CN108042112B - Oviduct blockage diagnosis and treatment device - Google Patents
Oviduct blockage diagnosis and treatment device Download PDFInfo
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- CN108042112B CN108042112B CN201810030534.7A CN201810030534A CN108042112B CN 108042112 B CN108042112 B CN 108042112B CN 201810030534 A CN201810030534 A CN 201810030534A CN 108042112 B CN108042112 B CN 108042112B
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- connecting pipe
- balloon
- catheter
- oviduct
- microcatheter
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- 239000011248 coating agent Substances 0.000 claims description 19
- 238000000576 coating method Methods 0.000 claims description 19
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 16
- 238000007789 sealing Methods 0.000 claims description 16
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 14
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 14
- 229940119485 safflower extract Drugs 0.000 claims description 14
- 238000000227 grinding Methods 0.000 claims description 12
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 241000628997 Flos Species 0.000 claims description 8
- 239000001569 carbon dioxide Substances 0.000 claims description 8
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 8
- 238000004140 cleaning Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- 238000000643 oven drying Methods 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 7
- 238000005507 spraying Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 229960005070 ascorbic acid Drugs 0.000 claims description 4
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- 238000011049 filling Methods 0.000 abstract description 4
- 208000014674 injury Diseases 0.000 abstract description 2
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- 210000004696 endometrium Anatomy 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 22
- 238000002474 experimental method Methods 0.000 description 16
- 239000007788 liquid Substances 0.000 description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 239000000741 silica gel Substances 0.000 description 8
- 229910002027 silica gel Inorganic materials 0.000 description 8
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- 238000012986 modification Methods 0.000 description 4
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- 235000000069 L-ascorbic acid Nutrition 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- FINHMKGKINIASC-UHFFFAOYSA-N Tetramethylpyrazine Chemical compound CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
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- 229910052697 platinum Inorganic materials 0.000 description 2
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- 239000000829 suppository Substances 0.000 description 2
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 206010065790 Fallopian tube perforation Diseases 0.000 description 1
- 208000007984 Female Infertility Diseases 0.000 description 1
- 206010021928 Infertility female Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
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- 241000304195 Salvia miltiorrhiza Species 0.000 description 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 1
- 241000656145 Thyrsites atun Species 0.000 description 1
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
- A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
- A61B5/4318—Evaluation of the lower reproductive system
- A61B5/4325—Evaluation of the lower reproductive system of the uterine cavities, e.g. uterus, fallopian tubes, ovaries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The invention belongs to the technical field of medical appliances, and particularly discloses a device for diagnosing and treating fallopian tube blockage, which comprises a connector and a sleeve body, wherein the sleeve body comprises a guide wire, a microcatheter, a uterine horn catheter, an outer catheter and a balloon which are sleeved from inside to outside; the connecting head is connected with a micro-catheter connecting pipe, a catheter connecting pipe and a balloon three-way connecting pipe in a penetrating way, a pressure gauge is arranged on the balloon three-way connecting pipe, one-way valves are arranged at the proximal end of the micro-catheter connecting pipe, the proximal end of the catheter connecting pipe and the balloon three-way connecting pipe, and a reticular film is coated on the outer wall of the micro-catheter. The device can accurately judge the pressure change in the balloon by arranging the pressure gauge, prevent the overfilling or insufficient filling caused by inaccurate judgment of the pressure in the balloon, and effectively avoid the trauma to the endometrium and the fallopian tube by the conical elbow.
Description
Technical Field
The invention belongs to the technical field of medical appliances, and particularly relates to a device for diagnosing and treating oviduct blockage.
Background
The oviduct dredging operation is used for treating female infertility caused by oviduct stenosis or blockage due to oviduct or pelvic peritoneal inflammation, and clinically common oviduct dredging operation is cervical oviduct dredging operation and Gong Fuqiang mirror combined oviduct dredging operation.
The device for dredging the oviduct has various structures, different adopted product standards, and the most commonly used oviduct dredging device is a single conduit, and liquid is injected into the oviduct and the uterine cavity through the conduit, but the dredging effect is general because the expansion pressure of the liquid in the oviduct is limited.
The oviduct dredging kit DBH-100 double balloon catheter and FTC-550-NT of the company cook in the United states. The far end and the near end of the DBH-100 double-balloon catheter are both provided with silica gel balloons, which can play a role in stabilizing and manufacturing and preventing contrast agents from overflowing, but the problem is that the DBH-100 double-balloon catheter determines the water injection amount required by the double-image silica gel balloons each time through the experience value of medical staff, and the pressure change after the balloon expansion in the body is difficult to accurately judge. The FTC-550-NT comprises an elbow conduit, a microcatheter wire, a double-balloon conduit and the like, wherein the head end of the elbow conduit is provided with a woven net for enhancing torsion control, the microcatheter is made of nylon materials, the head end is provided with a radio-opaque mark, the microcatheter wire is made of nickel-titanium materials, and the head end is made of platinum materials; however, there is a problem in that the elbow catheter head end is flat and too stiff, and once improperly operated, the fallopian tube perforation is easily induced.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide a device for diagnosing and treating the oviduct blockage, which can accurately judge the pressure change in a silica gel balloon by arranging a pressure gauge when water or air is injected into the silica gel balloon, and reduce the damage of a guide wire to an oviduct by arranging a hydrophilic coating and a uterine horn catheter of a conical elbow.
The invention provides a device for diagnosing and treating fallopian tube blockage, which comprises a sleeve body and a connector arranged at the proximal end of the sleeve body, wherein the sleeve body comprises a guide wire, a microcatheter, a uterine horn catheter, an outer catheter and a balloon which are sleeved from inside to outside, the guide wire is coated with a hydrophilic coating, the outer wall of the microcatheter is coated with a reticular film, and the distal end of the uterine horn catheter is a conical elbow;
the connector comprises a connecting pipe, the connecting pipe is arranged at the position of the opening at the proximal end of the outer catheter, a microcatheter connecting pipe, an outer catheter connecting pipe and a balloon three-way connecting pipe are arranged on the connecting pipe in a penetrating manner, the distal end of the microcatheter connecting pipe is communicated with the opening at the proximal end of the microcatheter, the distal end of the outer catheter connecting pipe is communicated with the opening at the proximal end of the outer catheter, the balloon three-way connecting pipe is provided with a distal end opening, a first proximal end opening and a second proximal end opening, the distal end opening penetrates through the outer catheter and is communicated with the balloon, a pressure gauge is arranged on the first proximal end opening, and one-way valves are arranged at the positions of the proximal end of the microcatheter connecting pipe, the proximal end of the outer catheter connecting pipe and the second proximal end opening of the balloon three-way connecting pipe.
Preferably, in the above oviduct blockage diagnosis and treatment device, the cross-sectional shape of the sleeve body is circular or elliptical.
Preferably, in the oviduct blockage diagnosis and treatment device, X-ray-opaque marks are arranged on the edges of openings at two ends of the microcatheter, on the edges of openings at two ends of the uterine horn catheter and on the edges of openings at two ends of the outer catheter.
Preferably, in the oviduct blockage diagnosis and treatment device, the connector further comprises a sealing cover arranged at a pipe orifice at the proximal end of the connecting pipe, and the micro-catheter connecting pipe, the outer catheter connecting pipe and the balloon three-way connecting pipe are also arranged through the sealing cover; the micro-catheter plug is arranged on the proximal pipe orifice of the micro-catheter connecting pipe, the outer catheter plug is arranged on the proximal pipe orifice of the outer catheter connecting pipe, the balloon plug is arranged on the second proximal pipe orifice of the balloon three-way connecting pipe, and the rest part of the sealing cover is abutted to the proximal end of the sleeve body.
Preferably, in the above oviduct blockage diagnosis and treatment device, the oviduct dredging coating is attached to the mesh film, and the method for attaching the oviduct dredging coating to the mesh film is as follows:
and (3) stirring and mixing polyvinyl alcohol and water according to the mass ratio of 1:10-20 at 98 ℃ to obtain a polyvinyl alcohol solution, adding a dredging medicine to obtain a oviduct dredging object, spraying the oviduct dredging object on a reticular film while the oviduct dredging object is hot, and drying to finish the attachment of an oviduct dredging object coating on the reticular film.
Preferably, in the oviduct blockage diagnosis and treatment device, the dredging medicine is prepared from the following components in parts by weight: 20-30 parts of safflower extract, 5-10 parts of dried orange peel extract and 5-10 parts of lily extract.
Preferably, in the oviduct blockage diagnosis and treatment device, the dredging medicine is prepared according to the following method:
s1, preparing safflower extract
Cleaning fresh Carthami flos, oven drying, grinding into powder, sieving with 40 mesh sieve, extracting with supercritical carbon dioxide under reflux for 2-3 hr at 35Mpa and 50deg.C to obtain extractive solution, concentrating under reduced pressure until the relative density of the solution is 1.2 to obtain Carthami flos extract;
s2, preparing dried orange peel extract
Washing pericarpium Citri Tangerinae, oven drying, grinding into powder, sieving with 40 mesh sieve, extracting with supercritical carbon dioxide under reflux for 2-3 hr at 35Mpa and 50deg.C to obtain extractive solution, concentrating the extractive solution under reduced pressure until the relative density of the solution is 1.2 to obtain pericarpium Citri Tangerinae extract;
s3, preparing lily extract
Cleaning and drying fresh lily petals, grinding the dried lily petals into powder, soaking in an ascorbic acid solution, performing ultrasonic extraction, filtering, and concentrating to a relative density of 1.15 to obtain a lily extract;
s4, weighing the following components in parts by weight: 20-30 parts of safflower extract, 5-10 parts of dried orange peel extract and 5-10 parts of lily extract;
mixing the above materials, membrane filtering, and spray drying to obtain the final product.
Compared with the prior art, the oviduct blockage diagnosis and treatment device has the following beneficial effects:
1. according to the oviduct blockage diagnosis and treatment device, the pressure gauge is arranged, so that the pressure change in the balloon can be accurately judged, the problem that the inflation pressure of the silica gel balloon is easy to be blocked at the oviduct blockage position, the problem that a patient feels uncomfortable due to overfilling caused by inaccurate judgment of the pressure in the balloon is avoided, and the problem that liquid in the oviduct is lost due to insufficient filling caused by inaccurate judgment of the pressure can be also avoided; the balloon is used for blocking the uterine cavity so as to facilitate the cervical extension through the outer catheter, thereby performing radiography and oviduct dredging operations.
The oviduct dredge is adhered to the reticular film, and is gradually dissolved and absorbed in the oviduct before being inserted into the microcatheter, so that the solid medicine is not easy to run off, the use of liquid medicine is reduced, the loss of the medicine is reduced, and the number of coating layers of the reticular film and the type of oviduct dredge on the reticular film can be selected according to actual requirements;
the balloon three-way connecting pipe is selected, so that liquid can be prevented from flowing through the pressure gauge continuously, abrasion of the pressure gauge is reduced, and absorption and loss of reagent and medicine on the pressure gauge are also reduced.
2. The FTC550 catheter in the prior art is prepared by adopting a platinum head, and the elbow catheter has flat head which is easy to cause endometrial trauma or oviduct perforation although the hardness is good and the supporting force is strong.
Drawings
FIG. 1 is a schematic diagram of a device for diagnosing and treating fallopian tube blockage according to the present invention;
FIG. 2 is a close-up view of the proximal end of the tubal occlusion diagnostic treatment device of the present invention;
fig. 3 is a schematic cross-sectional view of a tubal occlusion diagnostic treatment device of the present invention.
Reference numerals illustrate:
1. guide wire, 2, microcatheter, 21, uterine horn catheter, 3, outer catheter, 4, balloon, 5, connecting tube, 6, sealing cover, 61, microcatheter connecting tube, 611, microcatheter plug, 62, outer catheter connecting tube, 621, outer catheter plug, 63, balloon tee connecting tube, 631, pressure gauge, 632, balloon plug.
Detailed Description
The following detailed description of embodiments of the invention is, therefore, to be taken in conjunction with the accompanying drawings, and it is to be understood that the scope of the invention is not limited to the specific embodiments.
1-3, the device comprises a sleeve body and a connector arranged at the proximal end of the sleeve body, wherein the sleeve body comprises a guide wire 1, a microcatheter 2, a uterine horn catheter 21, a catheter 3 and a balloon 4 which are arranged from inside to outside and are coaxially sleeved, the distal end of the guide wire 1 or the whole body is coated with a hydrophilic coating (PU film) of a polyurethane film with the thickness of 0.01-0.02mm, the outer wall of the microcatheter 2 is coated with a reticular film, the distal end of the uterine horn catheter 21 is a conical elbow, namely, the head end is a conical tip and is bent to 100-120 degrees;
the connector comprises a connecting pipe 5, the connecting pipe 5 is arranged at the position of the proximal pipe orifice of the outer catheter 3, a micro-catheter connecting pipe 61, an outer catheter connecting pipe 62 and a balloon three-way connecting pipe 63 are arranged on the connecting pipe 5in a penetrating way, the distal end of the micro-catheter connecting pipe 61 is communicated with the proximal pipe orifice of the micro-catheter 2, the distal end of the outer catheter connecting pipe 62 is communicated with the proximal pipe orifice of the catheter 3, the balloon three-way connecting pipe 63 is provided with a distal pipe orifice, a first proximal pipe orifice and a second proximal pipe orifice, the distal pipe orifice penetrates through the outer catheter 3 and is communicated with the balloon 4, a pressure gauge 631 is arranged on the first proximal pipe orifice, and one-way valves are arranged at the positions of the proximal end of the micro-catheter connecting pipe 61, the proximal end of the outer catheter connecting pipe 62 and the balloon three-way connecting pipe 63, which are close to the second proximal port;
the outer wall of the micro-catheter 2 is coated with a reticular film, and a oviduct dredging coating is attached to the reticular film.
The connector also comprises a sealing cover 6 which is arranged at the pipe orifice at the proximal end of the connecting pipe 5 and is used for sealing the connecting pipe 5, and a micro-catheter connecting pipe 61, an outer-catheter connecting pipe 62 and a sacculus three-way connecting pipe 63 are also arranged through the sealing cover 6; the proximal end of the microcatheter connection tube 61 is provided with a microcatheter plug 611, the proximal end orifice of the outer catheter connection tube 62 is provided with an outer catheter plug 621, the second proximal end orifice of the balloon tee connection tube 63 is provided with a balloon plug 632, and the rest of the sealing cap 6 is in abutment with the proximal end of the cannula body, so that the microcatheter 2, catheter 3 and balloon 4 are all connected with the outside of the sealing cap 6.
The sealing cover 6 is a silica gel balloon or a silica gel sheet with the thickness of 0.5 cm to 1cm, and the sealing cover 6 is embedded in the orifice of the proximal end of the connecting pipe 5.
In the embodiment of the invention, the number of the guide wires 1 is two, and the sizes are respectively 0.035inch multiplied by 90cm and 0.018inch multiplied by 90cm, wherein the guide wires 1 with the size of 0.035inch multiplied by 90cm are used for introducing the uterine horn catheter 21, and the guide wires 1 with the size of 0.018inch multiplied by 90cm are used for introducing the micro catheter 2. The specific operation mode is as follows: the invention relates to a oviduct blockage diagnosis and treatment device, which is characterized in that a balloon 4 and a catheter 3 are implanted from the cervix, the balloon is slowly filled, the dosage of filling water is controlled according to a pressure gauge 631, then a contrast agent is injected from the catheter 3, the uterine morphology is known, the oviduct blockage situation is known, then a guide wire 1 of 0.035inch multiplied by 90cm is inserted from the catheter 3, an uterine horn catheter 21 is introduced along the guide wire 1, the head end of the uterine horn catheter 21 is positioned at the left uterine horn or the right uterine horn, then the guide wire 1 of 0.035inch multiplied by 90cm is pulled out, the guide wire 1 of 0.018inch multiplied by 90cm is inserted from the uterine horn catheter 21 again, then a micro catheter 2 is introduced, the guide wire 1 is matched with the micro catheter 2 to gently break through the oviduct blockage section, and the adhesion part is separated, and the stenosis is expanded. Finally, the guide wire 1 with the length of 0.018inch multiplied by 90cm is pulled out, the liquid medicament is injected through the micro-catheter 2, and the oviduct is recanalized by utilizing the pushing action of hydrostatic pressure, so that the re-adhesion is prevented. Finally, the sleeve body is buckled and provided with a connector, the sealing cover 6 is tightly abutted with the proximal end of the sleeve body, and as the micro-catheter 2, the catheter 3, the uterine horn catheter 21 and the balloon 4 are communicated with the outside of the sealing cover 6, the micro-catheter plug 611 is taken out, gas or liquid medicament can be injected again through the micro-catheter 2 according to actual needs, the outer catheter plug 621 is taken out, gas or liquid medicament can be injected again through the catheter 3 according to actual needs, the balloon plug 632 is taken out, and gas or liquid can be injected into the balloon 4 again through the balloon three-way connecting pipe 63 according to actual needs, so as to fill the balloon 4. The microcatheter plug 611, the outer catheter plug 621, and the balloon plug 632 are used to prevent foreign matters from entering the microcatheter connection tube 61, the outer catheter connection tube 62, and the balloon three-way connection tube 63. The embodiment of the invention can adopt a disposable connector.
By arranging the pressure gauge 631, the pressure change in the balloon 4 can be accurately judged, the problem of discomfort of a patient caused by overfilling due to inaccurate pressure judgment in the balloon 4 can be prevented, and the problem of liquid loss in the oviduct caused by insufficient filling due to inaccurate pressure judgment can also be prevented. The balloon three-way connecting pipe 63 is selected, so that the pressure gauge 631 can prevent liquid or gas from flowing through the pressure gauge 631 continuously, abrasion of the pressure gauge 631 is reduced, and absorption and loss of reagent and medicine on the pressure gauge 631 are also reduced. Note that the length of the tube on the pressure gauge 631 is 1-5cm from the junction of the balloon three-way connection tube 63 to prevent excessive liquid waste.
According to the invention, the guide wire 1, the micro-catheter 2, the uterine horn catheter 21, the catheter 3 and the balloon 4 are connected through the connector, so that the components can be used simultaneously, the outer wall of the micro-catheter 2 is coated with the reticular film, and the coating layer number of the reticular film can be selected according to actual requirements. The outer wall of the microcatheter 2 is coated with a mesh film, so that the meshes in the mesh film can adsorb accumulated water and plugs in the oviduct to help dredge the oviduct. The reticular film is a silica gel film or a medical polyester film, and micropores with the pore diameter of 1-10 microns are uniformly formed on the reticular film.
The cross section of the sleeve body is round or oval, and is basically consistent with the shape of the oviduct, so that the lubrication degree is increased, and the discomfort of a patient is relieved.
X-ray impermeable marks are arranged on the edges of openings at the two ends of the microcatheter 2, the edges of openings at the two ends of the uterine horn catheter 21 and the edges of openings at the two ends of the catheter 3, so that X-rays can be conveniently positioned under the X-rays.
In the device for diagnosing and treating fallopian tube blockage according to the present invention, the "distal end" refers to the end far away from the medical operator, and the "proximal end" refers to the end held by the medical operator.
The oviduct blockage diagnosis and treatment device provided by the invention is used for oviduct recanalization interventional operation, can be matched with intravenous injection of the salvia miltiorrhiza ligustrazine for transfusion for 10 days after the operation, and has better oviduct blockage treatment effect by oral administration of the drugs for promoting blood circulation and removing blood stasis.
The oviduct dredging coating is attached to the reticular film, the types of the oviduct dredging on the reticular film can be selected according to actual conditions, when the microcatheter 2 is placed at the uterine horn, the oviduct dredging is gradually dissolved and absorbed in the oviduct, the solid medicine is not easy to run off, the use of liquid medicine is reduced, and the medicine loss is reduced. And (3) stirring and mixing polyvinyl alcohol and water according to the mass ratio of 1:10-20 at 98 ℃ to obtain a polyvinyl alcohol solution, adding a dredging medicine to obtain a oviduct dredging object, spraying the oviduct dredging object on a reticular film while the oviduct dredging object is hot, and drying to finish the attachment of an oviduct dredging object coating on the reticular film. Wherein the length of the reticular film is 5-15cm, the thickness of the reticular film is 0.5-1mm, and the thickness of the coating of the oviduct dredging object is 0.5-1mm, and the method specifically comprises the following examples.
Example 1
A method of attaching a oviduct dredge coating to the mesh film comprising the steps of:
taking 1g of polyvinyl alcohol, stirring and mixing the polyvinyl alcohol (the polyvinyl alcohol is used as a water-soluble drug carrier) and water at the mass ratio of 1:10 to obtain a polyvinyl alcohol solution, adding a dredging drug, wherein the mass ratio of the dredging drug to the polyvinyl alcohol is 1:1, obtaining a oviduct dredging object, spraying the oviduct dredging object on a reticular film while the oviduct dredging object is hot, and drying to finish attaching an oviduct dredging object coating on the reticular film. Wherein the length of the reticular film is 5cm, the thickness of the reticular film is 1mm, the reticular film is positioned at the far end of the micro-catheter 2, and the thickness of the coating for attaching the oviduct dredging object is 1mm.
Example 2
A method for attaching a fallopian tube dredge to the mesh film, comprising the steps of:
taking 1.5g of polyvinyl alcohol, stirring and mixing the polyvinyl alcohol and water at 98 ℃ according to the mass ratio of 1:20 to obtain a polyvinyl alcohol solution, adding a dredging medicine to obtain a oviduct dredging object, spraying the oviduct dredging object on a reticular film while the oviduct dredging object is hot, and drying to finish the attachment of an oviduct dredging object coating on the reticular film. Wherein the length of the reticular film is 15cm, the thickness of the reticular film is 0.5mm, the reticular film is positioned at the far end of the micro-catheter 2, and the thickness of the coating for attaching the oviduct dredging object is 0.5mm.
The invention also provides a formula of the dredging medicine, which is prepared from the following components in parts by weight: 20-30 parts of safflower extract, 5-10 parts of dried orange peel extract and 5-10 parts of lily extract. The dredging medicine is prepared according to the following method:
s1, preparing safflower extract
Cleaning fresh Carthami flos, oven drying, grinding into powder, sieving with 40 mesh sieve, extracting with supercritical carbon dioxide under reflux for 2-3 hr at 35Mpa and 50deg.C to obtain extractive solution, concentrating under reduced pressure until the relative density of the solution is 1.2 to obtain Carthami flos extract;
s2, preparing dried orange peel extract
Washing pericarpium Citri Tangerinae, oven drying, grinding into powder, sieving with 40 mesh sieve, extracting with supercritical carbon dioxide under reflux for 2-3 hr at 35Mpa and 50deg.C to obtain extractive solution, concentrating the extractive solution under reduced pressure until the relative density of the solution is 1.2 to obtain pericarpium Citri Tangerinae extract;
s3, preparing lily extract
Taking fresh lily petals, cleaning, drying, grinding the dried lily petals into powder, sieving with a 40-mesh sieve, soaking in 1g/L ascorbic acid solution, performing 400W ultrasonic extraction for 30min, filtering, and concentrating to a relative density of 1.15 to obtain lily extract;
s4, weighing the following components in parts by weight: 20-30 parts of safflower extract, 5-10 parts of dried orange peel extract and 5-10 parts of lily extract;
mixing the above materials, membrane filtering, and spray drying to obtain dredging medicine.
The safflower in the formula of the dredging medicine can promote blood circulation to remove blood stasis and promote absorption of chronic inflammation; chen Pike it has effects in regulating qi-flowing, invigorating spleen, eliminating dampness, and dispelling blood stasis; the known actions of lily are nourishing yin, moistening dryness, tranquilizing mind.
The following examples are specifically included.
Example 3
A formula of a dredging medicine is prepared from the following components in parts by weight: 20 parts of safflower extract, 10 parts of dried orange peel extract and 10 parts of lily extract. The dredging medicine is prepared according to the following method:
s1, preparing safflower extract
Cleaning fresh Carthami flos, oven drying, grinding into powder, sieving with 40 mesh sieve, performing countercurrent extraction with supercritical carbon dioxide for 2 hr under 35Mpa at 50deg.C to obtain extractive solution, concentrating under reduced pressure until the relative density of the solution is 1.2 to obtain Carthami flos extract;
s2, preparing dried orange peel extract
Washing pericarpium Citri Tangerinae, oven drying, grinding into powder, sieving with 40 mesh sieve, extracting with supercritical carbon dioxide under reflux for 2-3 hr at 35Mpa and 50deg.C to obtain extractive solution, concentrating the extractive solution under reduced pressure until the relative density of the solution is 1.2 to obtain pericarpium Citri Tangerinae extract;
s3, preparing lily extract
Taking fresh lily petals, cleaning, drying, grinding the dried lily petals into powder, sieving with a 40-mesh sieve, soaking in 1g/L ascorbic acid solution, performing 400W ultrasonic extraction for 30min, filtering, and concentrating to a relative density of 1.15 to obtain lily extract;
s4, weighing the following components in parts by weight: 20 parts of safflower extract, 10 parts of dried orange peel extract and 10 parts of lily extract;
mixing the above materials, filtering with film of phi 0.22 μm, and spray drying to obtain dredging medicine.
Example 4
A formula of a dredging medicine is prepared from the following components in parts by weight: 30 parts of safflower extract, 5 parts of dried orange peel extract and 5 parts of lily extract. The preparation method of the dredging medicine is the same as that of the embodiment 4, and the difference is that the extraction time in S1 is 3h, and the extraction time in S2 is 2h.
Example 5
A formula of a dredging medicine is prepared from the following components in parts by weight: 26 parts of safflower extract, 8 parts of dried orange peel extract and 8 parts of lily extract. The preparation method of the dredging medicine is the same as that of the example 4.
In order to prove the effect of dredging drugs, we designed the following experiments:
experiment group: the dredging medicine prepared by the method of example 3.
Experiment two groups: the dredging medicine prepared by the method of example 4.
Experiment three groups: the formulation of the dredging agent is basically the same as in example 3, except that the lily extract is replaced with sterile water.
Experiment four groups: the formulation of the dredge drug was essentially the same as in example 4, except that the lily extract was replaced with sterile water.
The medicines in each group are prepared into suppositories, and the curative effect is observed.
1. Therapeutic effect of oviduct obstruction
The experimental method comprises the following steps: selecting 100 patients with oviduct obstruction by contrast diagnosis, wherein each group of 25 patients adopts drug suppositories of experiment one group, experiment two group, experiment three group and experiment four group, and continuously treats for 14 days by rectal administration, rechecks the last menstrual period after the three menstrual periods are treated, and heals if the oviduct is completely unobstructed or is pregnant; if the oviduct is open but not smooth, the oviduct is effective; if it is still blocked, it is not valid.
Treatment effect analysis:
the experiment shows that 13 cases are cured in one group, 4 cases are effective, 8 cases are ineffective, and the total effective rate is 68%; 14 cases are cured in the experiment two groups, 4 cases are effective, 7 cases are ineffective, and the total effective rate is 72%; 7 cases are cured in three groups of experiments, 2 cases are effective, 16 cases are ineffective, and the total effective rate is 36%; four groups of experiments cure 6 cases, 2 cases with effective cases and 17 cases with ineffective cases, and the total effective rate is 32%. Experiment one, two, and experiment three, four groups had a statistical P <0.05. The addition of lily has good treatment effect on oviduct blockage.
It should be noted that, when reference is made to a numerical range in the claims of the present invention, it should be understood that two endpoints of each numerical range and any numerical value between the two endpoints are optional, and since the adopted steps are the same as those of the above embodiments, the preferred embodiments are described in order to prevent redundancy, but other variations and modifications may be made to these embodiments once the basic inventive concept is known to those skilled in the art. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (3)
1. The oviduct blockage diagnosis and treatment device is characterized by comprising a sleeve body and a connector arranged at the proximal end of the sleeve body, wherein the sleeve body comprises a guide wire (1), a microcatheter (2), a uterine horn catheter (21), an outer catheter (3) and a balloon (4) which are sleeved from inside to outside, a hydrophilic coating is coated on the guide wire (1), a reticular film is coated on the outer wall of the microcatheter (2), and the distal end of the uterine horn catheter (21) is a conical elbow;
the connector comprises a connecting pipe (5), the connecting pipe (5) is arranged at the position of a proximal pipe orifice of the outer catheter (3), a microcatheter connecting pipe (61), an outer catheter connecting pipe (62) and a balloon tee connecting pipe (63) are arranged on the connecting pipe (5) in a penetrating mode, the distal end of the microcatheter connecting pipe (61) is communicated with the proximal pipe orifice of the microcatheter (2), the distal end of the outer catheter connecting pipe (62) is communicated with the proximal pipe orifice of the outer catheter (3), the balloon tee connecting pipe (63) is provided with a distal pipe orifice, a first proximal pipe orifice and a second proximal pipe orifice, the distal pipe orifice penetrates through the outer catheter (3) and is communicated with the balloon (4), a pressure gauge (631) is arranged on the first proximal pipe orifice, and check valves are arranged at the proximal end of the microcatheter connecting pipe (61), the proximal end of the outer catheter connecting pipe (62) and the second proximal port of the balloon tee connecting pipe (63);
the oviduct dredging coating is attached to the reticular film, and the method for attaching the oviduct dredging coating to the reticular film is as follows:
stirring and mixing polyvinyl alcohol and water according to the mass ratio of 1:10-20 at 98 ℃ to obtain a polyvinyl alcohol solution, adding a dredging medicine to obtain a oviduct dredging object, spraying the oviduct dredging object on a reticular film while the oviduct dredging object is hot, and drying to finish the attachment of an oviduct dredging object coating on the reticular film;
the dredging medicine is prepared from the following components in parts by weight: 20-30 parts of safflower extract, 5-10 parts of dried orange peel extract and 5-10 parts of lily extract;
the dredging medicine is prepared according to the following method:
s1, preparing safflower extract
Cleaning fresh Carthami flos, oven drying, grinding into powder, sieving with 40 mesh sieve, extracting with supercritical carbon dioxide under reflux for 2-3 hr at 35Mpa and 50deg.C to obtain extractive solution, concentrating under reduced pressure until the relative density of the solution is 1.2 to obtain Carthami flos extract;
s2, preparing dried orange peel extract
Washing pericarpium Citri Tangerinae, oven drying, grinding into powder, sieving with 40 mesh sieve, extracting with supercritical carbon dioxide under reflux for 2-3 hr at 35Mpa and 50deg.C to obtain extractive solution, concentrating the extractive solution under reduced pressure until the relative density of the solution is 1.2 to obtain pericarpium Citri Tangerinae extract;
s3, preparing lily extract
Cleaning and drying fresh lily petals, grinding the dried lily petals into powder, soaking in an ascorbic acid solution, performing ultrasonic extraction, filtering, and concentrating to a relative density of 1.15 to obtain a lily extract;
s4, weighing the following components in parts by weight: 20-30 parts of safflower extract, 5-10 parts of dried orange peel extract and 5-10 parts of lily extract;
mixing the above components, membrane filtering, and spray drying to obtain dredging medicine;
the cross-sectional shape of the sleeve body is circular or elliptical.
2. The oviduct blockage diagnosis and treatment device according to claim 1, wherein X-ray impermeable marks are arranged on the edges of openings at both ends of the microcatheter (2), the edges of openings at both ends of the uterine horn catheter (21) and the edges of openings at both ends of the outer catheter (3).
3. The oviduct blockage diagnosis and treatment device according to claim 1, wherein the connector further comprises a sealing cover (6) mounted at a proximal end orifice of the connecting pipe (5), and the microcatheter connecting pipe (61), the outer catheter connecting pipe (62) and the balloon three-way connecting pipe (63) are also arranged through the sealing cover (6); a microcatheter plug (611) is arranged on a proximal pipe orifice of the microcatheter connecting pipe (61), an outer catheter plug (621) is arranged on a proximal pipe orifice of the outer catheter connecting pipe (62), a balloon plug (632) is arranged on a second proximal pipe orifice of the balloon three-way connecting pipe (63), and the rest part of the sealing cover (6) is abutted to the proximal end of the sleeve body.
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