CN1079675C - External use drug made of hops and vegetable oil - Google Patents
External use drug made of hops and vegetable oil Download PDFInfo
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- CN1079675C CN1079675C CN97106530A CN97106530A CN1079675C CN 1079675 C CN1079675 C CN 1079675C CN 97106530 A CN97106530 A CN 97106530A CN 97106530 A CN97106530 A CN 97106530A CN 1079675 C CN1079675 C CN 1079675C
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Abstract
The present invention discloses an external application medicine of hop and vegetable oil, which is characterized in that the main components of the external application medicine are the alpha-acid and beta-acid of hop resin, wherein the alpha-acid is a general name of humulon and the allotrope thereof, the beta-acid is a general name of lupulone and the allotrope thereof. Solvents used are neutral vegetable oil, and main raw materials used are hop resin extract. A finished medicine product of the hop and vegetable oil is prepared by heating, sterilizing and cooling the neutral vegetable oil, preparing the cooled neutral vegetable oil with the hop resin extract together and grinding, emulsifying, filtering and filling the prepared neutral vegetable oil and hop resin extract.
Description
The present invention addresses a kind of external use drug made of hops and vegetable oil, is a kind of antibacterials that treatment ulcer skin ulcer is hindered, genus medical chemistry field of being exclusively used in.
Skin ulcers such as traditional treatment scald, burn, chronic ulcer, decubital ulcer are hindered medicines such as generally all using SD silver cold cream, ethacridine, though these medicines also have certain therapeutic effect, but its function is more single with effect, lack the integrated multifunctional therapeutical effect, lack special antibiotic anti-infection performance, and lack the effect that promotes wound convergence healing, accelerates the granulation tissue growth, promptly lack good removing the necrotic tissue and promoting granulation effect.Hops are that the formal name used at school of hops is Fols lupuli (latin name Humulus LupulusL. English name Hop), is the perennial climing property herbaceous plant of Cannabaceae Humulus as a kind of raw material of producing medicated beer.Hops are carried out deep processing can extract alpha-acid, the resin extractum that β-acid content is higher can be used for Beer Production.The peculiar chemical analysis of hops is hop resin, hop oil and polyphenol substance.Alpha-acid in the hop resin and β-acid have special medical function.According to data and performance study, can utilize alpha-acid and β-acid to make a kind of new antibacterials that the ulcer skin ulcer is hindered for the treatment of.Past people only is used for Beer Production with hop resin extractum, nowadays finds to utilize wherein the characteristic of alpha-acid and β-acid to make medicine after deliberation.
The object of the present invention is to provide a kind of external used medicine with multi-functional therapeutical effect, utilize alpha-acid and the special medicine effect of β-acid preparation in the hop resin to have higher anti-microbial property, can promote wound to restrain healing fast, have the medicine of new generation of good removing the necrotic tissue and promoting granulation effect.Another object of the present invention provides a kind of compounding process of making this novel drugs, enables to guarantee to obtain special good curative effect effect, and meets the specifications of quality of drug manufacture.
Above-mentioned purpose of the present invention is finished by following technical proposals.
Learn according to data and development test: the alpha-acid in the hop resin extractum and β-acid have following performance:
Alpha-acid is the general name of oxadiazon ex hoc genus anne isomeric compound, and it has extremely strong antiseptic power, and it is 3.3 times of potassium metabisulfite, is 41.7 times of sodium carbonate.
β-acid is the general name of .beta.-bitter acid ex hoc genus anne isomeric compound, and it can suppress gram-positive bacteria, and high concentration also can suppress gram-negative bacteria.
The chemical structural formula of alpha-acid and β-acid ex hoc genus anne isomeric compound is as follows:
Alpha-acid β-acid
Oxadiazon ex hoc genus anne isomeric compound .beta.-bitter acid ex hoc genus anne isomeric compound
R representative-CO-R ' acyl group in the formula (containing the acyl group that different R ' substitute gene)
Hops are carried out deep processing extract gained hop resin extractum, alpha-acid wherein and β-acid are the main chemical of medicine.
The prescription and the scope thereof of external use drug made of hops and vegetable oil of the present invention are as follows:
Indeterminate plant oil (solvent) 100 grams
Alpha-acid extractum 2～6 grams (2～6%)
β-acidleach cream 2～7 grams (2～7%)
Perhaps adopt following prescription:
Indeterminate plant oil (solvent) 100 grams
Hop resin extractum 4～12 grams (4～12%)
Above-mentioned percent by weight (%) serves as to calculate benchmark with solvent indeterminate plant oil all.
The compound method of external use drug made of hops and vegetable oil of the present invention is as follows:
Indeterminate plant oil through the pasteurization postcooling, with alpha-acid and β-acidleach cream, is perhaps lumped together with the assembly of hop resin extractum, through grinding and emulsify at a high speed, the extractum middle acid substance is dissolved in the indeterminate plant oil, behind the filter and remove residue, dresses up drug made of hops and vegetable oil medicine finished product then.Whole process for preparation is from batching, grinding, emulsifying, be filled into fill and must carry out 10,000 grades of clean room's environment.
External use drug made of hops and vegetable oil of the present invention has obvious antibacterial action and promotes granulation growth effect, the wound that can be used for bacterial infections such as tubercule bacillus, bacillus pyocyaneus, staphylococcus aureus, Bacillus proteus, escherichia coli, also have to reduce and ooze out, add rapid convergence, promote the granulation tissue growth of wound, the edge of a knife, the open sore part, the effect that promptly has removing the necrotic tissue and promoting granulation, to the infection of the postoperative edge of a knife, skin ulcer wound and healing and to the bacterial infection that prevents of decubital ulcer, scald, burn, preventing suppurates to ooze out all obvious effects.In addition,, be difficult for adhesion, have the better protect effect evident in efficacy the skin ulcer mask because medicinal liquid moistens.
Now with drug made of hops and vegetable oil of the present invention at Shanghai Huashan Hospital's surgery; Shanghai Medical Univ's Kingsoft hospital burn department; Shanghai Chinese Medicine Hospital, the clinical test results of units such as attached Yueyang hospital of Shuguang Hospital and Shanghai Univ. of Traditional Chinese Medicine are slightly remembered in the back:
One, Shanghai Huashan Hospital's surgical clinical uses drug made of hops and vegetable oil of the present invention totally 20 routine cases, the appraisal standards branch: produce effects, effective, invalid three grades, and the result shows, 14 routine produce effects, 5 examples are effective, and 1 example is invalid, and total effective rate reaches 95%.
Two, Shanghai Medical Univ Kingsoft hospital burn department contrasts drug made of hops and vegetable oil and the traditional SD-Ag frost therapeutic effect to 2 degree burns, making 20 routine case results altogether shows, both curative effect zero differences, stimulation is significantly less than the SD-Ag frost but drug made of hops and vegetable oil is to wound surface, for later stage infection granulation wound, drug made of hops and vegetable oil has obvious bacteriostasis, can shorten wound healing time, promote granulation and epithelial growth, can give full play to the effect of removing the necrotic tissue and promoting granulation.
Three, the Shanghai Chinese Medicine Hospital is used in treatment sores ulceration of skin 26 examples to drug made of hops and vegetable oil of the present invention, and clinical efficacy is comparatively desirable.Efficacy determination is divided into recovery from illness, produce effects, effective, invalid four grades.The result shows, 23 examples of fully recovering, and effective 1 example, invalid 2 examples, promptly cure rate is 88.5%, and effective percentage is 3.8%, and inefficiency is 7.7%.After the drug made of hops and vegetable oil treatment, total effective rate reaches 92.3%.Further the proof drug made of hops and vegetable oil can be used for the bacterial infection wound surface, has certain antibacterial action.
Four, Shuguang Hospital is to chronic skin infection 27 examples of drug made of hops and vegetable oil treatment skin of the present invention, and clinical efficacy is comparatively satisfied.Criterion of therapeutical effect is divided into recovery from illness, produce effects, effective, invalid four grades.The result shows, 11 examples of fully recovering, produce effects 8 examples, effective 6 examples, invalid 2 examples.The clinical total effective rate of this group case reaches 92.6% by statistics.
Five, the attached Yueyang of Shanghai Univ. of Traditional Chinese Medicine hospital application drug made of hops and vegetable oil treatment of the present invention skin ulcer 25 examples obtain better curative effect.Criterion of therapeutical effect is divided into recovery from illness, produce effects, effective, invalid four grades.The result shows, 13 examples of fully recovering, and produce effects 6 examples, effective 5 examples, invalid 1 example, total effective rate reaches 96%.Prove that this oil preparation has stronger bacteriostasis to antibacterial, particularly to mushrooms such as staphylococcus aureuses, antibacterial effect is obvious, and can promote granulation growth effect.
Above various big hospital is made faces application test, has convincingly demonstrated antibiotic property and removing the necrotic tissue and promoting granulation effect and the significant curative effect of Lupulin agent of the present invention to skin ulcer wound, ulcer, wound, decubital ulcer, burn, the various infectious skin ulcer faces of scald etc.
Now the embodiment of the invention is described in down:
Embodiment one
In 100 gram indeterminate plant oil, allocate 2 gram alpha-acid extractum into, 2 gram β-acidleach cream, perhaps add 4 gram hop resin extractum, after being fitted in together, through grinding and emulsify at a high speed, the extractum middle acid substance is dissolved in the indeterminate plant oil, then filter and remove residue, fill becomes drug made of hops and vegetable oil medicine finished product again, and whole process for preparation carries out in 10,000 grades of clean rooms.Indeterminate plant oil must use after the pasteurization cooling in advance.By the medicine of this formula proportion gained, through application test, the result still can, general equal the use, its therapeutic effect is general.
Embodiment two
Indeterminate plant oil heat kill bacterium and cooling back is stand-by.Get 100 gram indeterminate plant oil, make itself and 6 gram alpha-acid extractum and 7 restrain β-acidleach cream, perhaps be combined together with 12 gram hop resin extractum, through grinding and emulsify at a high speed, the extractum middle acid substance is dissolved in the indeterminate plant oil, filter and remove residue then, fill becomes drug made of hops and vegetable oil medicine finished product.Whole process for preparation carries out in 10,000 grades of clean rooms.By the medicine of this formula proportion gained, through application test, the result also still can, general equal the use, its therapeutic effect is general.
Embodiment three
Prepare with quadrat method by above-mentioned, but its formula proportion is as follows:
Indeterminate plant oil (solvent) 100 grams
Alpha-acid extractum 3～4 grams
β-acidleach cream 3～4.5 grams or the following prescription of employing:
Indeterminate plant oil (solvent) 100 grams
Hop resin extractum 5～7 grams
This prescription is best proportioning of the present invention, and preparing process is same as the previously described embodiments.The clinical trial of doing at various big hospital proves that the drug made of hops and vegetable oil medicine of this prescription gained is the pharmaceutical preparation that optimum is used, and its therapeutic effect is described in the above-mentioned relevant content of good effect of the present invention.
Claims (3)
1, a kind of external use drug made of hops and vegetable oil is characterized in that medicine is dissolved in the indeterminate plant oil by hop resin extractum to constitute, and by weight percentage, it consists of:
Hop resin extractum 5-7%,
Surplus is an indeterminate plant oil.
2, external use drug made of hops and vegetable oil according to claim 1, it is characterized in that extract .alpha.-bitter acid ex hoc genus anne isomeric compound extractum by in the hops and .beta.-bitter acid ex hoc genus anne isomeric compound extractum is dissolved in the indeterminate plant oil constitutes, by weight percentage, it consists of:
.alpha.-bitter acid ex hoc genus anne isomeric compound extractum: 3～4%,
.beta.-bitter acid ex hoc genus anne isomeric compound extractum: 3～4.5%,
Surplus is an indeterminate plant oil.
3, a kind of compound method according to the described external use drug made of hops and vegetable oil of claim 1, it is characterized in that preparation steps is: indeterminate plant oil is through the pasteurization postcooling, add hop resin extractum by selected proportioning, through grinding and emulsify at a high speed, the extractum middle acid substance is dissolved in the indeterminate plant oil, then filter and remove residue, no granule exists, the fill finished product, whole process for preparation is from batching, grinding, emulsifying, be filtered to fill and must carry out 10,000 grades of clean room's environment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97106530A CN1079675C (en) | 1997-07-23 | 1997-07-23 | External use drug made of hops and vegetable oil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97106530A CN1079675C (en) | 1997-07-23 | 1997-07-23 | External use drug made of hops and vegetable oil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1176122A CN1176122A (en) | 1998-03-18 |
| CN1079675C true CN1079675C (en) | 2002-02-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97106530A Expired - Fee Related CN1079675C (en) | 1997-07-23 | 1997-07-23 | External use drug made of hops and vegetable oil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1079675C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104117049B (en) * | 2014-07-30 | 2017-12-08 | 马健 | One kind treats Bromhidrosis treating paste |
| CZ309266B6 (en) * | 2021-04-19 | 2022-06-29 | Výzkumný ústav potravinářský Praha, v.v.i. | Beta acid from hops for hard to heal wounds as a substitute for antibiotics |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4222138Y1 (en) * | 1964-09-21 | 1967-12-18 | ||
| JPS5959623A (en) * | 1982-09-29 | 1984-04-05 | Daigo Eiyou Kagaku Kk | Antidiabetic agent |
| CN1060964A (en) * | 1990-10-29 | 1992-05-13 | 洛洪程 | A kind of preparation method of thermal burn medicine |
| CN1096509A (en) * | 1994-01-15 | 1994-12-21 | 沈阳佳源国际医疗科技有限公司 | The method for preparing tetrahydro-iso-humulone by hop extract |
-
1997
- 1997-07-23 CN CN97106530A patent/CN1079675C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4222138Y1 (en) * | 1964-09-21 | 1967-12-18 | ||
| JPS5959623A (en) * | 1982-09-29 | 1984-04-05 | Daigo Eiyou Kagaku Kk | Antidiabetic agent |
| CN1060964A (en) * | 1990-10-29 | 1992-05-13 | 洛洪程 | A kind of preparation method of thermal burn medicine |
| CN1096509A (en) * | 1994-01-15 | 1994-12-21 | 沈阳佳源国际医疗科技有限公司 | The method for preparing tetrahydro-iso-humulone by hop extract |
Non-Patent Citations (1)
| Title |
|---|
| 《中医信息》(3) 1997.3.31 王春阳等，中药啤酒花的生药鉴定 * |
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| Publication number | Publication date |
|---|---|
| CN1176122A (en) | 1998-03-18 |
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Owner name: SHANGHAI GUANSHENGYUAN HUAGUANG BREWERY PHARMACEUT Free format text: FORMER NAME OR ADDRESS: HUAGUANG BREWAGE PHARMACY CO., LTD., SHANGHAI |
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Patentee after: Guanshengyuan Huaguang Brewage & Pharmacy Co., Ltd., Shanghai Patentee before: Huaguang Brewage Pharmacy Co., Ltd., Shanghai |
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