CN107970419A - 治疗抑郁的中药组合物的制备方法 - Google Patents
治疗抑郁的中药组合物的制备方法 Download PDFInfo
- Publication number
- CN107970419A CN107970419A CN201711372594.9A CN201711372594A CN107970419A CN 107970419 A CN107970419 A CN 107970419A CN 201711372594 A CN201711372594 A CN 201711372594A CN 107970419 A CN107970419 A CN 107970419A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- small
- seed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 24
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 230000000994 depressogenic effect Effects 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- MUKYLHIZBOASDM-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid 2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound NC(=N)N(C)CC(O)=O.OCC(O)C(O)C(O)C(O)C(O)=O MUKYLHIZBOASDM-UHFFFAOYSA-N 0.000 claims abstract description 14
- 240000009206 Hemerocallis fulva Species 0.000 claims abstract description 14
- 235000002941 Hemerocallis fulva Nutrition 0.000 claims abstract description 14
- 239000009636 Huang Qi Substances 0.000 claims abstract description 14
- 235000002789 Panax ginseng Nutrition 0.000 claims abstract description 14
- 240000002924 Platycladus orientalis Species 0.000 claims abstract description 14
- 241001533104 Tribulus terrestris Species 0.000 claims abstract description 14
- 239000012530 fluid Substances 0.000 claims abstract description 6
- 239000000126 substance Substances 0.000 claims abstract description 6
- 238000011282 treatment Methods 0.000 claims description 13
- 238000000605 extraction Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 25
- 238000004519 manufacturing process Methods 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 9
- 208000019901 Anxiety disease Diseases 0.000 abstract description 7
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract description 5
- 239000011149 active material Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000006870 function Effects 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 238000005728 strengthening Methods 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000020925 Bipolar disease Diseases 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 208000028683 bipolar I disease Diseases 0.000 description 1
- 208000025307 bipolar depression Diseases 0.000 description 1
- 230000005059 dormancy Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 230000006996 mental state Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000001671 psychotherapy Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及到医疗领域,具体而言是治疗抑郁的中药组合物,将萱草花、郁金、红参、黄芪、柏子仁、蒺藜、刺五加、三棱和半枝莲混合后加8‑12倍的水,煎煮1小时,再次加水至原料药总质量的10‑12倍,再次煎煮2小时;第三次加水至总药量6‑8倍,煎煮3次,每次1小时,提取过滤液,得到活性物质。本发明的制造方法简单,并且工艺不复杂,对于工艺环境的要求也不高,国内企业很容易制得,无需额外对生产设备进行投资和购买。本发明完全采用中药组份,具有抗抑郁、抗焦虑的功能,治疗抑郁症、焦虑症疗效确切、起效快。各个配方之间能够相互配合,发挥效力。
Description
技术领域
本发明涉及到医疗领域,具体而言是治疗抑郁的中药组合物的制备方法。
背景技术
抑郁症的诊断主要应根据病史、临床症状、病程及体格检查和实验室检查,典型病例诊断一般不困难。国际上通用的诊断标准一般有ICD-10和DSM-IV。国内主要采用ICD-10,是指首次发作的抑郁症和复发的抑郁症,不包括双相抑郁。患者通常具有心境低落、兴趣和愉快感丧失、精力不济或疲劳感等典型症状。其他常见的症状是①集中注意和注意的能力降低;②自我评价降低;③自罪观念和无价值感(即使在轻度发作中也有);④认为前途暗淡悲观;⑤自伤或自杀的观念或行为;⑥睡眠障碍;⑦食欲下降。病程持续至少2周。有人对抑郁症患者追踪10年的研究发现,有75%~80%的患者多次复发,故抑郁症患者需要进行预防性治疗。发作3次以上应长期治疗,甚至终身服药。维持治疗药物的剂量多数学者认为应与治疗剂量相同,还应定期门诊随访观察。心理治疗和社会支持系统对预防本病复发也有非常重要的作用,应尽可能解除或减轻患者过重的心理负担和压力,帮助患者解决生活和工作中的实际困难及问题,提高患者应对能力,并积极为其创造良好的环境,以防复发。
但是现在治疗抑郁的药物的制备方法对于设备和环境的要求太高,一般的药厂需要投入巨资对现有的厂房设备进行改进和升级。
发明内容
为了克服现有的技术存在的上述问题,现特别提出一种对人体副作用小,但是失眠疗效和西药相当的中药组合物。
为实现上述技术目的,本发明的技术方案如下:
治疗抑郁的中药组合物,其特征在于:将萱草花、郁金、红参、黄芪、柏子仁、蒺藜、刺五加、三棱和半枝莲混合后加8-12倍的水,煎煮1小时,再次加水至原料药总质量的10-12倍,再次煎煮2小时;第三次加水至总药量6-8倍,煎煮3次,每次1小时,提取过滤液,得到活性物质。
所述萱草花50-70份,郁金20-35份,红参15-25份,黄芪10-20份,柏子仁15-20份,蒺藜22-35份。
所述萱草花55-65份,郁金25-30份,红参17-23份,黄芪12-18份,柏子仁17-19份,蒺藜27-31份。
所述萱草花60份,郁金28份,红参21份,黄芪14份,柏子仁18份,蒺藜30份。
所述刺五加12-18份,三棱5-8份,半枝莲12-20份。
所述刺五加15份,三棱6份,半枝莲16份。
本发明的优点在于:
本发明的制造方法简单,并且工艺不复杂,对于工艺环境的要求也不高,国内企业很容易制得,无需额外对生产设备进行投资和购买。本发明完全采用中药组份,具有抗抑郁、抗焦虑的功能,治疗抑郁症、焦虑症疗效确切、起效快。各个配方之间能够相互配合,发挥效力,而且对人体副作用较之西药降低很多,原料种类少,易于获得,并且无论在预防和/或治疗抑郁症还是在更年期综合症上都具有良好的效果。药物组合物具有疏肝健脾、解郁安神的功效,可有效地抗抑郁,并且价格低廉、易于较大范围地使用。
具体实施方式
实施例1
治疗抑郁的中药组合物,其特征在于:将萱草花、郁金、红参、黄芪、柏子仁、蒺藜、刺五加、三棱和半枝莲混合后加8-12倍的水,煎煮1小时,再次加水至原料药总质量的10-12倍,再次煎煮2小时;第三次加水至总药量6-8倍,煎煮3次,每次1小时,提取过滤液,得到活性物质。本发明的制造方法简单,并且工艺不复杂,对于工艺环境的要求也不高,国内企业很容易制得,无需额外对生产设备进行投资和购买。本发明完全采用中药组份,具有抗抑郁、抗焦虑的功能,治疗抑郁症、焦虑症疗效确切、起效快。各个配方之间能够相互配合,发挥效力,而且对人体副作用较之西药降低很多,原料种类少,易于获得,并且无论在预防和/或治疗抑郁症还是在更年期综合症上都具有良好的效果。药物组合物具有疏肝健脾、解郁安神的功效,可有效地抗抑郁,并且价格低廉、易于较大范围地使用。
实施例2
治疗抑郁的中药组合物,其特征在于:将萱草花、郁金、红参、黄芪、柏子仁、蒺藜、刺五加、三棱和半枝莲混合后加8-12倍的水,煎煮1小时,再次加水至原料药总质量的10-12倍,再次煎煮2小时;第三次加水至总药量6-8倍,煎煮3次,每次1小时,提取过滤液,得到活性物质。所述萱草花50-70份,郁金20-35份,红参15-25份,黄芪10-20份,柏子仁15-20份,蒺藜22-35份。所述刺五加12-18份,三棱5-8份,半枝莲12-20份。本发明的制造方法简单,并且工艺不复杂,对于工艺环境的要求也不高,国内企业很容易制得,无需额外对生产设备进行投资和购买。本发明完全采用中药组份,具有抗抑郁、抗焦虑的功能,治疗抑郁症、焦虑症疗效确切、起效快。各个配方之间能够相互配合,发挥效力,而且对人体副作用较之西药降低很多,原料种类少,易于获得,并且无论在预防和/或治疗抑郁症还是在更年期综合症上都具有良好的效果。药物组合物具有疏肝健脾、解郁安神的功效,可有效地抗抑郁,并且价格低廉、易于较大范围地使用。
实施例3
治疗抑郁的中药组合物,其特征在于:将萱草花、郁金、红参、黄芪、柏子仁、蒺藜、刺五加、三棱和半枝莲混合后加8-12倍的水,煎煮1小时,再次加水至原料药总质量的10-12倍,再次煎煮2小时;第三次加水至总药量6-8倍,煎煮3次,每次1小时,提取过滤液,得到活性物质。所述萱草花60份,郁金28份,红参21份,黄芪14份,柏子仁18份,蒺藜30份。所述刺五加15份,三棱6份,半枝莲16份。本发明的制造方法简单,并且工艺不复杂,对于工艺环境的要求也不高,国内企业很容易制得,无需额外对生产设备进行投资和购买。本发明完全采用中药组份,具有抗抑郁、抗焦虑的功能,治疗抑郁症、焦虑症疗效确切、起效快。各个配方之间能够相互配合,发挥效力,而且对人体副作用较之西药降低很多,原料种类少,易于获得,并且无论在预防和/或治疗抑郁症还是在更年期综合症上都具有良好的效果。药物组合物具有疏肝健脾、解郁安神的功效,可有效地抗抑郁,并且价格低廉、易于较大范围地使用。
Claims (6)
1.治疗抑郁的中药组合物,其特征在于:将萱草花、郁金、红参、黄芪、柏子仁、蒺藜、刺五加、三棱和半枝莲混合后加8-12倍的水,煎煮1小时,再次加水至原料药总质量的10-12倍,再次煎煮2小时;第三次加水至总药量6-8倍,煎煮3次,每次1小时,提取过滤液,得到活性物质。
2.根据权利要求1所述的治疗抑郁的中药组合物,其特征在于:所述萱草花50-70份,郁金20-35份,红参15-25份,黄芪10-20份,柏子仁15-20份,蒺藜22-35份。
3.根据权利要求1所述的治疗抑郁的中药组合物,其特征在于:所述萱草花55-65份,郁金25-30份,红参17-23份,黄芪12-18份,柏子仁17-19份,蒺藜27-31份。
4.根据权利要求1所述的治疗抑郁的中药组合物,其特征在于:所述萱草花60份,郁金28份,红参21份,黄芪14份,柏子仁18份,蒺藜30份。
5.根据权利要求1所述的治疗抑郁的中药组合物,其特征在于:所述刺五加12-18份,三棱5-8份,半枝莲12-20份。
6.根据权利要求1所述的治疗抑郁的中药组合物,其特征在于:所述刺五加15份,三棱6份,半枝莲16份。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711372594.9A CN107970419A (zh) | 2017-12-19 | 2017-12-19 | 治疗抑郁的中药组合物的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711372594.9A CN107970419A (zh) | 2017-12-19 | 2017-12-19 | 治疗抑郁的中药组合物的制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107970419A true CN107970419A (zh) | 2018-05-01 |
Family
ID=62006923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711372594.9A Withdrawn CN107970419A (zh) | 2017-12-19 | 2017-12-19 | 治疗抑郁的中药组合物的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107970419A (zh) |
-
2017
- 2017-12-19 CN CN201711372594.9A patent/CN107970419A/zh not_active Withdrawn
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101934032B (zh) | 一种治疗糖尿病的中药复方外用制剂及其制备方法和应用 | |
CN111991480A (zh) | 用于预防新型冠状病毒肺炎感染的中药组合物 | |
CN101829182B (zh) | 一种治疗前列腺疾病的药物 | |
CN110507665A (zh) | 甘草酸在制备抗呼吸道病毒感染的药物中的应用 | |
CN107970419A (zh) | 治疗抑郁的中药组合物的制备方法 | |
CN110013502A (zh) | 一种防治急慢性鼻炎、鼻窦炎的组合物 | |
CN105232759B (zh) | 一种治疗鼻炎的药物组合物及其制备方法 | |
CN107582702A (zh) | 用于中医蜡疗的药蜡组合物及其制备方法 | |
CN104491828B (zh) | 一种温通止痛中药制剂及其膏剂制备方法 | |
CN102198182A (zh) | 一种治疗间质性肺炎的药物 | |
CN107582753A (zh) | 一种用于防治支气管哮喘的药物组合物 | |
CN102698202B (zh) | 一种用于治疗胆结石的中药组合物及其制备方法和应用 | |
Singh | Biochemical appraisal of Gomutra (Cow urine) | |
CN104510955A (zh) | 一种用于治疗脚气的中药组方 | |
CN107875354A (zh) | 治疗抑郁的中药组合物 | |
CN109692255A (zh) | 一种治疗急性气管-支气管炎的中药组合物及其制备方法和用途 | |
CN108339094A (zh) | 用于治疗冠心病的中药组合物及其制备方法 | |
CN103432204B (zh) | 一种用于治疗精神分裂症的中药有效部位组合物及其制备方法 | |
CN107823301A (zh) | 一种治疗灰指甲的外用药液及其制备方法 | |
CN102764421B (zh) | 一种褥疮膏 | |
CN101336990A (zh) | 一种治疗胆囊炎的药物 | |
CN102028832A (zh) | 一种治疗人体蠕形螨病的中药复方乳液及其制备方法 | |
CN1247222C (zh) | 治疗艾滋病的药物组合物 | |
CN101152361A (zh) | 治疗慢性单纯性鼻炎的中药 | |
Akter | A review on antidiabetic property of mangrove plants |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180501 |
|
WW01 | Invention patent application withdrawn after publication |