CN108040482B - 用于结肠清洁和胃肠病症治疗的组合物 - Google Patents

用于结肠清洁和胃肠病症治疗的组合物 Download PDF

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Publication number
CN108040482B
CN108040482B CN201680032088.2A CN201680032088A CN108040482B CN 108040482 B CN108040482 B CN 108040482B CN 201680032088 A CN201680032088 A CN 201680032088A CN 108040482 B CN108040482 B CN 108040482B
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cys
seq
glu leu
peptide
cth
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Chinese (zh)
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CN108040482A (zh
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M.G.卡里
R.索林加
C.莱泰泽
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Ironwood Pharmaceuticals Inc
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Ironwood Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201680032088.2A 2015-05-01 2016-04-29 用于结肠清洁和胃肠病症治疗的组合物 Active CN108040482B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210288669.XA CN114716514A (zh) 2015-05-01 2016-04-29 用于结肠清洁和胃肠病症治疗的组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562156077P 2015-05-01 2015-05-01
US62/156077 2015-05-01
PCT/US2016/030061 WO2016178979A1 (en) 2015-05-01 2016-04-29 Compositions for colon cleansing and the treatment of gastrointestinal disorders

Related Child Applications (1)

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CN202210288669.XA Division CN114716514A (zh) 2015-05-01 2016-04-29 用于结肠清洁和胃肠病症治疗的组合物

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CN108040482A CN108040482A (zh) 2018-05-15
CN108040482B true CN108040482B (zh) 2022-03-29

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CN202210288669.XA Pending CN114716514A (zh) 2015-05-01 2016-04-29 用于结肠清洁和胃肠病症治疗的组合物
CN201680032088.2A Active CN108040482B (zh) 2015-05-01 2016-04-29 用于结肠清洁和胃肠病症治疗的组合物

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CN202210288669.XA Pending CN114716514A (zh) 2015-05-01 2016-04-29 用于结肠清洁和胃肠病症治疗的组合物

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US (2) US10618938B2 (enExample)
EP (2) EP4218789A3 (enExample)
JP (5) JP6930919B2 (enExample)
KR (2) KR102783759B1 (enExample)
CN (2) CN114716514A (enExample)
CA (2) CA2984437C (enExample)
CY (1) CY1126031T1 (enExample)
DK (1) DK3288578T5 (enExample)
EA (1) EA201792401A1 (enExample)
ES (1) ES2947591T3 (enExample)
FI (1) FI3288578T3 (enExample)
HR (1) HRP20230381T1 (enExample)
HU (1) HUE061954T2 (enExample)
LT (1) LT3288578T (enExample)
MA (1) MA41985B1 (enExample)
MD (1) MD3288578T2 (enExample)
MX (2) MX2017013928A (enExample)
PL (1) PL3288578T3 (enExample)
PT (1) PT3288578T (enExample)
RS (1) RS64160B1 (enExample)
SI (1) SI3288578T1 (enExample)
SM (1) SMT202300114T1 (enExample)
WO (1) WO2016178979A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102783759B1 (ko) * 2015-05-01 2025-03-21 아이언우드 파마슈티컬스, 인코포레이티드 결장 세정을 위한 조성물 및 위장 장애의 치료
SMT202200173T1 (it) 2016-06-01 2022-05-12 Athira Pharma Inc Composti
EP4436980A1 (en) * 2021-11-24 2024-10-02 Ironwood Pharmaceuticals, Inc. Synthetic process for production of modified gcc receptor agonists
MX2024006317A (es) * 2021-11-24 2024-06-19 Ironwood Pharmaceuticals Inc Proceso sintetico para la produccion de agonistas del receptor de guanilato ciclasa c (gcc) modificados.
EP4440595A1 (en) * 2021-11-29 2024-10-09 Ironwood Pharmaceuticals, Inc. Pharmaceutical compositions for the treatment of visceral pain

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102869677A (zh) * 2010-02-17 2013-01-09 硬木药品公司 胃肠病症的治疗
WO2014131024A2 (en) * 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH689139A5 (de) 1995-04-03 1998-10-30 Cerbios Pharma Sa Verfahren zur Herstellung einer liposomalen, in Wasser dispergierbaren, oral zu verabreichenden, festen, trockenen therapeutischen Formulierung.
US5912014A (en) 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
DE602004028678D1 (de) * 2003-01-28 2010-09-23 Ironwood Pharmaceuticals Inc Zusammensetzungen zur Behandlung von Magen-Darm-Störungen
US7494979B2 (en) * 2003-06-13 2009-02-24 Ironwood Pharmaceuticals, Inc. Method for treating congestive heart failure and other disorders
CA2619650A1 (en) * 2005-08-19 2007-02-22 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP2331561A4 (en) * 2008-09-03 2013-02-27 Xenome Ltd PEPTIDE CONJUGATE LIBRARIES AND METHODS OF MAKING SAME
KR102034748B1 (ko) * 2011-03-01 2019-10-21 시너지 파마슈티컬즈 인코포레이티드 구아닐레이트 사이클라제 c 작용제의 제조 방법
EP4424697A3 (en) * 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2016015055A1 (en) * 2014-07-25 2016-01-28 Ironwood Pharmaceuticals, Inc. Colon cleansing compositions
KR102783759B1 (ko) * 2015-05-01 2025-03-21 아이언우드 파마슈티컬스, 인코포레이티드 결장 세정을 위한 조성물 및 위장 장애의 치료

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102869677A (zh) * 2010-02-17 2013-01-09 硬木药品公司 胃肠病症的治疗
WO2014131024A2 (en) * 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity;Mohammed Akhter Hossai等;《Organic & Biomolecular Chemistry》;20090421;摘要和Conclusions *

Also Published As

Publication number Publication date
RS64160B1 (sr) 2023-05-31
FI3288578T3 (fi) 2023-05-03
JP2025169325A (ja) 2025-11-12
HUE061954T2 (hu) 2023-09-28
DK3288578T3 (da) 2023-05-01
JP2022121734A (ja) 2022-08-19
SMT202300114T1 (it) 2023-05-12
WO2016178979A1 (en) 2016-11-10
HRP20230381T1 (hr) 2023-07-07
CA2984437C (en) 2025-11-18
LT3288578T (lt) 2023-04-25
US20180148476A1 (en) 2018-05-31
BR112017023539A2 (pt) 2018-08-14
EA201792401A1 (ru) 2018-05-31
KR20250042844A (ko) 2025-03-27
KR102783759B1 (ko) 2025-03-21
SI3288578T1 (sl) 2023-07-31
JP6930919B2 (ja) 2021-09-01
MA41985B1 (fr) 2023-04-28
JP2024015335A (ja) 2024-02-01
CN108040482A (zh) 2018-05-15
CA2984437A1 (en) 2016-11-10
ES2947591T3 (es) 2023-08-11
CA3172777A1 (en) 2016-11-10
EP3288578A1 (en) 2018-03-07
MA41985A (fr) 2018-03-07
MX2017013928A (es) 2018-01-15
PL3288578T3 (pl) 2023-08-14
MX2022013283A (es) 2022-12-13
PT3288578T (pt) 2023-03-28
EP4218789A3 (en) 2023-09-27
KR20180005675A (ko) 2018-01-16
EP3288578B8 (en) 2023-03-29
US10618938B2 (en) 2020-04-14
EP4218789A2 (en) 2023-08-02
EP3288578B1 (en) 2023-03-15
CN114716514A (zh) 2022-07-08
MD3288578T2 (ro) 2023-08-31
US20240199697A1 (en) 2024-06-20
CY1126031T1 (el) 2023-11-15
JP2018519254A (ja) 2018-07-19
DK3288578T5 (da) 2024-10-07
JP2020203954A (ja) 2020-12-24

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