CN108020504A - Optical measuring instrument and sample refractive index, optical rotatory spectrum and chiral molecules Enantiomeric excess measurement analysis method based on the weak measurement of quantum - Google Patents
Optical measuring instrument and sample refractive index, optical rotatory spectrum and chiral molecules Enantiomeric excess measurement analysis method based on the weak measurement of quantum Download PDFInfo
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Abstract
The invention discloses a kind of optical measuring instrument and sample refractive index based on the weak measurement of quantum, optical rotatory spectrum and chiral molecules Enantiomeric excess measurement analysis method, the present invention is based on the weak e measurement technology of quantum, in optical path, to select to construct the weak optical path of the first quantum between quantum state after first in preceding the selection quantum state and reflected light path in input path, to select to construct the weak optical path of the second quantum between quantum state after second in the preceding selection quantum state and refractive light paths in input path, by adjusting incident beam, the reflected beams and deflecting light beams polarization state, the reflected beams spin-spin splitting value and deflecting light beams spin-spin splitting value can be made to expand at least 103Times, so as to fulfill the measure to the minimum change of sample refractive index, faint chiral optical signal (such as angle of rotation), chiral molecules Enantiomeric excess, it is expected to realize the analysis of chiral medicine in unimolecule aspect；There is significant application value in multiple ambits such as biomedical engineering, life science, analytical chemistry.
Description
Technical Field
The invention relates to the technology of optical instruments, in particular to an optical measuring instrument based on quantum weak measurement, which can simultaneously measure the refractive index and the optical rotation spectrum of a liquid, gaseous or solid transparent sample, especially the refractive index and the optical rotation spectrum of a solution with lower concentration and less chiral molecules; the optical measuring instrument can also realize the determination of the content of the enantiomer in the solution containing the chiral molecular substance, and the optical measuring instrument based on quantum weak measurement can be suitable for high-precision chiral drug analysis and chiral chemical analysis, and can be used for manufacturing high-sensitivity chiral molecular sensors and the like.
Background
Chemical molecules and biological macromolecules in nature such as DNA, proteins, polysaccharides, nucleic acids and the like have chiral features, so that chemical and biological (biochemical of substances) processes are often accompanied by changes in molecular configuration and associated weak chiral optical signal changes. The drug targets in the human body have chiral characteristics (such as various receptors, enzymes, proteins and the like are all composed of L-type amino acids), when the chiral drug targets act with enantiomers of chiral drugs, the corresponding pharmacological activity, metabolic process, toxicity and the like have obvious differences, and even show opposite pharmacological activities. Therefore, after the drug is successfully developed, strict chiral activity and toxicity tests are carried out to avoid the adverse effect of another chiral molecule contained in the drug on human health.
In view of the sufficient understanding of the difference of the chiral drugs in the pharmacological activity and physiological action, namely the metabolic process, people increase the research and development strength of the chiral drugs, so that the chiral drugs are developed vigorously and occupy more than two thirds of the research and development of common chemical drugs in the world. The accurate chiral drug analysis technology is an important basic stone for developing chiral drugs, and the accurate determination of the content of the chiral molecular enantiomer is the technical core and key bottleneck of chiral drug analysis and chiral chemical analysis.
At present, the measurement of chiral optical signals (circular dichroism spectrum and optical rotation angle) of substances is an effective method for detecting the optical activity of drug molecules and determining the absolute configuration of molecular enantiomers. However, the chiral optical signal (chiral) is a very weak optical effect, and typically only the achiral background absorbs 10 of the signal -6 ～10 -4 The magnitude (for the interaction process of weak-handed drugs or biomolecules, chiral optical signals are weaker), the direct measurement is difficult by adopting the existing optical measurement equipment, the measurement precision of the polarimeter Autopol series of Ludaofu company in America can reach 0.002 degrees at most by a polarization extinction method, but the measurement precision of the traditional measurement technology based on light intensity is equivalent to the noise level of the instrument due to the influence of inherent factors such as light source stability, environmental noise, temperature and the like, and the measurement precision is difficult to be further improved. In addition, the existing optical rotatory measuring equipment does not have the function of measuring the content of different chiral enantiomers.
Disclosure of Invention
The invention aims to provide an optical measuring instrument based on quantum weak measurement, which not only can realize the measurement and analysis of the refractive index and the optical rotation spectrum of a transparent or semitransparent sample, but also can realize the measurement and analysis of the content of an enantiomer of a chiral molecule.
The second purpose of the invention is to provide a method for measuring and analyzing the refractive index and the optical rotation spectrum of a sample based on quantum weak measurement based on the optical measuring instrument based on quantum weak measurement.
The third purpose of the invention is to provide a method for measuring and analyzing the content of the chiral molecule enantiomer based on quantum weak measurement, aiming at the problem that the prior art lacks of a technical means for accurately measuring the content of the chiral molecule enantiomer.
The idea of the invention is to convert the refractive index and the optical rotation spectrum of a sample to be measured into measurement quantity related to photon spin splitting, and since the photon spin splitting is very sensitive to the refractive index and the optical rotation and is insensitive to the fluctuation of a light source and environmental noise, the noise can be well inhibited, and the measurement precision is improved. The spin splitting of the photon can be amplified through quantum weak measurement (the phenomenon that after the photon passes through a front polarization state and a rear polarization state, the centroid position of a light spot on a detector moves for a distance, and the centroid position of the light spot is the energy centroid position calculated according to energy distribution), so that the accurate measurement is carried out, the high-precision refractive index and the high-precision optical rotation spectrum of a sample to be measured are obtained at the same time, and the content of an enantiomer in the sample is obtained through the two parameters. Based on the above analysis, the present invention is directed to developing a device, wherein a light beam is incident on a surface of a sample medium, reflected or refracted by the surface of the sample medium, and a polarization state or a phase difference of an incident light beam, a reflected light beam or a refracted light beam is adjusted to expand a spin splitting value (i.e., a traverse distance of a centroid of the reflected light beam or the refracted light beam with respect to a center of gravity of light energy at an interface of the sample medium, referred to as a traverse distance of the centroid of the reflected light beam or the centroid of the refracted light beam) associated with the polarization state or the phase difference, so that the light beam can be accurately measured, and a refractive index and a light spectrum of a sample can be calculated and obtained according to the measured spin splitting value of the reflected light beam or the refracted light beam. For a solution containing a chiral molecular substance, the chiral molecular enantiomer content is related to the solution refractive index and optical rotation, which can be calculated from spin-split values associated with polarization states or phase differences, so that the chiral molecular enantiomer content can be accurately determined based on the spin-split values determined by quantum weak measurement techniques.
The invention provides an optical measuring instrument based on quantum weak measurement, which comprises a light generating device, a polarization state preparation device, a prism, a sample, a first polarization state selector, a second polarization state selector, a first light receiving device and a second light receiving device, wherein the first polarization state selector is connected with the first light receiving device; the sample is provided with a light incident surface and a light emergent surface, and the light incident surface is attached to one side surface of the prism; the light beam emitted by the light generating device is incident to the light incidence surface of the sample through the polarization state preparation device and the prism to generate a reflected light beam and a refracted light beam, the reflected light beam is received by the first light receiving device through the first polarization state selector, and the refracted light beam is received by the second light receiving device through the second polarization state selector; the polarization state of the light beam incident to the sample light incident surface is a front selection quantum state, the polarization state of the light beam after the reflected light beam passes through the first polarization state selector is a first rear selection quantum state, and the polarization state of the light beam after the refracted light beam passes through the second polarization state selector is a second rear selection quantum state; a first quantum weak measurement light path part is formed between the front selection quantum state in the incident light path and the first rear selection quantum state in the reflection light path, and a second quantum weak measurement light path part is formed between the front selection quantum state in the incident light path and the second rear selection quantum state in the refraction light path.
According to the optical measuring instrument based on the quantum weak measurement, the obtained reflected light beam spin splitting value or refracted light beam spin splitting value can be expanded by adjusting the included angle between the front selected quantum state and the first rear selected quantum state or the included angle between the front selected quantum state and the second rear selected quantum state, so that the measurement accuracy of the solution refractive index or the optical rotation angle is ensured; when the angle between the first post-selected quantum state and the pre-selected quantum state is 90 ° ± Δ '(Δ' is not greater than 5 °), the reflected beam spin split value may be enlarged by at least 10 with respect to the incident beam spin split value 3 Doubling; when the included angle between the second rear selected quantum state and the front selected quantum state is 90 degrees plus or minus delta ' (' delta ' is not more than 5 degrees), the refraction beam spin splitting value is opposite to the incident beam spin splitting valueThe value can be expanded by at least 10 3 And (4) doubling.
The optical measuring instrument based on quantum weak measurement aims at a transparent or semitransparent solid, liquid or gas sample; when the sample is a liquid or a gas, it is necessary to place it in a transparent, translucent container (the refractive index of the container is known) for measurement.
The optical measuring instrument based on quantum weak measurement comprises a light source generator, an energy regulator and a first light beam converter, wherein the energy regulator and the first light beam converter are arranged on an emergent light path of the light source generator; the light source generator is used for providing a polarized light source and can be a laser, a laser diode, a super-radiation light emitting diode, a white light generator and a quantum light source generator; the energy regulator is used for regulating the energy of the light beam emitted by the light source generator and can be a half wave plate or a neutral attenuation plate; for the half wave plate, the adjustment of light energy is realized by adjusting the included angle between the polarization direction of the half wave plate and the polarization direction of incident light; the first light beam converter is used for light beam convergence and can be a single lens or a lens group consisting of a plurality of lenses.
According to the optical measuring instrument based on quantum weak measurement, the polarization state preparation is used for constructing a proper front selection quantum state, the first polarization state selector and the second polarization state selector are used for constructing a proper rear selection quantum state, the rear selection quantum state is approximately perpendicular to the front selection quantum state, the included angle is 90 degrees +/-delta ', delta' is not more than 5 degrees, so that a sufficient quantum weak value amplification effect is guaranteed, and high-precision and high-sensitivity measurement is realized; the polarization state preparation device is one of a polarizer or a combination of a polarizer and a quarter-wave plate and a phase compensator (such as a Babinet phase compensator), wherein the quarter-wave plate or the phase compensator is positioned behind the polarizer; the first polarization state selector and the second polarization state selector are the same or different in structure and are one of a polarizer or a combination of the polarizer and a quarter-wave plate and a phase compensator (such as a Babinet phase compensator), and the quarter-wave plate or the phase compensator is positioned in front of the polarizer; the polarizer is a glan laser polarizing prism or a polarizing beam splitter (e.g., wolas prism).
In the optical measuring instrument based on quantum weak measurement, the prism is used for generating a proper incident angle at the sample incident interface, in a preferred mode, the incident beam after passing through the prism generates brewster angle reflection or total reflection and the like at the sample incident interface, and the prism can be a triangular prism, a quadrangular prism, a pentagonal prism and the like.
In the optical measuring instrument based on quantum weak measurement, the first light receiving device includes a first photodetector and a second light beam converter located in front of the first photodetector; the second light receiving device comprises a second photoelectric detector and a third light beam converter positioned in front of the second photoelectric detector; the first photoelectric detector and the second photoelectric detector are used for realizing weak light detection, can have the same or different structures and are one of a charge coupled device, a spectrometer, a photomultiplier, a position sensitive detector and a four-quadrant detector; the second light beam converter and the third light beam converter are used for adjusting the light beams into parallel light beams, the structures of the second light beam converter and the third light beam converter can be the same or different, and the second light beam converter and the third light beam converter are a lens group consisting of a single lens or a plurality of lenses; the equivalent focal length of the second light beam converter is greater than that of the first light beam converter, and the first light beam converter and the second light beam converter form a confocal system; the equivalent focal length of the third light beam converter is larger than that of the first light beam converter, and the first light beam converter and the third light beam converter form a confocal system.
The invention further provides a sample refractive index and optical rotation spectrum measurement and analysis method based on quantum weak measurement, the optical measurement instrument based on quantum weak measurement is adopted, and the measurement and analysis steps are as follows:
(1) The light emitted by the light generating device is incident to the sample incidence interface through the polarization state preparation device and the prism to generate a reflected light beam and a refracted light beam, the reflected light beam is received by the first light receiving device through the first polarization state selector, and the refracted light beam is received by the second light receiving device through the second polarization state selector; recording the traverse distance of the centroid of the reflected light beam by the first light receiving device as the photon spin split value of the reflected light beam<y r > through a second optical connectionThe receiving device records the transverse moving distance of the centroid of the refracted beam as the photon spin split value of the refracted beam<y t >；
(2) The selected quantum state before the incident beam incident on the light entrance face of the sample is obtained according to the following formula (i):
wherein,being the transverse wave-vector of the incident light beam,i represents the incident beam, | ψ i &The polarization state of the incident beam after passing through the polarization state preparation device;
(3) Obtaining a first post-selected quantum state of the reflected beam after passing through the first polarization state selector and a second post-selected quantum state of the refracted beam after passing through the second polarization state selector according to the following formula (ii):
where v = r, t respectively denote a reflected light path and a refracted light path, | Ψ v >, is the quantum state of the reflected beam before passing through the first polarization state selector or the refracted beam before passing through the second polarization state selector,is the transverse wave vector of the reflected beam or refracted light path,as a function of the wave pattern of the reflected or refracted beam, | ψ v > is the polarization of the reflected beam before passing through the first polarization state selector or the refracted beam before passing through the second polarization state selectorState;is composed ofThe conjugate of (a) to (b),the polarization state of the reflected light beam after passing through the first polarization state selector or the polarization state of the refracted light beam after passing through the second polarization state selector, H>, is the polarization state along the horizontal direction, | V&The polarization state is along the vertical direction, and delta is the optical rotation angle of the sample under the specified wavelength;
(4)|ψ v >, and | psi i >, satisfies the following relation:
wherein
The light beam emitted from the light generating device is reflected and refracted by the prism and each interface of the sample, and m =1,2,3,4,5 represents the angle of incidence theta m The interface of (1);expressed is the angle of incidence theta m Angle of refraction of (d); fresnel refractive index of the glassAndare respectively represented as;k m is the central wave vector of the wave,is the component of the beam in the y-direction; alpha is an included angle between an optical axis set by the polarization state preparation device and the horizontal direction; r is p ，r s Is the Fresnel reflection coefficient of light entering the sample from the prism when reflected at the prism and sample surface, refractive index of sample
(5) According toCalculating photon spin split value<y v >：
(6) Recorded according to step (1)<y r >, and<y t &and simultaneously (i) to (viii) calculating to obtain the refractive index n of the sample and the optical rotation angle delta of the sample at a specified wavelength, wherein the optical rotation angles of the sample at different wavelengths form an optical rotation spectrum.
According to the sample refractive index and optical rotation spectrum measurement and analysis method based on quantum weak measurement, when light emitted by the light generation device passes through the polarization state preparation device and the prism and enters the sample medium incidence interface at the Brewster angle to generate the reflected light beam and the refracted light beam, the optimal sensitivity of the sample refractive index and optical rotation spectrum measurement can be ensured.
According to the sample refractive index and optical rotation spectrum measurement and analysis method based on quantum weak measurement, the light generation device, the prism, the sample, the first light receiving device and/or the second light receiving device are/is adjusted, so that the propagation directions of the reflected light beam and the refracted light beam are respectively vertical or nearly vertical to the sample reflected light beam emergent surface and the refracted light beam emergent surface, and a large weak measurement amplification effect is achieved.
The method for measuring and analyzing the refractive index and the optical rotation spectrum of the sample based on the quantum weak measurement can further comprise the following steps on the basis of the steps (1) to (6):
(7) Preparing a series of standard samples with different concentrations, and repeating the steps (1) to (6) to obtain a reflected light beam centroid traverse distance-refractive index change curve and a refracted light beam centroid traverse distance-optical rotation angle change curve of the series of standard samples;
(8) And (2) measuring the reflected beam centroid traverse distance and the reflected beam centroid traverse distance of the sample to be detected according to the step (1), obtaining the concentration, the refractive index and the optical rotation angle of the sample to be detected according to the reflected beam centroid traverse distance-refractive index change curve and the refracted beam centroid traverse distance-optical rotation angle change curve obtained in the step (7), and forming the optical rotation spectrum by the optical rotation angles of the sample to be detected under different wavelengths.
On the basis of establishing a reflected light beam centroid traverse distance-refractive index change curve and a refracted light beam centroid traverse distance-optical rotation angle change curve, for a solution with a lower concentration, the refractive index, the optical rotation spectrum and the solution concentration of the solution can be accurately obtained only by testing the solution to be measured through an optical measuring instrument and recording the reflected light beam centroid traverse distance and the refracted light beam centroid traverse distance, so that the concentration and the optical performance of the solution with the low concentration are accurately measured, and the measuring efficiency is improved.
The invention further provides a chiral molecule enantiomer content measurement and analysis method based on quantum weak measurement, the optical measurement instrument based on quantum weak measurement is adopted, the sample is a solution containing chiral molecules, and the method comprises the following steps:
(1) The light emitted by the light generating device is incident to the sample incidence interface through the polarization state preparation device and the prism to generate a reflected light beam and a refracted light beam, the reflected light beam is received by the first light receiving device through the first polarization state selector, and the refracted light beam is received by the second light receiving device through the second polarization state selector; recording the traverse distance of the centroid of the reflected light beam by the first light receiving device as the photon spin split value of the reflected light beam<y r > recording the transverse moving distance of the centroid of the refracted beam through a second light receiving device as a photon spin split value of the refracted beam<y t >；
(2) According to the photon spin split value of the reflected light beam obtained in the step (1)<y r &Refractive beam photon spin split value<y t &The ratio k in solution of chiral molecule-containing material relative to the optical rotation spectrum and refractive index properties of levorotatory material 1 、k 3 Ratio k in solution of substance containing chiral molecules related to optical rotation spectrum and refractive index property of D-substance 2 、k 4 And (2) simultaneously calculating the levorotatory substance content x and the dextrorotatory substance content y in the solution according to the following formulas (ix) and (x):
k 1 x-k 2 y＝<y t > (ix)
k 3 x+k 4 y＝<y r > (x)
k is the same as 1 When a single levorotatory substance exists, the refractive beam photon spin splitting value has the coefficient of change along with the concentration or the optical rotation angle of the solution containing the single levorotatory substance; k is the same as 2 When the single dextro substance exists, the refractive beam photon spin splitting value has the variation coefficient along with the concentration or the optical rotation angle of the solution containing the single dextro substance; k is 3 When single levorotatory substance exists, the variation coefficient of the photon spin splitting value of the reflected light beam along with the concentration or refractive index of the solution containing the single levorotatory substance; k is 4 When single dextro substance exists, the spin splitting value of reflected beam photon changes along with the concentration or refractive index of the solution containing single dextro substance.
The content determination method of the chiral molecular enantiomer based on the quantum weak measurement is characterized in that the optical rotation angle and the refractive index of the solution containing the single levorotatory substance or the single dextrorotatory substance are obtained by the method for measuring and analyzing the refractive index and the optical rotation spectrum of the sample based on the quantum weak measurement, the method comprises the steps of firstly preparing a series of solution standard samples containing the single levorotatory substance with different concentrations, measuring the refractive indexes of the standard samples with different concentrations and the optical rotation angle under the specified wavelength according to the steps (1) to (6) of the method for measuring and analyzing the refractive index and the optical rotation spectrum based on the quantum weak measurement, then obtaining a reflected light beam distance-refractive index change curve (or a refracted light beam center transverse movement distance-optical rotation angle change curve) of the series of standard samples according to the reflected light beam center transverse movement distance (or the refracted light beam center transverse movement distance) and the refractive index (optical rotation angle) under the conditions with different concentrations, and obtaining the slope coefficient k of the reflected light beam distance-refractive index change curve (or the reflected light beam distance-refractive index change curve) which is the reflected light beam distance-refractive index change curve 3 (or k) 1 ) (ii) a For the solution containing single dextrorotation substance, the operation steps are the same, and the slope of the finally obtained reflected beam mass center transverse moving distance-refractive index change curve (or refracted beam mass center transverse moving distance-optical rotation angle change curve) is the coefficient k 4 (or k) 2 )。
The prior art at presentIn the method, the optical properties (such as refractive index, optical rotation spectrum and the like) of the sample are mainly obtained by macroscopic measurement analysis, and the chiral optical signal (only 10- 6 ～10- 4 Magnitude), direct measurement is difficult, the precision is low, and the content of chiral molecular enantiomers in substances containing chiral molecules (such as chiral drugs) cannot be obtained.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention is based on the quantum weak measurement technology, in the measurement light path, a first quantum weak measurement light path is constructed between a front selection quantum state in an incident light path and a first rear selection quantum state in a reflection light path, and the spin splitting value of a reflection light beam can be expanded by at least 10 by adjusting the polarization states of the incident light beam and the reflection light beam 3 The method has the advantages that the measurement of the minimum change of the sample refraction is realized, a good research and development idea is provided for the development of the high-sensitivity refractive index sensor, and the method has a good application prospect;
2. the invention is based on the quantum weak measurement technology, in the measurement light path, a second quantum weak measurement light path is constructed between a front selection quantum state in an incident light path and a second rear selection quantum state in a refraction light path, and the spin splitting value of the refraction light beam can be expanded by at least 10 by adjusting the polarization states of the incident light beam and the refraction light beam 3 Therefore, the measurement of a sample weak chiral optical signal (such as an optical rotation angle) is realized, and the method can be used as an optical high-precision polarization state measurement means and has a good application prospect;
3. the invention not only can realize the measurement of the refractive index and chiral optical signal (such as the optical rotation angle) of the sample at the same time, but also can determine the content of chiral molecule enantiomer in the solution according to the correlation between the content of levorotatory substance and dextrorotatory substance in the solution containing chiral molecule substance and the refractive index and optical rotation spectrum and the spin splitting caused by the change of the refractive index and optical rotation spectrum of the solution, thereby breaking through the bottleneck of chiral chemical analysis in the field;
4. the quantum weak measurement technology provided by the invention is a novel lossless direct quantum state measurement technology, is concentrated on quantum state change caused by observable physical quantity (such as photon spin), is insensitive to external interference, and has very small disturbance introduced in the measurement process, so that the chiral drug can be measured with high precision and high sensitivity in the natural state (solution environment), and the chiral drug can be expected to be analyzed in a single molecular level;
5. the invention plays an important role in the fields of drug analysis and drug development and has important application value in a plurality of subject fields of biomedical engineering, life science, analytical chemistry and the like.
Drawings
FIG. 1 is a schematic diagram of an optical measuring instrument based on quantum infinitesimal measurement according to the present invention; the device comprises a light generating device 1, a light source generator 11, a light source generator 12, an energy regulator 13, a first light beam converter 2, a polarization state preparation device 3, a prism 4, a sample 5, a first polarization state selector 6, a first light receiving device 61, a second light beam converter 62, a first photoelectric detector 7, a second polarization state selector 8, a second light receiving device 81, a third light beam converter 82 and a second photoelectric detector.
FIG. 2 is a schematic diagram of the light path of the incident beam reflected and refracted by multiple interfaces on the prism and the sample surface.
Fig. 3 is a schematic diagram of the variation curve of the traverse distance of the centers of mass of the incident beam and the reflected beam with the concentration of a solution containing chiral molecular substances or the variation curve of the refractive index and the optical rotation angle, wherein (a) is a schematic diagram of the variation curve of the traverse distance of the centers of mass of the refracted beam with the concentration of a glucose solution or the optical rotation angle when the solution is a single glucose solution, (b) is a schematic diagram of the variation curve of the traverse distance of the centers of mass of the reflected beam with the concentration of a glucose solution or the variation curve of the refractive index coefficient when the solution is a single glucose solution, (c) is a schematic diagram of the variation curve of the traverse distance of the centers of mass of the refracted beam with the concentration of a fructose solution or the optical rotation angle when the solution is a single fructose solution, and (d) is a schematic diagram of the variation curve of the traverse distance of the centers of the reflected beam with the concentration of a fructose solution or the refractive index when the solution is a single fructose solution.
FIG. 4 is a schematic diagram of a curve (a) showing the variation of the optical rotation angle of a mixed solution of glucose and fructose along with the traverse distance of the centroid of a refracted light beam and a curve (b) showing the variation of the refractive index coefficient of the mixed solution of glucose and fructose along with the traverse distance of the centroid of a reflected light beam.
Detailed Description
The embodiments of the present invention will be given below with reference to the accompanying drawings, and the technical solutions of the present invention will be further clearly and completely described through the embodiments. It is to be understood that the described embodiments are merely some embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the disclosure of the invention without any inventive step, are within the scope of the invention
Example 1
The optical measuring instrument based on quantum weak measurement provided by this embodiment has a structure as shown in fig. 1, and includes a light generating device 1, a polarization state preparation device 2, a prism 3, a sample 4, a first polarization state selector 5, a second polarization state selector 7, a first light receiving device 6, and a second light receiving device 8. The light generating device 1 is formed by combining a light source generator 11, an energy regulator 12 and a first light beam converter 13, wherein the light source generator 11 is a collimation laser, the energy regulator 12 is a half wave plate, and the first light beam converter 13 is a convex lens. The polarization state maker 2 is a glan laser polarizing prism for constructing appropriate quantum states. The prism 3 is a right-angled triple prism and is used for incidence on the surface of the solution to be measured at the Brewster angle. Sample 4 is the mixed solution of glucose and fructose that awaits measuring, and this mixed solution holds in glass container, and glass container's shape is used for guaranteeing that final refraction light beam is perpendicular or close perpendicular to exit surface, and a side of prism 3 is laminated with the glass container that holds sample 4 mutually. The first polarization state selector 5 and the second polarization state selector 7 are both formed by combining a phase compensator and a glan laser polarization prism and are used for constructing proper quantum states. The first light receiving device 6 is formed by combining a second light beam converter 61 and a first light detector 62, the second light receiving device 8 is formed by a third light beam converter 81 and a second light detector 82, the first light detector 62 and the second light detector 82 are both Charge Coupled Devices (CCDs) for detecting weak light intensity signals, the second light beam converter 61 and the third light beam converter 81 are both convex lenses, the focal length of the second light beam converter 61 is greater than that of the first light beam converter 13, the first light beam converter 13 and the second light beam converter 61 form a confocal system, the focal length of the third light beam converter 81 is greater than that of the first light beam converter 13, and the first light beam converter 13 and the third light beam converter 81 form the confocal system.
The working principle of the optical measuring instrument based on quantum weak measurement is as follows: the laser beam emitted from the light source generator 11 is incident on the light incident surface of the sample 4 at the brewster angle through the energy adjuster 12, the first beam converter 13, the polarization state maker 2, and the prism 3 in this order to generate a reflected beam and a refracted beam, the reflected beam reflected from the prism is received by the first photodetector 62 through the first polarization state selector 5 and the second beam converter 61 in this order, and the refracted beam transmitted through the sample and emitted from the exit surface of the sample is received by the second photodetector 82 through the second polarization state selector 7 and the third beam converter 81 in this order.
The polarization state of the light beam incident to the light incident surface of the sample 4 is a front selection quantum state, the polarization state of the light beam after the reflected light beam passes through the first polarization state selector 5 is a first rear selection quantum state, and the polarization state of the light beam after the refracted light beam passes through the second polarization state selector 7 is a second rear selection quantum state; a first quantum weak measurement light path part for realizing sample refractive index measurement is formed between the front selected quantum state in the incident light path and the first rear selected quantum state in the reflection light path, and a second quantum weak measurement light path part for realizing sample optical rotation spectrum measurement is formed between the front selected quantum state in the incident light path and the second rear selected quantum state in the refraction light path; the polarization state preparation device 2, the first polarization state selector 5 and the second polarization state selector 7 are adjusted so that the rear selected quantum state is approximately perpendicular to the front selected quantum state with an included angle of 90 degrees plus or minus delta '(delta' is not more than 5 degrees).
Example 2
In this embodiment, based on the quantum weak measurement technology, the optical measurement apparatus based on quantum weak measurement provided in embodiment 1 is used to measure and analyze the refractive index and optical rotation spectrum of the glucose and fructose mixed solution sample, and the steps are as follows:
(1) Laser light emitted from a light source generator 11 is incident on a light incident surface of a sample 4 at a Brewster angle sequentially through an energy adjuster 12, a first beam converter 13, a polarization state preparation device 2 and a prism 3 to generate a reflected beam and a refracted beam, the reflected beam reflected from the prism is received by a first photodetector 62 sequentially through a first polarization state selector 5 and a second beam converter 61, and the refracted beam transmitted through the sample and emitted from an exit surface of the sample is received by a second photodetector 82 sequentially through a second polarization state selector 7 and a third beam converter 81; the light intensity is recorded by the first photodetector 62, and the transverse shift distance of the reflected beam centroid is read as the reflected beam photon spin split value<y r > the light intensity is recorded by the second photodetector 82, and the traverse distance of the centroid of the refracted beam is read as the photon spin split value of the refracted beam<y t >。
(2) The selected quantum state before the incident beam incident on the light entrance face of the sample is obtained according to the following formula (i):
wherein,being the transverse wave-vector of the incident light beam,as a function of the mode shape of the incident beam, the present embodiment uses a gaussian beam,i represents the incident beam, | ψ i > is the polarization state of the incident beam after passing through the polarization state preparation deviceIn the examples, | ψ i >＝|H&And gt, the polarization state of the incident beam passing through the polarization state preparation device is along the horizontal direction.
(3) Obtaining a first post-selected quantum state of the reflected beam after passing through the first polarization state selector and a second post-selected quantum state of the refracted beam after passing through the second polarization state selector according to the following formula (ii):
where v = r, t respectively denote a reflected light path and a refracted light path, | Ψ v >, is the quantum state of the reflected beam before passing through the first polarization state selector or the refracted beam before passing through the second polarization state selector,is the transverse wave vector of the reflected beam or refracted light path,as a function of the wave pattern of the reflected or refracted beam, since the present embodiment employs a gaussian beam,|ψ v &the polarization state of a reflected light beam before passing through the first polarization state selector or a refracted light beam before passing through the second polarization state selector;is composed ofThe conjugate of (a) to (b),the polarization state of the reflected light beam after passing through the first polarization state selector or the polarization state of the refracted light beam after passing through the second polarization state selector, for the polarization state of the beam along the horizontal direction, | V&And gt is the polarization state of the light beam along the vertical direction, and delta is the optical rotation angle of the sample at the specified wavelength.
(4) The process is shown in figure 2, the light beam incident on the prism interface (1) enters the prism through refraction to reach the sample medium interface (2), the light beam is refracted and reflected, the reflected light beam reaches the prism exit interface (5) and forms a light path 2 through refraction, the refracted light beam reaches the sample medium exit interface (3) and enters a glass container medium to reach an interface (4) of the glass container medium and forms the light path 1 through refraction; the light path 2 and the light path 1 are formed as a final reflected light beam and a refracted light beam, and the polarization state between the two satisfies | ψ v >, and | psi i >, satisfies the following relation:
wherein
The light beam emitted from the light generating device is reflected and refracted by the prism and each interface of the sample, and m =1,2,3,4,5 represents the angle corresponding to the incident angle theta m The interface of (2);is shown to correspond to the incident angle theta m Angle of refraction of (d); fresnel refractive index of the glassAndare respectively represented as;k m is the central wave vector of the wave,is the component of the beam in the y-direction; alpha is an included angle between an optical axis set by the polarization state preparation device and the horizontal direction; r is p ，r s Is the Fresnel reflection coefficient when light enters the sample from the prism and is reflected on the surface of the sample, refractive index of sample
(5) According to | Ψ fv >, calculating photon spin splitting value<y v >：
(6) Recorded according to step (1)<y r >, and<y t &and simultaneously (i) to (viii) calculating to obtain the refractive index n of the sample and the optical rotation angle delta of the sample at a specified wavelength, wherein the optical rotation angles of the sample at different wavelengths form an optical rotation spectrum.
In this example, mixed solution standards of glucose and fructose with concentrations of 3mg/ml, 4mg/ml, 5mg/ml, 6mg/ml, 7mg/ml, 8mg/ml and 9mg/ml were prepared in sequence, and the centroid traverse distance of the reflected light beam, the traverse distance of the refracted light beam, and the refractive index and the optical rotation angle corresponding to each concentration standard were obtained according to the steps (1) to (6). To facilitate the description of the refractive index measurement and analysis method provided by the present invention to achieve the measurement of the minimal change in the sample refraction, in this embodiment, the refractive index of deionized water (n) is subtracted from the refractive index of each concentration standard sample obtained 0 = 1.33250) the index coefficient change deltan for each concentration standard relative to deionized water. The experimental results of the refractive index change Δ n corresponding to each concentration standard as a function of the traverse distance of the centroid of the reflected light beam and the optical rotation angle as a function of the traverse distance of the centroid of the refracted light beam are shown in fig. 4 (a) and (b).
And drawing a reflected light beam centroid traverse distance-refractive index change curve by using the reflected light beam centroid traverse distance corresponding to each obtained concentration standard sample and the relative refractive index of the reflected light beam centroid traverse distance relative to deionized water, and drawing a refracted light beam centroid traverse distance-optical angle change curve by using the refracted light beam centroid traverse distance corresponding to each obtained concentration standard sample and the optical rotation angle of the refracted light beam. On the basis of establishing a reflected light beam centroid traverse distance-refractive index change curve and a refracted light beam centroid traverse distance-rotation angle change curve, for a glucose and fructose mixed solution (to-be-detected sample) with unknown concentration, the reflected light beam centroid traverse distance of the to-be-detected sample can be measured according to the step (1)<y r &Transverse shift distance of centroid of reflected light beam<y t &And traversing distance according to the obtained mass center of the reflected light beamAnd obtaining the concentration, the refractive index and the optical rotation angle of the sample to be detected by a refractive index change curve and a refractive beam centroid traverse distance-optical rotation angle change curve, wherein the optical rotation angles of the sample to be detected under different wavelengths form an optical rotation spectrum.
Example 3
In this embodiment, based on the quantum weak measurement technology, the optical measurement apparatus based on quantum weak measurement provided in embodiment 1 is used to measure and analyze the content of the levorotatory substance and the dextrorotatory substance in the glucose and fructose mixed solution sample, and the steps are as follows:
(1) Respectively preparing a series of pure glucose solution standard samples and fructose solution standard samples, wherein the concentrations of the glucose solution standard samples are 1mg/ml, 2mg/ml, 3mg/ml, 4mg/ml, 5mg/ml, 6mg/ml, 7mg/ml, 8mg/ml and 9mg/ml, and the concentrations of the fructose solution standard samples are 1mg/ml, 2mg/ml, 3mg/ml, 4mg/ml, 5mg/ml, 6mg/ml, 7mg/ml, 8mg/ml and 9mg/ml.
(2) The reflected light beam centroid traverse distance, refracted light beam traverse distance, and refractive index and optical rotation angle corresponding to each concentration standard were obtained as in steps (1) to (6) of example 2. To facilitate the description of the refractive index measurement and analysis method provided by the present invention to achieve the measurement of the minimal change in the sample refraction, in this embodiment, the refractive index of deionized water (n) is subtracted from the refractive index of each concentration standard sample obtained 0 = 1.33250) yields the index of refraction change Δ n for each concentration standard relative to deionized water. And (c) drawing a curve of the transverse shift distance of the center of mass of the refracted light beam-change of the optical rotation angle [ as shown in fig. 3 (a) and (c) ] (a) is glucose and (c) is fructose ] by using the transverse shift distance of the center of mass of the refracted light beam corresponding to each concentration standard and the change delta n of the refractive index relative to deionized water, and drawing a curve of the transverse shift distance of the center of mass of the reflected light beam-change of the refractive index [ as shown in fig. 3 (b) and (d) ] (b) is glucose and (d) is fructose ]. In FIG. 3 (a), the variation coefficient (curve slope) of photon spin splitting value of refracted beam with the optical rotation angle of glucose solution is k 1 FIG. 3 (c) shows the photon spin split value of refracted beam with fructose solutionThe coefficient of variation (slope of the curve) of the angle of liquid rotation is k 2 In FIG. 3 (b), the coefficient of variation (slope of the curve) of the spin-splitting value of the reflected beam photon with the refractive index of the glucose solution is k 3 In FIG. 3 (d), the coefficient of variation (slope of the curve) of the photon spin splitting value of the reflected beam with the refractive index of the fructose solution is k 4 。
(3) For glucose and fructose mixed solutions (samples 1,2,3 to be tested); the traverse distance of the centroid of the reflected beam of the sample to be measured can be measured according to the step (1) of the embodiment 2<y r &Transverse shift distance of centroid of reflected light beam<y t >, then combining k obtained in the step (2) 1 、k 2 、k 3 、k 4 According to formula k 1 x-k 2 y＝<y t >: (ix) and k 3 x+k 4 y＝<y r &And gt and x, calculating to obtain the content of the levorotatory substance and the content of the dextrorotatory substance in the sample to be detected, wherein the results are shown in table 1.
TABLE 1 determination of glucose and fructose content in the Mixed solution
Note: the samples 1,2, and 3 to be measured are mixed solutions prepared in advance with glucose and fructose, the concentrations of glucose and fructose in the mixed solutions are known (i.e., the prepared concentrations of glucose and fructose), and the concentrations of glucose and fructose in the mixed solutions (i.e., the measured concentrations of glucose and fructose) are measured by the chiral molecular enantiomer content measurement and analysis method provided in this embodiment, so that the feasibility of the chiral molecular enantiomer content measurement method provided in this embodiment is verified.
As can be seen from the table, the glucose concentration and the fructose concentration in the mixed solution obtained by measuring the samples 1 to 3 to be measured are very close to the glucose concentration and the fructose concentration during preparation, and the error is very small, so that the optical measuring instrument based on weak measurement provided by the invention can realize the measurement of the content of the levorotatory substance and the dextrorotatory substance in the mixed solution with lower concentration, and by analogy, the content of the chiral molecule enantiomer in the solution with lower concentration can also be measured.
Furthermore, k 1 、k 2 、k 3 、k 4 After determination, it can be determined according to formula k 1 x-k 2 y＝<y t >, (ix) and k 3 x+k 4 y＝<y r >, (x) determining the corresponding relation between the content x of any levorotatory substance and the content y of any dextrorotatory substance<y r >, and<y t &and (c) obtaining theoretical prediction curves (solid lines) of the reflected beam centroid traverse distance-mixed solution concentration change and the refracted beam centroid traverse distance-mixed solution concentration change in the graphs of fig. 4 (a) and (b), wherein the solution concentrations are in one-to-one correspondence with the refractive indexes and the optical rotation angles, so that the theoretical prediction curves of the reflected beam centroid traverse distance-refractive index change and the refracted beam centroid traverse distance-optical rotation angle change are obtained. As can be seen from the figure, the experimental results of the refractive index change Δ n corresponding to each concentration standard sample in the embodiment (2) along with the traverse distance of the reflected beam centroid and the optical rotation angle along with the traverse distance of the refracted beam centroid are very consistent with the theoretical prediction curve, so that the sample refractive index and optical rotation spectrum measurement and analysis method based on the quantum weak measurement provided by the invention can realize the measurement of the sample refractive index minimum change and the sample weak chiral optical signal (such as the optical rotation angle), can be used as an optical high-precision polarization state measurement means, and has a good application prospect.
Claims (10)
1. An optical measuring instrument based on quantum weak measurement is characterized by comprising a light generating device (1), a polarization state preparation device (2), a prism (3), a sample (4), a first polarization state selector (5), a second polarization state selector (7), a first light receiving device (6) and a second light receiving device (8); the sample (4) is provided with a light incidence surface and a light emergence surface, and the light incidence surface is attached to one side surface of the prism (3); the light beam emitted by the light generating device (1) enters the light incidence surface of the sample (4) through the polarization state preparation device (2) and the prism (3) to generate a reflected light beam and a refracted light beam, the reflected light beam is received by the first light receiving device (6) through the first polarization state selector (5), and the refracted light beam is received by the second light receiving device (8) through the second polarization state selector (7);
the polarization state of the light beam incident to the light incident surface of the sample (4) is a front selection quantum state, the polarization state of the light beam after the reflected light beam passes through the first polarization state selector (5) is a first rear selection quantum state, and the polarization state of the light beam after the refracted light beam passes through the second polarization state selector (7) is a second rear selection quantum state; a first quantum weak measurement optical path part is formed between the front selection quantum state in the incident optical path and the first rear selection quantum state in the reflection optical path, and a second quantum weak measurement optical path part is formed between the front selection quantum state in the incident optical path and the second rear selection quantum state in the refraction optical path.
2. The optical measuring instrument based on quantum weak measurement as claimed in claim 1, characterized in that the included angle between the first post-selected quantum state and the pre-selected quantum state is 90 ° ± Δ 'and Δ' is not more than 5 °; the included angle between the second post-selected quantum state and the pre-selected quantum state is 90 degrees +/-Delta 'and Delta' is not more than 5 degrees.
3. The quantum dot intensity measuring system according to claim 1 or 2, wherein the light generating device (1) comprises a light source generator (11), and an energy regulator (12) and a first beam transformer (13) disposed on the outgoing light path of the light source generator; the light source generator (11) is a laser, a laser diode, a super-radiation light emitting diode, a white light generator and a quantum light source generator; the energy regulator (12) is a half wave plate or a neutral attenuation plate; the first light beam converter (13) is a single lens or a lens group consisting of a plurality of lenses.
4. Optical measuring instrument based on quantum weak measurements according to claim 1 or 2, characterized in that the polarization state preparation device (2) is a polarizer or one of a combination of a polarizer with a quarter wave plate, a phase compensator; the first polarization state selector (5) and the second polarization state selector (7) are the same or different in structure and are one of polarizers or a combination of the polarizers, quarter-wave plates and phase compensators; the polarizer is a Glan laser polarizing prism or a polarizing beam splitter.
5. The system for quantum infinitesimal measurement with both refractive index and optical rotation spectrum analysis according to claim 1 or 2, characterized in that the first light receiving means (6) comprises a first photodetector (62) and a second beam converter (61) located in front of the first photodetector; the second light receiving device (8) comprises a second photoelectric detector (82) and a third light beam converter (81) positioned in front of the second photoelectric detector; the first photoelectric detector (62) and the second photoelectric detector (82) have the same or different structures, and are one of a charge coupled device, a spectrometer, a photomultiplier, a position sensitive detector and a four-quadrant detector for realizing weak light detection; the second light beam converter (61) and the third light beam converter (81) have the same or different structures and are a single lens or a lens group consisting of a plurality of lenses; the equivalent focal length of the second light beam converter (61) is greater than that of the first light beam converter (13), and the first light beam converter (13) and the second light beam converter (61) form a confocal system; the equivalent focal length of the third light beam converter (81) is larger than that of the first light beam converter (13), and the first light beam converter (13) and the third light beam converter (81) form a confocal system.
6. A method for measuring and analyzing the refractive index and optical rotation spectrum of a sample based on quantum weak measurement, which is characterized in that the optical measuring instrument based on quantum weak measurement as claimed in any one of claims 1 to 5 is adopted, and the measuring and analyzing steps are as follows:
the method comprises the following steps that (1) light emitted by a light generating device (1) is incident to an incident interface of a sample (4) through a polarization state preparation device (2) and a prism (3) to generate a reflected light beam and a refracted light beam, the reflected light beam is received by a first light receiving device (6) through a first polarization state selector (5), and the refracted light beam is received by a second light receiving device (8) through a second polarization state selector (7); the traverse distance of the centroid of the reflected beam is recorded by the first light-receiving device (6) as the photon spin split value of the reflected beam<y r > the transverse moving distance of the centroid of the refracted beam is recorded by a second light receiving device (8) and is used as the photon spin splitting value of the refracted beam<y t >；
(2) The selected quantum state before the incident beam incident on the light entrance face of the sample is obtained according to the following formula (i):
wherein,is the transverse wave vector of the incident light beam,i represents the incident beam, | ψ i > is the polarization state of the incident beam after passing through the polarization state preparation device;
(3) Obtaining a first post-selected quantum state of the reflected beam after passing through the first polarization state selector and a second post-selected quantum state of the refracted beam after passing through the second polarization state selector according to the following formula (ii):
where v = r, t respectively denote a reflected light path and a refracted light path, | Ψ v >, is the quantum state of the reflected beam before passing through the first polarization state selector or the refracted beam before passing through the second polarization state selector,is the transverse wave vector of the reflected beam or refracted light path,as a wave-form function of the reflected or refracted light beam, | ψ v > is reflected light beam passing through the firstThe polarization state before the polarization state selector or before the refracted light beam passes through the second polarization state selector;is composed ofThe conjugate of (a) to (b),is the polarization state after the first polarization state selector of the reflected beam or after the refracted beam passes through the second polarization state selector, |H>, is the polarization state along the horizontal direction, | V&The polarization state is along the vertical direction, and delta is the optical rotation angle of the sample under the specified wavelength;
(4)|ψ v >, and | psi i >, satisfies the following relation:
wherein
The light beam emitted from the light generating device is reflected and refracted by the prism and each interface of the sample, and m =1,2,3,4,5 represents the angle corresponding to the incident angle theta m The interface of (1);expressed is the angle of incidence theta m Angle of refraction of (d); fresnel refractive index of the glassAndare respectively represented as;k m is the central wave vector of the wave,is the component of the beam in the y-direction; alpha is an included angle between an optical axis set by the polarization state preparation device and the horizontal direction; r is p ，r s Is the Fresnel reflection coefficient when light enters the sample from the prism and is reflected on the surface of the sample, refractive index of sample
(5) According toCalculating photon spin split value<y v >：
(6) Recorded according to step (1)<y r >, and<y t &and (i) simultaneously (i) to (viii) calculating the refractive index n of the sample and the optical rotation angle delta of the sample at a specified wavelength, wherein the optical rotation angles of the sample at different wavelengths form an optical rotation spectrum.
7. The method for measuring and analyzing the refractive index and the optical rotation spectrum of the sample based on the quantum weak measurement as claimed in claim 6, wherein the light emitted from the light generating device is incident on the incident interface of the sample medium at the Brewster angle through the polarization state preparation device and the prism to generate the reflected light beam and the refracted light beam.
8. The method for the measurement and analysis of refractive index and optical rotation spectrum of the sample based on the quantum dot reduction measurement as claimed in claim 6 or 7, further comprising:
(7) Preparing a series of standard samples with different concentrations, and repeating the steps (1) to (6) to obtain a reflected light beam centroid traverse distance-refractive index change curve and a refracted light beam centroid traverse distance-optical rotation angle change curve of the series of standard samples;
(8) And (2) measuring the reflected beam centroid traverse distance and the reflected beam centroid traverse distance of the sample to be detected according to the step (1), and then obtaining the concentration, the refractive index and the optical rotation angle of the sample to be detected according to the reflected beam centroid traverse distance-refractive index change curve and the refracted beam centroid traverse distance-optical rotation angle change curve obtained in the step (7), wherein the optical rotation angles of the sample to be detected under different wavelengths form an optical rotation spectrum.
9. A method for measuring and analyzing the content of chiral molecular enantiomer based on quantum weak measurement, characterized in that the optical measuring instrument based on quantum weak measurement as claimed in any one of claims 1 to 5 is adopted, the sample is a solution of a substance containing chiral molecules, and the method comprises the following steps:
the method comprises the following steps that (1) light emitted by a light generating device (1) is incident to an incident interface of a sample (4) through a polarization state preparation device (2) and a prism (3) to generate a reflected light beam and a refracted light beam, the reflected light beam is received by a first light receiving device (6) through a first polarization state selector (5), and the refracted light beam is received by a second light receiving device (8) through a second polarization state selector (7); the traverse distance of the centroid of the reflected beam is recorded by the first light-receiving device (6) as the photon spin split value of the reflected beam<y r > the transverse moving distance of the centroid of the refracted beam is recorded by a second light receiving device (8) and is used as the photon spin splitting value of the refracted beam<y t >；
(2) According to the reflected light beam photon spin splitting value obtained in the step (1)<y r &Photon spin split value of refracted beam<y t &The ratio k in solution of chiral molecule-containing material relative to the optical rotation spectrum and refractive index properties of levorotatory material 1 、k 3 Ratio k in solution of substance containing chiral molecule related to optical rotation spectrum and refractive index property of dextrorotatory substance 2 、k 4 And (2) simultaneously calculating the levorotatory substance content x and the dextrorotatory substance content y in the solution according to the following formulas (ix) and (x):
k 1 x-k 2 y＝<y t > (ix)
k 3 x+k 4 y＝<y r > (x)
k is 1 When a single levorotatory substance exists, the refractive beam photon spin splitting value has the coefficient of change along with the concentration or the optical rotation angle of the solution containing the single levorotatory substance; k is 2 When the single dextro substance exists, the refractive beam photon spin splitting value has the variation coefficient along with the concentration or the optical rotation angle of the solution containing the single dextro substance; the describedk 3 When a single levorotatory substance exists, the change coefficient of the photon spin splitting value of the reflected light beam along with the concentration or the refractive index of the solution containing the single levorotatory substance; k is 4 When single dextro substance exists, the spin splitting value of reflected beam photon changes along with the concentration or refractive index of the solution containing single dextro substance.
10. The method for measuring and analyzing the content of chiral molecular enantiomers based on quantum weak measurement as claimed in claim 9, characterized in that the optical rotation angle and refractive index of the solution containing single levorotatory substance or single dextrorotatory substance are obtained by the measuring and analyzing method as claimed in any one of claims 6 to 8.
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| CN110388995B (en) * | 2019-07-02 | 2020-07-14 | 上海交通大学 | Optical high-precision temperature monitoring device and method based on quantum weak measurement theory |
| CN110579444A (en) * | 2019-09-28 | 2019-12-17 | 中国科学院合肥物质科学研究院 | Visible-near infrared light polarization spectrum detection probe and detection method thereof |
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| CN111812061A (en) * | 2020-06-29 | 2020-10-23 | 浙江工业大学 | Refractive index measuring method and system |
| CN112577928A (en) * | 2020-11-24 | 2021-03-30 | 北京邮电大学 | Design method of high-sensitivity chiral molecule detection structure based on TDBCs-Kretschmann |
| CN113587848A (en) * | 2021-08-16 | 2021-11-02 | 中国海洋大学 | Ultra-high precision optical element surface profile meter based on weak measurement theory |
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