CN108033449A - A kind of preparation method of medicinal carbon - Google Patents
A kind of preparation method of medicinal carbon Download PDFInfo
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- CN108033449A CN108033449A CN201810020114.0A CN201810020114A CN108033449A CN 108033449 A CN108033449 A CN 108033449A CN 201810020114 A CN201810020114 A CN 201810020114A CN 108033449 A CN108033449 A CN 108033449A
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Abstract
The invention discloses a kind of preparation method of medicinal carbon.The preparation method of this medicinal carbon comprises the following steps：1) sieving is ground for raw material with least one of cocoanut active charcoal, palm shell activated carbon；2) activated carbon after sieving is placed in reaction kettle and carries out pickling；3) measure pickling after activated carbon iron and content of ashes index；4) activated carbon of qualified is washed；5) alkali salt, immersion are added；6) ultrasonic cleaning is carried out；7) drying and moulding.Medicinal carbon obtained by present invention the advantages that specific surface area itself is big except active charcoal, and pore structure is flourishing, but also have the advantages that tenor, the ash impurity that grades are low-down, the standard of injection-use activated carbon can be reached.
Description
Technical field
The present invention relates to a kind of preparation method of medicinal carbon.
Background technology
Medicinal carbon is a kind of novel absorbent charcoal, dedicated for pharmaceutical field, is mainly used for solution in pharmacy procedure
Impurity and small molecule heavy metal in decoloration and adsorbent solution, are the most common means of depyrogenation.Its maximum feature is exactly de-
The features such as color speed is fast, and adsorption capacity is strong, and endoporus gap structure is flourishing, and specific surface area is big, can effectively adsorb the color in liquid medicine
Element, and the impurity of liquid medicine is reduced, other active ingredient concentration and pharmacological property without influencing liquid medicine.
Medicinal carbon is also used as a kind of outstanding GI tract cleanser, remaining harmful in adsorbable digestive tract wall
Material, including environmental carcinogen and the various pathogenic bacterias such as some remainss of pesticide, heavy metal, bioxin and body produce in itself
Various toxin, it is mainly by the abundant pore structure of medicinal carbon, and huge specific surface area is to these nuisances
Matter is adsorbed, and reaches the effect of purification.Medical charcoal is alternatively arranged as the carrier of fortimicin catalyst, for the side such as blood perfusion
Face.
The preparation process of medicinal carbon is mainly using the raw materials such as red cedar, lignin, bamboo charcoal, preparation method master at present
To use ZnCl2Method, phosphoric acid method, Physical etc., the sample products quality that these techniques prepare, impurity index etc. are difficult to reach
To requiring.
The content of the invention
It is an object of the invention to provide a kind of preparation method of medicinal carbon.
The technical solution used in the present invention is：
A kind of preparation method of medicinal carbon, comprises the following steps：
1) 120~200 mesh sieves were ground for raw material with least one of cocoanut active charcoal, palm shell activated carbon；
2) activated carbon after sieving and acid are mixed, adds water dilution, be subsequently placed in reaction kettle and carry out pickling；
3) measure pickling after activated carbon iron and content of ashes index；
4) activated carbon of qualified is washed；
5) alkali salt, immersion are added；
6) ultrasonic cleaning is carried out；
7) by the activated carbon drying and moulding after ultrasonic cleaning, medicinal carbon is obtained.
In step 2), the time of pickling is 5h~10h.
In step 2), sour addition is the 8%~15% of quality of activated carbon；The addition of water is the 5 of quality of activated carbon
~10 times.
In step 2), acid is hydrochloric acid.
In step 4), the standard of qualified is：Mass content≤0.02% of iron in activated carbon, the mass content of ash content
≤ 3%.
In step 4), the pH for being washed to solution is 4~6.
In step 5), the addition of alkali salt is the 1%~4% of quality of activated carbon.
In step 5), alkali salt is at least one of alkali carbonate, alkali metal hydrogencarbonate.
In step 5), the time of immersion is 7h~10h.
It is dry for centrifugation drying in step 7).
The beneficial effects of the invention are as follows：
Specific surface area itself is big except active charcoal for medicinal carbon obtained by the present invention, and pore structure prosperity etc. is excellent
Point, but also have the advantages that tenor, the ash impurity that grades are low-down, the standard of injection-use activated carbon can be reached.
Specifically：
For the present invention mainly using being raw material with good cocoanut active charcoal, palm shell activated carbon, it mainly has ash content
The low, advantage such as content of beary metal is low.Mainly there is reaction kettle in preparation process, its vapor is not in contact with activated carbon, so
Son is more much lower than the yield of normal acid cleaning process Process Impurity, and used cleaning device is activated carbon during cleaning
Dedicated ultrasonic cleaning equipment, can efficiently remove metal ion, ash inside activated carbon and grade impurity.
Brief description of the drawings
Fig. 1 is the process flow diagram that the present invention prepares medicinal carbon.
Embodiment
A kind of preparation method of medicinal carbon, comprises the following steps：
1) 120~200 mesh sieves were ground for raw material with least one of cocoanut active charcoal, palm shell activated carbon；
2) activated carbon after sieving and acid are mixed, adds water dilution, be subsequently placed in reaction kettle and carry out pickling；
3) measure pickling after activated carbon iron and content of ashes index；
4) activated carbon of qualified is washed；
5) alkali salt, immersion are added；
6) ultrasonic cleaning is carried out；
7) by the activated carbon drying and moulding after ultrasonic cleaning, medicinal carbon is obtained.
Preferably, in step 1), 150 mesh sieves were ground.
Preferably, in step 2), the time of pickling is 5h~10h.
Preferably, in step 2), sour addition is the 8%~15% of quality of activated carbon.
Preferably, in step 2), the addition of water is 5~10 times of quality of activated carbon.
Preferably, in step 2), acid is hydrochloric acid；The hydrochloric acid is the hydrochloric acid of concentration 36%.
Preferably, in step 3), it is measured according to the standard of injection-use activated carbon, reference《GB/T 13803.4-
1999》。
Preferably, in step 4), the standard of qualified is：Mass content≤0.02% of iron in activated carbon, ash content
Mass content≤3%.
Preferably, in step 4), the pH for being washed to solution is 4~6..
Preferably, in step 5), the addition of alkali salt is the 1%~4% of quality of activated carbon；It is further preferred that step
5) in, the addition of alkali salt is the 1% of quality of activated carbon.
Preferably, in step 5), alkali salt is at least one of alkali carbonate, alkali metal hydrogencarbonate；Further
Preferably, in step 5), alkali salt is at least one of sodium carbonate, potassium carbonate, sodium acid carbonate, saleratus；It is further excellent
Choosing, in step 5), alkali salt is sodium acid carbonate.
Preferably, in step 5), the time of immersion is 7h~10h.
Preferably, in step 6), the device used in ultrasonic cleaning is activated carbon special-purpose ultrasonic cleaning device.
Preferably, it is dry for centrifugation drying in step 7).
Further illustrate that the technical solution of the invention for preparing medicinal carbon is as follows：
1st, using reaction kettle cleaning device during pickling, its operation principle be internal layer be put into activated carbon with
Hydrochloric acid solution, is put into hot water circulation heated in interlayer, and wherein vapor is not directly contacted with the activated carbon of internal layer, and reaction finishes,
Material can be released from the discharge port of bottom, and operation is extremely convenient.Under being contrasted with normal acid cleaning process, most important advantage is water
Steam is not directly contacted with activated carbon, so it is possible to prevente effectively from being mixed into other impurity in acid cleaning process.
2nd, can effectively be removed in reaction kettle using the dedicated ultrasonic cleaning equipment of activated carbon in cleaning process
In the impurity that does not clean up.
Attached drawing 1 is the process flow diagram that the present invention prepares medicinal carbon.Below in conjunction with attached drawing 1, and by specific
Embodiment present disclosure is described in further detail.
Embodiment 1：
Using coconut husk, palm shell activated carbon as raw material, it is 80% to grind to 150 mesh percent of pass；Then charcoal amount is added
8% hydrochloric acid, concentration of hydrochloric acid 36%, adds the water of 10 times of charcoal quality to dilute, is placed in pickling 9h in reaction kettle；Measure molysite also
There is ash content, after reaching injection-use activated carbon standard, washed, to pH4-6；Addition 1% sodium acid carbonate of charcoal amount, immersion
8h；Ultrasonic cleaning is carried out, equipment therefor is the dedicated ultrasonic cleaning equipment of activated carbon；After centrifuging drying forming, reality is obtained
Apply the medicinal carbon of example 1.
Embodiment 2：
Using coconut husk, palm shell activated carbon as raw material, it is 80% to grind to 150 mesh percent of pass；Then charcoal amount is added
10% hydrochloric acid, concentration of hydrochloric acid 36%, adds the water of 8 times of charcoal quality to dilute, is placed in pickling 8.5h in reaction kettle；Measure molysite
Also ash content, after reaching injection-use activated carbon standard, is washed, to pH4-6；Addition 2% sodium acid carbonate of charcoal amount, immersion
8h；Ultrasonic cleaning is carried out, equipment therefor is the dedicated ultrasonic cleaning equipment of activated carbon；After centrifuging drying forming, reality is obtained
Apply the medicinal carbon of example 2.
Embodiment 3：
Using coconut husk, palm shell activated carbon as raw material, it is 80% to grind to 150 mesh percent of pass；Then charcoal amount is added
12% hydrochloric acid, concentration of hydrochloric acid 36%, adds the water of 5 times of charcoal quality to be diluted with water, is placed in pickling 7h in reaction kettle；Measure iron
Salt also has ash content, after reaching injection-use activated carbon standard, is washed, to pH4-6；Addition 3% sodium acid carbonate of charcoal amount, leaching
Steep 8h；Ultrasonic cleaning is carried out, equipment therefor is the dedicated ultrasonic cleaning equipment of activated carbon；After centrifuging drying forming, obtain
The medicinal carbon of embodiment 3.
Embodiment 4：
Using coconut husk, palm shell activated carbon as raw material, it is 80% to grind to 150 mesh percent of pass；Then charcoal amount is added
15% hydrochloric acid, concentration of hydrochloric acid 36%, adds the water of 5 times of charcoal quality to be diluted with water, is placed in pickling 7h in reaction kettle；Measure iron
Salt also has ash content, after reaching injection-use activated carbon standard, is washed, to pH4-6；Addition 4% sodium acid carbonate of charcoal amount, leaching
Steep 8h；Ultrasonic cleaning is carried out, equipment therefor is the dedicated ultrasonic cleaning equipment of activated carbon；After centrifuging drying forming, obtain
The medicinal carbon of embodiment 4.
Comparative example 1：
Using coconut husk, palm shell activated carbon as raw material, it is 80% to grind to 150 mesh percent of pass；Then charcoal amount is added
12% hydrochloric acid, concentration of hydrochloric acid 36%, is diluted with water, heating pickling 8h；Measure molysite also has ash content, reaches injection work
After property charcoal standard, washed, to pH4-6；Addition 3% sodium acid carbonate of charcoal amount, soaks 8h；Carry out ultrasonic cleaning, institute
It is the dedicated ultrasonic cleaning equipment of activated carbon with device；After centrifuging drying forming, the medicinal carbon of comparative example 1 is obtained.
Comparative example 2：
Using coconut husk, palm shell activated carbon as raw material, it is 80% to grind to 150 mesh percent of pass；Then charcoal amount is added
12% hydrochloric acid, concentration of hydrochloric acid 36%, is diluted with water, and is placed in pickling 8h in reaction kettle；Measure molysite also has ash content, reaches
After injection-use activated carbon standard, washed, to pH4-6；Addition 3% sodium acid carbonate of charcoal amount, soaks 8h；Carry out pure water punching
Wash, after centrifuging drying forming, obtain the medicinal carbon of comparative example 2.
Table 1 show the medicinal carbon testing result of embodiment 1~4 and comparative example 1~2.
1 medicinal carbon testing result of table
It was found from the data analysis of table 1, activated carbon that normal process is produced, such as former material used by among embodiment
Material is that ash of active carbon iron content etc. of coconut husk palm shell is exceeded, also the not up to standard of injection active carbon, and among the present invention
The impurity index such as content of ashes and iron content is effectively reduced using reaction kettle cleaning and ultrasonic cleaning process.
Claims (10)
- A kind of 1. preparation method of medicinal carbon, it is characterised in that：Comprise the following steps：1) 120~200 mesh sieves were ground for raw material with least one of cocoanut active charcoal, palm shell activated carbon；2) activated carbon after sieving and acid are mixed, adds water dilution, be subsequently placed in reaction kettle and carry out pickling；3) measure pickling after activated carbon iron and content of ashes index；4) activated carbon of qualified is washed；5) alkali salt, immersion are added；6) ultrasonic cleaning is carried out；7) by the activated carbon drying and moulding after ultrasonic cleaning, medicinal carbon is obtained.
- A kind of 2. preparation method of medicinal carbon according to claim 1, it is characterised in that：In step 2), pickling Time is 5h~10h.
- A kind of 3. preparation method of medicinal carbon according to claim 1, it is characterised in that：In step 2), sour adds Enter 8%~15% that amount is quality of activated carbon；The addition of water is 5~10 times of quality of activated carbon.
- A kind of 4. preparation method of medicinal carbon according to claim 3, it is characterised in that：In step 2), acid is salt Acid.
- A kind of 5. preparation method of medicinal carbon according to claim 1, it is characterised in that：In step 4), index is closed The standard of lattice is：Mass content≤0.02% of iron in activated carbon, mass content≤3% of ash content.
- A kind of 6. preparation method of medicinal carbon according to claim 5, it is characterised in that：In step 4), it is washed to The pH of solution is 4~6.
- A kind of 7. preparation method of medicinal carbon according to claim 1, it is characterised in that：In step 5), alkali salt Addition is the 1%~4% of quality of activated carbon.
- A kind of 8. preparation method of medicinal carbon according to claim 7, it is characterised in that：In step 5), alkali salt is At least one of alkali carbonate, alkali metal hydrogencarbonate.
- A kind of 9. preparation method of medicinal carbon according to claim 1, it is characterised in that：In step 5), immersion Time is 7h~10h.
- A kind of 10. preparation method of medicinal carbon according to claim 1, it is characterised in that：In step 7), drying is Centrifugation drying.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112357919A (en) * | 2020-11-06 | 2021-02-12 | 天津亚德尔生物质科技股份有限公司 | Preparation method of medicinal activated carbon |
| CN112429734A (en) * | 2020-12-21 | 2021-03-02 | 安徽金叶碳素科技有限公司 | Medicinal activated carbon with strong adsorption performance and preparation method thereof |
| CN113493203A (en) * | 2021-07-27 | 2021-10-12 | 福建省鑫森炭业股份有限公司 | Preparation method of activated carbon for regeneration treatment of kidney dialysate and activated carbon |
| CN115382506A (en) * | 2022-10-26 | 2022-11-25 | 成都天佑晶创科技有限公司 | Zinc-silver-copper loaded active carbon composite material and preparation method and application thereof |
| CN116062752A (en) * | 2023-03-14 | 2023-05-05 | 广东韩研活性炭科技股份有限公司 | Process for preparing medicinal active carbon by phosphoric acid method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112357919A (en) * | 2020-11-06 | 2021-02-12 | 天津亚德尔生物质科技股份有限公司 | Preparation method of medicinal activated carbon |
| CN112429734A (en) * | 2020-12-21 | 2021-03-02 | 安徽金叶碳素科技有限公司 | Medicinal activated carbon with strong adsorption performance and preparation method thereof |
| CN113493203A (en) * | 2021-07-27 | 2021-10-12 | 福建省鑫森炭业股份有限公司 | Preparation method of activated carbon for regeneration treatment of kidney dialysate and activated carbon |
| CN115382506A (en) * | 2022-10-26 | 2022-11-25 | 成都天佑晶创科技有限公司 | Zinc-silver-copper loaded active carbon composite material and preparation method and application thereof |
| CN116062752A (en) * | 2023-03-14 | 2023-05-05 | 广东韩研活性炭科技股份有限公司 | Process for preparing medicinal active carbon by phosphoric acid method |
| CN116062752B (en) * | 2023-03-14 | 2023-12-22 | 广东韩研活性炭科技股份有限公司 | Process for preparing medicinal active carbon by phosphoric acid method |
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Effective date of registration: 20191202 Address after: 364112 Xiayang Dongshan Industrial Park, Xiayang Town, Yongding District, Longyan City, Fujian Province Applicant after: Fujian Hanyan Environmental Protection Technology Co., Ltd Address before: 528300 five place of No. 6, Sha Kun Industrial Zone, Daliang five neighborhood committee, Shunde District, Foshan, Guangdong. Applicant before: Foshan Han Yan Activated Carbon Manufacturing Co., Ltd. |
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Application publication date: 20180515 |