CN107970644A - A kind of extraction separation device for bio-pharmaceuticals - Google Patents
A kind of extraction separation device for bio-pharmaceuticals Download PDFInfo
- Publication number
- CN107970644A CN107970644A CN201711127280.2A CN201711127280A CN107970644A CN 107970644 A CN107970644 A CN 107970644A CN 201711127280 A CN201711127280 A CN 201711127280A CN 107970644 A CN107970644 A CN 107970644A
- Authority
- CN
- China
- Prior art keywords
- extraction
- cucurbit
- bio
- condenser pipe
- separation device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
The invention discloses a kind of extraction separation device for bio-pharmaceuticals,Including base,The upper surface of base is provided with extraction equipment and separator,Extraction equipment includes supporting rack and extraction body,The top of extraction body is provided with lid,Lid is provided centrally with through hole,Through hole is internally provided with shaft,Some stirring sheets are evenly arranged with shaft,Extractant entrance is provided with extraction body left surface,The bottom of extraction body is provided with discharge port,Discharge port is linked together by the first pipeline with separator,Separator includes distilling period and condenser pipe,Distilling period includes cucurbit and some heating rods,Cucurbit left end links together with discharge port,The right end of cucurbit links together with condenser pipe,The upper end of condenser pipe is provided with water inlet,The lower end of condenser pipe is provided with water outlet,It can realize the function of extract and separate,It can effectively solve the problem that the problem of background technology proposes,It is worthy to be popularized.
Description
Technical field
The present invention relates to biopharmaceutical technology, is specially a kind of extraction separation device for bio-pharmaceuticals.
Background technology
Bio-pharmaceutical refers to the achievement in research with microbiology, biology, medicine, biochemistry etc., from organism, life
The science such as thing tissue, cell, organ, body fluid etc., comprehensive utilization microbiology, chemistry, biochemistry, biotechnology, pharmacy
Principle and one kind of method manufacture are used for the product that prevents, treat and diagnose, bio-pharmaceuticals raw material using natural biomaterial as
It is main, including microorganism, human body, animal, plant, marine organisms etc., with the reach of science, bio-pharmaceuticals is in field of medical technology
Be more and more widely used, existing bio-pharmaceuticals in process of production, it is necessary to using extract and separate operation, existing extraction
Lock out operation is taken to include extraction, distillation and condense, in distillation process, generally use alcolhol burner is heated, which deposits
It is even in uneven heating, heat the shortcomings that slow, and also existing bio-pharmaceuticals extraction separation device is when carrying out extracting operation, and it is spent
Time it is long, during due to extraction, solution to be extracted and extractant upon mixing, it is necessary to stand a very long time could reality
Now it is layered, so as to carry out follow-up extracting operation, if it is possible to extractant is sufficiently mixed with solution to be extracted, then stand, then
The required time is just greatly reduced, and conventional hybrid operation is mostly manually to complete, and the work for considerably increasing the producer bears
Load, improves the operating cost of bio-pharmaceuticals, furthermore, existing bio-pharmaceuticals extraction separation device is all often split type knot
Structure, first extracts, and then realizes separation on another device, it is impossible to completes the operation of extract and separate in same device, structure compares
It is complicated.
The content of the invention
In order to overcome the shortcomings of prior art, the present invention provides a kind of extraction separation device for bio-pharmaceuticals,
It is simple in structure, easy to operate, it can realize the function of extract and separate, can effectively solve the problem that the problem of background technology proposes, be worth
Promote.
The technical solution adopted by the present invention to solve the technical problems is：A kind of extract and separate for bio-pharmaceuticals fills
Put, including base, the upper surface of the base is provided with extraction equipment and separator, the extraction equipment include supporting rack and
Columned extraction body, the extraction body are arranged on the top of supporting rack, and the top of the extraction body is provided with lid,
The lid is provided centrally with through hole, and the through hole is internally provided with shaft, and the top of the shaft is connected by belt and motor
It is connected together, the bottom of the shaft extends to the inside of extraction body through through hole, and the bottom of the shaft is infinitely close
Extract the bottom of body but do not contact, some stirring sheets are evenly arranged with the shaft, are set on the extraction body left surface
Extractant entrance is equipped with, the bottom of the extraction body is provided with discharge port, and the discharge port is by the first pipeline with separating dress
Put and be connected together, valve is provided with first pipeline, the separator includes distilling period and condenser pipe, the distilling period
Including cucurbit and some heating rods, the heating rod is arranged on the inside of cucurbit, and the cucurbit left end connects with discharge port
It is connected together, right end and the condenser pipe of the cucurbit link together, and the condenser pipe is double-decker, the condenser pipe
Upper end is provided with water inlet, and the lower end of the condenser pipe is provided with water outlet, liquid-collecting bottle is provided with the right side of the condenser pipe.
As a kind of preferable technical solution of the present invention, the condenser pipe includes internal layer and outer layer, the outer layer and internal layer
Integral structure, is hollow interlayer between the internal layer and outer layer, and the left and right both ends of the internal layer extend to the left and right of outer layer
On the outside of both ends, left end and the cucurbit of the internal layer link together, and the right end of the internal layer is connected with casing, the collection
Liquid bottle is arranged on the underface of casing.
As a kind of preferable technical solution of the present invention, the inner surface of the internal layer is provided with copper, described copper
Thermal grease layer is provided between internal layer.
As a kind of preferable technical solution of the present invention, the position of water inlet is provided with cascade in the hollow interlayer
Device, the water screen apparatus include seal cup and water distributing tray, and the seal cup is arranged on the inside of water inlet, the seal cup
Top is extended on the outside of water inlet, and the bottom of the seal cup extends to the inner side of water inlet, and the water distributing tray is arranged on overflow
The lower section of disk.
As a kind of preferable technical solution of the present invention, two spout holes, the water distributing tray are provided with the seal cup
On be provided with four water distributing pores.
As a kind of preferable technical solution of the present invention, feet block is provided with below the base, the feet block
Lower section is provided with anti-skid rubber cushion, and the surface of the anti-skid rubber cushion is provided with the protrusion of some spherical structures, and the feet
The height of block is between 1cm-2cm.
As a kind of preferable technical solution of the present invention, the stirring sheet is made of soft plastic material.
As a kind of preferable technical solution of the present invention, the heating rod is uniformly arranged on cucurbit bottom and cucurbit
On medial surface.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) present invention realizes the function after being stirred, is added in body is extracted by setting shaft and stirring sheet
After extractant and solution to be extracted, first drive stirring sheet to rotate using shaft, be sufficiently mixed it, then stop stirring, then it is quiet
After putting a period of time, you can complete extracting operation, substantially reduce the time that need to be stood, improve the efficiency of bio-pharmaceuticals.
(2) present invention realizes the function of extraction and separation one, completes extracting operation by setting separator
Afterwards, you can carry out lock out operation so that the structure of overall extraction separation device is simpler, and operation is also more convenient, so that
Accelerate the speed of extract and separate, improve production efficiency.
(3) present invention directly can heat the liquid in cucurbit in the inside of cucurbit by setting heating rod,
Greatly accelerate the speed of heating so that overall inside cucurbit to be heated evenly, so as to improve efficiency and the distillation of distillation
Quality.
Brief description of the drawings
Fig. 1 is the overall structure diagram of the present invention；
Fig. 2 is copper and the condenser pipe attachment structure schematic diagram of the present invention；
Fig. 3 is the water screen apparatus structure diagram of the present invention.
In figure：1- bases；2- extraction equipments；3- separators；4- supporting racks；5- extracts body；6- lids；7- through holes；
8- shafts；9- stirring sheets；10- extractant entrances；11- discharge ports；The first pipelines of 12-；13- distilling periods；14- condenser pipes；15- steams
Evaporate bottle；16- heating rods；18- valves；19- water inlets；20- water outlets；21- liquid-collecting bottles；22- internal layers；23- outer layers；24- is hollow
Interlayer；25- casings；Copper of 26-；27- thermal grease layers；28- water screen apparatus；29- seal cups；30- water distributing trays；31- overflows
Hole；32- water distributing pores；33- feet blocks；34- anti-skid rubber cushions.
Embodiment
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other without making creative work
Embodiment, belongs to the scope of protection of the invention.
The explanation of following embodiment is refer to the attached drawing, can be to the specific embodiment implemented to the example present invention.
The direction and position term that the present invention is previously mentioned, for example, " on ", " in ", " under ", "front", "rear", "left", "right", " interior ", "
Outside ", " side " etc., is only direction and position with reference to annexed drawings.Therefore, the direction and position term used is to illustrate
And understand the present invention, and it is not used to the limitation present invention.
Embodiment：
As shown in Figure 1, a kind of extraction separation device for bio-pharmaceuticals, including base 1, the upper surface of the base 1
Extraction equipment 2 and separator 3 are provided with, the extraction equipment 2 includes supporting rack 4 and columned extraction body 5, the extraction
Body 5 is taken to be arranged on the top of supporting rack 4, the top of the extraction body 5 is provided with lid 6, and the lid 6 is provided centrally with
Through hole 7, the through hole 7 are internally provided with shaft 8, and the top of the shaft 8 is linked together by belt and motor, described turn
The bottom of axis 8 extends to the inside of extraction body 5 through through hole 7, and the bottom of the shaft 8 is infinitely close to extraction body 5
Bottom but do not contact, some stirring sheets 9 are evenly arranged with the shaft 8, extraction is provided with extraction 5 left surface of body
Agent entrance 10, opens lid 6, pours into solution to be extracted, then extractant is injected through extractant entrance 10, in the effect of motor
Under so that shaft 8 rotates, and shaft 8, which rotates, drives stirring sheet 9 to rotate, so as to fulfill extractant and solution to be extracted is fully mixed
The effect of conjunction, then stands, and the bottom of the extraction body 5 is provided with discharge port 11, and the discharge port 11 passes through the first pipeline
12 are connected together with separator 3, and valve 18 is provided with first pipeline 12, and the separator 3 includes distilling period 13
With condenser pipe 14, the distilling period 13 includes cucurbit 15 and some heating rods 16, and the heating rod 16 is arranged on cucurbit 15
Inside, heating rod 16 plays the role of cucurbit 15 heating, and 15 left end of cucurbit links together with discharge port 11,
The right end of the cucurbit 15 links together with condenser pipe 14, and the condenser pipe 14 is double-decker, the condenser pipe 14
Upper end is provided with water inlet 19, and the lower end of the condenser pipe 14 is provided with water outlet 20, and the right side of the condenser pipe 14 is provided with
Liquid-collecting bottle 21, during condensation, injects cold water by water inlet 19, the hot gas in cucurbit 15 is carried out in condenser pipe 14 cold
After solidifying, flowed out through water outlet 20；The condenser pipe 14 includes internal layer 22 and outer layer 23, the knot integrated with internal layer 22 of outer layer 23
Structure, is hollow interlayer 24 between the internal layer 22 and outer layer 23, the left and right both ends of the internal layer 22 extend to a left side for outer layer 23,
On the outside of right both ends, left end and the cucurbit 15 of the internal layer 22 link together, and the right end of the internal layer 22 is connected with casing 25,
The liquid-collecting bottle 21 is arranged on the underface of casing 25；The lower section of the base 1 is provided with feet block 33, and the feet block 33
Height between 1cm-2cm, the setting of feet block 33 plays the role of protecting base 1, enhances the corrosion resistant of 1 bottom surface of base
Corrosion, improves its service life, and the lower section of the feet block 33 is provided with anti-skid rubber cushion 34, the setting of anti-skid rubber cushion 34
Play anti-skidding effect；The stirring sheet 9 is made of soft plastic material, and soft plastic material is good, prolonged resistance to plasticity
The advantages of using；The heating rod 16 is uniformly arranged on 15 medial surface of 15 bottom of cucurbit and cucurbit so that cucurbit 15
Inside is heated evenly.
As shown in Fig. 2, the inner surface of the internal layer 22 is provided with copper 26, described copper 26 sets between internal layer 22
It is equipped with thermal grease layer 27, the setting of copper 26 and thermal grease layer 27 plays the role of heat conduction, will flow through internal layer 22
The temperature of interior hot gas is quickly passed to internal layer 22 through copper 26 and thermal grease layer 27, then by internal layer 22 outside it is hollow
Cold water in interlayer 24 condenses it.
As shown in figure 3, the position in the hollow interlayer 24 close to water inlet 19 is provided with water screen apparatus 28, the cascade
Device 28 includes seal cup 29 and water distributing tray 30, and the seal cup 29 is arranged on the inside of water inlet 19, the seal cup 29
Top extends to the outside of water inlet 19, and the bottom of the seal cup 29 extends to the inner side of water inlet 19, and the water distributing tray 30 is set
Put and add condensation time of the cold water in condenser pipe 14 in the lower section of seal cup 29, the setting of water screen apparatus 28, make cucurbit
The hot gas produced in 15 can fully be condensed in condenser pipe 14；Two spout holes are provided with the seal cup 29
31, four water distributing pores 32 are provided with the water distributing tray 30, spout hole 31 and water distributing pore 32 are set so that cold water is in condenser pipe 14
In it is longer with the time of contact of hot gas, so as to improve condensation effect.
In conclusion the main characteristic of the invention lies in that：
(1) present invention realizes the function after being stirred, is added in body is extracted by setting shaft and stirring sheet
After extractant and solution to be extracted, first drive stirring sheet to rotate using shaft, be sufficiently mixed it, then stop stirring, then it is quiet
After putting a period of time, you can complete extracting operation, substantially reduce the time that need to be stood, improve the efficiency of bio-pharmaceuticals.
(2) present invention realizes the function of extraction and separation one, completes extracting operation by setting separator
Afterwards, you can carry out lock out operation so that the structure of overall extraction separation device is simpler, and operation is also more convenient, so that
Accelerate the speed of extract and separate, improve production efficiency.
(3) present invention directly can heat the liquid in cucurbit in the inside of cucurbit by setting heating rod,
Greatly accelerate the speed of heating so that overall inside cucurbit to be heated evenly, so as to improve efficiency and the distillation of distillation
Quality.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.Any reference numeral in claim should not be considered as to the involved claim of limitation.
Claims (8)
1. a kind of extraction separation device for bio-pharmaceuticals, including base (1), the upper surface of the base (1) is provided with extraction
Take device (2) and separator (3), it is characterised in that：The extraction equipment (2) includes supporting rack (4) and columned extraction
Body (5), the extraction body (5) are arranged on the top of supporting rack (4), and the top of the extraction body (5) is provided with lid
(6), the lid (6) is provided centrally with through hole (7), and the through hole (7) is internally provided with shaft (8), the top of the shaft (8)
End is linked together by belt and motor, and the bottom of the shaft (8) extends to the interior of extraction body (5) through through hole (7)
Portion, and the bottom of the shaft (8) close to the bottom of extraction body (5) but does not contact infinitely, is uniformly arranged on the shaft (8)
There are some stirring sheets (9), extractant entrance (10) is provided with described extraction body (5) left surface, the extraction body (5)
Bottom is provided with discharge port (11), and the discharge port (11) is connected together by the first pipeline (12) and separator (3), described
Valve (18) is provided with first pipeline (12), the separator (3) includes distilling period (13) and condenser pipe (14), the steaming
Evaporating section (13) includes cucurbit (15) and some heating rods (16), and the heating rod (16) is arranged on the inside of cucurbit (15),
Cucurbit (15) left end links together with discharge port (11), and the right end of the cucurbit (15) is connected with condenser pipe (14)
Together, the condenser pipe (14) is double-decker, and the upper end of the condenser pipe (14) is provided with water inlet (19), the condensation
The lower end of pipe (14) is provided with water outlet (20), and liquid-collecting bottle (21) is provided with the right side of the condenser pipe (14).
A kind of 2. extraction separation device for bio-pharmaceuticals according to claim 1, it is characterised in that：The condenser pipe
(14) include internal layer (22) and outer layer (23), the outer layer (23) and internal layer (22) integral structure, the internal layer (22) with it is outer
It is hollow interlayer (24) between layer (23), the left and right both ends of the internal layer (22) are extended to outside the left and right both ends of outer layer (23)
Side, left end and the cucurbit (15) of the internal layer (22) link together, and the right end of the internal layer (22) is connected with casing (25),
The liquid-collecting bottle (21) is arranged on the underface of casing (25).
A kind of 3. extraction separation device for bio-pharmaceuticals according to claim 2, it is characterised in that：The internal layer
(22) inner surface is provided with copper (26), and thermal grease layer is provided between copper (26) and internal layer (22)
(27)。
A kind of 4. extraction separation device for bio-pharmaceuticals according to claim 2, it is characterised in that：The hollow folder
Position in layer (24) close to water inlet (19) is provided with water screen apparatus (28), and the water screen apparatus (28) includes seal cup (29)
With water distributing tray (30), the seal cup (29) is arranged on the inside of water inlet (19), and the top of the seal cup (29) extends to
On the outside of water inlet (19), the bottom of the seal cup (29) extends to the inner side of water inlet (19), and the water distributing tray (30) is set
In the lower section of seal cup (29).
A kind of 5. extraction separation device for bio-pharmaceuticals according to claim 4, it is characterised in that：The seal cup
(29) two spout holes (31) are provided with, four water distributing pores (32) are provided with the water distributing tray (30).
A kind of 6. extraction separation device for bio-pharmaceuticals according to claim 1, it is characterised in that：The base
(1) it is provided with feet block (33) below, and the height of the feet block (33) is between 1cm-2cm, the feet block (33)
Lower section be provided with anti-skid rubber cushion (34).
A kind of 7. extraction separation device for bio-pharmaceuticals according to claim 1, it is characterised in that：The stirring sheet
(9) it is made of soft plastic material.
A kind of 8. extraction separation device for bio-pharmaceuticals according to claim 1, it is characterised in that：The heating rod
(16) it is uniformly arranged on cucurbit (15) bottom and cucurbit (15) medial surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711127280.2A CN107970644A (en) | 2017-11-15 | 2017-11-15 | A kind of extraction separation device for bio-pharmaceuticals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711127280.2A CN107970644A (en) | 2017-11-15 | 2017-11-15 | A kind of extraction separation device for bio-pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107970644A true CN107970644A (en) | 2018-05-01 |
Family
ID=62013480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711127280.2A Pending CN107970644A (en) | 2017-11-15 | 2017-11-15 | A kind of extraction separation device for bio-pharmaceuticals |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107970644A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1118278A (en) * | 1995-06-12 | 1996-03-13 | 张贺忠 | Multifunctional continuous extracting pot |
| CN105154236A (en) * | 2015-09-23 | 2015-12-16 | 陈富强 | Full-automatic electric heating triple-effect plant essential oil extracting and purifying integrated device |
| CN205269085U (en) * | 2015-12-31 | 2016-06-01 | 李世德 | Draw distillation plant of volatility traditional chinese medicine in plant |
| CN205590650U (en) * | 2016-04-25 | 2016-09-21 | 遵义市永胜金属设备有限公司 | Making wine cooler |
| CN206476930U (en) * | 2017-02-09 | 2017-09-08 | 武汉天惠生物工程有限公司 | A kind of preparation facilities of AVM |
-
2017
- 2017-11-15 CN CN201711127280.2A patent/CN107970644A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1118278A (en) * | 1995-06-12 | 1996-03-13 | 张贺忠 | Multifunctional continuous extracting pot |
| CN105154236A (en) * | 2015-09-23 | 2015-12-16 | 陈富强 | Full-automatic electric heating triple-effect plant essential oil extracting and purifying integrated device |
| CN205269085U (en) * | 2015-12-31 | 2016-06-01 | 李世德 | Draw distillation plant of volatility traditional chinese medicine in plant |
| CN205590650U (en) * | 2016-04-25 | 2016-09-21 | 遵义市永胜金属设备有限公司 | Making wine cooler |
| CN206476930U (en) * | 2017-02-09 | 2017-09-08 | 武汉天惠生物工程有限公司 | A kind of preparation facilities of AVM |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN206315491U (en) | A kind of vacuum distillation system | |
| CN202478645U (en) | Ultrasonic extraction and concentration circulation device | |
| CN206591098U (en) | A kind of wine distilling apparatus | |
| CN107970644A (en) | A kind of extraction separation device for bio-pharmaceuticals | |
| CN206965191U (en) | Alcohol precipitation concentration systems and alcohol sinking system | |
| CN100534407C (en) | Concentrated machine for distilling Chinese herbal medicine | |
| CN206543429U (en) | A kind of pressurized high-temperature extraction element extracted for donkey-hide gelatin | |
| CN206715366U (en) | A kind of Microwave Extraction Chinese traditional medicine purification device | |
| CN207726772U (en) | A kind of grease treatment box | |
| CN206996494U (en) | A kind of heating stirring system | |
| CN205686916U (en) | A kind of a species of small clam living in fresh water juice fill tank of Anti-solidification | |
| CN205379681U (en) | Highly enriched extrinsic cycle MVR evaporimeter | |
| CN207356615U (en) | Hot reflux extracting-concentration machine group | |
| CN209237380U (en) | It is a kind of with gas from the fine chemicals distillation still of backflow functionality | |
| CN205516610U (en) | Energy -saving traditional chinese medicine granule circulation extraction device | |
| CN206915798U (en) | A kind of multitower continuous still preparation system of low deuterium-oxide | |
| CN207755792U (en) | A kind of honey concentrator | |
| CN207575460U (en) | A kind of medicine materical crude slice component extracting of Ginseng-plum lozenge | |
| CN213977499U (en) | Antibody extraction equipment | |
| CN206404344U (en) | A kind of new fractionating column | |
| CN207646167U (en) | A kind of extraction of essential oil device | |
| CN2596984Y (en) | Chinese medicine extraction and concentration machine | |
| CN207169102U (en) | A kind of highly effective and safe performance Chinese herbal medicine effective ingredientses extractor | |
| CN206008224U (en) | A kind of membrane type filter core for olive oil production line | |
| CN205758983U (en) | A kind of multi-functional Chinese medicine decoction pieces maker |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180501 |
|
| RJ01 | Rejection of invention patent application after publication |