CN107961352A - A kind of preparation method of compound Moschus injection - Google Patents
A kind of preparation method of compound Moschus injection Download PDFInfo
- Publication number
- CN107961352A CN107961352A CN201711258205.XA CN201711258205A CN107961352A CN 107961352 A CN107961352 A CN 107961352A CN 201711258205 A CN201711258205 A CN 201711258205A CN 107961352 A CN107961352 A CN 107961352A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- preparation
- compound moschus
- moschus injection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation method of compound Moschus injection, first by muscone, Pogostemon cablin, Radix Curcumae and grass-leaved sweetflag pass through fore-running, it is spare that redistillation obtains re-distilled liquid refrigeration, then by borneol, the mixed dissolution in absolute ethyl alcohol is uniform with stearic acid for menthol, it is slowly added to pass through high-speed stirred in the mixed liquor of polyoxyethylene sorbitan monoleate and water for injection, vacuum distillation and high-pressure homogeneous emulsification obtain composite Nano lotion, finally re-distilled liquid is mixed with composite Nano lotion, add activated carbon refrigerated overnight, charcoal is taken off through stud coarse filtration, it is filtered again, embedding, sterilizing, lamp inspection, packaging, storage, obtain compound Moschus injection.Compound Moschus injection prepared by the present invention not only has the advantages that dispersiveness and stability are good, but also toxic side effect is low, and using effect is good.
Description
Technical field
The present invention relates to technical field of medicine, more particularly to a kind of preparation method of compound Moschus injection.
Background technology
The main component of compound Moschus injection includes muscone, Radix Curcumae, Pogostemon cablin, grass-leaved sweetflag, borneol, menthol,
With eliminating phlegm for resuscitation, the effect of refreshment and tranquilization, the treatment for the apoplectic coma being mainly used for caused by being closed in phlegm heat.At present, compound musk deer
The preparation method of fragrant parenteral solution is to collect muscone, Pogostemon cablin, Radix Curcumae, grass-leaved sweetflag after just distillation, redistillation to steam again
Distillate, borneol, menthol are dissolved with re-distilled liquid, then diluted, filtered with water for injection, sterilizing obtains.But due to wherein
Borneol, the principle active component poorly water-soluble such as menthol, cause parenteral solution stability prepared by conventional method not good enough；And
The components such as borneol have certain toxicity, and obtained compound Moschus injection has certain side effect.Therefore, it is necessary to existing
Some compound Moschus injection preparation methods make improvements.
The content of the invention
A kind of the defects of the object of the invention is exactly to make up prior art, there is provided preparation side of compound Moschus injection
Method.
The present invention is achieved by the following technical solutions：
A kind of preparation method of compound Moschus injection, comprises the following steps：
（1）By 2-2.5 parts by weight muscone, 25-30 parts by weight Pogostemon cablin, 25-30 parts by weight Radix Curcumae and 25-30 parts by weight stones
Calamus adds water of 8-10 times equivalent to medicinal material gross weight, opens steam distillation to equivalent to 4-6 times of medicinal material gross weight, obtains fore-running
Liquid, then redistillation is carried out to equivalent to 2.5-3.5 times of medicinal material gross weight, obtained re-distilled liquid is refrigerated spare；
（2）0.2-0.25 parts by weight borneol, 0.15-0.2 parts by weight menthol are added into the common addition anhydrous second of 20-25 parts by weight
It is uniformly dissolved in alcohol, then adds 0.5-1 parts by weight stearic acid and stir 3-5min in 50-60 DEG C, be then slowly added into 5-6 weight
The mixed liquor high speed of part Tween-80 and 250-300 parts by weight waters for injection stirs evenly, and first vacuum distillation removes second
Alcohol, then high-pressure homogeneous emulsification, obtains composite Nano lotion；
（3）By step（1）Obtained re-distilled liquid and step（2）Obtained composite Nano lotion is uniformly mixed, and then uses hydrogen-oxygen
Change sodium solution and pH is adjusted to 6.0-7.0, add 0.05-0.1 parts by weight of activated carbon, refrigerated overnight, takes off charcoal through stud coarse filtration, then passes through
Filter element filtering, inflated with nitrogen embedding, sterilizing, lamp inspection, is packed, and storage, obtains compound Moschus injection.
The step（2）In high-speed stirred rotating speed be 1000-1500r/min.
The step（2）In the pressure of high-pressure homogeneous emulsification be 100-1000bar.
The concentration of the sodium hydroxide solution is 3-5%.
The step（3）The step of middle filtering is to first pass through 0.45um coarse filtration, then by 0.22um refined filtrations.
The step（3）In sterilising conditions be 115-121 DEG C, 15-30min.
It is an advantage of the invention that：
It is standby that muscone, Pogostemon cablin, Radix Curcumae and grass-leaved sweetflag are first obtained re-distilled liquid refrigeration by the present invention by fore-running, redistillation
With then by borneol, menthol and stearic acid, mixed dissolution is uniform in absolute ethyl alcohol, is slowly added to Tween-80 and note
Penetrate in the mixed liquor with water and obtain composite Nano lotion by high-speed stirred, vacuum distillation and high-pressure homogeneous emulsification, finally will weight
Distillate mixes with composite Nano lotion, adds activated carbon refrigerated overnight, takes off charcoal through stud coarse filtration, then filtered, embedding, goes out
Bacterium, lamp inspection, packaging, storage, obtain compound Moschus injection.The present invention by borneol, menthol and stearic acid by being dissolved in nothing
In water-ethanol, then add surfactant aqueous solution in, stearic acid is formed a film, then by high-speed stirred, vacuum distillation and
High-pressure homogeneous emulsification, forms the medicament nano lotion of stearic acid parcel, effectively increases borneol, menthol active ingredient in water
Dispersiveness and stability, and realize slow-release function, reduce too fast, excessive contacting drug induced toxic side effect.This hair
The compound Moschus injection of bright preparation not only has the advantages that dispersiveness and stability are good, but also toxic side effect is low, using effect
It is good.
Embodiment
A kind of preparation method of compound Moschus injection, comprises the following steps：
（1）2kg muscones, 25kg Pogostemon cablin, 25kg Radix Curcumaes and 25kg grass-leaved sweetflags are added equivalent to 8 times of medicinal material gross weight
Water, opens steam distillation to equivalent to 4 times of medicinal material gross weight, obtains just distillate, then carry out redistillation to equivalent to medicinal material gross weight
2.5 times, obtained re-distilled liquid is refrigerated spare；
（2）0.2kg borneols, 0.15kg menthols are added common add in 20kg absolute ethyl alcohols to be uniformly dissolved, then added
0.5kg stearic acid stirs 3min in 50 DEG C, is then slowly added into the mixed liquor of 5kg Tween-80s and 250kg waters for injection
High-speed stirred is uniform, and first vacuum distillation removes ethanol, and then high-pressure homogeneous emulsification, obtains composite Nano lotion；
（3）By step（1）Obtained re-distilled liquid and step（2）Obtained composite Nano lotion is uniformly mixed, and then uses hydrogen-oxygen
Change sodium solution and pH is adjusted to 6.0, add 0.05kg activated carbons, then add refrigerated overnight, take off charcoal through stud coarse filtration, then through filter core
Filtering, inflated with nitrogen embedding, sterilizing, lamp inspection, is packed, and storage, obtains compound Moschus injection.
The step（2）In high-speed stirred rotating speed be 1000r/min.
The step（2）In the pressure of high-pressure homogeneous emulsification be 100bar.
The concentration of the sodium hydroxide solution is 5%.
The step（3）The step of middle filtering is to first pass through 0.45um coarse filtration, then by 0.22um refined filtrations.
The step（3）In sterilising conditions be 115 DEG C, 30min.
Claims (6)
1. a kind of preparation method of compound Moschus injection, it is characterised in that comprise the following steps：
（1）By 2-2.5 parts by weight muscone, 25-30 parts by weight Pogostemon cablin, 25-30 parts by weight Radix Curcumae and 25-30 parts by weight stones
Calamus adds water of 8-10 times equivalent to medicinal material gross weight, opens steam distillation to equivalent to 4-6 times of medicinal material gross weight, obtains fore-running
Liquid, then redistillation is carried out to equivalent to 2.5-3.5 times of medicinal material gross weight, obtained re-distilled liquid is refrigerated spare；
（2）0.2-0.25 parts by weight borneol, 0.15-0.2 parts by weight menthol are added into the common addition anhydrous second of 20-25 parts by weight
It is uniformly dissolved in alcohol, then adds 0.5-1 parts by weight stearic acid and stir 3-5min in 50-60 DEG C, be then slowly added into 5-6 weight
The mixed liquor high speed of part Tween-80 and 250-300 parts by weight waters for injection stirs evenly, and first vacuum distillation removes second
Alcohol, then high-pressure homogeneous emulsification, obtains composite Nano lotion；
（3）By step（1）Obtained re-distilled liquid and step（2）Obtained composite Nano lotion is uniformly mixed, and then uses hydrogen-oxygen
Change sodium solution and pH is adjusted to 6.0-7.0, add 0.05-0.1 parts by weight of activated carbon, refrigerated overnight, takes off charcoal through stud coarse filtration, then passes through
Filter element filtering, inflated with nitrogen embedding, sterilizing, lamp inspection, is packed, and storage, obtains compound Moschus injection.
A kind of 2. preparation method of compound Moschus injection according to claim 1, it is characterised in that the step（2）
In high-speed stirred rotating speed be 1000-1500r/min.
A kind of 3. preparation method of compound Moschus injection according to claim 1, it is characterised in that the step（2）
In the pressure of high-pressure homogeneous emulsification be 100-1000bar.
A kind of 4. preparation method of compound Moschus injection according to claim 1, it is characterised in that the sodium hydroxide
The concentration of solution is 3-5%.
A kind of 5. preparation method of compound Moschus injection according to claim 1, it is characterised in that the step（3）
The step of middle filtering is to first pass through 0.45um coarse filtration, then by 0.22um refined filtrations.
A kind of 6. preparation method of compound Moschus injection according to claim 1, it is characterised in that the step（3）
In sterilising conditions be 115-121 DEG C, 15-30min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711258205.XA CN107961352A (en) | 2017-12-04 | 2017-12-04 | A kind of preparation method of compound Moschus injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711258205.XA CN107961352A (en) | 2017-12-04 | 2017-12-04 | A kind of preparation method of compound Moschus injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107961352A true CN107961352A (en) | 2018-04-27 |
Family
ID=61999259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711258205.XA Pending CN107961352A (en) | 2017-12-04 | 2017-12-04 | A kind of preparation method of compound Moschus injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107961352A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109350671A (en) * | 2018-11-13 | 2019-02-19 | 禹州市中医院 | It is a kind of for treating the compound Houttuynia cordata injection of tympanitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1891287A (en) * | 2005-07-08 | 2007-01-10 | 张晴龙 | Nano compound musk injection preparion, and its preparing method |
| CN102188664A (en) * | 2010-03-16 | 2011-09-21 | 博安兄弟制药（中国）有限公司 | Method for preparing compound musk injection |
| CN104117007A (en) * | 2013-04-26 | 2014-10-29 | 成都力思特制药股份有限公司 | Polyoxyethylene-660-12-hydroxy stearate containing compound musk injection preparation and preparation method thereof |
-
2017
- 2017-12-04 CN CN201711258205.XA patent/CN107961352A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1891287A (en) * | 2005-07-08 | 2007-01-10 | 张晴龙 | Nano compound musk injection preparion, and its preparing method |
| CN102188664A (en) * | 2010-03-16 | 2011-09-21 | 博安兄弟制药（中国）有限公司 | Method for preparing compound musk injection |
| CN104117007A (en) * | 2013-04-26 | 2014-10-29 | 成都力思特制药股份有限公司 | Polyoxyethylene-660-12-hydroxy stearate containing compound musk injection preparation and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109350671A (en) * | 2018-11-13 | 2019-02-19 | 禹州市中医院 | It is a kind of for treating the compound Houttuynia cordata injection of tympanitis |
| CN109350671B (en) * | 2018-11-13 | 2021-04-06 | 禹州市中医院 | Compound houttuynia cordata injection for treating otitis media |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR072858A1 (en) | HIGH DENSITY COMPOSITIONS CONTAINING POSACONAZOL AND FORMULATIONS THAT INCLUDE IT | |
| CN104586758B (en) | A kind of paracetamol injection determined and preparation method thereof | |
| CN107961352A (en) | A kind of preparation method of compound Moschus injection | |
| CN101422277A (en) | Method for adjusting and controlling nicotine content in tobacco extract | |
| CN104323987A (en) | Mequindox injection and preparation method thereof | |
| CN102836123A (en) | Injection containing levetiracetam active ingredient and technology for preparing injection | |
| CN103565760A (en) | Fosaprepitant dimeglumine freeze-dried powder and preparation method thereof | |
| EP4097022A1 (en) | Non-crystallizing cannabidiol blends | |
| CN108938826A (en) | The method that tea polyphenols are extracted using resin adsorption | |
| CN102552136A (en) | Propofol medium/long-chain injection and preparation method thereof | |
| CN100417381C (en) | Nicorandil freeze-drying powder preparation method | |
| CN103239397B (en) | Oxiracetam injection composition and preparation method thereof | |
| CN103127036A (en) | Method for preparing film agent by using chitosan and Arabic gum as matrix | |
| CN109170806B (en) | Method for reducing ethyl carbamate formation in fermented food production process | |
| CN108272695A (en) | A kind of extracting method of tea polyphenols for cosmetics | |
| CN107865784A (en) | A kind of nanosized micelles toner based on collaboration whitening function | |
| CN103405361A (en) | Perfume containing durian fruit shell | |
| CN107115349A (en) | A kind of vitaminAD E microemulsion injections for animals and preparation method thereof | |
| CN105669780A (en) | Method for raising polyphenol content and water-solubility of grape seed extract | |
| CN105079107A (en) | Medicine composite of honeysuckle hydrochloric acid extract injection and preparation method thereof | |
| CN105770852A (en) | Preparation method of compound amino acid injection containing peptides | |
| CN103655477A (en) | Entecavir high-density lipoprotein enveloping preparation, and preparation method and use thereof | |
| CN103622932B (en) | The preparation method of a kind of antihistamine and hypnotic soft capsule | |
| CN104382984A (en) | Method for preparing medicinal extract containing intermediate peashrub seeds | |
| PH12018050517A1 (en) | Ribavirin pharmaceutical composition for injection, its preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180427 |