CN107970896A - 环糊精－纤维素尿酸吸附剂的制备方法 - Google Patents

环糊精－纤维素尿酸吸附剂的制备方法 Download PDF

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CN107970896A
CN107970896A CN201610917046.9A CN201610917046A CN107970896A CN 107970896 A CN107970896 A CN 107970896A CN 201610917046 A CN201610917046 A CN 201610917046A CN 107970896 A CN107970896 A CN 107970896A
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cyclodextrin
cellulose
agent
uric acid
preparation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了一种环糊精－纤维素尿酸吸附剂的制备方法，属于尿酸吸附剂技术，该方法包括以下过程，将纤维素溶于NaOH溶液中，在该碱溶液中加入交联剂，在30－60℃进行2－10小时聚合反应；再按聚合物与环糊精的质量比为2－6∶1加入环糊精，在30－60℃反应2－6小时，反应结束后经干燥、粉碎，得到环糊精－纤维素吸附剂，所述纤维素为微晶纤维素或Α－纤维素；所述交联剂选自环氧氯丙烷、1，2－乙二醇二缩水甘油醚或1，2－丁二醇二缩水甘油醚；所述环糊精为Β－环糊精、甲基Β－环糊精或羟丙基Β－环糊精，本发明的优点在于制备工艺简单，制得吸附剂吸附速率快、结合能力强、不易脱落，在4h吸附能力为150μg/G，并且无毒副作用，制作原料来源方便，价格便宜。

Description

环糊精－纤维素尿酸吸附剂的制备方法
技术领域
本发明是关于一种环糊精-纤维素尿酸吸附剂的制备方法，属于尿酸吸附剂技术。
背景技术
尿酸是人体内一种重要的代谢物，尤其出现在慢性肾功能衰竭、高尿酸血症和高脂血症等疾病中，临床上一般采用血液透析的方法，而口服吸附剂是一种新型的、使用方便、有效的治疗方法，其原理是，服下的吸附剂到达人体的肠道后，吸附蓄积在体内的毒物，随同粪便一起排出体外，从而可以达到缓解病症，抑制病情进一步恶化的目的，迄今国内没有关于尿酸口服吸附剂的研究报道。
发明内容
本发明的目的在于提供一种环糊精-纤维素尿酸吸附剂的制备方法，该方法制备工艺简单、所制备的吸附剂对尿酸吸附能力强，价格低廉，本发明是通过下述技术方案加以实现的，一种制备环糊精-纤维素尿酸吸附剂的方法，其特征包括以下过程1)将纤维素溶于浓度为20-30％的NaOH溶液中，按其与交联剂的体积比25-300％，在碱溶液中加入交联剂，在30-60℃进行2-10小时聚合反应；2)在上述反应液中，按聚合物与环糊精的质量比为2-6∶1加入环糊精，在30-60℃反应2-6小时，反应结束后经干燥、粉碎，得到环糊精-纤维素吸附剂，上述纤维素为微晶纤维素或Α-纤维素，上述交联剂选自环氧氯丙烷、1，2-乙二醇二缩水甘油醚或1，2-丁二醇二缩水甘油醚，上述环糊精为Β-环糊精、甲基Β-环糊精或羟丙基Β-环糊精，本发明的优点在于制备工艺简单，所制得吸附剂吸附速率快、结合能力强、不易脱落，在4h吸附能力为150μg/G，并且无毒副作用，制作原料来源方便，价格便宜。

Claims (1)

1.一种环糊精-纤维素尿酸吸附剂的制备方法，其特征包括以下过程1)将纤维素溶于浓度为20-30％的NaOH溶液中，按其与交联剂的体积比25-300％，在碱溶液中加入交联剂，在30-60℃进行2-10小时聚合反应；2)在上述反应液中，按聚合物与环糊精的质量比为2-6∶1加入环糊精，在30-60℃反应2-6小时，反应结束后经干燥、粉碎，得到环糊精-纤维素吸附剂。
CN201610917046.9A 2016-10-21 2016-10-21 环糊精－纤维素尿酸吸附剂的制备方法 Pending CN107970896A (zh)

Priority Applications (1)

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CN201610917046.9A CN107970896A (zh) 2016-10-21 2016-10-21 环糊精－纤维素尿酸吸附剂的制备方法

Applications Claiming Priority (1)

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CN201610917046.9A CN107970896A (zh) 2016-10-21 2016-10-21 环糊精－纤维素尿酸吸附剂的制备方法

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CN107970896A true CN107970896A (zh) 2018-05-01

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109908875A (zh) * 2019-04-12 2019-06-21 兰州大学 一种去除污水中正电性药物的方法
CN115301215A (zh) * 2022-08-16 2022-11-08 西安交通大学 一种2-羟丙基-β-环糊精聚合物吸附剂的制备方法和应用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109908875A (zh) * 2019-04-12 2019-06-21 兰州大学 一种去除污水中正电性药物的方法
CN109908875B (zh) * 2019-04-12 2021-06-15 兰州大学 一种去除污水中正电性药物的方法
CN115301215A (zh) * 2022-08-16 2022-11-08 西安交通大学 一种2-羟丙基-β-环糊精聚合物吸附剂的制备方法和应用

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Application publication date: 20180501