CN107998013A - A kind of hand cleanser - Google Patents
A kind of hand cleanser Download PDFInfo
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- CN107998013A CN107998013A CN201711256406.6A CN201711256406A CN107998013A CN 107998013 A CN107998013 A CN 107998013A CN 201711256406 A CN201711256406 A CN 201711256406A CN 107998013 A CN107998013 A CN 107998013A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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Abstract
The invention belongs to daily chemical product field, and in particular to a kind of hand cleanser.The present invention is using sodium alginate as film forming binder,Chitosan is the raw material of blend film,Due to having primary amino radical in chitosan molecule chain,The strand of sodium alginate has carboxyl,Under electrostatic force,Can be by just,Negative electrical charge attracts to form polyelectrolyte film,So as to leave layer protecting film in skin,And the plasticizer glycerine for passing through small molecule,Interact between plasticizer molecule and polymer,Weaken the interaction force between macromolecular,So that intramolecule hydrogen bond action weakens,Reduce the crystal region of film and the ratio of amorphous region,Improve the infiltration vapor transmission rates of film,So as to prevent or slow down the loss of skin internal moisture,Keep the wetability of skin,Add Rosemary Oil,Essential oil molecule is set to be stored in the film with countless micropores,After the active material with bacteriostasis enters film in essential oil molecule,Film surface is gradually diffused to by micropore,So as to improve the anti-microbial property of skin surface.
Description
Technical field
The invention belongs to daily chemical product field, and in particular to a kind of hand cleanser.
Background technology
For people in life, both hands are readily accessible bacterium, dirt, and if hand in time, cannot be cleaned effectively,
Health may then be endangered.For the special occupation crowd such as doctor, nurse, hand cleaning more seems particularly heavy
Will.There is evening as a kind of new hand cleaning product, compared with traditional cleaning supplies such as perfumed soap, soap in hand cleanser, but it is because of tool
There is easy to use, time saving water-saving, avoid cross-infection, is easily stored, reducing the features such as nature consumption, therefore be subject to more and more disappear
Expense person's likes.With the raising that people require quality of life, the properties of product requirement to hand cleanser also increases therewith, not only
Ensure its cleannes, also to there is certain health-care efficacy, no skin irritatin, very few chemical addition agent etc..
But the function that existing hand cleanser products have is less, some fungicide use chemical products, some addition anti-corrosions
Agent etc..And hand cleanser of the prior art, largely there are cleaning dynamics it is not strong the characteristics of, and can produce in use big
For the foam of amount, it is necessary to consume substantial amounts of water, cleaning is difficult.
In addition, although the main function of hand cleanser is to play the role of cleaning, sterilization and skin care, compared to soap, perfumed soap
For, the component such as general without phosphorus, aluminium, alkali, sodium alkyl benzene sulfonate, using the principle of gentle decontamination, is easily received by skin.But
For the people of skin sensitivity, the synthetic chemical in hand cleanser may stimulate hand skin, to the easy allergy of skin
People be not suitable for using.
In summary, currently on the market hand cleanser brand, species is various, but majority is simply to play cleaning, decontamination
Effect, antibacterial, antibacterial or sterilization effect are poor, and most of is chemicals, and the chemical substance in hand cleanser can stimulate hand
Portion's skin, is not suitable for using to the people of the easy allergy of skin.
With the maturation of hand cleanser consumption market, consumer is needed it is desirable that multi-functional and mild hand cleanser
A kind of safety and the preferable hand cleanser of effect are wanted, to meet the needs of different crowd.
The content of the invention
The technical problems to be solved by the invention：It is the work for playing cleaning, decontamination for hand cleanser currently on the market
With the effect of antibacterial is poor, and most of the problem of being chemicals, stimulating hand skin, there is provided a kind of hand cleanser.
In order to solve the above technical problems, the present invention is using technical solution as described below：
A kind of hand cleanser, is counted in parts by weight, including 30 ~ 40 parts of surfactants, 1 ~ 4 part of thickener, 0.1 ~ 0.2 part of pH are adjusted
Agent, further includes 2 ~ 4 portions of protective agents, 0.05 ~ 0.1 portion of toner.
The surfactant is in mass ratio 10 ~ 13：1~2：3~6：4 ~ 8, by lauryl sodium sulfate, carboxymethyl cellulose
Plain sodium, dodecyldimethylamine oxide, alkylolamides are mixed, up to surfactant.
The thickener is sodium chloride.
The pH adjusting agent be tartaric acid, malic acid metatartaric acid it is therein any one.
Protectant preparation method：
（1）In mass ratio 1：3 ~ 4, sodium alginate, water are mixed, are heated to 50 ~ 60 DEG C, and carry out with 150 ~ 200r/min
Stirring, until being completely dissolved, adds the glycerine of sodium alginate quality 2 ~ 3%, obtains mixed liquor, in mass ratio 1：3 ~ 4, by chitosan,
1.0mol/L acetums are mixed, and are stirred with 120 ~ 150r/min, until being completely dissolved, add chitosan mass
1 ~ 2% crosslinking agent, adjusts pH value 5 ~ 6, obtains lysate, in mass ratio 5 ~ 6：1 ~ 2, lysate, mixed liquor are mixed, and
10 ~ 15min is stirred with 200 ~ 300r/min, liquid must be stirred；
（2）Rosemary leave is crushed, obtains crushed material, crushed material is put into extraction kettle, with 30 ~ 40mL/min
Flow velocity 1.0mol/L ethanol solutions are added into extraction kettle, and surpassed at 10 ~ 50MPa of pressure, 40 ~ 60 DEG C of temperature
Critical carbon dioxide fluid extraction, extraction time are 2 ~ 4h, obtain extract, in mass ratio 10 ~ 15：2~3：1 ~ 2, it will be stirred
Liquid, extract, preservative are mixed, and are stirred 8 ~ 10min with 100 ~ 200r/min, up to protective agent.
The step（2）Middle preservative be sodium benzoate, sorbic acid, potassium sorbate it is therein any one.
The toner is to wash with water red meat dragon fruit pericarp, section, then is freeze-dried, and obtains dried object, will
Dried object is crushed, and is crossed 30 ~ 40 mesh sieves, is obtained sieving, in mass ratio 1：20~30：0.2 ~ 0.3, by sieving, 1.0mol/L
Ethanol solution, citric acid carry out mixing extraction, and 40 ~ 60 DEG C of Extracting temperature, 60 ~ 80min of extraction time, obtains extracting solution, up to increasing
Toner.
Compared with other methods, advantageous effects are the present invention：
（1）For the present invention using sodium alginate as film forming binder, chitosan is the raw material of blend film, big due to having in chitosan molecule chain
The primary amino radical of amount, has substantial amounts of carboxyl on the strand of sodium alginate, under electrostatic force, can be inhaled by positive and negative electric charge
Draw to form polyelectrolyte film, so as to leave layer protecting film in skin, and by adding the plasticizer glycerine of small molecule, plasticising
Interact between agent molecule and polymer, weaken the interaction force between macromolecular so that intramolecule hydrogen bond action subtracts
It is weak, the crystal region of film and the ratio of amorphous region are reduced, improves the infiltration vapor transmission rates of film, so as to prevent or slow down in skin
The loss of portion's moisture, keeps the wetability of skin, while adds Rosemary Oil, essential oil molecule is present in film, and film is
With countless micropores, after there is the active material of bacteriostasis to enter film in essential oil molecule, film table is gradually diffused to by micropore
Face, so as to improve the anti-microbial property of skin surface.
（2）The present invention extracts a kind of extracting solution for assigning hand cleanser color from red meat dragon fruit pericarp, is washed so as to strengthen
The color of hand liquid, and extracting solution has scavenging action to superoxide anion, so that extracting solution has antioxidation activity, addition is washed one's hands
In liquid, oxidation-resistant active ingredient carries out free radical excessive in skin electron pairing, and reduction becomes water or other harmless things
Matter, so that slowing down free radical spreads unchecked caused ageing processes of skin.
（3）Hand cleanser in the present invention, is cooperated by each component, so as to assign antibacterial skin, wetability, antioxygen
The property changed, makes skin more moisten, and is made of the component of non-stimulated to human body or extremely low stimulation, and sensitive skin will not be produced
Stimulate, being capable of long-term safety use.
Embodiment
Surfactant is in mass ratio 10 ~ 13：1~2：3~6：4 ~ 8, by lauryl sodium sulfate, carboxymethyl cellulose
Sodium, dodecyldimethylamine oxide, alkylolamides are mixed, up to surfactant.
Thickener is sodium chloride.
PH adjusting agent be tartaric acid, malic acid metatartaric acid it is therein any one.
Protectant preparation method：
（1）In mass ratio 1：3 ~ 4, sodium alginate, water are mixed, are heated to 50 ~ 60 DEG C, and with
150 ~ 200r/min is stirred, until being completely dissolved, is added the glycerine of sodium alginate quality 2 ~ 3%, is obtained mixed liquor, press
Mass ratio 1：3 ~ 4, chitosan, 1.0mol/L acetums are mixed, and be stirred with 120 ~ 150r/min, until complete
Fully dissolved, adds the crosslinking agent of chitosan mass 1 ~ 2%, adjusts pH value 5 ~ 6, obtains lysate, in mass ratio 5 ~ 6：1 ~ 2, it will dissolve
Liquid, mixed liquor are mixed, and are stirred 10 ~ 15min with 200 ~ 300r/min, must be stirred liquid；
（2）Rosemary leave is crushed, obtains crushed material, crushed material is put into extraction kettle, with 30 ~ 40mL/min
Flow velocity 1.0mol/L ethanol solutions are added into extraction kettle, and surpassed at 10 ~ 50MPa of pressure, 40 ~ 60 DEG C of temperature
Critical carbon dioxide fluid extraction, extraction time are 2 ~ 4h, obtain extract, in mass ratio 10 ~ 15：2~3：1 ~ 2, it will be stirred
Liquid, extract, preservative are mixed, and are stirred 8 ~ 10min with 100 ~ 200r/min, up to protective agent.
Preservative be sodium benzoate, sorbic acid, potassium sorbate it is therein any one.
Toner is to wash with water red meat dragon fruit pericarp, section, then is freeze-dried, and dried object is obtained, by drying
Thing is crushed, and is crossed 30 ~ 40 mesh sieves, is obtained sieving, in mass ratio 1：20~30：0.2 ~ 0.3, by sieving, 1.0mol/L ethanol
Solution, citric acid carry out mixing extraction, and 40 ~ 60 DEG C of Extracting temperature, 60 ~ 80min of extraction time, obtains extracting solution, up to toner.
A kind of hand cleanser, including 30 ~ 40 parts of surfactants, 1 ~ 4 part of thickener, 0.1 ~ 0.2 part of pH adjusting agent, further include
2 ~ 4 portions of protective agents, 0.05 ~ 0.1 portion of toner.
Embodiment 1
Surfactant is in mass ratio 10：1：3：4, by lauryl sodium sulfate, sodium carboxymethylcellulose, dimethyl
Base amine oxide, alkylolamides are mixed, up to surfactant.
Thickener is sodium chloride.
PH adjusting agent is tartaric acid.
Protectant preparation method：
（1）In mass ratio 1：3, sodium alginate, water are mixed, are heated to 50 DEG C, and be stirred with 150r/min, until
It is completely dissolved, adds the glycerine of sodium alginate quality 2%, obtain mixed liquor, in mass ratio 1：3, by chitosan, 1.0mol/L acetic acid
Solution is mixed, and is stirred with 120r/min, until being completely dissolved, is added the crosslinking agent of chitosan mass 1%, is adjusted
PH value 5, obtains lysate, in mass ratio 5：1, lysate, mixed liquor are mixed, and 10min is stirred with 200r/min,
Liquid must be stirred；
（2）Rosemary leave is crushed, obtains crushed material, crushed material is put into extraction kettle, with 30mL/min
Flow velocity 1.0mol/L ethanol solutions are added into extraction kettle, and carry out overcritical two at pressure 10MPa, 40 DEG C of temperature
Carbon oxide fluid extracts, and extraction time 2h, obtains extract, in mass ratio 10：2：1, liquid, extract, anti-corrosion will be stirred
Agent is mixed, and is stirred 8min with 100r/min, up to protective agent.
Preservative is sodium benzoate.
Toner is to wash with water red meat dragon fruit pericarp, section, then is freeze-dried, and dried object is obtained, by drying
Thing is crushed, and is crossed 30 mesh sieves, is obtained sieving, in mass ratio 1：20：0.2, by sieving, 1.0mol/L ethanol solutions, lemon
Acid carries out mixing extraction, and 40 DEG C of Extracting temperature, extraction time 60min, obtains extracting solution, up to toner.
A kind of hand cleanser, including 30 parts of surfactants, 1 part of thickener, 0.1 part of pH adjusting agent, further include 2 parts of protections
Agent, 0.05 portion of toner.
Embodiment 2
Surfactant is in mass ratio 11：1：4：6, by lauryl sodium sulfate, sodium carboxymethylcellulose, dimethyl
Base amine oxide, alkylolamides are mixed, up to surfactant.
Thickener is sodium chloride.
PH adjusting agent is tartaric acid.
Protectant preparation method：
（1）In mass ratio 1：3, sodium alginate, water are mixed, are heated to 55 DEG C, and be stirred with 180r/min, until
It is completely dissolved, adds the glycerine of sodium alginate quality 2%, obtain mixed liquor, in mass ratio 1：3, by chitosan, 1.0mol/L acetic acid
Solution is mixed, and is stirred with 130r/min, until being completely dissolved, is added the crosslinking agent of chitosan mass 1%, is adjusted
PH value 5, obtains lysate, in mass ratio 5：1, lysate, mixed liquor are mixed, and 12min is stirred with 250r/min,
Liquid must be stirred；
（2）Rosemary leave is crushed, obtains crushed material, crushed material is put into extraction kettle, with 35mL/min
Flow velocity 1.0mol/L ethanol solutions are added into extraction kettle, and overcritical two are carried out under pressure 20MPa, temperature 50 C
Carbon oxide fluid extracts, and extraction time 3h, obtains extract, in mass ratio 12：2：1, liquid, extract, anti-corrosion will be stirred
Agent is mixed, and is stirred 9min with 150r/min, up to protective agent.
Preservative is sodium benzoate.
Toner is to wash with water red meat dragon fruit pericarp, section, then is freeze-dried, and dried object is obtained, by drying
Thing is crushed, and is crossed 35 mesh sieves, is obtained sieving, in mass ratio 1：25：0.2, by sieving, 1.0mol/L ethanol solutions, lemon
Acid carries out mixing extraction, and 50 DEG C of Extracting temperature, extraction time 70min, obtains extracting solution, up to toner.
A kind of hand cleanser, including 35 parts of surfactants, 3 parts of thickeners, 0.1 part of pH adjusting agent, further include 3 parts of protections
Agent, 0.07 portion of toner.
Embodiment 3
Surfactant is in mass ratio 13：2：6：8, by lauryl sodium sulfate, sodium carboxymethylcellulose, dimethyl
Base amine oxide, alkylolamides are mixed, up to surfactant.
Thickener is sodium chloride.
PH adjusting agent is malic acid metatartaric acid.
Protectant preparation method：
（1）In mass ratio 1：4, sodium alginate, water are mixed, are heated to 60 DEG C, and be stirred with 200r/min, until
It is completely dissolved, adds the glycerine of sodium alginate quality 3%, obtain mixed liquor, in mass ratio 1：3, by chitosan, 1.0mol/L acetic acid
Solution is mixed, and is stirred with 120r/min, until being completely dissolved, is added the crosslinking agent of chitosan mass 1%, is adjusted
PH value 5, obtains lysate, in mass ratio 5：1, lysate, mixed liquor are mixed, and 10min is stirred with 200r/min,
Liquid must be stirred；
（2）Rosemary leave is crushed, obtains crushed material, crushed material is put into extraction kettle, with 30mL/min
Flow velocity 1.0mol/L ethanol solutions are added into extraction kettle, and carry out overcritical two at pressure 10MPa, 40 DEG C of temperature
Carbon oxide fluid extracts, and extraction time 2h, obtains extract, in mass ratio 10：2：1, liquid, extract, anti-corrosion will be stirred
Agent is mixed, and is stirred 8min with 100r/min, up to protective agent.
Preservative is potassium sorbate.
Toner is to wash with water red meat dragon fruit pericarp, section, then is freeze-dried, and dried object is obtained, by drying
Thing is crushed, and is crossed 40 mesh sieves, is obtained sieving, in mass ratio 1：20：0.3, by sieving, 1.0mol/L ethanol solutions, lemon
Acid carries out mixing extraction, and 60 DEG C of Extracting temperature, extraction time 80min, obtains extracting solution, up to toner.
A kind of hand cleanser, including 40 parts of surfactants, 4 parts of thickeners, 0.2 part of pH adjusting agent, further include 4 parts of protections
Agent, 0.1 portion of toner.
Comparative example 1
Surfactant is in mass ratio 13：2：6：8, by lauryl sodium sulfate, sodium carboxymethylcellulose, dimethyl
Base amine oxide, alkylolamides are mixed, up to surfactant.
Thickener is sodium chloride.
PH adjusting agent is malic acid metatartaric acid.
Preservative is potassium sorbate.
A kind of hand cleanser, including 40 parts of surfactants, 4 parts of thickeners, 0.2 part of pH adjusting agent.
Comparative example 2
Surfactant is in mass ratio 13：2：6：8, by lauryl sodium sulfate, sodium carboxymethylcellulose, dimethyl
Base amine oxide, alkylolamides are mixed, up to surfactant.
Thickener is sodium chloride.
PH adjusting agent is malic acid metatartaric acid.
Protectant preparation method：
（1）In mass ratio 1：4, sodium alginate, water are mixed, are heated to 60 DEG C, and be stirred with 200r/min, until
It is completely dissolved, adds the glycerine of sodium alginate quality 3%, obtain mixed liquor, in mass ratio 1：3, by chitosan, 1.0mol/L acetic acid
Solution is mixed, and is stirred with 120r/min, until being completely dissolved, is added the crosslinking agent of chitosan mass 1%, is adjusted
PH value 5, obtains lysate, in mass ratio 5：1, lysate, mixed liquor are mixed, and 10min is stirred with 200r/min,
Liquid must be stirred；
（2）Rosemary leave is crushed, obtains crushed material, crushed material is put into extraction kettle, with 30mL/min
Flow velocity 1.0mol/L ethanol solutions are added into extraction kettle, and carry out overcritical two at pressure 10MPa, 40 DEG C of temperature
Carbon oxide fluid extracts, and extraction time 2h, obtains extract, in mass ratio 10：2：1, liquid, extract, anti-corrosion will be stirred
Agent is mixed, and is stirred 8min with 100r/min, up to protective agent.
Preservative is potassium sorbate.
A kind of hand cleanser, including 40 parts of surfactants, 4 parts of thickeners, 0.2 part of pH adjusting agent, further include 4 parts of protections
Agent.
Comparative example 3
Surfactant is in mass ratio 13：2：6：8, by lauryl sodium sulfate, sodium carboxymethylcellulose, dimethyl
Base amine oxide, alkylolamides are mixed, up to surfactant.
Thickener is sodium chloride.
PH adjusting agent is malic acid metatartaric acid.
Preservative is potassium sorbate.
Toner is to wash with water red meat dragon fruit pericarp, section, then is freeze-dried, and dried object is obtained, by drying
Thing is crushed, and is crossed 40 mesh sieves, is obtained sieving, in mass ratio 1：20：0.3, by sieving, 1.0mol/L ethanol solutions, lemon
Acid carries out mixing extraction, and 60 DEG C of Extracting temperature, extraction time 80min, obtains extracting solution, up to toner.
A kind of hand cleanser, including 40 parts of surfactants, 4 parts of thickeners, 0.2 part of pH adjusting agent, 0.1 portion of toner.
Comparative example 4：The hand cleanser of Guangzhou daily necessities Co., Ltd production
Method：According to the regulation of professional standard QB/T2850-2007, washing one's hands prepared by the embodiment and comparative example of equivalent is taken
Liquid, respectively carries out Escherichia coli and staphylococcus aureus fungistatic effect test, and activity is 1wt%, action time
It is 20 minutes, the quality of its anti-microbial property is characterized with this.
The specific detection case of hand cleanser such as table 1
Table 1
| Detection project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 |
| Escherichia coli antibiotic rate（%） | 52 | 65 | 78 | 50 | 47 | 43 | 37 |
| Staphylococcus aureus antibiotic rate（%） | 55 | 61 | 67 | 44 | 42 | 37 | 32 |
The hand cleanser that embodiment is produced with comparative example is chosen, four matter yellowish-brown adult guinea pigs are chosen, in its back both sides shaving
Hair-fields is gone into some.Swab stick used for cosmetic is coated with successively daily, detects the security of hand cleanser.
The specific detection case of hand cleanser security such as table 2
Table 2
| Detection project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 |
| Cutaneous safety | Have no adverse reaction | Have no adverse reaction | Have no adverse reaction | Have no adverse reaction | Skin turgor | Skin turgor | Skin turgor, allergy |
From the foregoing, it will be observed that embodiment 3 is example best in all embodiments, and various components used in above example are with good
Good synergistic effect, therefore, can be shown that from this patent, and the hand cleanser cleaning efficiency that the present invention is produced is high, and possesses good
Anti-microbial property, security and stability is high, is a kind of hand cleanser for being worthy to be popularized and using.
Claims (7)
1. a kind of hand cleanser, is counted in parts by weight, including 30 ~ 40 parts of surfactants, 1 ~ 4 part of thickener, 0.1 ~ 0.2 part of pH tune
Save agent, it is characterised in that further include 2 ~ 4 portions of protective agents, 0.05 ~ 0.1 portion of toner.
2. hand cleanser according to claim 1, it is characterised in that the surfactant is in mass ratio 10 ~ 13：1~2：3~
6：4 ~ 8, lauryl sodium sulfate, sodium carboxymethylcellulose, dodecyldimethylamine oxide, alkylolamides are mixed
Close, up to surfactant.
3. hand cleanser according to claim 1, it is characterised in that the thickener is sodium chloride.
4. hand cleanser according to claim 1, it is characterised in that the pH adjusting agent is tartaric acid, malic acid metatartaric acid
It is therein any one.
5. hand cleanser according to claim 1, it is characterised in that protectant preparation method：
（1）In mass ratio 1：3 ~ 4, sodium alginate, water are mixed, are heated to 50 ~ 60 DEG C, and carry out with 150 ~ 200r/min
Stirring, until being completely dissolved, adds the glycerine of sodium alginate quality 2 ~ 3%, obtains mixed liquor, in mass ratio 1：3 ~ 4, by chitosan,
1.0mol/L acetums are mixed, and are stirred with 120 ~ 150r/min, until being completely dissolved, add chitosan mass
1 ~ 2% crosslinking agent, adjusts pH value 5 ~ 6, obtains lysate, in mass ratio 5 ~ 6：1 ~ 2, lysate, mixed liquor are mixed, and
10 ~ 15min is stirred with 200 ~ 300r/min, liquid must be stirred；
（2）Rosemary leave is crushed, obtains crushed material, crushed material is put into extraction kettle, with 30 ~ 40mL/min
Flow velocity 1.0mol/L ethanol solutions are added into extraction kettle, and surpassed at 10 ~ 50MPa of pressure, 40 ~ 60 DEG C of temperature
Critical carbon dioxide fluid extraction, extraction time are 2 ~ 4h, obtain extract, in mass ratio 10 ~ 15：2~3：1 ~ 2, it will be stirred
Liquid, extract, preservative are mixed, and are stirred 8 ~ 10min with 100 ~ 200r/min, up to protective agent.
6. hand cleanser according to claim 5, it is characterised in that the step（2）Middle preservative is sodium benzoate, sorb
Acid, potassium sorbate it is therein any one.
7. hand cleanser according to claim 1, it is characterised in that the toner is that red meat dragon fruit pericarp water is clear
Wash, cut into slices, then be freeze-dried, obtain dried object, dried object is crushed, cross 30 ~ 40 mesh sieves, sieving is obtained, by quality
Than 1：20~30：0.2 ~ 0.3, sieving, 1.0mol/L ethanol solutions, citric acid are subjected to mixing extraction, Extracting temperature 40 ~ 60
DEG C, 60 ~ 80min of extraction time, obtains extracting solution, up to toner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711256406.6A CN107998013A (en) | 2017-12-04 | 2017-12-04 | A kind of hand cleanser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711256406.6A CN107998013A (en) | 2017-12-04 | 2017-12-04 | A kind of hand cleanser |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107998013A true CN107998013A (en) | 2018-05-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711256406.6A Withdrawn CN107998013A (en) | 2017-12-04 | 2017-12-04 | A kind of hand cleanser |
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| CN (1) | CN107998013A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109431889A (en) * | 2018-10-22 | 2019-03-08 | 中国热带农业科学院农产品加工研究所 | A kind of stems of dragon fruits hand cleanser and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109431889A (en) * | 2018-10-22 | 2019-03-08 | 中国热带农业科学院农产品加工研究所 | A kind of stems of dragon fruits hand cleanser and preparation method thereof |
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Application publication date: 20180508 |
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