier in a computer
Spectrum, and form detection model；
Pre- tabletting 701 is positioned on hollow conveyer belt 702, the both sides of pre- tabletting 701 are carried on a shoulder pole respectively in hollow 702 both sides of conveyer belt
Conveyer belt on；Pre- tabletting 701 is emitted first 303 lower section by Raman, and the first 303 transmitting Raman detection laser of Raman outgoing is drawn
Graceful detection laser is collected through pre- tabletting 701 by Raman collection probe 306, and the light of collection enters raman spectroscopy instrument 304, Raman point
The data of light instrument 304 are transferred into computer 7, and computer 7 judges whether the pre- tabletting 701 is qualified；Into next if qualified
Procedure sends to the first sliding block if unqualified and instructs, slides unqualified pre- tabletting 701；
Lower section of the pre- tabletting 701 Jing Guo infrared outgoing first 403, the infrared first 403 transmitting infrared detection laser of outgoing, infrared detection swash
Light is collected through pre- tabletting 701 by infrared collection probe 406, and the light of collection enters Infrared Spectroscopy 404, Infrared Spectroscopy 404
Data be transferred into computer 7, computer 7 judges whether the pre- tabletting 701 qualified；Enter next process if qualified,
It sends and instructs to the first sliding block if unqualified, slide unqualified pre- tabletting 701；
4）Pre- tabletting 701 is superimposed；Qualified pre- tabletting 701 is transferred into superposition conveyer belt 501 after testing, bond nozzle 502 to
Binding agent is sprayed in pre- tabletting 701, and the pre- tabletting 701 through spraying binding agent enters into slot 503, multiple pre- tablettings 701 are superimposed
After being superimposed slot 503, superposition pressing plate 504 falls, and multiple pre- tablettings 701 form tablet under the extruding of superposition pressing plate 504；
5）Tablet is packed：Seed-coating machine is coated tablet processing, and packing machine is sprayed the Fufang Danshen Pian after Cotton seeds
Bag, mounted box.
Claims (4)
1. one kind can on-line checking Chinese patent medicine tablet preparation system, including raw material mixing system（1）, sheeting system（2）, Raman inspection
Examining system（3）, Fourier's infrared detection system（4）, overlapping system（5）And packaging system（6）；
The raw material mixing system（1）Including Raw material pail（101）, pulverizer（102）And mixer（103）, the Raw material pail
（101）Number be multiple, each Raw material pail（101）In equipped with a kind of Chinese patent drug prepare raw material, the Chinese patent drug prepares former
Expect to prepare auxiliary material for herb powder or tablet；The multiple Raw material pail（101）Respectively with pulverizer（102）Entrance connect, it is middle into
Medicine prepares raw material by pulverizer（102）Entrance enters pulverizer（102）, and in pulverizer（102）It is middle sufficiently to be crushed；Institute
State pulverizer（102）Mixing roll and oscillator are included, Chinese patent drug can be prepared to raw material and be fully ground and vibrate mixing；The powder
Broken machine（102）Connect mixer（103）, the mixer（103）Containing water inlet, the Chinese patent drug after grinding prepares raw material entrance
Mixer（103）Afterwards plus water is mixed to form Chinese patent drug and prepares raw material cream；
The sheeting system（2）With mixer（103）Outlet be connected, the sheeting system（2）It is provided with feeding port, squeezes
Pallet（201）, scraper plate, precompressed pressing plate（202）, Chinese patent drug prepare raw material cream by feeding port reach squeeze pallet（201）On, institute
State extruding pallet（201）It is provided with the pre- indent of array-like（203）, the pre- indent（203）Depth for 0.7-1mm, it is described
Scraper plate is arranged at extruding pallet（201）Top, for pre- indent will to be exceeded（203）Chinese patent drug prepare raw material cream and scrape one
Side；The precompressed pressing plate（202）It is arranged on extruding pallet（201）Top, the precompressed pressing plate（202）On be provided with and squeeze
Pallet（201）On pre- indent（203）Corresponding protrusion, the precompressed pressing plate（202）The height of upper protrusion is 0.2-0.5mm,
The protrusion is used for pre- indent（203）In Chinese patent drug prepare raw material cream and be pressed into pre- tabletting（701）；
The extruding pallet（201）The bottom of slot is provided with inflatable mouth（204）, the inflatable mouth（204）Can be with blow out air, it will
Pre- tabletting（701）It blows out outside slot；
Raman detection system（3）Including first laser device（301）, Raman the output optical fiber（302）, Raman outgoing head（303）, Raman
Collect probe（306）, Raman collection optical fiber（305）, raman spectroscopy instrument（304）；
Fourier's infrared detection system（4）Including second laser（401）, infrared the output optical fiber（402）, infrared outgoing head
（403）, infrared collection probe（406）, infrared collection optical fiber（405）, Infrared Spectroscopy（404）；
Chinese patent medicine tablet preparation system further includes computer（7）With hollow conveyer belt（702）, the hollow conveyer belt（702）For
Two parallel conveyer belts, the Raman are emitted head（303）With infrared outgoing head（403）It may be contained within hollow conveyer belt（702）
Top, Raman collection probe（306）It pops one's head in infrared collection（406）It is arranged on hollow conveyer belt（702）Downside, the hollow biography
Send band（702）Head is emitted positioned at Raman（303）With infrared outgoing head（403）The position of lower section is provided with transversely movable first
Sliding block and the second sliding block, first sliding block and the second sliding block are used for when the pre- tabletting（701）It is laterally moved when detecting unqualified
It is dynamic to make pre- tabletting（701）Fall on hollow conveyer belt（702）Outside；
The first laser device（301）, second laser（401）, raman spectroscopy instrument（304）, Infrared Spectroscopy（404）, first
Sliding block and the second sliding block are and computer（7）Connection；The computer（7）Memory contains qualified pre- tabletting（701）Raman and
Infrared spectrum model, computer（7）According to raman spectroscopy instrument（304）And Infrared Spectroscopy（404）Spectroscopy data judge it is tested
The pre- tabletting surveyed（701）It is whether qualified；Instruction is sent to the first sliding block and the second sliding block if unqualified, makes unqualified pre- tabletting
（701）It slides；
The overlapping system（5）Including being superimposed conveyer belt（501）, bond nozzle（502）, superposition slot（503）With superposition pressing plate
（504）, the cohesive nozzle（502）It is arranged on superposition conveyer belt（501）Top, for pre- tabletting（701）Spray binding agent,
The binding agent is edible binding agent；The superposition conveyer belt（501）End is provided with superposition slot（503）, it is superimposed pressing plate
（504）It is arranged at superposition slot（503）Top, be superimposed pressing plate（504）On be provided with being superimposed slot（503）Corresponding protrusion；In advance
Tabletting（701）By being superimposed conveyer belt（501）Into superposition slot（503）Afterwards, by being superimposed pressing plate（504）Extruding formed superposition
Tablet；
The packaging system（6）Seed-coating machine and packing machine are provided with, seed-coating machine is coated tablet processing, and packing machine will be coated
Treated, and tablet is packaged, mounted box.
2. a kind of as described in claim 1 can on-line checking Chinese patent medicine tablet preparation system, it is characterised in that：
The first laser device（301）For He-Ne laser or Nd：YAG laser, the launch wavelength of He-Ne laser are
632.8nm, Nd：The launch wavelength of YAG laser is 1064nm；Condenser lens is provided in the Raman emission head, it is described poly-
The focal length of focus lens is 150-250mm, and optical filter is provided with before the Raman collection probe；
The test position of the Raman detection system is provided with spuious light shielding mask, and the shielding case appearance is a cuboid, is drawn
Graceful outgoing head（303）, Raman collection probe（306）It is arranged on inside shielding case；
The superposition slot（503）Depth for 3-4mm, the superposition pressing plate（504）The height of upper protrusion is 1-2mm.
3. a kind of as claimed in claim 2 can on-line checking Chinese patent medicine tablet preparation system, it is characterised in that：The tablet system
Standby auxiliary material includes the one or more in starch, Icing Sugar, dextrin, lactose, microcrystalline cellulose or mannitol；
The superposition slot（503）Bottom is additionally provided with heat drying apparatus, and the dry heat device is connected with computer, passes through
Computer can control the temperature of heat drying apparatus, and the heater is infrared ray heating tube, infrared ray heating tube transmitting
Infrared ray alignment superposition trench bottom, is evenly heated superposition slot.
4. a kind of method that system using claim 3 carries out tablet preparation, it is characterised in that comprise the following steps：
1）Raw material mixes；The required raw material for preparing Chinese patent medicine tablet is separately added into different Raw material pails（101）In, raw material passes through
Raw material pail（101）Into pulverizer（102）, in pulverizer（102）Middle progress is sufficiently crushed and vibrated；By crushing and vibrating
Raw material after enter mixer（103）, raw material is in mixer（103）In plus water, be sufficiently stirred to form Chinese patent drug and prepare raw material
Cream；
2）Pre- tabletting（701）It prepares；The Chinese patent drug prepares raw material cream outflow mixer（103）Afterwards into extruding pallet（201）
On pre- indent（203）, scraper plate moves so that extruding pallet（201）On be higher by pre- indent（203）Chinese patent drug prepare raw material cream
It is scraped to one side, precompressed pressing plate（202）It falls, squeezes pre- indent（203）In Chinese patent drug prepare raw material cream, prepare Chinese patent drug
Raw material cream is squeezed into laminar pre- tabletting（701）；
3）Optical detection；By pre- tabletting（701）It is positioned over hollow conveyer belt（702）On, pre- tabletting（701）Both sides carry on a shoulder pole respectively
Hollow conveyer belt（702）On the conveyer belt of both sides；Pre- tabletting（701）Head is emitted by Raman（303）Lower section, Raman outgoing head
（303）Emit Raman detection laser, Raman detection laser passes through pre- tabletting（701）It is popped one's head in by Raman collection（306）It collects, collects
Light enter raman spectroscopy instrument（304）, raman spectroscopy instrument（304）Data be transferred into computer（7）, computer（7）Judge
The pre- tabletting（701）It is whether qualified；Into next process if qualified, if unqualified sent to the first sliding block instructs, make
Unqualified pre- tabletting（701）It slides；
Pre- tabletting（701）By infrared outgoing head（403）Lower section, infrared outgoing head（403）Emit infrared detection laser, it is infrared
It detects laser and passes through pre- tabletting（701）It is popped one's head in by infrared collection（406）It collects, the light of collection enters Infrared Spectroscopy（404）, it is red
Outer spectroscope（404）Data be transferred into computer（7）, computer（7）Judge the pre- tabletting（701）It is whether qualified；If it closes
Lattice then into next process, send to the first sliding block if unqualified and instruct, make unqualified pre- tabletting（701）It slides；
4）Pre- tabletting（701）Superposition；Qualified pre- tabletting after testing（701）It is transferred into superposition conveyer belt（501）, bond nozzle
（502）To pre- tabletting（701）Binding agent is sprayed, through the pre- tabletting for spraying binding agent（701）Into superposition slot（503）, it is multiple
Pre- tabletting（701）Into superposition slot（503）Afterwards, it is superimposed pressing plate（504）It falls, multiple pre- tablettings（701）In superposition pressing plate（504）
Extruding under form tablet；
5）Tablet is packed：Seed-coating machine is coated tablet processing, and the tablet after Cotton seeds is packaged by packing machine, dress
Box.
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| CN201810042180.8A CN108042363B (en) | 2018-01-17 | 2018-01-17 | Preparation system and method capable of detecting Chinese patent medicine tablets on line |
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Cited By (2)
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| JP2020085513A (en) * | 2018-11-17 | 2020-06-04 | 学校法人就実学園 | Drug identifying device and method |
| CN115214181A (en) * | 2022-09-19 | 2022-10-21 | 兰州和盛堂制药股份有限公司 | Tablet Chinese patent medicine forming equipment |
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